LOCUS       NM_182762               9153 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MET transcriptional regulator MACC1 (MACC1), mRNA.
ACCESSION   NM_182762 XM_294213 XM_353564
VERSION     NM_182762.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9153)
  AUTHORS   Gao,S., Zhang,H., Zhang,X., Wang,J., Bai,W. and Jiang,B.
  TITLE     COX19 Is a New Target of MACC1 and Promotes Colorectal Cancer
            Progression by Regulating Copper Transport in Mitochondria
  JOURNAL   J Nutr 154 (2), 381-394 (2024)
   PUBMED   38141772
  REMARK    GeneRIF: COX19 Is a New Target of MACC1 and Promotes Colorectal
            Cancer Progression by Regulating Copper Transport in Mitochondria.
REFERENCE   2  (bases 1 to 9153)
  AUTHORS   Schmid,F., Dahlmann,M., Rohrich,H., Kobelt,D., Hoffmann,J.,
            Burock,S., Walther,W. and Stein,U.
  TITLE     Calcium-binding protein S100P is a new target gene of MACC1, drives
            colorectal cancer metastasis and serves as a prognostic biomarker
  JOURNAL   Br J Cancer 127 (4), 675-685 (2022)
   PUBMED   35597866
  REMARK    GeneRIF: Calcium-binding protein S100P is a new target gene of
            MACC1, drives colorectal cancer metastasis and serves as a
            prognostic biomarker.
REFERENCE   3  (bases 1 to 9153)
  AUTHORS   Wang,W., Jin,W., Liu,X. and Zheng,L.
  TITLE     Circ_0002577/miR-126-5p/MACC1 axis promotes endometrial carcinoma
            progression by regulation of proliferation, migration, invasion,
            and apoptosis of endometrial carcinoma cells
  JOURNAL   Arch Gynecol Obstet 306 (2), 481-491 (2022)
   PUBMED   35103833
  REMARK    GeneRIF: Circ_0002577/miR-126-5p/MACC1 axis promotes endometrial
            carcinoma progression by regulation of proliferation, migration,
            invasion, and apoptosis of endometrial carcinoma cells.
REFERENCE   4  (bases 1 to 9153)
  AUTHORS   Shi,Y., Li,M.Y., Wang,H., Li,C., Liu,W.Y., Gao,Y.M., Wang,B.,
            Song,J.W. and Ma,Y.Q.
  TITLE     The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and
            Prognosis in ESCC
  JOURNAL   Anal Cell Pathol (Amst) 2022, 9651503 (2022)
   PUBMED   35242498
  REMARK    GeneRIF: The Relationship between MACC1/c-Met/Cyclin D1 Axis
            Expression and Prognosis in ESCC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9153)
  AUTHORS   Bahr,I., Jaeschke,L., Nimptsch,K., Janke,J., Herrmann,P.,
            Kobelt,D., Kielstein,H., Pischon,T. and Stein,U.
  TITLE     Obesity, colorectal cancer and MACC1 expression: A possible novel
            molecular association
  JOURNAL   Int J Oncol 60 (2) (2022)
   PUBMED   35014688
  REMARK    GeneRIF: Obesity, colorectal cancer and MACC1 expression: A
            possible novel molecular association.
REFERENCE   6  (bases 1 to 9153)
  AUTHORS   Stein,U., Dahlmann,M. and Walther,W.
  TITLE     MACC1 - more than metastasis? Facts and predictions about a novel
            gene
  JOURNAL   J Mol Med (Berl) 88 (1), 11-18 (2010)
   PUBMED   19787327
  REMARK    GeneRIF: Summarized are MACC1 genomic localization and
            organization, its predicted splice variants, and single nucleotide
            polymorphisms, predicted expressions of MACC1 in normal and
            malignant human tissues.
            Review article
REFERENCE   7  (bases 1 to 9153)
  AUTHORS   Voss,M., Lettau,M. and Janssen,O.
  TITLE     Identification of SH3 domain interaction partners of human FasL
            (CD178) by phage display screening
  JOURNAL   BMC Immunol 10, 53 (2009)
   PUBMED   19807924
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 9153)
  AUTHORS   Stein,U., Smith,J., Walther,W. and Arlt,F.
  TITLE     MACC1 controls Met: what a difference an Sp1 site makes
  JOURNAL   Cell Cycle 8 (15), 2467-2469 (2009)
   PUBMED   19556890
  REMARK    GeneRIF: MACC1 acts via a specific consensus sequence of the Met
            promoter, described as an Sp1 binding site.
REFERENCE   9  (bases 1 to 9153)
  AUTHORS   Stein,U., Walther,W., Arlt,F., Schwabe,H., Smith,J., Fichtner,I.,
            Birchmeier,W. and Schlag,P.M.
  TITLE     MACC1, a newly identified key regulator of HGF-MET signaling,
            predicts colon cancer metastasis
  JOURNAL   Nat Med 15 (1), 59-67 (2009)
   PUBMED   19098908
REFERENCE   10 (bases 1 to 9153)
  AUTHORS   Kokoszynska,K., Krynski,J., Rychlewski,L. and Wyrwicz,L.S.
  TITLE     Unexpected domain composition of MACC1 links MET signaling and
            apoptosis
  JOURNAL   Acta Biochim Pol 56 (2), 317-323 (2009)
   PUBMED   19499089
  REMARK    GeneRIF: study revealed MACC1 protein consists of 4 domains: ZU5,
            SH3 & 2 C-terminal death domains; bioinformatic analysis indicates
            MACC1, besides its involvement in signal transduction from the MET
            receptor, links MET signaling & apoptosis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131400.1, AJ313524.1, AC007001.2 and CB240872.1.
            
            On May 17, 2019 this sequence version replaced NM_182762.3.
            
            Summary: MACC1 is a key regulator of the hepatocyte growth factor
            (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway,
            which is involved in cellular growth, epithelial-mesenchymal
            transition, angiogenesis, cell motility, invasiveness, and
            metastasis. Expression of MACC1 in colon cancer (MIM 114500)
            specimens is an independent prognostic indicator for metastasis
            formation and metastasis-free survival (Stein et al., 2009 [PubMed
            19098908]).[supplied by OMIM, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131400.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400331.10/ ENSP00000383185.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AK131400.1         7-309
            304-2862            AJ313524.1         1-2559
            2863-8588           AC007001.2         3504-9229
            8589-9153           CB240872.1         9-573               c
FEATURES             Location/Qualifiers
     source          1..9153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..9153
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="MET transcriptional regulator MACC1"
                     /db_xref="GeneID:346389"
                     /db_xref="HGNC:HGNC:30215"
                     /db_xref="MIM:612646"
     exon            1..86
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            87..151
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            152..295
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            296..418
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2862
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="putative binding protein 7a5; SH3 domain-containing
                     protein 7a5; metastasis associated in colon cancer 1;
                     MACC1, MET transcriptional regulator"
                     /codon_start=1
                     /product="metastasis-associated in colon cancer protein 1"
                     /protein_id="NP_877439.3"
                     /db_xref="CCDS:CCDS5369.1"
                     /db_xref="GeneID:346389"
                     /db_xref="HGNC:HGNC:30215"
                     /db_xref="MIM:612646"
                     /translation="MLITERKHFRSGRIAQSMSEANLIDMEAGKLSKSCNITECQDPD
                     LLHNWPDAFTLRGNNASKVANPFWNQLSASNPFLDDITQLRNNRKRNNISILKEDPFL
                     FCREIENGNSFDSSGDELDVHQLLRQTSSRNSGRSKSVSELLDILDDTAHAHQSIHNS
                     DQILLHDLEWLKNDREAYKMAWLSQRQLARSCLDLNTISQSPGWAQTQLAEVTIACKV
                     NHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPHMLNHDLSCTVSPLLEIM
                     LGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPFKVLSNCYIYKDTIQ
                     VKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSFTVVLTVCG
                     HNYMPGQLTISDIKKGGKNISPVVFQLWGKQSFLLDKPQDLSISIFSCDPDFEVKTEG
                     ERKEIKQKQLEAGEVVHQQFLFSLVEHREMHLFDFCVQVEPPNGEPVAQFSITTPDPT
                     PNLKRLSNLPGYLQKKEEIKSAPLSPKILVKYPTFQDKTLNFSNYGVTLKAVLRQSKI
                     DYFLEYFKGDTIALLGEGKVKAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMF
                     MSDSVFTTRNLLEQIVLPLKKLTYIYSVVLTLVSEKVYDWKVLADVLGYSHLSLEDFD
                     QIQADKESEKVSYVIKKLKEDCHTERNTRKFLYELIVALLKMDCQELVARLIQEAAVL
                     TSAVKLGKGWRELAEKLVRLTKQQMEAYEIPHRGNTGDVAVEMMWKPAYDFLYTWSAH
                     YGNNYRDVLQDLQSALDRMKNPVTKHWRELTGVLILVNSLEVLRVTAFSTSEEV"
     exon            419..2460
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2649
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..9153
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7388..7393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="hexamer: AATAAA"
     polyA_site      7411
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="major polyA site"
     regulatory      8488..8493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="hexamer: AATAAA"
     regulatory      8504..8509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="hexamer: AATAAT"
     polyA_site      8508
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="major polyA site"
     polyA_site      8526
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
     regulatory      8567..8572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="hexamer: AATAAA"
     polyA_site      8588
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
     regulatory      8766..8771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
                     /note="hexamer: AATACA"
     polyA_site      8789
                     /gene="MACC1"
                     /gene_synonym="7A5; SH3BP4L"
ORIGIN      
        1 gaagagtacc cgggtttggt agagtgactt ctattcacta aaaccatgtg tctgaactga
       61 agaagcttgg gctcacttcc acaaatgtag ccttgtcaga tgatatgcaa atgattcaca
      121 tcagtgtttg aagttcaaac caaggaaaac tatcagaaaa ggcttctgct ttctttaaaa
      181 aataaaacta cttgaaaaga aaaaaatcaa gaattagaaa gaagagtata acaataaaga
      241 aggaggggtc acaggtgaac gagatgtggt caacacacac aaaggagaac aaaaagtgga
      301 aaaatgctaa tcactgaaag aaaacatttt cggtcaggaa gaattgcaca aagtatgtct
      361 gaagcaaatt tgattgacat ggaagctgga aaactctcaa aaagttgcaa tattacagaa
      421 tgccaggacc cagacttgct tcacaattgg ccggatgctt tcacccttcg tggtaataat
      481 gcttccaaag ttgcaaatcc attctggaat caactgtctg cttctaaccc atttttggat
      541 gacataactc aactaagaaa taacaggaag agaaataata tttccatctt aaaggaagat
      601 ccttttcttt tctgtagaga aatagaaaat ggaaattctt ttgattcctc cggtgatgaa
      661 cttgatgtgc atcagttact taggcagact tcctcaagaa attctggaag atctaaaagt
      721 gtttcagaac ttctggacat tttagacgac acagcacatg cccatcagag tatacataac
      781 tctgaccaga tcctactaca cgacttagag tggcttaaaa atgatcggga ggcttataaa
      841 atggcttggt taagtcaacg ccagctggcc cgctcctgcc ttgatttgaa tacaattagt
      901 cagagccctg gatgggccca gacacaactt gcggaggtca ccatagcttg caaagtaaac
      961 catcaaggag ggtcagtaca attacctgaa tcagacatca ctgttcatgt gccccaaggt
     1021 catgtggctg tgggagaatt ccaagaggtg tctctaaggg ctttccttga tccgccacac
     1081 atgcttaacc atgatctttc gtgcactgtg agcccgttgt tggaaatcat gttaggcaac
     1141 ctcaatacaa tggaagccct tttgctggag atgaaaattg gggctgaagt aagaaaggat
     1201 cctttcagcc aagtcatgac agaaatggtg tgtttacaca gcttgggtaa agaaggccct
     1261 tttaaagttt taagcaactg ctacatttat aaagacacca tccaagtcaa gctaatcgac
     1321 ttgagtcagg taatgtatct agtggttgct gcacaagcta aagctcttcc gtcaccagct
     1381 gccaccattt gggattatat ccacaaaacc acctcaattg gaatttatgg acccaaatat
     1441 atccatccca gttttactgt tgttttaaca gtttgtggac acaattatat gccaggacag
     1501 cttacaattt ctgatattaa gaagggtgga aaaaacatat ctccagttgt gtttcagctc
     1561 tgggggaagc agtcattttt acttgacaag ccacaagatt taagtatttc tattttttcc
     1621 tgtgatcctg attttgaagt aaagacagaa ggagaaagga aagaaattaa acaaaagcag
     1681 ttggaagcag gtgaagtagt tcatcaacaa tttttatttt ctttagttga gcacagagag
     1741 atgcacttgt ttgatttttg tgttcaagtg gagcctccca atggtgaacc agttgcacag
     1801 ttctctatca ctactcctga tccaacccca aacctaaaaa gactctcgaa tctgccaggc
     1861 tatttgcaga agaaggagga aatcaagtct gctcctttat caccaaaaat tcttgttaaa
     1921 tatcctacat ttcaagataa aacattgaac tttagcaact atggggtaac cctgaaggca
     1981 gtgctaagac aaagcaagat tgattacttc cttgaatatt tcaaagggga cacaatagct
     2041 ctcctcgggg aaggtaaggt aaaagctatt ggtcagtcca aagtgaaaga atggtatgta
     2101 ggagtcctca gaggtaagat tggacttgta cactgcaaaa atgtcaaggt gatttcaaag
     2161 gagcaagtaa tgtttatgtc agatagtgtc tttacaacca gaaatcttct tgaacagatt
     2221 gtcctgcctt taaaaaaatt gacttatatc tactcagttg tattaacctt ggtgtcagaa
     2281 aaagtttatg attggaaagt tttagctgat gtcctgggtt actcacatct gtccctggaa
     2341 gattttgatc aaattcaagc agacaaagaa tcagagaaag tttcttatgt tataaagaag
     2401 ttaaaggaag attgccacac agagagaaat acaaggaagt ttctgtatga acttattgtg
     2461 gctcttctga aaatggattg ccaagagtta gtcgcacgtc tcatccaaga agctgctgtt
     2521 ctgacttcag ctgtcaagct tggaaaaggc tggagggaac tagctgaaaa gttagtacga
     2581 ctcacaaagc aacaaatgga ggcatatgaa attcctcatc gaggaaacac tggagatgtt
     2641 gctgttgaga tgatgtggaa acctgcctat gattttctgt atacctggag tgctcactat
     2701 ggaaataact acagagatgt gttacaagac cttcagtcag ctttggacag aatgaaaaac
     2761 cctgtgacta aacactggag agaattaact ggagttttaa tactagtaaa ttctttggag
     2821 gttttgagag taactgcatt ctccacttct gaggaagtat agaaacaaag cgtgtgtttt
     2881 tgatgggagg gaaaatgagg taatggtgtg tgtgtgtgtg tgtctgtgtg tgtctgtgtg
     2941 tgtctctgtg tgtctgtgtg tgtgtgtctg tgtgtgtgtg tctgtgtgtg tgtgtgtgtg
     3001 tgtgtaggaa agaaagaatc tcagaaaagc attatattaa ttttcttcat gctcaaaacc
     3061 agtttttttt tcctgatgaa agcacagcct aactgataac caagatgggt tttatcctca
     3121 aatatgtatt tttgtgtatg tttcaaatac aagtattagg ctgctttgtt cttagaaagg
     3181 aaagaaaaaa gaaaagtgcc ctctctctct ttcagtgtta ttttaaattt actaagtcaa
     3241 agctgtttga ataattacat cacacagata tctgggtaaa ctagagacta tcaacatgat
     3301 caaggcagtg ttcccaggag gcagctagaa agaggggaag caagcacaca ccctgtggcc
     3361 agtcacggct gcccgctttc cacacctgac ctcttcagtt catcagtggg gttcaccagc
     3421 atcaccccca tttttcatgg ggagaaactc agaagtggag agaacgtctg aggctacata
     3481 gccagtacaa agtaggtttt ctgcttgaaa aacctgtttc tatttctttt taaaaaatca
     3541 tactgcataa cagaatagta aaaacaaaat gcgtgttaag acttacaggg aaacagttgc
     3601 cgtttcattt taagtgagac ttgctactct ttttcatcgt ctcttgaaag actgacagaa
     3661 ggaaaatatg acttatcaga aatctgttgt ctgcatgcat ggacctagtg ttttcatcag
     3721 ctcccttcag catcttggga cctctctaat cctgcctaat ttgggacttt ttctgcagga
     3781 ttgtaatgta aaatagttct ttagctcttg gagattttta ataatacgag ttattaaaaa
     3841 ccaccaccac cagaaacttg attaacttga ttaccctgtt gagtagagag gtcttaacca
     3901 ccgaaaacac tgatatcttt atgttggcat gctcatgcaa acacatgtgt gtgtgtgtgt
     3961 gtgtgtgtgt gtgtgtgtgt gtaccacagt gttttataaa gcacagccta attgattata
     4021 taggacaaaa attgtatagg accctgggtc agtataaatg ctaatggctg acaaagttca
     4081 caaagagatg tattttgctt actcctctgt tcaatcctct ggttgcctgc cagtgtttat
     4141 gtgtgtattt ggacagacat tcatttattg tcattcagtc aataggtaga gtatatgtgt
     4201 ctattttttg gcaggcatat agatgcttga ggctaatggg aaaaaaccag catgaactct
     4261 gactttagta gtgctaagta atagataatt ttaaaaaatg acaccgttaa atagaaaatg
     4321 gcatgcatac taacagttgc aatggagagg ctgtgatgct acgagatata aacgtagaga
     4381 tgccatcatg tgaaactgga agtgggggtg ggtcagggaa atttgttctt ggaaagaaat
     4441 aatgaacctc aaggaagagt aggcattgtc ctggtgtggt ggggtgtaag cggtgatccc
     4501 acaaagcact gaagctctta gatgggtggg agctgaatag gtgcagatag caggggtgaa
     4561 ggagtgaaag gataaaagat tcaaggttga gatgaggatg gagcaagaag aagccacatt
     4621 agggccatta aggctgctag aatttagaaa gaaaacacac agcctcaaag aaatgtgggt
     4681 aagccaaaga aggattttgt tttgggaacc tgaataaaag atgtccattt ggctaaaaag
     4741 taaaagcaga atctttttag ggcttttaat atacccaccc tgggatattt ggtatgctgg
     4801 caatggtaat tcaaattggc gtttaagaat aatcttggcc gggcgcgatg gctcatgcct
     4861 gaaatcccag cactttggga ggccgaggcg ggcagatcac taggtcagga gatcgagacc
     4921 atcctggcta acgcggtgaa accccgtctc tactaaaaat acaaaaaatt agccgggcgt
     4981 ggtggcaggc gcctgtagtc ccagctactc aggaggctga ggcaggagaa tggcgtgaac
     5041 ccgggaggcg gagcttgcag tgagccgagt tcatgccact gcactccagc ctgggtgaca
     5101 ggctgtctca aaaaaaaaaa aaggaataat ctgtacggct ttcagtattt atatttgatt
     5161 ataagggaac acagcctgac caaataatta tgtatacaca ttcaaggaca gaatttattt
     5221 taattaaaaa taaattatga gagaaggaaa aaaaagcaca gtttttactt tcagaacaca
     5281 gtcctttttt gtggtgattt tgctttcttt agaacattct tggaatctta ttaacatgtc
     5341 agctaaccag agaattttgg gaagggatag tggggattaa taactgggtt tttccaggct
     5401 ccaagatcta agaagacaga gatcttgtta gctgattagt gtagtaagat taaataaata
     5461 atttaaggtt tacattgcat catgtattat gattgtgatt gagaataata agagtttaaa
     5521 aaaatgaaaa acaagatctc tgtaatttga ggatgaaaca atggttctaa tattaataca
     5581 cacaaatata ttttataatc ttgtaacaaa tccttccagg ggaaattttt tttttttttt
     5641 tttttttttt tttttgagcc agagtctggc tctgttgccc agactggagt gcggtgtttc
     5701 aatcttgact cactgcaacc tccacctcct gggttcaaaa gatccttctg cctccgcctc
     5761 ccaagtagct gggattacag gcatgcacca ccttgtccgg gtaatttttg tatttttagt
     5821 ggagacaagg ttttaccatt ttggccagac tggtctggaa ctcctgacct caggtcatcc
     5881 acctgcctcg gcctcccaga gtgctaggat tacaggcatg agccactgct cccagccttc
     5941 cagaggaatt ttaagcccat gtccaaacat tctgtttgta taaatatatt ctaattttta
     6001 aataaatagt ttctactttt ctgaacttta tattttttct tgctataatg gattttcata
     6061 atcagaaaag attaaattag taatcatgaa ttgccttcaa tatttggcag taagtcaatg
     6121 aaataataag gcacttatat accatctttg acatcattaa aagtatcaaa tcccattaat
     6181 ctaaaacttc tttaagcatt ttgaaagcag aaaatgttta catggttctt tcagttcctc
     6241 aggctttttg tctaatgatg cgtgacttag gataagattt gaattaagtg cccagcttga
     6301 aacataataa tttttctgta taagccacag atcctctacc tcctttgtgt taaagccttt
     6361 atatgaaaca attaagtaga agcattcaat agtgtgtcat taactgttca tactaataaa
     6421 tggatacagc acattttcat ggcctgtaat gtagaacata ctatataaag ttctcagttt
     6481 ggggatgact aggtttctgg aaggaataga atgctaaatc aatggatggc attgggctga
     6541 gaaacactgc tgctactaat cagccttgaa tgtgtaatgt gaacatgcaa aagagaacat
     6601 gcatacactc aaatttgtac aatgctataa ctggaagttg aaggacttga atttttatat
     6661 tgtgctattg ttatgttttc tgtaattgtt tatatctaag gaatttttga ggtaatataa
     6721 aagaaaaaga gaataatgaa caatgatgtc actggagggt ttttacatta aattagatca
     6781 tttttcttct tattcacaat aataatctta atctttaaga attaattata atttaatatt
     6841 ataattcata atctttaaga attaataatt ataatttaat attataatta ataatcttta
     6901 agaattaata atataattta atattataat taataatctt taagaattaa taattacaat
     6961 taataattaa taataatctt aatctttaag aattaataat aatccttaat cgcaataata
     7021 atcgcaagga ggagaagtaa gtccctcctc cttctgtatg aacttttctc ccacatgctg
     7081 ctgtatggtt tagtgagagt gaagttctaa agaacatcaa tatgattggt gggataatcc
     7141 aaagacattt tttcagaatc aaatggcatg tcgaaggttt gtttcttgca tatgtattta
     7201 ctggtccaca gcacaaaata aagtgaccac atatacatag gaaagttgaa tttgtacaca
     7261 tacagcatct gaaatgtatc tgatgttcag catcaagatt tcactgaaca ttgtagaaat
     7321 gtgtatcttt tgcatgtata ttttacattg attttctatt tatgtacatc tagaaagttt
     7381 taaccctaat aaatagtttt gtaattttga ataatagtgt cagtttatat gtgagggagt
     7441 agagacagag aggttagcac tggataataa ttagtaaggc caaaggagaa aatttcatag
     7501 aaaatattgt tgttgtcata atgagtacag catgaaaggc ttcctctaca agacactagt
     7561 caaagagttg agagctgcgg tttctaatct ttgtccatta ctcccttact ccctatgaga
     7621 ctgtggacct gtcacttggc ctctctggtc ttcagttttc tcaccagtaa aacaaggaac
     7681 ttgaaccaaa tgacctctag tgttcccctt gggtttaaat gtctataaat gttcaatgac
     7741 tagaatgtat tgcgtttttc tttattcttt ttgctttgag aaaagagaat gtgatttaag
     7801 agtaataatt tgaataccaa ttatccacat taaaattgtg tcctctatgt gtaaggcata
     7861 gcacatttag cacacataca taagcacact aagcacctta caaatatcct catttattct
     7921 ttacataatc ttttgaaatt gattatgtaa tacacactgt ttttgaacaa ttggtgactt
     7981 ccagctgttt aaaacaaact acagtatggt gcttgagtac tgacttagga ggtcagcatt
     8041 ggtttcacta ggagcttctc aaagcacgct gccaaacatg ctccagtctc attgtcaagg
     8101 ccttagacca ggcaatcatt acggcagtgg ttcttcaact tcagcagcag caaaacgatc
     8161 tggcgggggc ttggtgaaac agactgctgg gctcgaccac cagaatttct cattcagagg
     8221 gtctggcctg atcacttgca tttctaatca cttcccaggt gatgcagatg tttctggtcc
     8281 agggacccca gtttgagaac cactgtatta aaatttcctt catctctata gaaatggaaa
     8341 gattttttat aagtcctcta atttgcttta agataaatga gatttcactt aattctgttg
     8401 gagaaattgt tttaaaaatt gtgctaaaga accgaaaatc actttatgtt aaggctctat
     8461 ttatagcaag tgaacttttc atgagttaat aaaggcctac aaaaataatt ttgactgtga
     8521 aactaattaa aatctctgtg tttcatttaa agcataaaca tatttgaata aaaataggtt
     8581 aacaataatt tgggacatgt attcagtata attttaagat aattttacaa aatatatgta
     8641 acattgcatt tgtttctgta aaatatcttc ggaaaaagcc ttgttttccc tagtgtgtta
     8701 tttgttgaat ttcttgttaa atgtattttt tcccattgaa aaaaatgttt ttaatcaatg
     8761 tgatcaatac agctatctat atgccctgct ttcactgtag aattagaaag tgttaataag
     8821 gtgatcggat gttctttcta aggatcatat tccacattta aagagatggt gactgagaag
     8881 aggtggcaag ctgaaccatc tcactttgag attgacgtat cacgttttat cctctgccat
     8941 catttccttg ttaattgttt ttctttgggt gattggaaga atctatggct tccttttctc
     9001 tgttcttaaa gatatcaaga ctctgccctt ttgtgactgg aagtagattt taaatgtccc
     9061 taatgtttat atgctcactt aaactcaata catggaattt actggggcat ttaacttgtt
     9121 catgaaaata gagtgagtca ttgaaaaatc aaa
//
