LOCUS       NM_144634                909 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens lysozyme like 4 (LYZL4), transcript variant 1, mRNA.
ACCESSION   NM_144634
VERSION     NM_144634.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 909)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 909)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
            Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
            Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of neurocognition as an indicator
            of antipsychotic treatment response in schizophrenia
  JOURNAL   Neuropsychopharmacology 36 (3), 616-626 (2011)
   PUBMED   21107309
REFERENCE   3  (bases 1 to 909)
  AUTHORS   Zhang,K., Gao,R., Zhang,H., Cai,X., Shen,C., Wu,C., Zhao,S. and
            Yu,L.
  TITLE     Molecular cloning and characterization of three novel lysozyme-like
            genes, predominantly expressed in the male reproductive system of
            humans, belonging to the c-type lysozyme/alpha-lactalbumin family
  JOURNAL   Biol Reprod 73 (5), 1064-1071 (2005)
   PUBMED   16014814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092048.2, HY037577.1 and BC016747.2.
            
            On Nov 23, 2018 this sequence version replaced NM_144634.3.
            
            Summary: Lysozymes (see LYZ; MIM 153450), especially C-type
            lysozymes, are well-recognized bacteriolytic factors widely
            distributed in the animal kingdom and play a mainly protective role
            in host defense. LYZL4 is a member of a family of lysozyme-like
            genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016747.2, SRR5189661.124115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287748.8/ ENSP00000287748.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC092048.2         142735-142742       c
            9-37                HY037577.1         2-30
            38-729              BC016747.2         1-692
            730-730             AC092048.2         129394-129394       c
            731-909             BC016747.2         694-872
FEATURES             Location/Qualifiers
     source          1..909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..909
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /note="lysozyme like 4"
                     /db_xref="GeneID:131375"
                     /db_xref="HGNC:HGNC:28387"
                     /db_xref="MIM:612750"
     exon            1..194
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /inference="alignment:Splign:2.1.0"
     exon            195..425
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..727
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /note="lysozyme-like protein 4; lysozyme-4; lysozyme A"
                     /codon_start=1
                     /product="lysozyme-like protein 4 precursor"
                     /protein_id="NP_653235.1"
                     /db_xref="CCDS:CCDS2697.1"
                     /db_xref="GeneID:131375"
                     /db_xref="HGNC:HGNC:28387"
                     /db_xref="MIM:612750"
                     /translation="MKASVVLSLLGYLVVPSGAYILGRCTVAKKLHDGGLDYFEGYSL
                     ENWVCLAYFESKFNPMAIYENTREGYTGFGLFQMRGSDWCGDHGRNRCHMSCSALLNP
                     NLEKTIKCAKTIVKGKEGMGAWPTWSRYCQYSDTLARWLDGCKL"
     exon            426..578
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /inference="alignment:Splign:2.1.0"
     exon            579..657
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /inference="alignment:Splign:2.1.0"
     exon            658..909
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      887..892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /note="hexamer: AATAAA"
     polyA_site      909
                     /gene="LYZL4"
                     /gene_synonym="LYC4; LYZA"
                     /note="major polyA site"
ORIGIN      
        1 agaagagcat gtcatggaga actcttgggt gcagacaagt ggatgattaa tgaagtagca
       61 tctgaaaaac ccaaggaacc aaatgtaggt ggagcaactt ccctgcaaca cacgtcgaag
      121 ctgctgcagt ggctgttctt cccctcccct tggaaaggca ccaaaagcca gcctttggaa
      181 gggctggtgg actgtgccct tctttccctt cagagaacca gtgtccctgt gactccaccc
      241 actcatctgg ccaccgttgc cctgacctgc caggagcctg gagaagatga aggcatccgt
      301 ggttctctcc ctccttggct acctggtggt tccaagtggt gcttacatct tggggcgttg
      361 cacagtggct aagaaactcc acgatggagg cctggattat tttgagggct atagccttga
      421 gaactgggtg tgcctggcct acttcgagag caagttcaac cccatggcca tctacgagaa
      481 cacacgtgag ggctacactg gctttggcct ctttcagatg cgtggcagtg actggtgtgg
      541 cgaccatggc aggaaccgct gccatatgtc atgttccgct ttactgaatc ctaatttaga
      601 gaagacaatt aaatgtgcca agaccattgt aaaaggaaaa gaagggatgg gagcatggcc
      661 cacctggtcc cggtactgcc agtactccga taccctggca cggtggctgg atggttgcaa
      721 gctgtagcca cctgcatggc ccctgcagca ctcaccagtt gcatcttgtg aatgaaggtg
      781 cttttctgct tgctgcttca gtcaatcctt ttgatgatct caccacttta agagttccag
      841 atggaaaaag acaaaagttt gcttcatccg gggatgcagg atgcagaata aaccaaacta
      901 gttactcaa
//
