LOCUS       NM_006691               3247 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens lymphatic vessel endothelial hyaluronan receptor 1
            (LYVE1), mRNA.
ACCESSION   NM_006691 NM_016164
VERSION     NM_006691.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Feng,Z. and Wu,J.
  TITLE     hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular
            Carcinoma Progression by Sponging miR-492
  JOURNAL   Dis Markers 2023, 6978234 (2023)
   PUBMED   37810197
  REMARK    GeneRIF: hsa_circ_0129047 Upregulates LYVE1 to Inhibit
            Hepatocellular Carcinoma Progression by Sponging miR-492.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Burger,F., Baptista,D., Roth,A., Brandt,K.J., da Silva,R.F.,
            Montecucco,F., Mach,F. and Miteva,K.
  TITLE     Single-Cell RNA-Seq Reveals a Crosstalk between Hyaluronan Receptor
            LYVE-1-Expressing Macrophages and Vascular Smooth Muscle Cells
  JOURNAL   Cells 11 (3), 411 (2022)
   PUBMED   35159221
  REMARK    GeneRIF: Single-Cell RNA-Seq Reveals a Crosstalk between Hyaluronan
            Receptor LYVE-1-Expressing Macrophages and Vascular Smooth Muscle
            Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Karinen,S., Hujanen,R., Salo,T. and Salem,A.
  TITLE     The prognostic influence of lymphatic endothelium-specific
            hyaluronan receptor 1 in cancer: A systematic review
  JOURNAL   Cancer Sci 113 (1), 17-27 (2022)
   PUBMED   34775672
  REMARK    GeneRIF: The prognostic influence of lymphatic endothelium-specific
            hyaluronan receptor 1 in cancer: A systematic review.
            Review article
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Mezey,E., Szalayova,I., Hogden,C.T., Brady,A., Dosa,A., Sotonyi,P.
            and Palkovits,M.
  TITLE     An immunohistochemical study of lymphatic elements in the human
            brain
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33446503
  REMARK    GeneRIF: An immunohistochemical study of lymphatic elements in the
            human brain.
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Jackson,D.G.
  TITLE     The lymphatics revisited: new perspectives from the hyaluronan
            receptor LYVE-1
  JOURNAL   Trends Cardiovasc Med 13 (1), 1-7 (2003)
   PUBMED   12554094
  REMARK    Review article
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Cursiefen,C., Schlotzer-Schrehardt,U., Kuchle,M., Sorokin,L.,
            Breiteneder-Geleff,S., Alitalo,K. and Jackson,D.
  TITLE     Lymphatic vessels in vascularized human corneas:
            immunohistochemical investigation using LYVE-1 and podoplanin
  JOURNAL   Invest Ophthalmol Vis Sci 43 (7), 2127-2135 (2002)
   PUBMED   12091407
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Mouta Carreira,C., Nasser,S.M., di Tomaso,E., Padera,T.P.,
            Boucher,Y., Tomarev,S.I. and Jain,R.K.
  TITLE     LYVE-1 is not restricted to the lymph vessels: expression in normal
            liver blood sinusoids and down-regulation in human liver cancer and
            cirrhosis
  JOURNAL   Cancer Res 61 (22), 8079-8084 (2001)
   PUBMED   11719431
  REMARK    GeneRIF: LYVE-1 is not exclusive to the lymph vessels
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   Cunnick,G.H., Jiang,W.G., Gomez,K.F. and Mansel,R.E.
  TITLE     Lymphangiogenesis quantification using quantitative PCR and breast
            cancer as a model
  JOURNAL   Biochem Biophys Res Commun 288 (4), 1043-1046 (2001)
   PUBMED   11689016
  REMARK    GeneRIF: new approach measuring lymphangiogenesis using LYVE-1, a
            novel, specific lymphatic marker in breast cancer tissue
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Banerji,S., Ni,J., Wang,S.X., Clasper,S., Su,J., Tammi,R., Jones,M.
            and Jackson,D.G.
  TITLE     LYVE-1, a new homologue of the CD44 glycoprotein, is a
            lymph-specific receptor for hyaluronan
  JOURNAL   J Cell Biol 144 (4), 789-801 (1999)
   PUBMED   10037799
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358925.1, CA449932.1 and
            AC009532.9.
            
            On May 17, 2019 this sequence version replaced NM_006691.3.
            
            Summary: This gene encodes a type I integral membrane glycoprotein.
            The encoded protein acts as a receptor and binds to both soluble
            and immobilized hyaluronan. This protein may function in lymphatic
            hyaluronan transport and have a role in tumor metastasis. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.234417.1,
                                           SRR1803615.5397.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256178.8/ ENSP00000256178.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2335              AY358925.1         27-2361
            2336-2347           CA449932.1         19-30               c
            2348-3247           AC009532.9         8592-9491           c
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3247
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /note="lymphatic vessel endothelial hyaluronan receptor 1"
                     /db_xref="GeneID:10894"
                     /db_xref="HGNC:HGNC:14687"
                     /db_xref="MIM:605702"
     exon            1..218
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1102
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /note="extracellular link domain-containing 1; lymphatic
                     vessel endothelial hyaluronic acid receptor 1; cell
                     surface retention sequence binding protein-1;
                     extracellular link domain-containing protein 1"
                     /codon_start=1
                     /product="lymphatic vessel endothelial hyaluronic acid
                     receptor 1 precursor"
                     /protein_id="NP_006682.2"
                     /db_xref="CCDS:CCDS7804.1"
                     /db_xref="GeneID:10894"
                     /db_xref="HGNC:HGNC:14687"
                     /db_xref="MIM:605702"
                     /translation="MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLV
                     SKKANQQLNFTEAKEACRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISP
                     NPKCGKNGVGVLIWKVPVSRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTT
                     EFIVSDSTYSVASPYSTIPAPTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEP
                     FVENKAAFKNEAAGFGGVPTALLVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKE
                     MIETKVVKEEKANDSNPNEESKKTDKNPEESKSPSKTTVRCLEAEV"
     exon            219..390
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..530
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..836
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..915
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..3247
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /note="hexamer: ATTAAA"
     polyA_site      2346
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /note="major polyA site"
     regulatory      3025..3030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
                     /note="hexamer: AGTAAA"
     polyA_site      3048
                     /gene="LYVE1"
                     /gene_synonym="CRSBP-1; HAR; LYVE-1; XLKD1"
ORIGIN      
        1 atgaagtgga gcagtgagtg tgagcctcaa catagttcca gaactctcca tccggactag
       61 ttattgagca tctgcctctc atatcaccag tggccatctg aggtgtttcc ctggctctga
      121 aggggtaggc acgatggcca ggtgcttcag cctggtgttg cttctcactt ccatctggac
      181 cacgaggctc ctggtccaag gctctttgcg tgcagaagag ctttccatcc aggtgtcatg
      241 cagaattatg gggatcaccc ttgtgagcaa aaaggcgaac cagcagctga atttcacaga
      301 agctaaggag gcctgtaggc tgctgggact aagtttggcc ggcaaggacc aagttgaaac
      361 agccttgaaa gctagctttg aaacttgcag ctatggctgg gttggagatg gattcgtggt
      421 catctctagg attagcccaa accccaagtg tgggaaaaat ggggtgggtg tcctgatttg
      481 gaaggttcca gtgagccgac agtttgcagc ctattgttac aactcatctg atacttggac
      541 taactcgtgc attccagaaa ttatcaccac caaagatccc atattcaaca ctcaaactgc
      601 aacacaaaca acagaattta ttgtcagtga cagtacctac tcggtggcat ccccttactc
      661 tacaatacct gcccctacta ctactcctcc tgctccagct tccacttcta ttccacggag
      721 aaaaaaattg atttgtgtca cagaagtttt tatggaaact agcaccatgt ctacagaaac
      781 tgaaccattt gttgaaaata aagcagcatt caagaatgaa gctgctgggt ttggaggtgt
      841 ccccacggct ctgctagtgc ttgctctcct cttctttggt gctgcagctg gtcttggatt
      901 ttgctatgtc aaaaggtatg tgaaggcctt cccttttaca aacaagaatc agcagaagga
      961 aatgatcgaa accaaagtag taaaggagga gaaggccaat gatagcaacc ctaatgagga
     1021 atcaaagaaa actgataaaa acccagaaga gtccaagagt ccaagcaaaa ctaccgtgcg
     1081 atgcctggaa gctgaagttt agatgagaca gaaatgagga gacacacctg aggctggttt
     1141 ctttcatgct ccttaccctg ccccagctgg ggaaatcaaa agggccaaag aaccaaagaa
     1201 gaaagtccac ccttggttcc taactggaat cagctcagga ctgccattgg actatggagt
     1261 gcaccaaaga gaatgccctt ctccttattg taaccctgtc tggatcctat cctcctacct
     1321 ccaaagcttc ccacggcctt tctagcctgg ctatgtccta ataatatccc actgggagaa
     1381 aggagttttg caaagtgcaa ggacctaaaa catctcatca gtatccagtg gtaaaaaggc
     1441 ctcctggctg tctgaggcta ggtgggttga aagccaagga gtcactgaga ccaaggcttt
     1501 ctctactgat tccgcagctc agaccctttc ttcagctctg aaagagaaac acgtatccca
     1561 cctgacatgt ccttctgagc ccggtaagag caaaagaatg gcagaaaagt ttagcccctg
     1621 aaagccatgg agattctcat aacttgagac ctaatctctg taaagctaaa ataaagaaat
     1681 agaacaaggc tgaggatacg acagtacact gtcagcaggg actgtaaaca cagacagggt
     1741 caaagtgttt tctctgaaca cattgagttg gaatcactgt ttagaacaca cacacttact
     1801 ttttctggtc tctaccactg ctgatatttt ctctaggaaa tatactttta caagtaacaa
     1861 aaataaaaac tcttataaat ttctattttt atctgagtta cagaaatgat tactaaggaa
     1921 gattactcag taatttgttt aaaaagtaat aaaattcaac aaacatttgc tgaatagcta
     1981 ctatatgtca agtgctgtgc aaggtattac actctgtaat tgaatattat tcctcaaaaa
     2041 attgcacata gtagaacgct atctgggaag ctattttttt cagttttgat atttctagct
     2101 tatctacttc caaactaatt tttatttttg ctgagactaa tcttattcat tttctctaat
     2161 atggcaacca ttataacctt aatttattat taacatacct aagaagtaca ttgttacctc
     2221 tatataccaa agcacatttt aaaagtgcca ttaacaaatg tatcactagc cctccttttt
     2281 ccaacaagaa gggactgaga gatgcagaaa tatttgtgac aaaaaattaa agcatttaga
     2341 aaacttcttt gctttcttat ttacgtagat gcattatacc tttcatgtaa aattaaagtg
     2401 aggaccagat catatcatat tgtttgcaaa aataaaaggg acaatgttgg ttgttaaaat
     2461 acaagcatat gtcaaccaaa cagcatatat catatggggc tattcatgct ccaaacattt
     2521 tattttgagt tggccaagta catacacatt aaacagtcct ttactagaga tgctggccct
     2581 ccatttccat ccatttcaga attcaccagg gagccagaga tccaggatgg ctcattcgtc
     2641 tcacttttga ccgccctgct tctctagttt tctctttccc tcccgcttag actgctaatt
     2701 gtcttcttcc cctcaccagt gaccccacag ctccgtggtt ccttcggccc agatgccaca
     2761 acctgctggc ataatctttt ccggttggcc cacggagtat aatcttaaaa tttgatttca
     2821 tttccaggca ttaaaaatca agagatttca catggttaca tttctgggtt ccctctaaaa
     2881 atggaaagat ctggaagtaa agaacccatg ttccctcata gcaatcatta tctgatactg
     2941 agtagcagct gtcccctttc aatggggtct gctctttttg tttcaccaca gtcctcatga
     3001 ctctctgttg cacactcatg ccaaagtaaa ggtgcccttt cctatgaact ttgtaacact
     3061 gtggcctttt cttcacaccc agcccacgtc cctcatatat atcacctgcc tgccccagta
     3121 ggtctatgag tttgaaactg gtttgtcagt ccttaagctt tatcagcttc atccatttct
     3181 cagggagtaa agaagaaaag agggaaagcg cctaagtagt gatcttccct ctgtgtgtta
     3241 gctgaaa
//
