LOCUS       NM_000239               1490 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens lysozyme (LYZ), mRNA.
ACCESSION   NM_000239
VERSION     NM_000239.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Frese,A., Goode,C., Zhaliazka,K., Holman,A.P., Dou,T. and
            Kurouski,D.
  TITLE     Length and saturation of fatty acids in phosphatidylserine
            determine the rate of lysozyme aggregation simultaneously altering
            the structure and toxicity of amyloid oligomers and fibrils
  JOURNAL   Protein Sci 32 (8), e4717 (2023)
   PUBMED   37402649
  REMARK    GeneRIF: Length and saturation of fatty acids in phosphatidylserine
            determine the rate of lysozyme aggregation simultaneously altering
            the structure and toxicity of amyloid oligomers and fibrils.
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Vettore,N., Moray,J., Brans,A., Herman,R., Charlier,P.,
            Kumita,J.R., Kerff,F., Dobson,C.M. and Dumoulin,M.
  TITLE     Characterisation of the structural, dynamic and aggregation
            properties of the W64R amyloidogenic variant of human lysozyme
  JOURNAL   Biophys Chem 271, 106563 (2021)
   PUBMED   33640796
  REMARK    GeneRIF: Characterisation of the structural, dynamic and
            aggregation properties of the W64R amyloidogenic variant of human
            lysozyme.
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Carpentier,M. and Chomilier,J.
  TITLE     Analyses of displacements resulting from a point mutation in
            proteins
  JOURNAL   J Struct Biol 211 (2), 107543 (2020)
   PUBMED   32522553
  REMARK    GeneRIF: Analyses of displacements resulting from a point mutation
            in proteins.
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Bergkvist,L., Richards,D.R., Bernardo-Gancedo,A., Kumita,J.R.,
            Nilsson,P.R. and Brorsson,A.C.
  TITLE     Serum amyloid P component promotes formation of distinct aggregated
            lysozyme morphologies and reduces toxicity in Drosophila flies
            expressing F57I lysozyme
  JOURNAL   PLoS One 15 (1), e0227227 (2020)
   PUBMED   31978114
  REMARK    GeneRIF: Serum amyloid P component promotes formation of distinct
            aggregated lysozyme morphologies and reduces toxicity in Drosophila
            flies expressing human F57I lysozyme.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Bergamo,A., Gerdol,M., Pallavicini,A., Greco,S., Schepens,I.,
            Hamelin,R., Armand,F., Dyson,P.J. and Sava,G.
  TITLE     Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway
            Genes in Cells of the Monocyte Lineage
  JOURNAL   Int J Mol Sci 20 (21), 5502 (2019)
   PUBMED   31694163
  REMARK    GeneRIF: These results of the RNA-seq experiment show that lysozyme
            induces transcriptional modulation of the TNF-alpha/IL-1beta
            pathway genes in U937 monocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Schroder,J.M. and Harder,J.
  TITLE     Antimicrobial skin peptides and proteins
  JOURNAL   Cell Mol Life Sci 63 (4), 469-486 (2006)
   PUBMED   16416029
  REMARK    GeneRIF: Lysozyme functions as an antimicrobial peptide, with
            antibacterial activity.
            Review article
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Ohkubo,T., Taniyama,Y. and Kikuchi,M.
  TITLE     1H and 15N NMR study of human lysozyme
  JOURNAL   J Biochem 110 (6), 1022-1029 (1991)
   PUBMED   1794972
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Inaka,K., Taniyama,Y., Kikuchi,M., Morikawa,K. and Matsushima,M.
  TITLE     The crystal structure of a mutant human lysozyme C77/95A with
            increased secretion efficiency in yeast
  JOURNAL   J Biol Chem 266 (19), 12599-12603 (1991)
   PUBMED   2061330
REFERENCE   9  (bases 1 to 1490)
  AUTHORS   Redfield,C. and Dobson,C.M.
  TITLE     1H NMR studies of human lysozyme: spectral assignment and
            comparison with hen lysozyme
  JOURNAL   Biochemistry 29 (31), 7201-7214 (1990)
   PUBMED   2207098
REFERENCE   10 (bases 1 to 1490)
  AUTHORS   Reitamo,S., Klockars,M., Adinolfi,M. and Osserman,E.F.
  TITLE     Human lysozyme (origin and distribution in health and disease)
  JOURNAL   Ric Clin Lab 8 (4), 211-231 (1978)
   PUBMED   366724
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK130149.1, J03801.1 and
            AC020656.33.
            
            On Aug 31, 2019 this sequence version replaced NM_000239.2.
            
            Summary: This gene encodes human lysozyme, whose natural substrate
            is the bacterial cell wall peptidoglycan (cleaving the
            beta[1-4]glycosidic linkages between N-acetylmuramic acid and
            N-acetylglucosamine). Lysozyme is one of the antimicrobial agents
            found in human milk, and is also present in spleen, lung, kidney,
            white blood cells, plasma, saliva, and tears. The protein has
            antibacterial activity against a number of bacterial species.
            Missense mutations in this gene have been identified in heritable
            renal amyloidosis. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004147.2, AK130149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000261267.7/
                                                  ENSP00000261267.2
            Protein has antimicrobial activity :: PMID: 16416029
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-589               AK130149.1         33-621
            590-653             J03801.1           587-650
            654-1489            AK130149.1         686-1521
            1490-1490           AC020656.33        122405-122405
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..1490
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /note="lysozyme"
                     /db_xref="GeneID:4069"
                     /db_xref="HGNC:HGNC:6740"
                     /db_xref="MIM:153450"
     exon            1..164
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..475
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /EC_number="3.2.1.17"
                     /note="1,4-beta-N-acetylmuramidase C; lysozyme C; c-type
                     lysozyme; lysozyme F1"
                     /codon_start=1
                     /product="lysozyme C precursor"
                     /protein_id="NP_000230.1"
                     /db_xref="CCDS:CCDS8989.1"
                     /db_xref="GeneID:4069"
                     /db_xref="HGNC:HGNC:6740"
                     /db_xref="MIM:153450"
                     /translation="MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLA
                     NWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSAL
                     LQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV"
     exon            165..329
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /inference="alignment:Splign:2.1.0"
     exon            330..408
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /inference="alignment:Splign:2.1.0"
     exon            409..1490
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /note="hexamer: ATTAAA"
     polyA_site      1490
                     /gene="LYZ"
                     /gene_synonym="AMYLD5; LYZF1; LZM"
                     /note="major polyA site"
ORIGIN      
        1 agcctagcac tctgacctag cagtcaacat gaaggctctc attgttctgg ggcttgtcct
       61 cctttctgtt acggtccagg gcaaggtctt tgaaaggtgt gagttggcca gaactctgaa
      121 aagattggga atggatggct acaggggaat cagcctagca aactggatgt gtttggccaa
      181 atgggagagt ggttacaaca cacgagctac aaactacaat gctggagaca gaagcactga
      241 ttatgggata tttcagatca atagccgcta ctggtgtaat gatggcaaaa ccccaggagc
      301 agttaatgcc tgtcatttat cctgcagtgc tttgctgcaa gataacatcg ctgatgctgt
      361 agcttgtgca aagagggttg tccgtgatcc acaaggcatt agagcatggg tggcatggag
      421 aaatcgttgt caaaacagag atgtccgtca gtatgttcaa ggttgtggag tgtaactcca
      481 gaattttcct tcttcagctc attttgtctc tctcacatta agggagtagg aattaagtga
      541 aaggtcacac taccattatt tccccttcaa acaaataata tttttacaga agcaggagca
      601 aaatatggcc tttcttctaa gagatataat gttcactaat gtggttattt tacattaagc
      661 ctacaacatt tttcagtttg caaatagaac taatactggt gaaaatttac ctaaaacctt
      721 ggttatcaaa tacatctcca gtacattccg ttcttttttt ttttgagaca gtctcgctct
      781 gtcgcccagg ctggagtgca gtggcgcaat ctcggctcac tgcaacctcc acctcccggg
      841 ttcacgccat tctcctgcct cagcctcccg agtagctggg attacgggcg cccgccacca
      901 cgcccggcta attttttgta tttttagtag agacagggtt tcaccgtgtt agccaggatg
      961 gtctcgatct cctgaccttg tgatccaccc acctcggcct cccaaagtgc tgggattaca
     1021 ggcgtgagcc actgcgcccg gccacattca gttcttatca aagaaataac ccagacttaa
     1081 tcttgaatga tacgattatg cccaatatta agtaaaaaat ataagaaaag gttatcttaa
     1141 atagatctta ggcaaaatac cagctgatga aggcatctga tgccttcatc tgttcagtca
     1201 tctccaaaaa cagtaaaaat aaccactttt tgttgggcaa tatgaaattt ttaaaggagt
     1261 agaataccaa atgatagaaa cagactgcct gaattgagaa ttttgatttc ttaaagtgtg
     1321 tttctttcta aattgctgtt ccttaatttg attaatttaa ttcatgtatt atgattaaat
     1381 ctgaggcaga tgagcttaca agtattgaaa taattactaa ttaatcacaa atgtgaagtt
     1441 atgcatgatg taaaaaatac aaacattcta attaaaggct ttgcaacaca
//
