LOCUS       NM_001318100            2862 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens leucine zipper tumor suppressor 2 (LZTS2), transcript
            variant 3, mRNA.
ACCESSION   NM_001318100 XM_005270223
VERSION     NM_001318100.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Liu,R., Zhou,D., Yu,B. and Zhou,Z.
  TITLE     Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway
  JOURNAL   Cell Signal 120, 111226 (2024)
   PUBMED   38740232
  REMARK    GeneRIF: Phosphorylation of LZTS2 by PLK1 activates the Wnt
            pathway.
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Peng,Y., Greenland,N.Y., Lang,U.E. and Stohr,B.A.
  TITLE     LZTS2: A novel and independent prognostic biomarker for clear cell
            renal cell carcinoma
  JOURNAL   Pathol Res Pract 232, 153831 (2022)
   PUBMED   35287088
  REMARK    GeneRIF: LZTS2: A novel and independent prognostic biomarker for
            clear cell renal cell carcinoma.
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Lu,Y., Li,X., Liu,H., Xue,J., Zeng,Z., Dong,X., Zhang,T., Wu,G.,
            Yang,K. and Xu,S.
  TITLE     beta-Trcp and CK1delta-mediated degradation of LZTS2 activates
            PI3K/AKT signaling to drive tumorigenesis and metastasis in
            hepatocellular carcinoma
  JOURNAL   Oncogene 40 (7), 1269-1283 (2021)
   PUBMED   33420362
  REMARK    Retracted:[Oncogene. 2025 Mar 17. doi: 10.1038/s41388-025-03344-w.
            PMID: 40097808]
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Schmeisser,M.J., Grabrucker,A.M., Bockmann,J. and Boeckers,T.M.
  TITLE     Synaptic cross-talk between N-methyl-D-aspartate receptors and
            LAPSER1-beta-catenin at excitatory synapses
  JOURNAL   J Biol Chem 284 (42), 29146-29157 (2009)
   PUBMED   19703901
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Sudo,H. and Maru,Y.
  TITLE     LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the
            inhibition of katanin-mediated microtubule severing
  JOURNAL   Hum Mol Genet 17 (16), 2524-2540 (2008)
   PUBMED   18490357
  REMARK    GeneRIF: LAPSER1 C terminal domain inhibits
            katanin(p80/p60)-mediated microtubule severing in vitro.
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   Cho,H.H., Song,J.S., Yu,J.M., Yu,S.S., Choi,S.J., Kim,D.H. and
            Jung,J.S.
  TITLE     Differential effect of NF-kappaB activity on beta-catenin/Tcf
            pathway in various cancer cells
  JOURNAL   FEBS Lett 582 (5), 616-622 (2008)
   PUBMED   18242184
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Hyun Hwa,Cho., Hye Joon,Joo., Ji Sun,Song., Yong Chan,Bae. and Jin
            Sup,Jung.
  TITLE     Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is
            mediated by lzts2 in human adipose tissue-derived mesenchymal stem
            cells
  JOURNAL   Biochim Biophys Acta 1783 (3), 419-428 (2008)
   PUBMED   17950943
  REMARK    GeneRIF: The reciprocal crosstalk between beta-catenin/Tcf pathway
            and NF-kappaB signaling in hMSCs is mediated through the regulation
            of lzts2 expression.
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Thyssen,G., Li,T.H., Lehmann,L., Zhuo,M., Sharma,M. and Sun,Z.
  TITLE     LZTS2 is a novel beta-catenin-interacting protein and regulates the
            nuclear export of beta-catenin
  JOURNAL   Mol Cell Biol 26 (23), 8857-8867 (2006)
   PUBMED   17000760
  REMARK    GeneRIF: LZTS2 is a beta-catenin-interacting protein and modulates
            beta-catenin signaling and localization
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Cabeza-Arvelaiz,Y., Thompson,T.C., Sepulveda,J.L. and Chinault,A.C.
  TITLE     LAPSER1: a novel candidate tumor suppressor gene from 10q24.3
  JOURNAL   Oncogene 20 (46), 6707-6717 (2001)
   PUBMED   11709705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133215.17, CN365632.1,
            BC058938.1 and BC006212.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001318100.1.
            
            Summary: The protein encoded by this gene belongs to the leucine
            zipper tumor suppressor family of proteins, which function in
            transcription regulation and cell cycle control. This family member
            can repress beta-catenin-mediated transcriptional activation and is
            a negative regulator of the Wnt signaling pathway. It negatively
            regulates microtubule severing at centrosomes, and is necessary for
            central spindle formation and cytokinesis completion. It is
            implicated in cancer, where it may inhibit cell proliferation and
            decrease susceptibility to tumor development. Alternative splicing
            of this gene results in multiple transcript variants. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (3) contains an alternate 5'
            terminal exon and it thus differs in the 5' UTR, compared to
            variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058938.1, DRR138524.296234.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454422.2/ ENSP00000416972.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL133215.17        82632-82637
            7-90                CN365632.1         1-84
            91-1051             BC058938.1         48-1008
            1052-2862           BC006212.2         934-2744
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..2862
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /note="leucine zipper tumor suppressor 2"
                     /db_xref="GeneID:84445"
                     /db_xref="HGNC:HGNC:29381"
                     /db_xref="MIM:610454"
     exon            1..145
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..595
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2197
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /note="isoform a is encoded by transcript variant 3;
                     protein LAPSER1; leucine zipper, putative tumor suppressor
                     2"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 2
                     isoform a"
                     /protein_id="NP_001305029.1"
                     /db_xref="CCDS:CCDS7507.1"
                     /db_xref="GeneID:84445"
                     /db_xref="HGNC:HGNC:29381"
                     /db_xref="MIM:610454"
                     /translation="MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAP
                     PRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPS
                     PSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPS
                     LPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLS
                     DSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRS
                     SSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLR
                     DREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL
                     QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEI
                     SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA
                     CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAG
                     VGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQM
                     YRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI"
     exon            596..1255
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1513
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2862
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2836..2841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /note="hexamer: ATTAAA"
     polyA_site      2862
                     /gene="LZTS2"
                     /gene_synonym="LAPSER1"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgggc cgggcagctc cgagtggcgg cgcgcgggcc agggccgggg ccggggccgg
       61 ggccggagcc ggagccgggg ccgggcggcg cgcctgtgga gcgctggggg cggcctgggg
      121 ctgagcatgg agcagcgcgg cggaggtcgc ctgcgaggcc gctggccagg cctgagcctc
      181 tgccaccatg gccattgtgc agactctgcc agtgccactg gagcctgctc ctgaagctgc
      241 cactgcccca caagctccag tcatgggtag tgtgagcagc cttatctcag gccggccctg
      301 tcccgggggg ccagctcctc cccgccacca cggccctcct gggcccacct tcttccgcca
      361 gcaggatggc ctgctacggg gtggctatga ggcacaggag ccgctgtgcc cagctgtgcc
      421 ccctaggaag gctgtccctg tcaccagctt cacctacatc aatgaggact tccggacaga
      481 gtcacccccc agcccaagca gtgatgttga ggatgcccga gagcagcggg cacacaatgc
      541 ccacctccgc ggcccaccac caaagctcat ccctgtctct ggaaagctgg agaagaacat
      601 ggagaagatc ctgatccgcc caacagcctt caagccagtg ctgcccaaac ctcgaggggc
      661 tccgtccctg cctagcttca tgggtcctcg ggccaccggg ctgtctggga gccagggcag
      721 cctgacgcag ctgtttgggg gccctgcctc ctcctcctcc tcttcctcct cctcttcagc
      781 tgctgacaaa cccctggcat ttagtggctg ggccagtggc tgcccatcag ggacgctatc
      841 cgactctggc cgaaactcac tgtccagcct gcccacctac agcaccggag gtgccgagcc
      901 aaccaccagc tccccaggcg ggcacctgcc ttcccatggc tctgggcgag gggcactgcc
      961 tgggccagcc cgaggggtcc ctactgggcc ctcccactca gacagtggcc ggtcctcctc
     1021 cagcaagagc acaggctccc tagggggccg tgtggctggg gggcttttgg gcagtggtac
     1081 tcgggcctcc cctgacagca gctcctgtgg ggagcgctca ccaccacccc cgcctccacc
     1141 tccttcggat gaggccctgc tgcactgtgt cctggaagga aagctccgag accgggaggc
     1201 agagcttcag cagctgcggg acagtctgga cgagaatgag gctaccatgt gccaggcata
     1261 cgaggagcgg cagcggcact ggcagcgaga gcgtgaggcc ctgcgagagg actgtgcggc
     1321 ccaggcacag cgggcacagc gggcccaaca gctgctgcag ctgcaggtgt tccagctgca
     1381 gcaggagaag cggcaattgc aggacgactt cgcacagctg ctgcaggagc gcgaacagct
     1441 ggagcggcgc tgcgccacct tggagcggga gcagcgggag ctcgggccga ggcttgagga
     1501 gaccaagtgg gaggtgtgcc agaaatcagg cgagatctcc ctgctgaagc agcagctgaa
     1561 agagtctcag gcagagctgg tgcagaaggg cagcgagctg gtggctctgc gggtggcgct
     1621 gcgggaggcc cgtgctacgc tgcgggtcag tgagggccgt gcgcggggtc tacaggaggc
     1681 cgcccgagct cgggagctgg agctggaagc ctgttcccag gagctgcagc gacaccgcca
     1741 ggaagctgag cagctgcggg agaaagctgg gcagttggat gctgaggcgg ccggactccg
     1801 ggagccccct gtgccacctg ccaccgctga cccattcctc ctggcagaga gtgatgaggc
     1861 caaagtgcag cgggcagcag ccggggttgg gggcagcttg cgggcccagg tggagcgatt
     1921 gcgggtggag ctgcagcggg agcggcggcg gggtgaggag cagcgggaca gctttgaggg
     1981 ggagcggctg gcctggcagg cagagaagga gcaggtgatc cgctaccaga agcagctgca
     2041 gcacaactac atccagatgt accggcgcaa ccggcagcta gagcaggagc tgcagcagct
     2101 cagcctggag ctggaggccc gggagctcgc tgacctgggc ctggccgagc aggccccctg
     2161 catctgcctg gaggagatca ctgctactga gatctagggc cctcagcaac cagctctgta
     2221 gggagctctg ccagaggggc agcagctgca gatccactta ggccccaggg tccacggatg
     2281 gccccaaagg ctgagggccc caaagccact tgtctcctag gatccaggcc tctgggcttc
     2341 tgccaagaac tcagggtggc cctatgactt ggaggagcaa gatcagaccg ctcaaaggtc
     2401 cccgtgttca ctgttaccca gaggctcttg ttactaccca cttcattccc caccgctgcc
     2461 agtgccactg ccaaccctgt tcacaggcgc ttccagccca ctccagccag gggagcaggg
     2521 aagaagaagg ggctccctcc tcttcacatt ccccccgacc ccaaagccag agaaagccag
     2581 atggcaccag ctgctccgga tgtgcctgcc cacattgggg gacagggccg ggcctgggct
     2641 cggttcccag gtttgagctc tgcagcctct ctcctggagt gagggggctg aagtcagacc
     2701 aaaggaagaa ctcagaaatg tcttgtttat ttgtgtttgt gaccaagcag cctctccctt
     2761 cacccaggtt tatggcctcg ttttcacttg tatatttttc acactgtaaa tttcttgtac
     2821 aaacccaaag aaaaaattaa aaaaaatttt tttgtttaaa aa
//
