LOCUS       NM_020408               1497 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens LYR motif containing 4 (LYRM4), transcript variant 1,
            mRNA.
ACCESSION   NM_020408
VERSION     NM_020408.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Freibert,S.A., Boniecki,M.T., Stumpfig,C., Schulz,V., Krapoth,N.,
            Winge,D.R., Muhlenhoff,U., Stehling,O., Cygler,M. and Lill,R.
  TITLE     N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by
            ISCU2 dimerization
  JOURNAL   Nat Commun 12 (1), 6902 (2021)
   PUBMED   34824239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Herrera,M.G., Noguera,M.E., Sewell,K.E., Agudelo Suarez,W.A.,
            Capece,L., Klinke,S. and Santos,J.
  TITLE     Structure of the Human ACP-ISD11 Heterodimer
  JOURNAL   Biochemistry 58 (46), 4596-4609 (2019)
   PUBMED   31664822
  REMARK    GeneRIF: In this work, the structure of the human mitochondrial
            ACP-ISD11 heterodimer was determined at 2.0 A resolution.
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Fox,N.G., Yu,X., Feng,X., Bailey,H.J., Martelli,A., Nabhan,J.F.,
            Strain-Damerell,C., Bulawa,C., Yue,W.W. and Han,S.
  TITLE     Structure of the human frataxin-bound iron-sulfur cluster assembly
            complex provides insight into its activation mechanism
  JOURNAL   Nat Commun 10 (1), 2210 (2019)
   PUBMED   31101807
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Anderson,C.A., Massey,D.C., Barrett,J.C., Prescott,N.J.,
            Tremelling,M., Fisher,S.A., Gwilliam,R., Jacob,J., Nimmo,E.R.,
            Drummond,H., Lees,C.W., Onnie,C.M., Hanson,C., Blaszczyk,K.,
            Ravindrarajah,R., Hunt,S., Varma,D., Hammond,N., Lewis,G.,
            Attlesey,H., Watkins,N., Ouwehand,W., Strachan,D., McArdle,W.,
            Lewis,C.M., Lobo,A., Sanderson,J., Jewell,D.P., Deloukas,P.,
            Mansfield,J.C., Mathew,C.G., Satsangi,J. and Parkes,M.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Investigation of Crohn's disease risk loci in ulcerative colitis
            further defines their molecular relationship
  JOURNAL   Gastroenterology 136 (2), 523-9 (2009)
   PUBMED   19068216
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Marelja,Z., Stocklein,W., Nimtz,M. and Leimkuhler,S.
  TITLE     A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur
            donor for MOCS3, a protein involved in molybdenum cofactor
            biosynthesis
  JOURNAL   J Biol Chem 283 (37), 25178-25185 (2008)
   PUBMED   18650437
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Shan,Y., Napoli,E. and Cortopassi,G.
  TITLE     Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU
            complex and multiple mitochondrial chaperones
  JOURNAL   Hum Mol Genet 16 (8), 929-941 (2007)
   PUBMED   17331979
  REMARK    GeneRIF: Frataxin interacts with ISD11 and multiple mitochondrial
            chaperones.
REFERENCE   9  (bases 1 to 1497)
  AUTHORS   Adam,A.C., Bornhovd,C., Prokisch,H., Neupert,W. and Hell,K.
  TITLE     The Nfs1 interacting protein Isd11 has an essential role in Fe/S
            cluster biogenesis in mitochondria
  JOURNAL   EMBO J 25 (1), 174-183 (2006)
   PUBMED   16341090
REFERENCE   10 (bases 1 to 1497)
  AUTHORS   Lai,C.H., Chiu,J.Y. and Lin,W.
  TITLE     Identification of the human crooked neck gene by comparative gene
            identification
  JOURNAL   Biochim Biophys Acta 1517 (3), 449-454 (2001)
   PUBMED   11342225
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY168919.1, AF170070.1,
            BC067762.1, AL035653.12 and CA310019.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_020408.5.
            
            Summary: The protein encoded by this gene is found in both
            mitochondria and the nucleus, where it binds cysteine desulfurase
            and helps free inorganic sulfur for Fe/S clusters. Disruption of
            this gene negatively impacts mitochondrial and cytosolic iron
            homeostasis. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4199672.1,
                                           SRR14038193.1186896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330636.9/ ENSP00000418787.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               HY168919.1         2-205
            205-857             AF170070.1         1-653
            858-1030            BC067762.1         529-701
            1031-1031           AL035653.12        36110-36110         c
            1032-1497           CA310019.1         18-483              c
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.1"
     gene            1..1497
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /note="LYR motif containing 4"
                     /db_xref="GeneID:57128"
                     /db_xref="HGNC:HGNC:21365"
                     /db_xref="MIM:613311"
     exon            1..303
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..493
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homolog of yeast Isd11; mitochondrial matrix Nfs1
                     interacting protein"
                     /codon_start=1
                     /product="LYR motif-containing protein 4 isoform 1"
                     /protein_id="NP_065141.3"
                     /db_xref="CCDS:CCDS4493.1"
                     /db_xref="GeneID:57128"
                     /db_xref="HGNC:HGNC:21365"
                     /db_xref="MIM:613311"
                     /translation="MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENK
                     NVKDPVEIQTLVNKAKRDLGVIRRQVHIGQLYSTDKLIIENRDMPRT"
     exon            304..424
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /inference="alignment:Splign:2.1.0"
     exon            425..1497
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /note="hexamer: AATAAA"
     polyA_site      844
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /note="major polyA site"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="LYRM4"
                     /gene_synonym="C6orf149; CGI-203; COXPD19; ISD11"
ORIGIN      
        1 gagccctgcc tgcgcccgcc cccgaagcgg cgcgggacgc ctggcgccgt ccgcgatccg
       61 cagggctgcc cgcttaggct taggcccggc ccgctggcaa agccgagccg cagcatttta
      121 tttcgttcgt ggtttccgca caggctggag tttcgtgggt tgggtcgtac ttgggacctc
      181 ggcgaagagg acccgtttat ttttttttct ttccaaaatg gcagcctcca gtcgcgcaca
      241 agtgttatct ctgtaccggg cgatgctgag agagagcaag cgtttcagcg cctacaatta
      301 cagaacatat gctgtcagga ggataagaga tgccttcaga gaaaataaaa atgtaaagga
      361 tcctgtagaa attcaaaccc tagtgaataa agccaagaga gaccttggag taattcgtcg
      421 acaggtccac attggccaac tgtattcaac tgacaagctg atcattgaga atcgagacat
      481 gcccaggacc tagcaagccg gggaccagcc accagtggcg gccagggacc accttcagca
      541 tccactctct gtttgagatg ggggctccca aaaccagctt acaatagcct tttgcgctgc
      601 ctgtcctgtg ggagctgata aaccaagtca catttgcatt ctgttgcagg cttagtgaaa
      661 aaggactgct gtctttcctt ggttcaagtg ttagaatgga gagctggagt tcgttcagaa
      721 tagtgctgtg tgttaccacg tctcccctgc accccattcc taccttgtag ctcatgacca
      781 ttgtgtatag catttctaca ctttgtttct tggtccttgg caataaaaag aatgatctcc
      841 ctgagccttt gaccccagat aaacccctcc caattaatgc attttcattt cctactgata
      901 caaggcctgg agagggctgt tgggggccct cagggagggt tcaactctga gacgagaact
      961 gccttggtga aggcaagttc aagcaccact tgagactggg ggcagcatgg agtagggcag
     1021 ggctacgggg atacacggtg caccctgcaa cttatacctg agcccagtac aacaaaggtg
     1081 acgggtgtgt aggtacacac ccagagatgg agcactgcag atcagcaacc tcagccccac
     1141 ctgggaattt gctggaaatg caggctcaag cccctcccca cacctggtga atgagagagc
     1201 cccagcctga cccaagccca gggcgactcc cataccctga agcctggggc atgctgggca
     1261 gcaccggtgc ccaaatctgg ctggtggaca gaagcacctg gagagttgga gagcttttta
     1321 aaaagacatc tctcagcact tccctctctg cagattctga ctcagtaagt gaggggtgag
     1381 gcacagtcat ttttctctat tctgaagctc tcccactgtt ttcaatgttt aaccaactgg
     1441 ggacccctgc tctttaagta tattacaggt aataaagata ttgtttgtat gctttta
//
