LOCUS       NM_006767               4282 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens leucine zipper like post translational regulator 1
            (LZTR1), mRNA.
ACCESSION   NM_006767
VERSION     NM_006767.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4282)
  AUTHORS   Busley,A.V., Gutierrez-Gutierrez,O., Hammer,E., Koitka,F.,
            Mirzaiebadizi,A., Steinegger,M., Pape,C., Bohmer,L., Schroeder,H.,
            Kleinsorge,M., Engler,M., Cirstea,I.C., Gremer,L., Willbold,D.,
            Altmuller,J., Marbach,F., Hasenfuss,G., Zimmermann,W.H.,
            Ahmadian,M.R., Wollnik,B. and Cyganek,L.
  TITLE     Mutation-induced LZTR1 polymerization provokes cardiac pathology in
            recessive Noonan syndrome
  JOURNAL   Cell Rep 43 (7), 114448 (2024)
   PUBMED   39003740
  REMARK    GeneRIF: Mutation-induced LZTR1 polymerization provokes cardiac
            pathology in recessive Noonan syndrome.
REFERENCE   2  (bases 1 to 4282)
  AUTHORS   Damianou,A., Liang,Z., Lassen,F., Vendrell,I., Vere,G., Hester,S.,
            Charles,P.D., Pinto-Fernandez,A., Santos,A., Fischer,R. and
            Kessler,B.M.
  TITLE     Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1
            E3 ligase complex
  JOURNAL   Life Sci Alliance 7 (5), e202302245 (2024)
   PUBMED   38453365
  REMARK    GeneRIF: Oncogenic mutations of KRAS modulate its turnover by the
            CUL3/LZTR1 E3 ligase complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4282)
  AUTHORS   Yu,Q.X., Zhen,L., Lin,X.M., Wen,Y.J. and Li,D.Z.
  TITLE     Prenatal diagnosis of autosomal recessive Noonan syndrome
            associated with biallelic LZTR1 variants presented with thick
            nuchal translucency and cardiac abnormalities
  JOURNAL   Prenat Diagn 43 (13), 1662-1665 (2023)
   PUBMED   37936555
  REMARK    GeneRIF: Prenatal diagnosis of autosomal recessive Noonan syndrome
            associated with biallelic LZTR1 variants presented with thick
            nuchal translucency and cardiac abnormalities.
REFERENCE   4  (bases 1 to 4282)
  AUTHORS   Wilcox,N., Dumont,M., Gonzalez-Neira,A., Carvalho,S., Joly
            Beauparlant,C., Crotti,M., Luccarini,C., Soucy,P., Dubois,S.,
            Nunez-Torres,R., Pita,G., Gardner,E.J., Dennis,J., Alonso,M.R.,
            Alvarez,N., Baynes,C., Collin-Deschesnes,A.C., Desjardins,S.,
            Becher,H., Behrens,S., Bolla,M.K., Castelao,J.E., Chang-Claude,J.,
            Cornelissen,S., Dork,T., Engel,C., Gago-Dominguez,M., Guenel,P.,
            Hadjisavvas,A., Hahnen,E., Hartman,M., Herraez,B., Jung,A.,
            Keeman,R., Kiechle,M., Li,J., Loizidou,M.A., Lush,M.,
            Michailidou,K., Panayiotidis,M.I., Sim,X., Teo,S.H., Tyrer,J.P.,
            van der Kolk,L.E., Wahlstrom,C., Wang,Q., Perry,J.R.B., Benitez,J.,
            Schmidt,M.K., Schmutzler,R.K., Pharoah,P.D.P., Droit,A.,
            Dunning,A.M., Kvist,A., Devilee,P., Easton,D.F. and Simard,J.
  CONSRTM   SGBCC Investigators
  TITLE     Exome sequencing identifies breast cancer susceptibility genes and
            defines the contribution of coding variants to breast cancer risk
  JOURNAL   Nat Genet 55 (9), 1435-1439 (2023)
   PUBMED   37592023
  REMARK    GeneRIF: Exome sequencing identifies breast cancer susceptibility
            genes and defines the contribution of coding variants to breast
            cancer risk.
            Erratum:[Nat Genet. 2023 Nov;55(11):2009. doi:
            10.1038/s41588-023-01549-x.. PMID: 37752376]
REFERENCE   5  (bases 1 to 4282)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 4282)
  AUTHORS   Nacak,T.G., Leptien,K., Fellner,D., Augustin,H.G. and Kroll,J.
  TITLE     The BTB-kelch protein LZTR-1 is a novel Golgi protein that is
            degraded upon induction of apoptosis
  JOURNAL   J Biol Chem 281 (8), 5065-5071 (2006)
   PUBMED   16356934
  REMARK    GeneRIF: LZTR-1 is the first BTB-kelch protein that exclusively
            localizes to the Golgi network
REFERENCE   7  (bases 1 to 4282)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 4282)
  AUTHORS   Kurahashi,H., Akagi,K., Inazawa,J., Ohta,T., Niikawa,N.,
            Kayatani,F., Sano,T., Okada,S. and Nishisho,I.
  TITLE     Isolation and characterization of a novel gene deleted in DiGeorge
            syndrome
  JOURNAL   Hum Mol Genet 4 (4), 541-549 (1995)
   PUBMED   7633402
REFERENCE   9  (bases 1 to 4282)
  AUTHORS   Dhamija,R., Plotkin,S., Gomes,A. and Babovic-Vuksanovic,D.
  TITLE     LZTR1- and SMARCB1-Related Schwannomatosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29517885
REFERENCE   10 (bases 1 to 4282)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA194822.1, BC026214.1 and
            CT841521.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006767.3.
            
            Summary: This gene encodes a member of the BTB-kelch superfamily.
            Initially described as a putative transcriptional regulator based
            on weak homology to members of the basic leucine zipper-like
            family, the encoded protein subsequently has been shown to localize
            exclusively to the Golgi network where it may help stabilize the
            Gogli complex. Deletion of this gene may be associated with
            DiGeorge syndrome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.151971.1,
                                           SRR1660809.37255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646124.2/ ENSP00000496779.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               DA194822.1         29-553
            526-1757            BC026214.1         456-1687
            1758-2660           CT841521.1         1702-2604
            2661-4282           BC026214.1         2591-4212
FEATURES             Location/Qualifiers
     source          1..4282
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..4282
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /note="leucine zipper like post translational regulator 1"
                     /db_xref="GeneID:8216"
                     /db_xref="HGNC:HGNC:6742"
                     /db_xref="MIM:600574"
     exon            1..275
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2598
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /note="leucine zipper like transcription regulator 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="leucine-zipper-like transcriptional regulator 1"
                     /protein_id="NP_006758.2"
                     /db_xref="CCDS:CCDS33606.1"
                     /db_xref="GeneID:8216"
                     /db_xref="HGNC:HGNC:6742"
                     /db_xref="MIM:600574"
                     /translation="MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLN
                     FGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKD
                     CSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATG
                     QWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEV
                     AQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRG
                     SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGG
                     AEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHA
                     AAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLG
                     EKEECVQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPL
                     LHVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLC
                     RQYIEASVDLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPL
                     IVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLEGAGAEFCDITLLLDGHPRPAHK
                     AILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSL
                     YLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVH
                     QFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI"
     exon            276..338
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..395
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..475
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..584
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..668
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            669..726
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..866
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1068
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1224
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1335
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1428
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1524
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1690
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1860
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2017
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2144
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2294
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2400
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2481
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..4282
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4248..4253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /note="hexamer: AATGAA"
     regulatory      4254..4259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /note="hexamer: ATTACA"
     polyA_site      4265
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
     polyA_site      4282
                     /gene="LZTR1"
                     /gene_synonym="BTBD29; LZTR-1; NS10; NS2; SWNTS2"
                     /note="major polyA site"
ORIGIN      
        1 gtggtttctc cagccggccc ggggcggtgg ccgcaagttg ggcttacagc gcggccgatc
       61 cggcgtggac ccgggatggc tggaccgggc agcacggggg ggcagatcgg ggctgcggcc
      121 ctggcaggcg gcgcgcggtc caaggtagcc ccgagcgtgg acttcgacca tagctgctcg
      181 gacagtgtcg agtacctgac gctcaacttc gggcccttcg aaacagtgca tcgctggcgg
      241 cgcctcccgc cctgcgacga gttcgtgggt gcccggcgca gcaagcacac agtggtggcc
      301 tataaagatg ccatttatgt atttggtgga gacaatggga agaccatgct caatgacctc
      361 ctgcggttcg atgtgaaaga ctgctcctgg tgcagggcct ttaccactgg gaccccaccg
      421 gccccccgtt accaccactc ggccgtcgtc tatgggagca gcatgtttgt ctttgggggt
      481 tacactgggg acatttattc caattctaac ttgaagaata aaaacgacct ctttgaatac
      541 aagtttgcaa ctggccagtg gacggagtgg aaaattgaag gacggttgcc agtcgctagg
      601 tcagcccatg gggccacggt gtacagtgac aagctgtgga tctttgctgg ctatgacggc
      661 aacgccaggt tgaatgacat gtggacaatt ggcctccagg accgagagct cacctgctgg
      721 gaggaggtgg cccagagtgg cgagatcccc ccatcttgct gcaacttccc cgtggctgtg
      781 tgccgggaca agatgtttgt attctctggg caaagcggag ccaaaataac caacaacctc
      841 ttccagtttg aattcaagga caagacgtgg acacgcatcc caactgaaca cctgctccgg
      901 ggctccccac cacccccgca gcggcgctac gggcatacca tggtggcctt tgaccgccac
      961 ctctatgtgt ttgggggtgc ggccgacaac acgctgccca acgagctgca ctgctatgac
     1021 gtggacttcc agacctggga ggtcgtccag cccagctccg acagcgaggt tggtggggct
     1081 gaagtgcccg agcgagcctg tgcttccgag gaggtgccca ccctgaccta tgaggagcgg
     1141 gttggcttca agaagtcccg agatgtgttt ggcctggact ttggcaccac ctcagccaag
     1201 cagcccaccc agcctgcctc ggagctgccc agtgggaggc tcttccacgc ggctgctgtc
     1261 atctcggacg ccatgtacat cttcgggggc acggtggaca acaacatccg cagcggggag
     1321 atgtacaggt tccagttctc ctgttaccct aaatgcacgc tgcacgagga ctacgggcgg
     1381 ctgtgggaga gccgccagtt ctgcgacgtg gagttcgtgc tgggtgagaa ggaggagtgc
     1441 gtgcagggcc acgtagccat tgtcacagcg cggagccgct ggcttcgcag gaagatcacg
     1501 caggcgcggg agaggctggc ccagaagctg gagcaggagg ccgccccagt tcccagggag
     1561 gcccccggcg tggctgctgg tggggcccgg ccgcccctgc tgcacgtggc catccgggag
     1621 gccgaggccc ggcccttcga ggtgctcatg cagttcctct acaccgacaa gatcaaatac
     1681 ccacggaaag gccatgtgga ggatgtgctg ctcatcatgg atgtgtacaa actggcactg
     1741 agcttccagt tgtgccgcct ggagcagctg tgccgccagt acatcgaggc ctccgtggac
     1801 ctgcagaacg tgctggttgt gtgcgagagt gccgcccggc tgcagctgag ccaactcaag
     1861 gagcactgcc tgaacttcgt ggtaaaggag tcccacttca accaggtgat catgatgaag
     1921 gagttcgagc gcctctcctc tccactgata gtggagattg tgcggcggaa gcagcagccg
     1981 ccccctcgca ctcccttgga ccagccagtg gacattggca catctctgat ccaggacatg
     2041 aaggcatacc tggagggagc gggcgcggaa ttctgtgaca tcactctgtt gcttgacggg
     2101 cacccacggc cagcccacaa ggctatcctg gccgcccgct ccagctactt tgaagccatg
     2161 ttccggtcct tcatgcccga agatgggcag gtgaacatct ccatcgggga gatggtgccc
     2221 agcaggcagg ccttcgagtc catgctgcgc tacatctact acggcgaggt caacatgccg
     2281 cccgaggact cgctctactt gtttgcggcc ccctactact acggcttcta caacaaccgg
     2341 ctgcaggcgt actgcaagca gaacctggag atgaacgtga cggtgcagaa cgtgctgcag
     2401 atcctggagg cagctgacaa aacgcaggca ctggacatga agcggcactg cctgcacatc
     2461 attgtgcacc agttcaccaa ggtctccaag ttgcccaccc tgcggtcgct gagccagcag
     2521 ctgctgctgg acatcataga ctccctggcc tcccacatct cagacaagca gtgcgcagag
     2581 ctgggcgccg acatctgagg ccctgtggcg cctgcccatt gtgaagaatc gccgtgcctg
     2641 cctgccctgc ctactgagaa gactaccggc tatgcgcatg cctatggcag tgggtgcacc
     2701 tgccaggcca agggtcaggg tgcccagagc ctccaaagag agctgagggg atgtggggcc
     2761 ccaaactcat taattcactg aagacacagg tcccacaggg agcggatgat gaagcagacc
     2821 ccctcctgtc atcaccctct cctggtgtag tgtggatgcg aggccacggc tcagtgatgg
     2881 gctcaccacc cagaagtggg gagagacttt gggcctccca cccagtgggg cttggcctgg
     2941 cttctgtggc ctgggcgtgt tgtggactca ggcactgggg cctgtcacca aggctcctcc
     3001 aacatgcggg aggaggctta gcagacttgc gctgcaccag cgaatctgcc tgggctgctc
     3061 ctgtcccacc caccctcact gagatccatg taaggggctc ctcttcccac ctggaacttg
     3121 tgagtgggga cccatgatgt atgggtctca cctgacttga ggtgaatttt ggagtgaagg
     3181 gccctgaggt cagctcccag gtcggtcgtg ctgggccagg cctggttttc acaggggctg
     3241 aaggatccca gtccacctgt gtgcatgtca gggctcggcc gggaagaagc cagcaaagtc
     3301 ccccgtgtcc cttgctgagt attctgtcac agacaagcct ccattaaagc cacagcagtg
     3361 ctacccacca cacacacctt gctggcccgg ccaccactgc tggcttcagc cccttgagca
     3421 gcccatggct tagcagaccc ccagatgtag gtcagtggcc ttacctgtct ctatccatgc
     3481 tgtcaactcc tgcctccacc tggggtcacc cagtcacatt gggaagggct gtgaaggcct
     3541 ccaggctggc cccttccagg ggaatcctgg aggcctgggg tgggctcctg ccccttctgc
     3601 cctgccttgc ccctgcacta tgctcttggc tcctgtggaa ggagggctgc cctcttgccc
     3661 tagtgagggc cccatgtgga tccactctag tgctgggagc cagcgctccc ttactgggaa
     3721 caggattcca ggaccccttt cttgttgtgg ctgccatgaa gccacagctc cttggggaag
     3781 tgacctgctc tcctttgggt gtatgcaggt gtgtgggggg ccctgagtgg caagttgctt
     3841 agctaacagg agatccatag gcagcctgca ggctaggaag tggcctagtg caagatgagc
     3901 tgggaacaag ggaggagaga gcaggagctg gggcagaggc tgagccggga ggcccttgag
     3961 gtgaggacac agcaggccca ggaccatggc tggggaggat atgtcagcac ctggaagtgg
     4021 agtgcaggct gcagcgccca gccatgtggg ccaggtgcat tcactcagag tggggccaca
     4081 cacccatcta cccagtttcc acaagatgtg gctcctgcca cacccacagg gcagcctcct
     4141 ccaaatccct cctggagggg cctacccaga agcctccttg aaccagtctg caaccctgct
     4201 ctatgctgac ccttgtcact gaaccctgat ctagacttat atgaataaat gaaattacat
     4261 gccaagggcc ctaaaaagca aa
//
