LOCUS       NM_001365618            4196 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens leucine zipper tumor suppressor family member 3
            (LZTS3), transcript variant 1, mRNA.
ACCESSION   NM_001365618 XM_005260892
VERSION     NM_001365618.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4196)
  AUTHORS   Gu,X., Chen,S., Wang,Z., Bu,Q. and An,S.
  TITLE     LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal
            Adenocarcinoma Through Regulating Cell Proliferation, Migration,
            and Actin Cytoskeleton
  JOURNAL   Arch Med Res 54 (7), 102894 (2023)
   PUBMED   37806182
  REMARK    GeneRIF: LZTS3/TAGLN Suppresses Cancer Progression in Human
            Colorectal Adenocarcinoma Through Regulating Cell Proliferation,
            Migration, and Actin Cytoskeleton.
REFERENCE   2  (bases 1 to 4196)
  AUTHORS   Feng,J., Li,J., Qie,P., Li,Z., Xu,Y. and Tian,Z.
  TITLE     Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer
            progression by up-regulating leucine zipper tumor suppressor
            (LZTS3) through sponging microRNA miR-1275
  JOURNAL   Bioengineered 12 (1), 196-207 (2021)
   PUBMED   33315502
  REMARK    GeneRIF: Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung
            cancer progression by up-regulating leucine zipper tumor suppressor
            (LZTS3) through sponging microRNA miR-1275.
REFERENCE   3  (bases 1 to 4196)
  AUTHORS   Grabrucker,A.M., Schmeisser,M.J., Schoen,M. and Boeckers,T.M.
  TITLE     Postsynaptic ProSAP/Shank scaffolds in the cross-hair of
            synaptopathies
  JOURNAL   Trends Cell Biol 21 (10), 594-603 (2011)
   PUBMED   21840719
  REMARK    GeneRIF: We thus propose a model where ProSAP/Shank proteins are in
            the center of a postsynaptic signaling pathway that is disrupted in
            several neuropsychiatric disorders.
            Review article
REFERENCE   4  (bases 1 to 4196)
  AUTHORS   Wendholt,D., Spilker,C., Schmitt,A., Dolnik,A., Smalla,K.H.,
            Proepper,C., Bockmann,J., Sobue,K., Gundelfinger,E.D., Kreutz,M.R.
            and Boeckers,T.M.
  TITLE     ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the
            postsynaptic density that links the spine-associated Rap-Gap (SPAR)
            to the scaffolding protein ProSAP2/Shank3
  JOURNAL   J Biol Chem 281 (19), 13805-13816 (2006)
   PUBMED   16522626
REFERENCE   5  (bases 1 to 4196)
  AUTHORS   Teufel,A., Weinmann,A., Galle,P.R. and Lohse,A.W.
  TITLE     In silico characterization of LZTS3, a potential tumor suppressor
  JOURNAL   Oncol Rep 14 (2), 547-551 (2005)
   PUBMED   16012743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121891.22.
            
            On Sep 13, 2018 this sequence version replaced XM_005260892.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968189
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000337576.7/ ENSP00000338166.6
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL121891.22        88561-88655         c
            96-319              AL121891.22        82844-83067         c
            320-796             AL121891.22        81811-82287         c
            797-1660            AL121891.22        80603-81466         c
            1661-4196           AL121891.22        77723-80258         c
FEATURES             Location/Qualifiers
     source          1..4196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..4196
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /note="leucine zipper tumor suppressor family member 3"
                     /db_xref="GeneID:9762"
                     /db_xref="HGNC:HGNC:30139"
                     /db_xref="MIM:610484"
     exon            1..95
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..319
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..796
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..2359
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proline rich synapse associated protein interacting
                     protein 1; ProSAP/Shank-interacting protein 1; leucine
                     zipper, putative tumor suppressor family member 3"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 3
                     isoform 1"
                     /protein_id="NP_001352547.1"
                     /db_xref="CCDS:CCDS13049.1"
                     /db_xref="GeneID:9762"
                     /db_xref="HGNC:HGNC:30139"
                     /db_xref="MIM:610484"
                     /translation="MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGV
                     AHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGE
                     LRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVR
                     PSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSD
                     SGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTS
                     DSGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPSALIQELEERLWEKEQE
                     VAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQ
                     VLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEIS
                     LLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELG
                     EGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGG
                     ESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYV
                     EMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIESTEI"
     exon            797..1660
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4196
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4030..4035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /note="hexamer: AAGAAA"
     polyA_site      4049
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /note="major polyA site"
     polyA_site      4164
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
     regulatory      4167..4172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /note="hexamer: AATAAA"
     polyA_site      4196
                     /gene="LZTS3"
                     /gene_synonym="PROSAPIP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgcgcc ccgccgggcg tgcttcgggc tgcgccagca agcggggccg gtggcgcccg
       61 tgtcggagac cccgcgccgg accctgaggc agcgaaggag aaaactgcag tccgggatgg
      121 ctcagtcggc ccctccaaag tcgcgcagct ggttcgggcc gagccccgac tgcgagagtg
      181 aggcacatgg cccctgcaga ccgggcctcg gagggtccca ggcttgagga cccgtcggcc
      241 cctcaacccc ttggaaaggc aaggagagaa gcctgcgctg gtagtgagct tccacttctg
      301 ccctgactgc aacacttagt gcccccctgg cttagtcatg gcgaagctgg agacgctgcc
      361 tgtgcgcgct gacccagggc gggatcctct cctggccttt gccccacggc cctccgagct
      421 tggacccccg gacccccgcc tggccatggg cagcgtgggc agtggggtgg cccatgccca
      481 ggagtttgcc atgaagagcg tgggtacccg cacagggggt gggggcagcc agggcagttt
      541 ccctggcccc cgaggcagtg gcagtggggc cagcagggag aggccgggcc gctacccctc
      601 agaggacaag ggtctcgcca actccctcta cctcaatggt gagctgcggg gcagtgacca
      661 caccgatgtc tgtggcaacg tggttggcag cagcggaggc agcagcagca gtggtggcag
      721 tgacaaagcc ccaccgcagt atcgtgagcc cagccaccca cccaagctcc tggccacctc
      781 tggcaagcta gaccagtgct cagaaccact agttcggccg tcggccttca agcctgtcgt
      841 acccaagaat ttccactcca tgcagaattt gtgccccccg cagaccaatg ggactcctga
      901 gggacggcag ggccctggtg gcctcaaagg cggactggac aagtctcgga ccatgactcc
      961 agcgggtggg agtgggagtg gcctctcaga ctcaggccgg aactccctca caagcctgcc
     1021 cacctacagc tccagctaca gccagcacct ggcacccctc agtgcctcca ccagccacat
     1081 taaccgcatt ggcactgcca gctatggtag tggtagtggc ggcagcagcg gtggggggtc
     1141 gggctaccag gacctgggga cctccgatag tggacgggcc tccagcaaga gtgggtcgtc
     1201 gtcatctatg gggcggccag gccacctggg ctctggggag ggcggaggtg gaggcctgcc
     1261 tttcgcggcc tgctcaccgc cctcccccag tgcactcatc caggagctgg aggagcggct
     1321 gtgggagaag gagcaggagg tggcagctct gcggcgcagc ctggagcaga gcgaggcggc
     1381 tgtggcccag gtactggagg agcggcagaa ggcgtgggag cgggagctgg ccgagctgcg
     1441 gcagggctgc agcgggaagc tacagcaggt ggcccgacgt gcccagcgcg cccagcaggg
     1501 cctacagctg caggtgttgc ggctgcagca ggacaagaag cagctgcagg aggaggcggc
     1561 ccggctgatg cggcagcggg aagagctgga ggacaaggtg gccgcctgcc agaaggagca
     1621 ggccgacttc ctgccccgga tagaggaaac taagtgggag gtgtgccaga aggctggcga
     1681 gatctccctc ctgaagcagc agctgaagga ctcgcaggcg gatgtgtcgc agaagttgag
     1741 tgagatcgtg ggactgcgct cgcagctgcg ggagggccgg gcttcgctgc gggagaagga
     1801 ggagcagctg ctcagcctgc gggactcctt cagcagcaag caggccagcc tggagctggg
     1861 cgaaggcgag ctgcctgccg cctgcctcaa gccggcgctg acccccgtgg acccggccga
     1921 gccacaggat gctctggcca cctgcgagag cgacgaggct aagatgcgcc gtcaggccgg
     1981 ggtggccgct gccgcctcct tggtttccgt ggacggggag gcggaggctg gcggggagag
     2041 cgggacgcgg gccctgcggc gggaggtggg gcggctgcag gccgagctgg cggctgagcg
     2101 gcgggcccgg gagcgccagg gtgccagctt cgccgaggag cgccgcgtgt ggctggagga
     2161 gaaggagaag gtgatcgagt accagaagca gctgcagctg agctacgtgg agatgtacca
     2221 gcgcaaccag cagctggagc gcaggctgcg ggagcgcggg gccgcagggg gtgcaagcac
     2281 gcccactccc cagcatggcg aggagaagaa ggcctggacc ccctcccgcc tcgagcgcat
     2341 tgagtccaca gaaatctgat cgacctgggc actcggcatt ttgacacatg tcctgtcaaa
     2401 aggccagagt ccccagtgtc ccctcccctc catctctctt ccccatagac cccataaccc
     2461 cagaccaaag aggttctcta agcagctgtg accaggttcc tccctcccca cctgccctcc
     2521 tagctccagc actgcccccg tggcagccca cttggacccc cctaaaagga gggaatagga
     2581 ggagggcagg gtgagtgggg gcaatcctag gtggtggggg agtcatgctc cctttctcgg
     2641 cacccccttg ttggagatgg aggcagcaga cgtgcagtgc cataaggtgc cccagtcctt
     2701 ctggaggcct gggctgctac tgttggccac cctgtgtcta gtgatgctct ctgtgctcac
     2761 ctcctaggcc atggagcctg agggggcctg caccaggttt gctgaaactg acagagcctg
     2821 ggctccagac ctctctccct cctacagtgc tctccctccc tgggcagatt ggcaggacaa
     2881 gtgggagcag atggcctgcc tttggctgag agggctacct gcccagcccc tcccccaaca
     2941 agatctcttg gactcaggcc tcagagcctg gcctggttgt gagtgtgtgt ccctgtgtgt
     3001 gtgttgcggg aggggaggac tggggctgga agtccagcac ccagggaaga tctgtcctcc
     3061 tgttcttggg aagcgttgcc tgacggcttc tcggctctac cctcaccctt ctggccagga
     3121 tcccgcaggg caacagcccc atctgcttgg ctgaccccac acccaggacc actgtccggc
     3181 tctaacacag ctattaagtg ctacctgcct ctcaggcact ctcctcgccc agtttctgag
     3241 gtcagacgag tgtctgcgat gtcttcccgc actctattcc cccagcctct ttctgctttc
     3301 atgctcagca catcatcttc ctaggcagtc tcttccccaa agtctcacct tttcttccaa
     3361 tagaaaattc cgcttgacct ttggtgcact gcccacttcc cagctccact ggcccaagtc
     3421 tgagccggag gcccttgttt tgggggcggg gggagagttg gatgtgattg cccttgaaga
     3481 acaaggctga cctgagaggt tcctggcgcc ctgaggtggc tcagcacctg cccagggtag
     3541 gcctggcatg aggggttagg tcagccaatg tcagctgctt ctcttggggc cctctcagag
     3601 tctatctccc caagacagga agggaaaagc aaatttctaa ttcaccagca ataaaaattg
     3661 gaggaggctt ggccctcagc ccttatatct ctctcttttt cactctcttc ctcccacccc
     3721 caagactgag ttttgggggg caaggtggag agagctggca actactgtga gcaagtcccc
     3781 tagcccctga ccagcctcct cccatgactg gtgactgttt aatgagctgt gcatccccca
     3841 caaaaacatg agtgcccctc tgtgtggcct ctaaccctct gcacagccct tctgggtggt
     3901 cctcaccagg tctctgagct gggtgggagg ccatcctggc gaccactgcc cattccattc
     3961 acccctcact gtacctgccc tagaacctgg gcctaggcca caggggcagg gagaagagaa
     4021 ggcattagta agaaaaaaat agaaaaaaat atgaacagac tcagctttgg gacgtccaac
     4081 cacaaaagaa attatatata aatatatata aatatatatc tctaccatat gtgatggaaa
     4141 gactttttgt tttcctttcc caaagaaata aaacggaaaa agcctcttga gtggta
//
