LOCUS       NM_001076680            1419 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LYR motif containing 9 (LYRM9), mRNA.
ACCESSION   NM_001076680
VERSION     NM_001076680.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1419)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1419)
  AUTHORS   Dibley,M.G., Formosa,L.E., Lyu,B., Reljic,B., McGann,D.,
            Muellner-Wong,L., Kraus,F., Sharpe,A.J., Stroud,D.A. and Ryan,M.T.
  TITLE     The Mitochondrial Acyl-carrier Protein Interaction Network
            Highlights Important Roles for LYRM Family Members in Complex I and
            Mitoribosome Assembly
  JOURNAL   Mol Cell Proteomics 19 (1), 65-77 (2020)
   PUBMED   31666358
REFERENCE   3  (bases 1 to 1419)
  AUTHORS   van der Valk,R.J., Duijts,L., Timpson,N.J., Salam,M.T., Standl,M.,
            Curtin,J.A., Genuneit,J., Kerhof,M., Kreiner-Moller,E., Caceres,A.,
            Gref,A., Liang,L.L., Taal,H.R., Bouzigon,E., Demenais,F., Nadif,R.,
            Ober,C., Thompson,E.E., Estrada,K., Hofman,A., Uitterlinden,A.G.,
            van Duijn,C., Rivadeneira,F., Li,X., Eckel,S.P., Berhane,K.,
            Gauderman,W.J., Granell,R., Evans,D.M., St Pourcain,B., McArdle,W.,
            Kemp,J.P., Smith,G.D., Tiesler,C.M., Flexeder,C., Simpson,A.,
            Murray,C.S., Fuchs,O., Postma,D.S., Bonnelykke,K., Torrent,M.,
            Andersson,M., Sleiman,P., Hakonarson,H., Cookson,W.O.,
            Moffatt,M.F., Paternoster,L., Melen,E., Sunyer,J., Bisgaard,H.,
            Koppelman,G.H., Ege,M., Custovic,A., Heinrich,J., Gilliland,F.D.,
            Henderson,A.J., Jaddoe,V.W. and de Jongste,J.C.
  CONSRTM   EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium
  TITLE     Fraction of exhaled nitric oxide values in childhood are associated
            with 17q11.2-q12 and 17q12-q21 variants
  JOURNAL   J Allergy Clin Immunol 134 (1), 46-55 (2014)
   PUBMED   24315451
  REMARK    GeneRIF: 3 SNPs associated with the fraction of exhaled nitric
            oxide in childhood asthma are rs3751972 in LYRM9; rs944722 in NOS2;
            and rs8069176 near GSDMB; all at 17q12-q21.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB474433.1, DR155808.1, AC005697.1 and AI804732.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001076680.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1744366.1,
                                           SRR18074967.2156758.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379102.8/ ENSP00000368396.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DB474433.1         19-54
            37-388              DR155808.1         20-371
            389-954             AC005697.1         96207-96772         c
            955-1419            AI804732.1         59-523              c
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1419
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /note="LYR motif containing 9"
                     /db_xref="GeneID:201229"
                     /db_xref="HGNC:HGNC:27314"
     exon            1..49
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /inference="alignment:Splign:2.1.0"
     exon            50..193
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..304
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /note="UPF0631 protein C17orf108"
                     /codon_start=1
                     /product="LYR motif-containing protein 9"
                     /protein_id="NP_001070148.1"
                     /db_xref="CCDS:CCDS45631.1"
                     /db_xref="GeneID:201229"
                     /db_xref="HGNC:HGNC:27314"
                     /translation="MAPLPGAELVRRPLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSF
                     RVHSDEDNPERIQQIIKRAIEDADWIMNKYKKQN"
     exon            194..286
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /inference="alignment:Splign:2.1.0"
     exon            287..1419
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1401..1406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /note="hexamer: AATATA"
     polyA_site      1419
                     /gene="LYRM9"
                     /gene_synonym="C17orf108; HSD24"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgtcg ccgcggcggc gtccggggct ggcgttcccc tggaggctgg gacagagggt
       61 ctcacggatg gccccgctgc caggagcaga actggttcgg aggccactgc agctctaccg
      121 atacttgctg cgctgttgcc agcagctgcc gaccaagggc atccagcagc attacaagca
      181 tgctgtcagg cagagttttc gggttcattc agatgaagac aaccctgaga gaatccagca
      241 gattattaaa agagccattg aagatgctga ctggatcatg aacaaatata aaaaacaaaa
      301 ctgagagctc cgagggtgag ccttcctggc ctctggaagt tgagaggccc ctcttctgga
      361 gctcagcagc agcagctggt ttggaagagc cattggcctt gttggctgaa agccagaaat
      421 caggggagaa gctgaccttg ctccagaggc tcctcttgcc gcggccatgt tgctagcatc
      481 ctttatgttt gcacttccag ccacttacga tgtgaaattt ggggagaatg tagtattttt
      541 ttgcttcttt tgtgtgtttt ttatttttgt gtttttgttc ttttactttt ctctgaaagt
      601 gattcattta ttctggagat ctctttatca ttctctgagt cccagagcag atgtcccctc
      661 aggtagcaac ctgtacagaa gaaagcacgt gggttttaga accagacaga tctggatttg
      721 aatcccagat gcaataagat gaaggtgaag tgcctcacac aggatgtggc acatgacagt
      781 gcctgaaggg ctcccttcaa ggaagccgtc ctgccccgcc ccctcctctg ctcctgcagc
      841 gccctgcaca gctctgctcc ccgcatgcac cgcatcgggt ctcagttttt tgtttgcgag
      901 cttgccctgt ccctgcttgt agcccctgag ccctcacagt tgtcacacac ccagcagtct
      961 gccaaggagc tgcttttcct gactactgtc tctccatgcc tagggaagtc aaagccctgg
     1021 gccttgcctt cagggagttg acagtgtcct tgaagtggtg aagtgcccac cacatgaacc
     1081 aaggagagac gccaaagcag ctgccatgga ctctggcctg tccaagcctc tgtgcacctg
     1141 cagtctcttt ccactggcac ttccctgctt tgctaccatc gtggaagaat ggaagggagg
     1201 gggagaaggt gggtgggctc agggagaacg gccagagtgg ccagaagatg cagagagaag
     1261 ccccactggg atctgagtat tccccaaggg cactcagcca cagggatgaa ctagtgtttg
     1321 tttgtatcct tgcagttatg tgacttaaag tgactcagag atatctatgt atgcgagtgt
     1381 actccgctgg caatgaagta aatatatcaa tttgtggaa
//
