LOCUS       NM_021020               5706 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens leucine zipper tumor suppressor 1 (LZTS1), transcript
            variant 1, mRNA.
ACCESSION   NM_021020 XM_005273394
VERSION     NM_021020.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5706)
  AUTHORS   Xu,Y., Pepe,D., Yao,S., Boudhan,L., Verbandt,S., Pu,T.,
            Creemers,J.W.M., Liu,M., Tejpar,S., He,Z., Zhu,J. and Wang,Y.
  TITLE     Unveiling the oncogenic role of LZTS1 in colorectal cancer
  JOURNAL   J Cell Mol Med 28 (14), e18441 (2024)
   PUBMED   39023696
  REMARK    GeneRIF: Unveiling the oncogenic role of LZTS1 in colorectal
            cancer.
REFERENCE   2  (bases 1 to 5706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5706)
  AUTHORS   He,Y. and Liu,X.
  TITLE     The tumor-suppressor gene LZTS1 suppresses hepatocellular carcinoma
            proliferation by impairing PI3K/Akt pathway
  JOURNAL   Biomed Pharmacother 76, 141-146 (2015)
   PUBMED   26653561
  REMARK    GeneRIF: Compared with the normal hepatocyte cells, LZTS1
            expression in hepatocellular carcinoma cells was significantly
            lower
REFERENCE   4  (bases 1 to 5706)
  AUTHORS   Olasz,E.B., Seline,L.N., Schock,A.M., Duncan,N.E., Lopez,A.,
            Lazar,J., Flister,M.J., Lu,Y., Liu,P., Sokumbi,O., Harwood,C.A.,
            Proby,C.M., Neuburg,M. and Lazarova,Z.
  TITLE     MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in
            Cutaneous Squamous Cell Carcinoma
  JOURNAL   PLoS One 10 (5), e0125412 (2015)
   PUBMED   25938461
  REMARK    GeneRIF: miR-135b expression inversely correlated with LZTS1
            staining intensity and the Cutaneous Squamous Cell Carcinoma grade.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5706)
  AUTHORS   Syx,D., Symoens,S., Steyaert,W., De Paepe,A., Coucke,P.J. and
            Malfait,F.
  TITLE     Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome
            8p22-8p21.1 in an Extended Belgian Family
  JOURNAL   Dis Markers 2015, 828970 (2015)
   PUBMED   26504261
  REMARK    GeneRIF: missense variant in the LZTS1 gene was identified in two
            Ehlers-Danlos syndrome patients in an extended family.
REFERENCE   6  (bases 1 to 5706)
  AUTHORS   Ono,K., Uzawa,K., Nakatsuru,M., Shiiba,M., Mochida,Y., Tada,A.,
            Bukawa,H., Miyakawa,A., Yokoe,H. and Tanzawa,H.
  TITLE     Down-regulation of FEZ1/LZTS1 gene with frequent loss of
            heterozygosity in oral squamous cell carcinomas
  JOURNAL   Int J Oncol 23 (2), 297-302 (2003)
   PUBMED   12851677
  REMARK    GeneRIF: Down-regulation of FEZ1/LZTS1 gene with frequent loss of
            heterozygosity is associated with oral squamous cell carcinomas
REFERENCE   7  (bases 1 to 5706)
  AUTHORS   Hawkins,G.A., Mychaleckyj,J.C., Zheng,S.L., Faith,D.A., Kelly,B.,
            Isaacs,S.D., Wiley,K.E., Chang,B.L., Ewing,C.M., Bujnovszky,P.,
            Bleecker,E.R., Walsh,P.C., Meyers,D.A., Isaacs,W.B. and Xu,J.
  TITLE     Germline sequence variants of the LZTS1 gene are associated with
            prostate cancer risk
  JOURNAL   Cancer Genet Cytogenet 137 (1), 1-7 (2002)
   PUBMED   12377406
  REMARK    GeneRIF: variation in the germline sequence is associated with
            prostate cancer risk
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5706)
  AUTHORS   Ishii,H., Vecchione,A., Murakumo,Y., Baldassarre,G., Numata,S.,
            Trapasso,F., Alder,H., Baffa,R. and Croce,C.M.
  TITLE     FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates
            mitosis
  JOURNAL   Proc Natl Acad Sci U S A 98 (18), 10374-10379 (2001)
   PUBMED   11504921
REFERENCE   9  (bases 1 to 5706)
  AUTHORS   Cabeza-Arvelaiz,Y., Sepulveda,J.L., Lebovitz,R.M., Thompson,T.C.
            and Chinault,A.C.
  TITLE     Functional identification of LZTS1 as a candidate prostate tumor
            suppressor gene on human chromosome 8p22
  JOURNAL   Oncogene 20 (31), 4169-4179 (2001)
   PUBMED   11464283
REFERENCE   10 (bases 1 to 5706)
  AUTHORS   Ishii,H., Baffa,R., Numata,S.I., Murakumo,Y., Rattan,S., Inoue,H.,
            Mori,M., Fidanza,V., Alder,H. and Croce,C.M.
  TITLE     The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein,
            and its expression is altered in multiple human tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3928-3933 (1999)
   PUBMED   10097140
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY107963.1, AF123659.1,
            AC025853.17 and BX344344.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021020.4.
            
            Summary: This gene encodes a tumor suppressor protein that is
            ubiquitously expressed in normal tissues. In uveal melanomas,
            expression of this protein is silenced in rapidly metastasizing and
            metastatic tumor cells but has normal expression in slowly
            metastasizing or nonmetastasizing tumor cells. This protein may
            have a role in cell-cycle control by interacting with the
            Cdk1/cyclinB1 complex. This gene is located on chromosomal region
            8p22. Loss of heterozygosity (LOH) in the 8p arm is a common
            characteristic of many types of cancer. [provided by RefSeq, Nov
            2009].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.78217.1,
                                           DRR138518.257325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381569.5/ ENSP00000370981.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               HY107963.1         22-268
            248-2491            AF123659.1         1-2244
            2492-2508           AC025853.17        28118-28134
            2509-4522           AF123659.1         2262-4275
            4523-4523           BX344344.2         731-731
            4524-5292           AF123659.1         4276-5044
            5293-5293           AC025853.17        30919-30919
            5294-5706           AF123659.1         5046-5458
FEATURES             Location/Qualifiers
     source          1..5706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..5706
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /note="leucine zipper tumor suppressor 1"
                     /db_xref="GeneID:11178"
                     /db_xref="HGNC:HGNC:13861"
                     /db_xref="MIM:606551"
     exon            1..224
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..703
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2149
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /note="F37/Esophageal cancer-related gene-coding
                     leucine-zipper motif; leucine zipper, putative tumor
                     suppressor 1"
                     /codon_start=1
                     /product="leucine zipper putative tumor suppressor 1"
                     /protein_id="NP_066300.1"
                     /db_xref="CCDS:CCDS6015.1"
                     /db_xref="GeneID:11178"
                     /db_xref="HGNC:HGNC:13861"
                     /db_xref="MIM:606551"
                     /translation="MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRF
                     GFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPST
                     PPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQ
                     ELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIV
                     LQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGA
                     LQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQ
                     VLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEIS
                     LLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVC
                     ENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLR
                     AELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQ
                     LARGDSAGEPLEVDLEGADIPYEDIIATEI"
     exon            704..1507
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..5706
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5677..5682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /note="hexamer: AATAAA"
     polyA_site      5706
                     /gene="LZTS1"
                     /gene_synonym="F37; FEZ1"
                     /note="major polyA site"
ORIGIN      
        1 gcagaggccg gcgcgcctgg agctggcggg ttggcagcgg ccgggcgggg aggccgaaag
       61 tttctctgcc cgcctcggcc agtgagtggg agccgggagc tgcatcccgc gcagtgggac
      121 cggcccggcc cgctcagcag ctctggaaaa agagagacgg gaacacaccg ggaaacactg
      181 ggaaaaaaaa aaagtctcaa gtgcgcccga ggcgcagggg gcaggtctac ggctctcgca
      241 ggctctgtga gggctttgct atgacctcag tcccctcacg gagccacgac tgccccttgc
      301 tgccacagcc tttccaagac cctgcccggc cctgccccat cctcagcccc gagtcaccat
      361 gggcagcgtc agtagcctca tctccggcca cagcttccac agcaagcact gccgggcttc
      421 gcagtacaag ctgcgcaagt cctcccacct caagaagctc aaccggtatt ccgacgggct
      481 gctgaggttt ggcttctccc aggactccgg tcacggcaag tccagctcca aaatgggcaa
      541 gagcgaagac ttcttctaca tcaaggtcag ccagaaagcc cggggctccc atcacccaga
      601 ttacacggca ctgtccagcg gggatttagg gggccaggct ggggtggact ttgacccgtc
      661 cacacccccc aagctcatgc ccttctccaa tcagctagaa atgggctccg agaagggtgc
      721 agtgaggccc acagccttca agcctgtgct gccacggtca ggagccatcc tgcactcctc
      781 cccggagagt gccagccacc agctgcaccc cgcccctcca gacaagccca aggagcagga
      841 gctgaagcct ggcctgtgct ctggggcgct gtcagactcc ggccggaact ccatgtccag
      901 cctgcccaca cacagcacca gcagcagcta ccagctggac ccgctggtca cacccgtggg
      961 acccacaagc cgttttgggg gctccgccca caacatcacc cagggcatcg tcctccagga
     1021 cagcaacatg atgagcctga aggctctgtc cttctccgac ggaggtagca agctgggcca
     1081 ctcgaacaag gcagacaagg gcccctcgtg tgtccgctcc cccatctcca cggacgagtg
     1141 cagcatccag gagctggagc agaagctgtt ggagagggag ggcgccctcc agaagctgca
     1201 gcgcagcttt gaggagaagg agcttgcctc cagcctggcc tacgaggagc ggccgcggcg
     1261 ctgcagggac gagctggagg gcccggagcc caaaggcggc aacaagctca agcaggcctc
     1321 gcagaagagc cagcgcgcgc agcaggtcct gcacctgcag gtactgcagc ttcagcagga
     1381 gaagcggcag ctccggcagg agctcgagag cctcatgaag gagcaggacc tgctggagac
     1441 caagctcagg tcctacgaga gggagaagac cagcttcggc cccgcgctgg aggagaccca
     1501 gtgggaggtg tgccagaagt caggcgagat ctccctcctg aagcagcagc tgaaggagtc
     1561 ccagacggag gtgaacgcca aggctagcga gatcctgggt ctcaaggcac agctgaagga
     1621 cacgcggggc aagctggagg gcctggagct gaggacccag gacctggagg gcgccctgcg
     1681 caccaagggc ctggagctgg aggtctgtga gaatgagctg cagcgcaaga agaacgaggc
     1741 ggagctgctg cgggagaagg tgaacctgct ggagcaggag ctgcaggagc tgcgggccca
     1801 ggccgccctg gcccgcgaca tggggccgcc caccttcccc gaggacgtcc ctgccctgca
     1861 gcgggagctg gagcggctgc gggccgagct gcgggaggag cggcaaggcc atgaccagat
     1921 gtcctcgggc ttccagcatg agcggctcgt gtggaaggag gagaaggaga aggtgattca
     1981 gtaccagaaa cagctgcagc agagctacgt ggccatgtac cagcggaacc agcgcctgga
     2041 gaaggccctg cagcagctgg cacgtgggga cagcgccggg gagcccttgg aggttgacct
     2101 ggaaggggct gacatcccct acgaggacat catagccact gagatctgag gggctgcctg
     2161 ggaaggcgag tctggggacc tggcactggg aggcagggct ctcccgtgca tcccccctgc
     2221 tcagcaattc agacccctct gagagacgcc actccctggg acacagaccc aggacccccg
     2281 aggggagggc aggatggcct ttccttccct ctctgatgtc ccagtgctca ccagccctgc
     2341 agcccaccag acgtcaggcc ctgactcctc tggctttccc aggagatggg tccaggggtc
     2401 tgtctgcttt ggttaagggc tccctaaact ttggcctttg ttcgaaatag atatcctctc
     2461 cccctcctcc agggaaggtg gccacagcaa gtacagcggc tcccctctgc ttctcatccc
     2521 aacctctttt tcctcctgga cacattggaa tgccttggaa atagaaagaa gccatatatg
     2581 accagaagcc ttggaaccag ccccatcaga acctgagcta ttttcctctg gccgcagagg
     2641 tgtaggggtg gaatgagccg cggggaagct ggctttgaaa cctcagggct gtcccagccc
     2701 cggcaagcca caggaaggag gggagagaca ggcagcccag cagtgtggag accctgccac
     2761 agccagagga gggcagaggg agaatccaag ggttgagagc cagtggcggg tgatggccag
     2821 cccctggggc ccagcccctg tttactggtt cttgcaaatg ggagctgagc agcctctgga
     2881 cagccagtga cctttgacct cggtgaccac tcttctttaa gccatagacc ctgaggccct
     2941 gggctgggtg ctgggaaggg agggttgaaa ccaccgtgaa ccagagggtg tggctttcca
     3001 ggcaccctca gggagcctcc ccatctgtcc agctggggcc agaggctggg agtccctacc
     3061 tgcttcacgt tggccggcgg ctactctgga atgtttttcc ctccccagaa tcaagctttt
     3121 gcttgatcca gaagagccca tatcactaag atggcatata tgtgatctgg gcattttcct
     3181 cctctgccta cagccaggtt tagcggcaaa cctttccccc ttagcacctt cagggctgag
     3241 ttctgggttt ctagaggtca ggacggctcc tcagagcgcc aggaagccag agccccaagc
     3301 aggacgaaaa agaggcatac acacagcagt gtgaatagcc tggccaccag ccatcctccc
     3361 tccacctcaa gacccccatt tgtcccagac taaaggatcc agagagcagc tccctttctc
     3421 aggagcttgg gcagtgcccc agggagtcca gggtttctct gcagatgtgc ggagcgggag
     3481 gcggtggtag agagagataa aaggtggagt ttctctgttg tttggttcag ggattttatt
     3541 tttaatttta tgagacaggg tcttgctctg tcccccaggc tggagtgcag tggcatgatc
     3601 atagctcact gcagcctcat actcctgggc tcaagcaatc ctcctgcctc agccttccaa
     3661 ctagctggga ctacaggtgc gcgccaccgt gcctggctaa cttttcattt tttttgtagg
     3721 gacggggtct cgttttgttg ccaaagctgg tctcaaactt gtggcctcaa gcaatccacc
     3781 tgccttggcc tcccaaagtg ctgagattgc agatgtgagc caccgtgcct ggccagattt
     3841 ttcttttatt cttctttctt tttctttttt gctttcttgt cttttcagaa gcaagccaga
     3901 cctagcaggc tgttccatgt tctatttttg actgtagcca cagctgctgt tctcaggaca
     3961 gcatcccttc ccacatgcct gcgcctgctg cctgctgaga tgaggagggg agcgtctggg
     4021 aacttgcgag tccaaggcca gtccccattt ctgcctcgct caccgctggc ccttagagac
     4081 cccgaggtag gggtggggag atgcttctct ccttgccccc cgccctcatg ggtcctagcc
     4141 cttccctgag tgcgggctga ggccagagtc accttttctg tggctggctc taccttcctg
     4201 tccctgaggt taaacggtgc ccatcctgcc atcctcaaac gacagaggag cttttctgga
     4261 atttcaaacc attgctctta gtcccaagct aggcttaaac ctggaatcta caagccaaaa
     4321 gtccctccct gcctgagggc agtaccctcc attgggcaca gtccagaccc aagtcaaaga
     4381 tgccccattc cttgcgcctc agccctcagt tccttcattt ccaccaggcc gtgccttgtt
     4441 tgagtttttc ctcccagtga gactgcccca cggagacaga ggaaagggct ggctccccct
     4501 ccccaggctg gagacccccc cccaactcca ggaaagagca gtcagagtcc agtgctctgc
     4561 ctcagacgtt gcctgagaag aagtggctgc cacacccagg ggaaggccct gaggcggagg
     4621 ctgtgctccg ccatggtgtc ccggtacctt ccatacacag aggagtgcag ccttctccat
     4681 atctccatgg ccctgtccca ggccggccca gatgtgtccc ccccaggcct tgtcctacgt
     4741 ccaaggtggc agatgtcttc cctgggctgc caccagcccc cgccccagag tggcccaccg
     4801 tggcactaga atgcaagtat cctgcgacct tgcaacctca ccttcctgtg ggtgttcttt
     4861 cctgccctgt ccaaaagcgc cctcactatt cttggaccat gccagattct gcctctctgg
     4921 aaagaggctc tggacagcag aagcctccaa gcacagagcc tggccccagg ccccagacag
     4981 ggtgggcttc ctgcccttcc ctctgggcac gcctgctggc cgacccactg acccactcgg
     5041 atggaccaac ctgctctgtc cccaaaggac gcctgcagga gagagcagca ctccgcatca
     5101 cctcaccaag gatcggactc tgcccctgga cctgggaacg actggactgt cacggggttc
     5161 cctcctagct ctcccagtga actcctgcca ggcacacaca gcccctatag cactgagctc
     5221 acatgggact gggatatggg ggcatctctt ccccagagag gcactcagtg agcctcctgt
     5281 gcctggcccc agcctgggcc atctcttagg tgagacagtt gcccgaaact aagccaggcc
     5341 tggctggagg agcagcagct tggggagagg gatttccctg cagacctcaa gccatcatgc
     5401 ggtgggtgct gccatgacag aggctgcacc cctgggccag cggggctgct cacccacctc
     5461 ttgtgcaagg tggcctttgt gctgcgcctg caggcagagc tggagccccc agcagaggca
     5521 ggctgggacg gaccagcatc tggaagatgt acatagttat ttttctcttt gtggtttctt
     5581 gtttggtttg gtttgctttt gacagcttca ttttattttt gacgtcactt tttggccatg
     5641 taaactattt gtggcaattt tatgttttta tttatgaata aagaatgcca tttctcacgc
     5701 cctcta
//
