LOCUS       NM_183058                809 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lysozyme like 2 (LYZL2), mRNA.
ACCESSION   NM_183058
VERSION     NM_183058.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 809)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
  REMARK    GeneRIF: We identified a significant genetic association between
            dental caries of the anterior mandibular teeth and LYZL2 (p value =
            9e-9), which codes a bacteriolytic agent thought to be involved in
            host defense.
REFERENCE   2  (bases 1 to 809)
  AUTHORS   Argyropoulos,G., Stutz,A.M., Ilnytska,O., Rice,T., Teran-Garcia,M.,
            Rao,D.C., Bouchard,C. and Rankinen,T.
  TITLE     KIF5B gene sequence variation and response of cardiac stroke volume
            to regular exercise
  JOURNAL   Physiol Genomics 36 (2), 79-88 (2009)
   PUBMED   18984674
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 809)
  AUTHORS   Zhang,K., Gao,R., Zhang,H., Cai,X., Shen,C., Wu,C., Zhao,S. and
            Yu,L.
  TITLE     Molecular cloning and characterization of three novel lysozyme-like
            genes, predominantly expressed in the male reproductive system of
            humans, belonging to the c-type lysozyme/alpha-lactalbumin family
  JOURNAL   Biol Reprod 73 (5), 1064-1071 (2005)
   PUBMED   16014814
REFERENCE   4  (bases 1 to 809)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451107.6, BC066294.1, AF139543.1 and AI637906.1.
            
            On Jul 26, 2018 this sequence version replaced NM_183058.2.
            
            Summary: Lysozymes (see LYZ; MIM 153450), especially C-type
            lysozymes, are well-recognized bacteriolytic factors widely
            distributed in the animal kingdom and play a mainly protective role
            in host defense. LYZL2 is a member of a family of lysozyme-like
            genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066294.1, AF139543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000647634.2/
                                                ENSP00000497408.1
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL451107.6         32902-32936         c
            36-557              BC066294.1         1-522
            558-616             AF139543.1         502-560
            617-802             BC066294.1         582-767
            803-809             AI637906.1         4-10                c
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.23"
     gene            1..809
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /note="lysozyme like 2"
                     /db_xref="GeneID:119180"
                     /db_xref="HGNC:HGNC:29613"
                     /db_xref="MIM:612748"
     exon            1..161
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /inference="alignment:Splign:2.1.0"
     exon            162..325
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..633
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /EC_number="3.2.1.17"
                     /note="lysozyme-like protein 2; lysozyme-2; lysozyme D2"
                     /codon_start=1
                     /product="lysozyme-like protein 2 precursor"
                     /protein_id="NP_898881.3"
                     /db_xref="CCDS:CCDS7167.3"
                     /db_xref="GeneID:119180"
                     /db_xref="HGNC:HGNC:29613"
                     /db_xref="MIM:612748"
                     /translation="MKAAGILTLIGCLVTGAESKIYTRCKLAKIFSRAGLDNYWGFSL
                     GNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGKLKENNHCHVACSALV
                     TDDLTDAIICAKKIVKETQGMNYWQGWKKHCEGRDLSDWKKDCEVS"
     exon            326..484
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..563
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..809
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      776..781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /note="hexamer: AATAAA"
     polyA_site      809
                     /gene="LYZL2"
                     /gene_synonym="LYZD2"
                     /note="major polyA site"
ORIGIN      
        1 aggaaaggat tactcgagcc ttgttagaat cagacatggc ttcaggggat gcaggacgct
       61 cccctgagct gcctgtcacc gactaagtgg agcagtgttt cttccgcaga ctcaactgag
      121 aagtcagcct ctgcggcagg caccaggaat ctgccttttc agttctgtct ccggcaggct
      181 ttgaggatga aggctgcggg cattctgacc ctcattggct gcctggtcac aggcgccgag
      241 tccaaaatct acactcgttg caaactggca aaaatattct cgagggctgg cctggacaat
      301 tactggggct tcagccttgg aaactggatc tgcatggcgt attatgagag cggctacaac
      361 accacagccc agacggtcct ggatgacggc agcatcgact acggcatctt ccagatcaac
      421 agcttcgcgt ggtgcagacg cggaaagctg aaggagaaca accactgcca cgtcgcctgc
      481 tcagccttgg tcactgatga cctcacagat gcgattatct gtgccaagaa aattgttaaa
      541 gagacacaag gaatgaacta ttggcaaggc tggaagaaac actgtgaggg gagagacctg
      601 tccgactgga aaaaagactg tgaggtttcc taaactggaa ctggacccag gatgctttgc
      661 agcaacgccc tagggtttgc agtgaatgtc caaatgcctg tgtcatcttg tcccgtttcc
      721 tcccaatatt ccttctcaaa cttggagagg gaaaattaag ctatactttt aagaaaataa
      781 atatttccat ttaaatgtct tcaccctga
//
