LOCUS       NM_032517                806 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens lysozyme like 1 (LYZL1), mRNA.
ACCESSION   NM_032517
VERSION     NM_032517.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   2  (bases 1 to 806)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   3  (bases 1 to 806)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   4  (bases 1 to 806)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 806)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP369317.1, BC021730.2, BF057063.1, AI393331.1, BG209290.1 and
            AL158167.15.
            
            On May 17, 2019 this sequence version replaced NM_032517.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.60363.1,
                                           SRR5189667.180902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000649382.2/
                                                ENSP00000498092.1
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BP369317.1         21-45
            26-85               BC021730.2         1-60
            86-87               BF057063.1         347-348             c
            88-370              BC021730.2         63-345
            371-372             AI393331.1         433-434             c
            373-799             BC021730.2         348-774
            800-803             BG209290.1         320-323
            804-806             AL158167.15        22777-22779
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1-p11.23"
     gene            1..806
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /note="lysozyme like 1"
                     /db_xref="GeneID:84569"
                     /db_xref="HGNC:HGNC:30502"
     exon            1..161
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /inference="alignment:Splign:2.1.0"
     exon            162..325
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..633
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /EC_number="3.2.1.17"
                     /note="lysozyme-like protein 1; lysozyme D1"
                     /codon_start=1
                     /product="lysozyme-like protein 1 precursor"
                     /protein_id="NP_115906.4"
                     /db_xref="CCDS:CCDS31174.2"
                     /db_xref="GeneID:84569"
                     /db_xref="HGNC:HGNC:30502"
                     /translation="MKAAGILTLIGCLVTGAESKIYTRCKLAKIFSRAGLDNYWGFSL
                     GNWICMAYYESGYNTTAQTVLDDGSIDYGIFQINSFAWCRRGKLKENNHCHVACSALI
                     TDDLTDAIICARKIVKETQGMNYWQGWKKHCEGRDLSEWKKGCEVS"
     exon            326..484
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /inference="alignment:Splign:2.1.0"
     exon            485..563
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /inference="alignment:Splign:2.1.0"
     exon            564..806
                     /gene="LYZL1"
                     /gene_synonym="bA534G20.1; KAAG648; LYC2; LYZD1; PRO1278"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaaaggat tactcgcgcc tcgttagaat cagacatggc ttcaggggat gcaggacgct
       61 cccctgagct gcctgtcacc gactaagtgg agcagtgttt cttccgcaga ctcaactgag
      121 aagtcagcct ctggggcagg caccaggaat ctgccttttc agttctgtct ccggcaggct
      181 ttgaggatga aggctgcggg cattctgacc ctcattggct gcctggtcac aggcgccgag
      241 tccaaaatct acactcgttg caaactggca aaaatattct cgagggctgg cctggacaat
      301 tactggggct tcagccttgg aaactggatc tgcatggcat attatgagag cggctacaac
      361 accacagccc agacggtcct ggatgacggc agcatcgact atggcatctt ccagatcaac
      421 agcttcgcgt ggtgcagacg cggaaagctg aaggagaaca accactgcca tgtcgcctgc
      481 tcagccttga tcactgatga cctcacagat gcaattatct gtgccaggaa aattgttaaa
      541 gagacacaag gaatgaacta ttggcaaggc tggaagaaac attgtgaggg cagagacctg
      601 tccgagtgga aaaaaggctg tgaggtttcc taaactggaa ctggacccag gatgctttgc
      661 agcaacgccc taggatttgc agtgaatgtc caaatgcctg tgtcatcttg tcccgtttcc
      721 tcccaatatt ccttctcaaa cttggagagg gaaaattaag ctatactttt aagaaaataa
      781 atatttccat ttaaatgtct tcaccc
//
