LOCUS       NM_032368               4989 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine zipper and CTNNBIP1 domain containing (LZIC),
            transcript variant 1, mRNA.
ACCESSION   NM_032368 XM_005263508
VERSION     NM_032368.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4989)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4989)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4989)
  AUTHORS   Skalka,G., Hall,H., Somers,J., Bushell,M., Willis,A. and
            Malewicz,M.
  TITLE     Leucine zipper and ICAT domain containing (LZIC) protein regulates
            cell cycle transitions in response to ionizing radiation
  JOURNAL   Cell Cycle 18 (9), 963-975 (2019)
   PUBMED   30973299
  REMARK    GeneRIF: LZIC is functionally involved in cellular response to
            ionizing radiation, and its expression level could serve as a
            biomarker for patient stratification in clinical cancer practice.
REFERENCE   4  (bases 1 to 4989)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 4989)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4989)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of LZIC, a novel gene
            encoding ICAT homologous protein with leucine zipper domain
  JOURNAL   Int J Mol Med 8 (6), 611-615 (2001)
   PUBMED   11712074
REFERENCE   7  (bases 1 to 4989)
  AUTHORS   Claudio,J.O., Liew,C.C., Dempsey,A.A., Cukerman,E., Stewart,A.K.,
            Na,E., Atkins,H.L., Iscove,N.N. and Hawley,R.G.
  TITLE     Identification of sequence-tagged transcripts differentially
            expressed within the human hematopoietic hierarchy
  JOURNAL   Genomics 50 (1), 44-52 (1998)
   PUBMED   9628821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357140.33, AA220235.1, BC007240.1 and CB241987.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032368.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.37222.1,
                                           SRR1803612.213526.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377223.6/ ENSP00000366430.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL357140.33        148203-148258       c
            57-62               AA220235.1         1-6
            63-1022             BC007240.1         1-960
            1023-4630           AL357140.33        131519-135126       c
            4631-4984           CB241987.1         17-370              c
            4985-4989           AL357140.33        131160-131164       c
FEATURES             Location/Qualifiers
     source          1..4989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..4989
                     /gene="LZIC"
                     /note="leucine zipper and CTNNBIP1 domain containing"
                     /db_xref="GeneID:84328"
                     /db_xref="HGNC:HGNC:17497"
                     /db_xref="MIM:610458"
     exon            1..143
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     exon            144..302
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     exon            303..411
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..883
                     /gene="LZIC"
                     /note="isoform a is encoded by transcript variant 1;
                     leucine zipper domain and ICAT homologous domain
                     containing; protein LZIC; leucine zipper and CTNNBIP1
                     domain-containing protein; leucine zipper and ICAT
                     homologous domain-containing protein"
                     /codon_start=1
                     /product="protein LZIC isoform a"
                     /protein_id="NP_115744.2"
                     /db_xref="CCDS:CCDS107.1"
                     /db_xref="GeneID:84328"
                     /db_xref="HGNC:HGNC:17497"
                     /db_xref="MIM:610458"
                     /translation="MASRGKTETSKLKQNLEEQLDRLMQQLQDLEECREELDTDEYEE
                     TKKETLEQLSEFNDSLKKIMSGNMTLVDELSGMQLAIQAAISQAFKTPEVIRLFAKKQ
                     PGQLRTRLAEMDRDLMVGKLERDLYTQQKVEILTALRKLGEKLTADDEAFLSANAGAI
                     LSQFEKVSTDLGSGDKILALASFEVEKTKK"
     exon            412..547
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     exon            548..646
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     exon            647..742
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     exon            743..824
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     exon            825..4989
                     /gene="LZIC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4868..4873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZIC"
                     /note="hexamer: AATAAA"
     polyA_site      4889
                     /gene="LZIC"
                     /note="major polyA site"
     regulatory      4950..4955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LZIC"
                     /note="hexamer: AATAAA"
     polyA_site      4989
                     /gene="LZIC"
ORIGIN      
        1 ggaagtgctc ccccggcgcg gtccgccagg ccagtgccct caggtaggcg gggcccctgg
       61 ccctaaactc tgggactggc gggcggtcag gcggcacagg gggaatcccg ggggcctaag
      121 gaggttgtcc cagtttttgt cagcatctcc accccgaggt ggtttgaact ttgagccttt
      181 tgtagtcctg atgaataatt tcattttcct caagtttatg acactcggaa cgtcaagaac
      241 tggaggtttg tgcaatttga gaccggtcgg cactgtgcag agatcagagt actaagagac
      301 agagattaaa atggcttcca gaggaaagac agagacaagc aaattaaagc agaatttaga
      361 agaacagttg gatagactca tgcaacaatt acaagatctg gaggaatgca gagaggaact
      421 tgatacagat gaatatgaag aaaccaaaaa ggaaactctg gagcaactaa gtgaatttaa
      481 tgattcacta aagaaaatta tgtctggaaa tatgactttg gtagatgaac taagtggaat
      541 gcagctggct attcaggcag ctatcagcca ggcctttaaa accccagagg tcatcagatt
      601 gtttgcaaag aaacaaccag gtcagcttcg gacaaggtta gcagagatgg atagagatct
      661 gatggtagga aagctggaaa gagacctgta cactcaacag aaagtggaga tactaacagc
      721 tcttaggaaa cttggagaga agctgactgc agatgatgag gccttcttgt cagcaaatgc
      781 aggtgctata ctcagccagt ttgagaaagt ctctacagac cttggctctg gagacaaaat
      841 tcttgctctg gcaagttttg aggttgaaaa aacaaaaaaa tgacatggtg cagaagcttg
      901 taacattgat cacattctta atgtaaatgg tgtctttctt ctggggtttt cagttattgc
      961 aaagaaatga agagattctg gaaatgcatc aataacctaa gaaaaagcga cataaaaata
     1021 tacttatggc ttgtgtttat gctcttcatc attgtgcgtt gtgtgcggtt acctgcttga
     1081 gtgatcctga acttgttgcg acagagggac tcactggact ctgttcgtta tgatttgtct
     1141 gtttaagaga gaaaacaaag tggacttgat ttttattaag gctgtttgtt tttaagtgtt
     1201 gatagtgaac gaaaagatgt gaagtaatga tatttttctg cttacaactt atccccactc
     1261 attggagtga acagtgacgc aagctcaata gacttcataa gtgttcatag aattttacaa
     1321 ttctgagtga tcttagaaat catttctgtt tttacaaaca aggaaactga ggtccagaaa
     1381 gagcaagcga ctttgcttaa agtcgcatca gagagctgag ggtaagactc aggtgtcctg
     1441 actcccagtt tagtatcttt tgaattttat ttctgtacca tttaaaaaaa ataattaaca
     1501 ctatttgtgc aagtcagtgt ttttgaaaat tcagtgtccc aataaaaagt ggactgcaca
     1561 ctaagggacc atcccccagc ctgtaagctg tctgtattaa tggggcccgt tgtatctcgg
     1621 aattttgagg ttggaacaat gggagccctg ttgagcgttt cctaaagtga cttagccgcc
     1681 tgcgttgttt gaccagggaa gcaacaggaa atggcagcta gaggccctcc ctgtgcgtga
     1741 cctcttgtca cactcagagg ggggtaactg tcagctgtta tctactcttc aggttttgga
     1801 gaaacacaaa ataagttatg aggaaaagca aatttctctc ctgagtattt acatgtctct
     1861 gtatgctcaa atatgcagat gtgtccctat gcgtgtatat tagcttattt tttaggctct
     1921 agccatttta tattctttca tgtgcttctc aatattcttt ttctttgcac tttatacaaa
     1981 ttaaaagcat ttttaaagct tcttctgtac tgtaaactac taggtgcttt gccaaccaga
     2041 cagattagag gacctccgct acactgatgc cttatttgga acttaaaaga ggtgaaattc
     2101 atatatcata aaattcacca ttttaaagtg taccattcgt tggcagaaca tttacagtgg
     2161 tgtgcaacca tcactactct ctagttgcag aacattctta tcacccccaa aggaggccct
     2221 atacctatta agcagttagt ccccattccc ttctcctccg actgctaaca atagccacta
     2281 atctgcaccc tgtctctgtg gatttaccta ttctggatat ttcatataaa tggaatcata
     2341 tgatatgtga cctttttatg tatctggctt ctttcactta gcataatatt ttcttttctt
     2401 tttttttttt tttttgagac agagttttac tcttattgcc caggctggag tgcaatggcg
     2461 caatctcaac ctccgcctcc caggttcaag agattctcct gcctcagctt cccaagtagc
     2521 tgggattact agtgtgtacc accacgccca gctaattttt gtacctttag tatagagaca
     2581 gggtttcacc atgttggccc agctggtcct gagctgacct caggtgatcc aactgcctcg
     2641 gcctcccaaa gtgctgggat tataggtgtg agctaccaca ccgggacatc atcatatttt
     2701 caagtttaac caacattata gcatgtatca gtactttatt cctttttatg gctaaataat
     2761 attccattgt atggatatca tattttgttt atccggtatc tgttgatgat ttgggttgtt
     2821 tccttctttt ggctattgtg aataatgctt cagtgaacat ttgtgtacaa atatttgttt
     2881 gaatacctgt tttcaatttt tttgggtgta cacctaggaa tggaattgct gcgtttgttg
     2941 ttgtgttgtt gttgttgtcg ttgttttttg agatggagtt tcactctgtt gcccaggctg
     3001 gagtgcaatg gcgtgatctc ggctcaccac aacttctgcc tcccaggttc aagcgattct
     3061 cctgcctcag cctcccgagt agctgggatt aaggcatgcg ccaccacacc tggctaattt
     3121 tgtgttttta gtagagatgg ggtttctcca tgttggtcag gctggtctcg aactcctgac
     3181 cttaggtgat ccacccgcct caacctccca gagtgctggg atgattacag gcatgagcca
     3241 ccatacccgg cctgagccac cacacccagc ctacgtttgt tttttaagcc atagaagatt
     3301 cttcccacca gtcgggcaca gtggctcaca cctgtaatcc cagcacttca ggaggccaag
     3361 gcgggcggat cacaagatca ggagctcaag accagcctgg ccaacacagt gaaactccat
     3421 ctctacaaaa attagccagg catagtggca ggtgcctgta gtctcagcta cttgggagac
     3481 tgaggcagga gaatcacttg aacctgggag gcagaggttt cggtgagccg agatggcgcc
     3541 actgcactcc agcctgggcg acagactgag acacggtctc aaaaaaaaaa aaaaaaaaaa
     3601 aaagaggaag aagattcttc ccttaccctg caatagtaga ccagaaaaat taggaatatc
     3661 ttgaatttga aagggaccta atgcctggca cagtggctca cgcatgtaat ctcagaactc
     3721 tgggaggcag aggtgggcgg atcgcctgaa ctcaggattt gagaccagcc tggccaacat
     3781 ggtgaaaccc tgtctctaaa aaaaaaaaaa aaattagcca ggcgtgatgg catgcacttg
     3841 tggtcccagc tactcaggaa gctgaggtca gaggatcacc tgaacctggg aagcagaggt
     3901 tgcagtgaac tgagatcacg ccactgtact ggctgacaaa gtgagacccc tgtctaaaaa
     3961 aaagataaag agagttacct gaatctggaa tccttaatct tggttttcct taaactttct
     4021 ataagtccag catctgaaat attttgtcaa ttatcacatt aatgtgttca ttttgtaagt
     4081 aagagtactc aatttaaaat gatcttactt taaaagtggc ctagtttgca gtgcccagca
     4141 ggacactgac agtcacagct gtgtgacttt ttgtgggtta cttaattttt ttgagcctcc
     4201 ttttctcttc tattcaatga ggataatagg gcctacctca taggattatt atgcattccc
     4261 ctctgttaat gcacgtaaag tttttacttg gaaaactaac tcaccattta acaaccattc
     4321 taagcaccat aggatatatt ttgtttcaca aatttggtat tcattcagaa taagtatttg
     4381 aaaagtgagt aaattctatg caattatagt tattaaatga cttataaact gtgtttctct
     4441 tccacttctt gctacattta atcttctagg tgttcagata tctttggaga ttataggcag
     4501 caataaagct aaggcagcta acctttcaac attcttgtgt caggctaata ttttggtgaa
     4561 aggaattctt gtgtttctca aagaactaga gctgaagcag aaataagttc caatgagcaa
     4621 gtgtccaatc ggaccattga atgaaatcta gtgttttaaa caattctgat gtttcaatgt
     4681 tttgttctgt tttcttttga tcttgtgagc agtaagacat attttatgtg ggtggtaaag
     4741 gaagaaatca agtaacagaa tgaggaattg ttcccaggaa gagttagagt tgggacaaat
     4801 gggttgttaa ctttgatttt tagatcttct ctgaagacat taaacatgga atggtcatct
     4861 ttagaaaaat aaaagactat gcaactccac cactgaaatg gtatcttatt acagtgaatg
     4921 atggataatc tgaaattact atagaaaaaa ataaacccag accattttgc ctagagcctt
     4981 tcaaccacc
//
