LOCUS       NM_001085437            2525 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mab-21 like 4 (MAB21L4), transcript variant 1, mRNA.
ACCESSION   NM_001085437
VERSION     NM_001085437.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Srivastava,A., Tommasi,C., Sessions,D., Mah,A., Bencomo,T.,
            Garcia,J.M., Jiang,T., Lee,M., Shen,J.Y., Seow,L.W., Nguyen,A.,
            Rajapakshe,K., Coarfa,C., Tsai,K.Y., Lopez-Pajares,V. and Lee,C.S.
  TITLE     MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of
            RET
  JOURNAL   Cancer Res 82 (17), 3143-3157 (2022)
   PUBMED   35705526
  REMARK    GeneRIF: MAB21L4 Deficiency Drives Squamous Cell Carcinoma via
            Activation of RET.
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Ogami,T., Tamura,Y., Toss,K., Yuki,K., Morikawa,M., Tsutsumi,S.,
            Aburatani,H., Miyazawa,K., Miyazono,K. and Koinuma,D.
  TITLE     MAB21L4 regulates the TGF-beta-induced expression of target genes
            in epidermal keratinocytes
  JOURNAL   J Biochem 171 (4), 399-410 (2022)
   PUBMED   34908107
  REMARK    GeneRIF: MAB21L4 regulates the TGF-beta-induced expression of
            target genes in epidermal keratinocytes.
            Erratum:[J Biochem. 2022 Mar 31;171(4):469. doi:
            10.1093/jb/mvac016.. PMID: 35181785]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104809.5.
            
            On Nov 22, 2018 this sequence version replaced NM_001085437.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056601.1, SRR11853562.20666.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388934.5/ ENSP00000373586.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-673               AC104809.5         109274-109946
            674-899             AC104809.5         113667-113892
            900-1053            AC104809.5         115272-115425
            1054-1410           AC104809.5         116782-117138
            1411-2525           AC104809.5         118268-119382
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..2525
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /note="mab-21 like 4"
                     /db_xref="GeneID:79919"
                     /db_xref="HGNC:HGNC:26216"
     exon            1..673
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1503
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C2orf54; protein mab-21-like 4"
                     /codon_start=1
                     /product="protein mab-21-like 4 isoform 1"
                     /protein_id="NP_001078906.3"
                     /db_xref="CCDS:CCDS42839.1"
                     /db_xref="GeneID:79919"
                     /db_xref="HGNC:HGNC:26216"
                     /translation="MPAPALPTSAMAVQVPLWHHYLQAIRSREAPRAQDFQRAENVLL
                     TVLERVHALDPRFIVDYSRGLEAFQFALRSSEDPMDMEVPLWVDAEALLIEEPEATQP
                     EDGLELCHLGVPREGAGLERWTTEDTFTASSEGDAKCRGHIVPSKVLCVLKDLLVAAI
                     VHCKHHSLIAPGSLNAASLREEQLHLSLLVSSGWRTISFHVVPVVRRKLGAPALEGVQ
                     QMPGFPEGSLRRILSQGVDLVPASAQLWRTSTDYLLTRLLGELGSLQGHRLDSLSILD
                     RVNHESWRDSGQTDGLTFGHLKMVLLWASVLFLAPEDWAELQGAVYRLLVVLLCCLAT
                     RKLPHFLHPQRNLLQGSGLDLGAIYQRVEGFASQPEAALRIHATHLGRSPPPRIGSGL
                     KALLQLPASDPTYWATAYFDVLLDKFQVFNIQDKDRISAMQSIFQKTRTLGGEES"
     exon            674..899
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1053
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1410
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..2525
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2505..2510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /note="hexamer: ATTAAA"
     polyA_site      2525
                     /gene="MAB21L4"
                     /gene_synonym="C2orf54"
                     /note="major polyA site"
ORIGIN      
        1 actgtgctgt cactctggaa ttctgctgtg tgggagctga ggccccacct gcagacctgc
       61 tgctcacctg ggcaggtgcc tcctcacagc ccatctgcac agctggcctg cggagtcctc
      121 ctcaggggcc actggccctc acctgccact gttgaaggga tgcctgcccc tgctctcccc
      181 acctcagcca tggccgtgca ggtgcccctg tggcaccact acctgcaggc catccggtcc
      241 cgggaggcgc cgcgtgccca ggacttccag cgcgcagaga acgtgctgct cacggtgctg
      301 gagcgcgtgc atgccctgga cccccgcttc atcgtggact actcccgtgg cctggaggcc
      361 ttccagttcg ccctgcgctc ctctgaggac ccaatggaca tggaggtgcc cctgtgggtg
      421 gatgccgagg ctctactgat tgaggaacca gaggccaccc agccggagga tggccttgaa
      481 ttatgccacc tgggtgtgcc cagggaaggg gctggcctgg agcggtggac caccgaggat
      541 accttcactg cctcctcgga gggtgacgcc aagtgccgtg gacacattgt gcccagcaag
      601 gtcctgtgtg tcctcaagga cctgctggta gcagccatcg tacactgcaa gcaccacagt
      661 ctcatcgcac caggttcgct gaacgcggcc agcctgaggg aggagcagct ccacctgtcc
      721 ttgctggtgt ccagcggctg gagaacaatc agcttccacg tggtgcccgt ggtgagaagg
      781 aagcttgggg cgcctgccct ggagggggtg cagcagatgc ccggattccc tgagggcagc
      841 ttgagaagga tcctcagcca aggggtggac ctggtgccgg ccagcgccca gctctggagg
      901 acctccactg actacctgct cacgaggctg ctgggggagc tgggctccct gcagggtcat
      961 cgcctggaca gcctctccat cctcgaccgg gtcaaccacg agagctggcg tgacagtggc
     1021 cagactgacg gcctgacctt tggccacctg aagatggtgc tgctgtgggc ctctgtgctc
     1081 ttcctggcgc ccgaggactg ggcagaactg cagggcgccg tgtaccgcct gctggtggtg
     1141 ctgctctgtt gcctggccac gcggaagctg ccccacttcc tccacccgca gcgcaacctg
     1201 ctgcagggca gcggcctgga ccttggtgcc atctaccagc gcgtggaggg cttcgccagc
     1261 cagcccgagg cggccctgcg catccacgcc acccacctgg gccgcagccc cccgccgcgc
     1321 atcggctccg ggctcaaggc gctcctgcag ctgccagcca gtgaccccac ttactgggcc
     1381 actgcctact tcgacgtcct gctggacaag ttccaggtct tcaacatcca ggataaggac
     1441 cggatctctg ccatgcagag catcttccag aagaccagga ctctgggagg cgaggagagc
     1501 tgagctgggc cacctggtct cagccacctg ttcttggctc cccaacagac tctgcactgc
     1561 accatgggag gctcctggga tgtttggaag aagaaacggg cttctccttg agggggtagt
     1621 ggagggattt tgtccccagc agtggcctct gagagtcttt cagtgcctgg tggggcaggg
     1681 caggcctctt ggagcacctc ctccctgggt cagggcctgg atgcaggtgc caagctctcc
     1741 atgtggtgca tgttgaccca gccacgtggt gttgtcaagc aaacagcatc ggcaggagac
     1801 ctggagctga ggacttggcc ctgcctgcac tgtatgccat tccttggtga cgaaatgctg
     1861 tatatttggt tttgaaaaaa tgaatgtgct gggtatacac agcagaaagg gtactgtcca
     1921 ctttttgtat atcagtgtgg aaaatatttc ccctagaagt agaaaaggct catgtgctga
     1981 tggataattt tgagtcttct ccattctctg tgaatgaccc ccttccccag gcatccccac
     2041 ctcctacctc gttcttagag caaactaaag ccaactgagg gtgcacacac agccatgagc
     2101 ccacctgccc aggactactc ccatctgctt cttcccgtcc ccgtggaagt ggcccctgat
     2161 atggattgta tctgtatccc cacccaaatc tcaggtagaa ttggatctgt gtccccaccc
     2221 aagtctcagg tagacttgta atccccagtg ttggaggagg ggcccagtgg gaggtgattg
     2281 gatcatgggg gtggatttct cccttactgt tctcatgata gtgagtgagt tctcatgaga
     2341 tctggttttt tgagtgtgtg gcccctcccc ctctcctttt gctctcttcc tctttctccg
     2401 gccatgtaag atatgcctcc ttctccttca ccttccacca tgattgtcag tttcctgagg
     2461 cctcccagcc atgcttcctg tatagcctgc gggactgtga gtcaattaaa cctctttatt
     2521 catta
//
