LOCUS       NM_020426               1074 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens lysozyme like 6 (LYZL6), transcript variant 2, mRNA.
ACCESSION   NM_020426 XM_005258013 XM_006725329
VERSION     NM_020426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Huang,P., Li,W., Yang,Z., Zhang,N., Xu,Y., Bao,J., Jiang,D. and
            Dong,X.
  TITLE     LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays
            a role in fertilization
  JOURNAL   PLoS One 12 (2), e0171452 (2017)
   PUBMED   28182716
  REMARK    GeneRIF: LYZL6, an acidic, bacteriolytic and human sperm-related
            protein, is likely important for fertilization but not for the
            innate immunity of the male reproductive tract.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Zhou,X., Yu,Y., Tao,J. and Yu,L.
  TITLE     Production of LYZL6, a novel human c-type lysozyme, in recombinant
            Pichia pastoris employing high cell density fed-batch fermentation
  JOURNAL   J Biosci Bioeng 118 (4), 420-425 (2014)
   PUBMED   24745549
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Wei,J., Li,S.J., Shi,H., Wang,H.Y., Rong,C.T., Zhu,P., Jin,S.H.,
            Liu,J. and Li,J.Y.
  TITLE     Characterisation of Lyzls in mice and antibacterial properties of
            human LYZL6
  JOURNAL   Asian J Androl 15 (6), 824-830 (2013)
   PUBMED   24013621
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Zhang,K., Gao,R., Zhang,H., Cai,X., Shen,C., Wu,C., Zhao,S. and
            Yu,L.
  TITLE     Molecular cloning and characterization of three novel lysozyme-like
            genes, predominantly expressed in the male reproductive system of
            humans, belonging to the c-type lysozyme/alpha-lactalbumin family
  JOURNAL   Biol Reprod 73 (5), 1064-1071 (2005)
   PUBMED   16014814
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244100.3, HY024713.1,
            DB462957.1, BC054481.1, AY742214.1 and BE550275.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020426.3.
            
            Summary: This gene encodes a member of the C-type
            lysozyme/alpha-lactalbumin family. C-type lysozymes are
            bacteriolytic factors that play a role in host defense, whereas
            alpha-lactalbumins mediate lactose biosynthesis. The encoded
            protein contains catalytic residues characteristic of C-type
            lysozymes and may play a role in male reproduction. Alternatively
            spliced transcript variants have been observed for this gene.
            [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY359018.1, AY742214.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615905.5/ ENSP00000483897.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC244100.3         108395-108397       c
            4-14                HY024713.1         5-15
            15-46               DB462957.1         1-32
            47-488              HY024713.1         48-489
            489-726             BC054481.1         332-569
            727-1061            AY742214.1         500-834
            1062-1074           BE550275.1         18-30               c
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1074
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /note="lysozyme like 6"
                     /db_xref="GeneID:57151"
                     /db_xref="HGNC:HGNC:29614"
                     /db_xref="MIM:612751"
     exon            1..147
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /inference="alignment:Splign:2.1.0"
     exon            148..488
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..796
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /EC_number="3.2.1.17"
                     /note="lysozyme homolog; lysozyme-like protein 6;
                     epididymis secretory sperm binding protein Li 6a; lysozyme
                     B"
                     /codon_start=1
                     /product="lysozyme-like protein 6 precursor"
                     /protein_id="NP_065159.1"
                     /db_xref="CCDS:CCDS11302.1"
                     /db_xref="GeneID:57151"
                     /db_xref="HGNC:HGNC:29614"
                     /db_xref="MIM:612751"
                     /translation="MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSL
                     SDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLL
                     NPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR"
     exon            489..647
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /inference="alignment:Splign:2.1.0"
     exon            648..726
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1074
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /note="hexamer: ATTAAA"
     polyA_site      1074
                     /gene="LYZL6"
                     /gene_synonym="HEL-S-6a; LYC1; LYZB; PRO1485; TKAL754;
                     UNQ754"
                     /note="major polyA site"
ORIGIN      
        1 agaacatgga gagctgttag ttgggcaggg ctgaagtgta tgtggtgagg aagaagaggc
       61 tcctactgta gacagccttg ttctacagat cctcccagaa atctctgggc caggtggaac
      121 ccagggtcag agagggatgg gagagaggtt taattttcca tgataaataa aaatctataa
      181 aataataaac aagagaaaag agattggaaa cagccaggtt ggagcagtga gtgagtaagg
      241 aaacctggct gccctctcca gattccccag gctctcagag aagatcagca gaaagtctgc
      301 aagaccctaa gaaccatcag ccctcagctg cacctcctcc cctccaagga tgacaaaggc
      361 gctactcatc tatttggtca gcagctttct tgccctaaat caggccagcc tcatcagtcg
      421 ctgtgacttg gcccaggtgc tgcagctgga ggacttggat gggtttgagg gttactccct
      481 gagtgactgg ctgtgcctgg cttttgtgga aagcaagttc aacatatcaa agataaatga
      541 aaatgcagac ggaagctttg actatggcct cttccagatc aacagccact actggtgcaa
      601 cgattataag agttactcgg aaaacctttg ccacgtagac tgtcaagatc tgctgaatcc
      661 caaccttctt gcaggcatcc actgcgcaaa aaggattgtg tccggagcac gggggatgaa
      721 caactgggta gaatggaggt tgcactgttc aggccggcca ctcttctact ggctgacagg
      781 atgccgcctg agatgaaaca gggtgcgggt gcaccgtgga gtcattccaa gactcctgtc
      841 ctcactcagg gattcttcat ttcttcttcc tactgcctcc acttcatgtt attttcttcc
      901 cttcccattt acaactaaaa ctgaccagag ccccaggaat aaatggtttt cttggcttcc
      961 tccttactcc catctggacc cagtcccctg gttcctgtct gttatttgta aactgaggac
     1021 cacaataaag aaatctttat atttatcgaa atattaaagc actcgctctg caaa
//
