LOCUS       NM_181705               6219 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LYR motif containing 7 (LYRM7), transcript variant 1,
            mRNA.
ACCESSION   NM_181705
VERSION     NM_181705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6219)
  AUTHORS   Shinde,A., Chandak,N., Singh,J., Roy,M., Mane,M., Tang,X.,
            Vasiyani,H., Currim,F., Gohel,D., Shukla,S., Goyani,S.,
            Saranga,M.V., Brindley,D.N. and Singh,R.
  TITLE     TNF-alpha induced NF-kappaB mediated LYRM7 expression modulates the
            tumor growth and metastatic ability in breast cancer
  JOURNAL   Free Radic Biol Med 211, 158-170 (2024)
   PUBMED   38104742
  REMARK    GeneRIF: TNF-alpha induced NF-kappaB mediated LYRM7 expression
            modulates the tumor growth and metastatic ability in breast cancer.
REFERENCE   2  (bases 1 to 6219)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 6219)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6219)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6219)
  AUTHORS   Hempel,M., Kremer,L.S., Tsiakas,K., Alhaddad,B., Haack,T.B.,
            Lobel,U., Feichtinger,R.G., Sperl,W., Prokisch,H., Mayr,J.A. and
            Santer,R.
  TITLE     LYRM7 - associated complex III deficiency: A clinical, molecular
            genetic, MR tomographic, and biochemical study
  JOURNAL   Mitochondrion 37, 55-61 (2017)
   PUBMED   28694194
  REMARK    GeneRIF: The authors identified homozygosity for a splice site
            destroying 4 base pair deletion in LYRM7 in a child with recurrent
            lactic acidotic crises and distinct early-onset leukencephalopathy.
REFERENCE   6  (bases 1 to 6219)
  AUTHORS   Maio,N., Singh,A., Uhrigshardt,H., Saxena,N., Tong,W.H. and
            Rouault,T.A.
  TITLE     Cochaperone binding to LYR motifs confers specificity of iron
            sulfur cluster delivery
  JOURNAL   Cell Metab 19 (3), 445-457 (2014)
   PUBMED   24606901
REFERENCE   7  (bases 1 to 6219)
  AUTHORS   Invernizzi,F., Tigano,M., Dallabona,C., Donnini,C., Ferrero,I.,
            Cremonte,M., Ghezzi,D., Lamperti,C. and Zeviani,M.
  TITLE     A homozygous mutation in LYRM7/MZM1L associated with early onset
            encephalopathy, lactic acidosis, and severe reduction of
            mitochondrial complex III activity
  JOURNAL   Hum Mutat 34 (12), 1619-1622 (2013)
   PUBMED   24014394
  REMARK    GeneRIF: LYRM7/MZM1L is a novel disease gene, causing
            cIII-defective, early onset, severe mitochondrial encephalopathy.
REFERENCE   8  (bases 1 to 6219)
  AUTHORS   Sanchez,E., Lobo,T., Fox,J.L., Zeviani,M., Winge,D.R. and
            Fernandez-Vizarra,E.
  TITLE     LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of
            mitochondrial Complex III assembly in human cells
  JOURNAL   Biochim Biophys Acta 1827 (3), 285-293 (2013)
   PUBMED   23168492
REFERENCE   9  (bases 1 to 6219)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 6219)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000803.1 and AC005179.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_181705.3.
            
            Summary: Inner mitochondrial membrane complex III (CIII) is the
            main enzyme complex in the mitochondrial respiratory chain, and
            Rieske Fe-S protein (UQCRFS1) is the last catalytic subunit added
            to the complex. The protein encoded by this gene is a
            nuclear-encoded mitochondrial matrix protein that stabilizes
            UQCRFS1 and chaperones it to the CIII complex. Defects in this gene
            are a cause of mitochondrial complex III deficiency, nuclear type
            8. Three transcript variants encoding two different isoforms have
            been found for this gene. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.179279.1,
                                           SRR1803611.212805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379380.9/ ENSP00000368688.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2133              AK000803.1         2-2134
            2134-6219           AC005179.1         7673-11758
FEATURES             Location/Qualifiers
     source          1..6219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3-q31.1"
     gene            1..6219
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="LYR motif containing 7"
                     /db_xref="GeneID:90624"
                     /db_xref="HGNC:HGNC:28072"
                     /db_xref="MIM:615831"
     exon            1..95
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..392
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="isoform 1 is encoded by transcript variant 1; LYR
                     motif-containing protein 7; Lyrm7 homolog; complex III
                     assembly factor LYRM7"
                     /codon_start=1
                     /product="complex III assembly factor LYRM7 isoform 1"
                     /protein_id="NP_859056.2"
                     /db_xref="CCDS:CCDS4148.1"
                     /db_xref="GeneID:90624"
                     /db_xref="HGNC:HGNC:28072"
                     /db_xref="MIM:615831"
                     /translation="MGRAVKVLQLFKTLHRTRQQVFKNDARALEAARIKINEEFKNNK
                     SETSSKKIEELMKIGSDVELLLRTSVIQGIHTDHNTLKLVPRKDLLVENVPYCDAPTQ
                     KQ"
     exon            96..168
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            169..239
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            240..321
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            322..6219
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      813..818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="hexamer: ATTAAA"
     polyA_site      831
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="major polyA site"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="hexamer: ATTAAA"
     polyA_site      3775
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
     regulatory      6190..6195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="hexamer: AATAAA"
     polyA_site      6219
                     /gene="LYRM7"
                     /gene_synonym="C5orf31; MC3DN8; MZM1L"
                     /note="major polyA site"
ORIGIN      
        1 agttcagtct ttgattggtt gctgagaggc ggggctactc gactgctctg gaggtagcgg
       61 ccgcggtgag gagagccatg ggacgggcag tcaaggtttt acagctcttt aaaacactgc
      121 acaggaccag acaacaagtt tttaaaaatg atgccagagc attagaagca gccagaataa
      181 agataaatga agaattcaaa aataataaaa gtgaaacttc ttctaagaaa atagaagagc
      241 taatgaaaat aggttctgat gttgaattat tactcagaac atctgttata caaggtattc
      301 acacagacca caatacactg aaactggtcc ctaggaaaga ccttcttgta gaaaatgtgc
      361 catattgtga tgcaccaact cagaagcaat gagttttcta gaatacaaca agtctttgta
      421 ctttttaact ttaaaatcta caactctggc aaaagtcctg gaaatgcaga cattttccct
      481 gaactggcat attgaaaatg aatgaattac agaatagctt catatttaaa tttcatgtta
      541 aaaggtcatt actgagaact aaagaacata attaagtatt tctaaaggaa attagataag
      601 aaaacatttc attttcattg aaaatcaaat ttcataaagc aaagtaaatg cttagggaga
      661 tatattcaat ctttgacctt gatgagtatt tgatcttacc atagctattt gagaatgtgg
      721 tgcttttaca aattggtgag ttttcctgcc atgtgaaatg caattattac atttaaattg
      781 ttagattaaa atgatattta gtcctgaaaa atattaaatt ggtcaaaaaa atcacagtgt
      841 atgccagctc tctacagaaa gtggcctttg ttttctaaag cactgggatt atttctgtag
      901 ctaatatata attgtacagt ttctttttag agatagagag tatctctgtg ttcttatgaa
      961 gacatttttt atcagttttc tgaaaataga tgaataaaat attatagtca cctagggtca
     1021 ctatggaata aagaaatcct agtttaaaga ggaaatagtg gcccttgatc aaactattta
     1081 atatggcctt agtagaatta gctgtattta gacaaagtta gactttagtg tgaaatgtaa
     1141 tcggtggcta cattctcatc gttttaatta atgaaactta aatggcttct cttcttccac
     1201 atgtcctgtc cttgacaaga tgggcagtat cacaaaaggt cctggcattc taccatctaa
     1261 cactaggaac tgtaaaatac tgtttaatat tcttcttgtt tctcttttat ctgtgtatct
     1321 ttgccattct attttctcag tgaatagtat gttttctccc attcactgat aaattctctc
     1381 atttgatgat gatacagggt ttttaatttt tgcaagattc tcaatgcaag cattgttatg
     1441 tatctagaaa ttatacctag agaaaaatga aagtcgtttc aaatttgaaa tttgcccttt
     1501 taagagaatg ctgaatgtca tcgcagtata taatcactat ataaatgtgc tgacttacag
     1561 ttattttagt gtctatatga catattttga ggaaagttgg ctgacgttat ttaaatttaa
     1621 tatatattct atattttagt gttattgaat attttatcac tgagcttttt tctttaacct
     1681 gaattccctg ttccattttt cattcatatt aatttaaata actccagatt tctttcttat
     1741 agtcattatt agtagcagat gagattaata attcacatgt ttattaaaga tagtggctta
     1801 gaaattttaa gatatattga tataggcccg ggcgctgtgg ctcacacctg taatcccgca
     1861 ctttgggagg ctgaggcggg cagatcacaa ggtcaggagt tcgagaccag cctggccaat
     1921 gtggtgaaac cccatctcta ctaaaaacac aaaaattagc caggtatggt ggcgggcgcc
     1981 tgtagtccca gctactcggg aggctgaggc aggaaaatca cttgaacccg ggaggtggag
     2041 gttgcagtga actgagattg tgccactgca ctccagcctg ggggacagag tgagactctg
     2101 tctcaaaaaa aaaaaagaaa aaaaaaggaa aaaggaaaaa aaaaagatat attgatacag
     2161 ataggtagat atgatattgt actttcatgc cataagacta cacaataaag ttcctgaaag
     2221 ttcctggctg ggcgcagtgg ctcacgcctg taatcccagc actttgggag gccgaggcag
     2281 gcagatcacc tgaggtcagg agttctagac cagcctgacc aacatgggga aaccctgtct
     2341 ctactaaaaa aaatacagaa ttagccaggt gtggtggcac atgtctgtaa tcccagctac
     2401 tcgggagact gaggcaggag aattgcttga acccaggaga cggaggttgc agtgagccga
     2461 gatcgcacca ttgcactcca gcctaggcaa caagagtgaa actccgtctc aaaaataaat
     2521 aaataaataa agttcctgtg aagtatataa acatgtcaac aacaggcttg actgtcacaa
     2581 aattctgaaa gatgtcgcac tctattctta tatagcatat gctaatttat ttatttattt
     2641 tttgagattg agttctgctg tgtcacccag gttggagtgc agtggcatgg tcatggtcca
     2701 ctaaagcctt gacccctggg gctcagcagt tatgccaact aagcctccca aatagctgag
     2761 actagaggta tgcgccacca cacctagcta ttttttttat ttttagtaag gacaaggtct
     2821 cattatgttg gccaggctgg tctcaaattc ctgagctcag ttgatcctcc cacctcagcc
     2881 tcccaaagtg ctgggattac aggtgtaagc cactgcaccc tgcctattct tataatcata
     2941 tatttatatt tcaaatggat tttaactggt tatttaatag tttaattaga taaagtaatt
     3001 catggctggg tgtggtggct cacgcctgta atcccagcac tttggcaggc tgaggcaggt
     3061 ggattacctg aggtcggaag ttcgagacca gcccaaccaa cgtggagaaa ccccatctct
     3121 attaaaaatg caaaattagc aggacatggt gatacacacc tgtaatccca gctagtcagg
     3181 aggctgaggc aggagaatta cttgagccag ggaagcagag gttgtggtga gctaagattg
     3241 tgccactgca ctccagcctg agagaacaag actccgtctc aaaaaaagaa aaaaagaaaa
     3301 cttttttaca catgggtatc tcaccatgtt gcccaggctg gagtgcagta gctattcata
     3361 ggcacagtca tagcacactg cagcctagaa tttctgacct caagcaatca tcctgcctca
     3421 gcctcctaag tagctaggac tacaggtgca taccaccata accagcttta attaaatgtt
     3481 ttttatttgg ttattttttt taagttttct gtattcacac aaggggttgc ccaaatataa
     3541 ttttgctttg actattgaga tctagtgaaa gtggggtata tgaattctaa ttgcaaatat
     3601 ccaggctcag aggcccagca ggactttcta acacaatctt ttagcggaag ttagaaatgg
     3661 tatatagcag gagagtcaga tttgagaagc atatgtagat tcgaagctgg gggaatatgg
     3721 caggtagttt gtacaacatc taattcagaa cattaaaatt aagattttag tcaaactgtg
     3781 tttaagttag ttcttatttt cctgtagatg catctcacag catcagtaca ataccaaaaa
     3841 agcacacaag aataagaata tgtggaattt ctatacctat tgacaaagca cataatttaa
     3901 ccataaacac aaagccatag gtcaacaaag aaatgaagat tccagttctg aaggtgagtt
     3961 ttctgaagcc aaagtggata catgcaaaat taatatagtt ttactgtata tcagttgtca
     4021 ccaatcagaa atggaaaaca gatcctattt ataattgcaa acaaaactgt aaaatagact
     4081 ttttaaagtc tgggaataga cttctaaaat aagctataac acttaaaaag gagagatata
     4141 ctatgttcct agataggaca attgaaaatt ctggagatga cagtttttca aaaatctatt
     4201 gaggccaggt gcagtggccc atgcctgtag ttccagtact ttgggaggcc taggtgggtg
     4261 gatcacctga ggttgggagt ttgagaccag cctgaccaac atggagaaac cccgtctcta
     4321 ctaaaaatac aaaattagcc aggcgtggtg gtgcatgcct gtaatcccag ctactcggga
     4381 ggctgaggcg tgagaatcgc ttgaacccgg taggcagatg ttgcagtgag ccgagatcgc
     4441 accattgcac tccagcctag gcaacaagag cgaaactcca tctcaaaaat agaaaaaaca
     4501 tttatcgaaa tcccaacaag ttgacaaata tatccacata aaaatataaa acttctgtat
     4561 tctgtgaaag ctactataaa taaagtttag agaaagttat ttgccaccta tgtcatgatt
     4621 gaaatagtta attgatcctg tgaatcagtt agcaaaacat aactcaatgg aaagataggc
     4681 aaatgataca aataagaaat tcacaaaaga agaaatacta agtctctagt gatgagagaa
     4741 atgtaaatta aaatgaaaca tgtttgttca tcaagttgtc acaagttaga caatcatatc
     4801 caatattttt aaaggttgta agactataag gaaatagcca ctgtcatatc atttttaaag
     4861 gaatataaat tatagggcct tttgtttctt tgggtttttt ttttttagag acaagatctc
     4921 tccgtgttgt ctaggctgga ctcaaacttc tggactcaag caatcctcgc aacatcatta
     4981 atagctgaga gtagagactt gagccaccac acctgactat agggcctttt tgaaaggaaa
     5041 attgacatca tcaaaatttt aaatatattc agtctatttc tcaaaaactc aaagaatact
     5101 aataaatgtg tactcaggta tatgtacaga aattgctgta acattataat tttaaacaat
     5161 ttaaaacaga ctgagtttcc aaagttaggg tacaatgaaa gaaaaggtgg cttatttata
     5221 ctctggaata ttttccaaga gttgaaaagg atgaggatac acacacacac acacacacac
     5281 acacacacac acacacacac acacagtttg ggtatcccta atccagaaat tcaaatgctc
     5341 caaagtccaa aactttctga cccaccaaca tgactgatgc tcaaaggaaa tggccactgg
     5401 aagatttcag attttcagat ttggagtgct caaccagtaa gtatataatg caaataatcc
     5461 aaaatacaaa aaaaaaaaaa aagaaatctg aaacacttct gatcccaagc atttcagaaa
     5521 acggatgttc atttgtgtgt gtgtgtgtgt gtaagcaggt gttgctagaa attcacttat
     5581 atacaagaaa actttttgtg tacatatttg catatatatg tacaaatggg tagaaacgat
     5641 acatgattaa tcttaatcgg gaaggaaaag agatttaggg aaggaagcag taagtgagaa
     5701 cttttattct atttactcct gcacgtttaa atattgttta cagtgagtat atcaacatgt
     5761 aagtgttaaa agacaataag ctactagtga tttttaatat aaaattaact ataaaatatt
     5821 ttaaatatta gcaaataata tagcacactc atgaacctaa ttcccacatt tgatagttgt
     5881 tacattttgc catgtttgtt taaaggtcta agtcataaaa tcttataaag ctaaacccca
     5941 cccttctctt tctcctctct ctccaggata attactgttt tatagtttgt ggatatcatt
     6001 cccttacttg tgtttatact tttaccaagt gtgtatgtat tcaaaaaaca gttgttttgt
     6061 gattttaaaa tgtaaatgaa tggcgttatg ctccatgtat tctgcaactt ttcatcatac
     6121 attaggtttt ggcgatttag ccataatttg gcatgaattc aggtctttta agttttattc
     6181 cattgtaaga ataaacaagt ttgttcattc atgtctcca
//
