LOCUS       NM_198273               4262 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LysM domain containing 3 (LYSMD3), transcript variant
            1, mRNA.
ACCESSION   NM_198273 XM_371760 XM_938559
VERSION     NM_198273.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4262)
  AUTHORS   Snee,M., Wever,J., Guyton,J., Beehler-Evans,R., Yokoyama,C.C. and
            Micchelli,C.A.
  TITLE     Peptidoglycan recognition in Drosophila is mediated by LysMD3/4
  JOURNAL   J Biol Chem 299 (6), 104758 (2023)
   PUBMED   37116706
REFERENCE   2  (bases 1 to 4262)
  AUTHORS   He,X., Howard,B.A., Liu,Y., Neumann,A.K., Li,L., Menon,N.,
            Roach,T., Kale,S.D., Samuels,D.C., Li,H., Kite,T., Kita,H.,
            Hu,T.Y., Luo,M., Jones,C.N., Okaa,U.J., Squillace,D.L., Klein,B.S.
            and Lawrence,C.B.
  TITLE     LYSMD3: A mammalian pattern recognition receptor for chitin
  JOURNAL   Cell Rep 36 (3), 109392 (2021)
   PUBMED   34289364
  REMARK    GeneRIF: LYSMD3: A mammalian pattern recognition receptor for
            chitin.
REFERENCE   3  (bases 1 to 4262)
  AUTHORS   Serebrenik,Y.V., Hellerschmied,D., Toure,M., Lopez-Giraldez,F.,
            Brookner,D. and Crews,C.M.
  TITLE     Targeted protein unfolding uncovers a Golgi-specific
            transcriptional stress response
  JOURNAL   Mol Biol Cell 29 (11), 1284-1298 (2018)
   PUBMED   29851555
REFERENCE   4  (bases 1 to 4262)
  AUTHORS   Yokoyama,C.C., Baldridge,M.T., Leung,D.W., Zhao,G., Desai,C.,
            Liu,T.C., Diaz-Ochoa,V.E., Huynh,J.P., Kimmey,J.M., Sennott,E.L.,
            Hole,C.R., Idol,R.A., Park,S., Storek,K.M., Wang,C., Hwang,S.,
            Viehmann Milam,A., Chen,E., Kerrinnes,T., Starnbach,M.N.,
            Handley,S.A., Mysorekar,I.U., Allen,P.M., Monack,D.M.,
            Dinauer,M.C., Doering,T.L., Tsolis,R.M., Dworkin,J.E.,
            Stallings,C.L., Amarasinghe,G.K., Micchelli,C.A. and Virgin,H.W.
  TITLE     LysMD3 is a type II membrane protein without an in vivo role in the
            response to a range of pathogens
  JOURNAL   J Biol Chem 293 (16), 6022-6038 (2018)
   PUBMED   29496999
REFERENCE   5  (bases 1 to 4262)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN994993.1, BC136741.1, AL832721.1 and CR933624.1.
            
            On Nov 16, 2013 this sequence version replaced NM_198273.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537972.1, SRR1660807.95816.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315948.11/ ENSP00000314518.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-653               DN994993.1         10-662
            654-2307            BC136741.1         546-2199
            2308-3121           AL832721.1         2289-3102
            3122-4262           CR933624.1         2709-3849
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..4262
                     /gene="LYSMD3"
                     /note="LysM domain containing 3"
                     /db_xref="GeneID:116068"
                     /db_xref="HGNC:HGNC:26969"
     exon            1..137
                     /gene="LYSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            138..403
                     /gene="LYSMD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1069
                     /gene="LYSMD3"
                     /note="isoform 1 is encoded by transcript variant 1; lysM
                     and putative peptidoglycan-binding domain-containing
                     protein 3; LysM, putative peptidoglycan-binding, domain
                     containing 3"
                     /codon_start=1
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 3 isoform 1"
                     /protein_id="NP_938014.1"
                     /db_xref="CCDS:CCDS43338.1"
                     /db_xref="GeneID:116068"
                     /db_xref="HGNC:HGNC:26969"
                     /translation="MAGRHQNRSFPLPGVQSSGQVHAFGNCSDSDILEEDAEVYELRS
                     RGKEKVRRSTSRDRLDDIIVLTKDIQEGDTLNAIALQYCCTVADIKRVNNLISDQDFF
                     ALRSIKIPVKKFSSLTETLCPPKGRQTSRHSSVQYSSEQQEILPANDSLAYSDSAGSF
                     LKEVDRDIEQIVKCTDNKRENLNEVVSALTAQQMRFEPDNKNTQRKDPYYGADWGIGW
                     WTAVVIMLIVGIITPVFYLLYYEILAKVDVSHHSTVDSSHLHSKITPPSQQREMENGI
                     VPTKGIHFSQQDDHKLYSQDSQSPAAQQET"
     exon            404..4262
                     /gene="LYSMD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4235..4240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYSMD3"
                     /note="hexamer: AATAAA"
     polyA_site      4262
                     /gene="LYSMD3"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgttg gcggcagagg cggaggcgga cggggtcagc ccaaagcaga ggctcggcca
       61 tgaacttacc cgggacagcg gcggcggcgg accttttggc catcttctcg cagagtgctc
      121 cctgctaacg gggacagatt ttaacattat ggcagggagg catcagaatc gtagttttcc
      181 tcttccagga gttcagtcaa gtggtcaagt acatgcattt ggaaattgtt cagacagtga
      241 tattttggag gaggatgctg aagtgtatga acttcgatcc agaggaaaag agaaagtccg
      301 aagaagtaca tcaagagata gacttgacga cattatagta ttaacaaaag atatacaaga
      361 aggagataca ttaaatgcaa tagcccttca gtactgttgt acggtagcag atatcaagag
      421 agttaacaat ctcatcagtg atcaagactt ttttgccctt aggtctatca aaattccagt
      481 aaaaaagttc agttccttga ccgaaacact ttgtcctcca aaaggaagac agacttcacg
      541 tcattcatct gttcaatact cttccgaaca acaggaaatt ttgccagcta atgattctct
      601 tgcttacagt gactcagctg gtagcttttt aaaagaagta gaccgagaca tagaacaaat
      661 agtaaagtgt acagacaata agagagagaa cctcaatgag gtagtatcgg ccttaacagc
      721 acaacaaatg cgttttgaac ctgataacaa aaacactcaa cgtaaagacc cctattatgg
      781 agcagactgg ggaatagggt ggtggacagc tgtagtgata atgttgatag taggtataat
      841 aacaccagtg ttttatttgt tgtattatga aattttagct aaggtggatg ttagtcatca
      901 ttcaacagtg gactcttcac atttacattc aaaaatcaca cccccatcac agcagagaga
      961 aatggaaaat ggaattgtgc caactaaagg aatacatttc agccaacaag atgatcataa
     1021 actgtatagt caagattctc agtcacctgc tgctcaacag gaaacatagc aattagctca
     1081 taatcaaatg ttagtggtca catgtgcatc tggaatgtgg tgaatcagtt atatccaata
     1141 atagcttcaa aggcagaatt tagagagatt gaggatgctt ttgtttttaa caaaagggtt
     1201 tcacactttg aaaatttttt gagcaactag ttgttgatgt tgagagcagt tgatccataa
     1261 atctggtgtg tgaatgtttc aagcagaaat taatttaaat gtgtgtttag gaagtactta
     1321 acttggaaga tgtatcattt ttcttaaaat gcatgtttaa attttatttt tttaagtaat
     1381 ttttaaaaag tttattaatg ttaaatttat gatgcagaat gatagcatca gatgtctgca
     1441 gctgaaaaaa atttactact atgaaccccc aaaatattca gttgcaagaa aatttgattc
     1501 taaaattatt catggtagga tacgtaacac accccttcaa aacttttaaa aaatacattt
     1561 agcacatgtg ctatgaaagc atacgtacaa agagaaaggg gaaagtgatt tataattcct
     1621 acaacagagg ccaagaaata gattaaaata ttttcaagac cccaaaataa tgtattatgg
     1681 ttgggaagtc agtagaacac tggaataggt gaagacctga cagtaatttt tgtcttaaga
     1741 atgctttctt taggacagac cctttaacct cacctctgtg catctgtttt taaaatgatt
     1801 atatttgcct ctgatatttg aaagcacttt tgtagttttg atgatgaaaa atatattaaa
     1861 cgtgcatatt accattattt aggaaataat tccttatata ctgtgataaa tcattgctgt
     1921 tacatacagt aacatgcctt aattacattt aatgccttac tgctttatgt aagtaaatcc
     1981 aagtttcaga attaaaaata agcattattt catatggtcc aatcagattc gttacatagg
     2041 ctatataaat ttgtctccat tttcaccatc aagcacaaat aattgggtca aaactgcctt
     2101 tgaggtctgt tgaagaaaat ggttcattaa gcaaaaaaga gtagaggtat tttatattag
     2161 cagtaacaga caaattattt agtaatccct taacctctgt ttttcaaaga gaaaatatcc
     2221 aatttagact tttttcctga tctctatata tagcatcaaa ttgggaaaca aaggccaaag
     2281 gtgtatagat tgcttgaaag ggggtggtag tgcctctttt taagatctgt tgagtcggct
     2341 acagtctggc taagtaagaa gcatttgcat actgattcca tcatttaatc tttaaaagta
     2401 tgtgttttaa aaatgtaacc agaatgattc ttcaatagaa atgagatttg gtggagtctg
     2461 gattgcctgt tttgtatata atatatactt aagatatata ataccacctc attttctggg
     2521 cattatttcc taattgttga tgtttcaggc ttttgataag tcattttata tatttcaaat
     2581 ttaactcaga ataagtaaat atttatggca aatgcagttt tatgtacttt caggagaaga
     2641 ccatcaggaa aagacaggac aaagaagtca aacattaaag cccttgcaaa tattagagga
     2701 ccttagacaa ttaccaaaaa gtgtttaata gggaagttgc aaatgattct cttagtaaat
     2761 taaacattta aaaagtagtt ttaatgtgcc ttgggcatct tgaaaagaag agtgtgatat
     2821 aatttatgct tagtgttaac tggtcatttt acattgtatt tattaagtct gctgaaaaat
     2881 gaggttttaa ggaagaaaat gcagattatt ttagggtaaa caggccaggt gtcctttgaa
     2941 gaactttgtt tacatcaaat tgatgaaatt acagtcagtg attccttact ttttttgcta
     3001 gttgtacttt gaaattgtta tgggttcgat ttccaaaata tgtaacttat tttttaaagg
     3061 aataaggtgt gctgtgtatt tgttgattaa aaatcatttg tcttgcagag tatccttttt
     3121 tgaaggaaat atacatcctt ataacacatc aggtagtttt cttttttctg tatttaaatt
     3181 atatatttga attaattgaa tataatttga gttacatata attctatata aaggttacat
     3241 attgaattat ggttctaatc tgtttaggaa agaaatgaat tttctaagca tttaatacat
     3301 ttggaataat tttagtttct aaaaagtact aatgtaagtt aagtttatat caaatgcaaa
     3361 ttaccttgta taactaacaa gcacagttat tgtttaacat tatggatttt aattgtgttg
     3421 acacccttct ttgaatttgt tgctttacat gtgtgtctgt gtgtgtgtct gcatgtgtgc
     3481 acgcatgtac ttgtatgcaa tgtaaaagta acagcagaat cattgcattt ggtttactta
     3541 aaattttgga gttagcaagt aaacaaaaag ctgatagttt tatgaagtct cggttaaaat
     3601 aaaatttctt tgctatctca ctcctaggaa gttatggagt tcatattttc aaaagatatg
     3661 ttaaaaatgg ttacacactc tgctggccac attaaaaatt agaagactca tgttaaatta
     3721 tctcctccaa aggacttttt atttacagct tttcttttcc tggactctac ctgcttggtt
     3781 cagtgtcctg aagagttatt taaatgaacc actacttagt aattagttct tttttaaagt
     3841 atctacttct aaaattacct agttgaaaat atgaaggata tgcttagttt tagaaatatc
     3901 atgaagcaag gatctagtca gtgttacagg gtaaaggtgg agttttttaa agtctgtatt
     3961 taaatggtgc actgatggat tcatttttaa tttgcattac aaaaatgttg ctcaggtaat
     4021 cagtattttc ttccacgtat gtgcatattg cactgttaga tcatagaaat atctgaatgc
     4081 tttaattttt atgtatgcaa aatctataaa tcttttgtat aatgtatttt atacaaatgt
     4141 aactgtagaa cattgttagc atgtgtatct gtaaaaccag tttttaaaat tttttgcccc
     4201 ttatttttca tattttgaaa gatctccaac atgtaataaa gtttctctta ttcaatctaa
     4261 aa
//
