LOCUS       NM_020466               5347 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens LYR motif containing 2 (LYRM2), transcript variant 1,
            mRNA.
ACCESSION   NM_020466
VERSION     NM_020466.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5347)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 5347)
  AUTHORS   Dibley,M.G., Formosa,L.E., Lyu,B., Reljic,B., McGann,D.,
            Muellner-Wong,L., Kraus,F., Sharpe,A.J., Stroud,D.A. and Ryan,M.T.
  TITLE     The Mitochondrial Acyl-carrier Protein Interaction Network
            Highlights Important Roles for LYRM Family Members in Complex I and
            Mitoribosome Assembly
  JOURNAL   Mol Cell Proteomics 19 (1), 65-77 (2020)
   PUBMED   31666358
REFERENCE   3  (bases 1 to 5347)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5347)
  AUTHORS   Huang,Q., Chen,Z., Cheng,P., Jiang,Z., Wang,Z., Huang,Y., Yang,C.,
            Pan,J., Qiu,F. and Huang,J.
  TITLE     LYRM2 directly regulates complex I activity to support tumor growth
            in colorectal cancer by oxidative phosphorylation
  JOURNAL   Cancer Lett 455, 36-47 (2019)
   PUBMED   31004700
  REMARK    GeneRIF: Authors identified a new Akt-S58phos-LYRM2-Complex I axis,
            which is responsible for the LYRM2-induced tumor growth and the
            activation of OXPHOS in colorectal cancer.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP280644.1, BC104668.1, AL096678.8 and BI492982.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020466.4.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.173923.1,
                                           SRR1803615.235383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000523377.2/ ENSP00000430025.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP280644.1         9-21
            14-577              BC104668.1         5-568
            578-4993            AL096678.8         25118-29533         c
            4994-5347           BI492982.1         17-370              c
FEATURES             Location/Qualifiers
     source          1..5347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..5347
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="LYR motif containing 2"
                     /db_xref="GeneID:57226"
                     /db_xref="HGNC:HGNC:25229"
     exon            1..76
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..298
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /codon_start=1
                     /product="LYR motif-containing protein 2"
                     /protein_id="NP_065199.1"
                     /db_xref="CCDS:CCDS5023.1"
                     /db_xref="GeneID:57226"
                     /db_xref="HGNC:HGNC:25229"
                     /translation="MAASRLPPATLTLKQFVRRQQVLLLYRRILQTIRQVPNDSDRKY
                     LKDWAREEFRRNKSATEEDTIRMMITQGNMQLKELEKTLALAKS"
     exon            77..217
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /inference="alignment:Splign:2.1.0"
     exon            218..5347
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1421..1426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="hexamer: AATAAA"
     polyA_site      1442
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="major polyA site"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="hexamer: AATACA"
     polyA_site      3350
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="major polyA site"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="hexamer: ATTAAA"
     polyA_site      3730
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="major polyA site"
     regulatory      5320..5325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
                     /note="hexamer: AATAAA"
     polyA_site      5347
                     /gene="LYRM2"
                     /gene_synonym="DJ122O8.2"
ORIGIN      
        1 gcgctgaggc tccggcggac ctctggtgga catggctgct tcccgcttac ccccagcgac
       61 gctaacgtta aagcagttcg taagaaggca acaagttctt ctcctctaca gaaggatttt
      121 gcaaacaatt cggcaagttc caaatgattc tgatcgcaaa tacctgaaag attgggcaag
      181 agaagaattc agaagaaaca aaagtgccac cgaagaggat acaatccgga tgatgattac
      241 tcaaggcaat atgcagctca aggagttaga aaaaacactt gctttagcaa aatcttaact
      301 atagcattat tctgaaggat tttcaaagtc tccatgtgtt ttgttgcatt taggattaac
      361 aatggacaac acaaagccca gtcttactat ttatatgtac agtatttggt gatagagagc
      421 aaaggaaaaa cacatcagaa cagttgcctt aacactgaaa aacataccct gcattttgaa
      481 aatgtttatg gatgtctcag cagttcttaa aagaagaaaa aaaccactaa caaatggcca
      541 gtagatgctg gacacaatca ttagggaagt gtaaatcaaa actactatga ggtcgggtgt
      601 agtggctcat gcttgtaatc ccagtacttt aggaggctgt ggtaggtgga tcacttgagg
      661 tcaggagttc aagaccagcc tggccagcat ggtgaaacct catctctact aaaaatacaa
      721 aaattagctt ggtgtggtgg tgcattgcct gtagtcccag ctacttggga ggctgaggca
      781 ggagaatcac ttgaacccag gaagtggagg ttgcagtgag ctgaggtcgt gccactgcac
      841 ttcagcctgg gtgacagagt gagacagtct ctaaaaaaaa aaaaaaaaaa caaccctgag
      901 attcacattc actagaatgg ctgtaattaa aaagagaaat aataataagt cttggtgaag
      961 atgtacagaa attacagaac cctcatacat tgctggtggg aatgtaaaat ggtgtagcca
     1021 cttcagaaaa cagacggtca gttcctcaaa agatgaaaca gctgctgtat gagttagcac
     1081 ttctacccca tgcccatagc cattatttgg cactaaaaag aaacgaagga cttatatata
     1141 ctaaacatgg ataaaccttg aaaacgttaa gtgaaagaag ccggtcacaa aagatcacat
     1201 gatgattcca ttcatacgaa atgtccagaa taggcagaaa gattagtggt tgcctaggct
     1261 ggctgtagat ggaatggagt aactgctaat gggtgtaggg ttccttttca gggtgatgaa
     1321 aatatcctac agttagcttg tggtgtaggc tgcacaactc ttgaatatat tcaaatccac
     1381 tgaactgtac attttaaatg taaggtatga attgtatctc aataaagctg ttattaaaaa
     1441 actcttgagg tgtaggactg aaagtatact gacaccagga gataccctgg aactttctcg
     1501 aaaaatcctg cattatccct gagggttgtt caggtacgtt cttcagatgt gtcatagttt
     1561 gatagagaac tcatcaaaaa gatcaccact gggaatctag atctttgttg aaaagggaag
     1621 agaaagagaa gcttaatgag cacattgaag cacttaccag aaagaagagg gaagacttct
     1681 ggatgaaacc tctgtgagta ccttaacatt cacatggaag tagtaaaaat aagattctgg
     1741 gtgcagttct ccaatgacag gaaaaaaaac aaagagaatt tgaagaatac gtcagagaca
     1801 aatacattac aaccaaaatt gacttcaagg cacttttgaa ggagatcaaa tttataacaa
     1861 aataatttag tgaaagtgaa agcttgtgga agatgttgga atcatccatc ctgaaaattg
     1921 aagtcttctg tttatcaaca gaacagctaa gaagctaatc taagaatgac cagcacctga
     1981 aagatgtaga caacattttg cagaatgata aatggtatcc agtactggac tgtgtctgag
     2041 aggcatcaac tgaatgtgga tgttaatgac ctggactgtc agggtccacc tctacctccc
     2101 agagcctcag agcccacaag acaaaataat tctgaatact gttccatggg ggtaatctac
     2161 taattcaaaa tgcctgcctg tgccaatttt caggttttta tgtagataag tattagttaa
     2221 cctgttgcaa aatgatctga caaacagaag catttgtgac gtttctgaac agagaacact
     2281 ttggaaatat tttttgtgtg acatgattga tagatacatg ctatctctag taaatctaaa
     2341 atcttgaaac tcaaaatcat ccttttatgg gtgtagaagt cagtgattta atgatgctct
     2401 tcctaacagt ggtgtgcatg gaaaggtttt cattaaagag cgtatgtggt ttgcatttgc
     2461 aagattcaac tagcacagac tccaagaaaa cctaagtttt tttgtttttt aaagcaggta
     2521 aggccgggca ctgtggctta cacaagtaat ccacacactt tgggaggctg aggtgggtgg
     2581 atcactttag gtcaggattt cgagactagc taggccacta gctagcctaa cctggtggca
     2641 cgtgcctgta attccagcta ctcaggaggg ctgcctcata ttgaacccgg gaggcagagg
     2701 ctgcagtgag ccgagaacac actactgcac tacagcctgg gcgaaagagt gagactcttg
     2761 tctcaaaaaa aataaaaaag tgccatcaag ttagaagttt taaattcatg gtacaagcat
     2821 tgccatagat gtgcctgcaa gaaacacaca gatgactttt ttttgagaca gggtctctgt
     2881 tgcacaagct ggagtgtggt ggcgcgaaca tggctcactg caaccttgag ctcctgggct
     2941 caagagatcc acctgcttca gattttcatt tagctgggac cacaggcatg tgccaccatg
     3001 accggctaat tttttttact tttcagagag aggaggggga atctcacttt gttgccaggc
     3061 tagtctcaaa ctcctgggct caagcaatcc acctgcctcg gtggccagag tgctaggatt
     3121 acaggtgtga gttgtttttt tttttaaaga gacagtctta cctcattctg tcacccagaa
     3181 tggaatgact ttctaaaatt gcagaaagca gaacatattc cttgctgttt ataatattat
     3241 agtcgtatca aagggaaaga gtatttctcc ttaaataaaa ttacaaataa gaaatgtatg
     3301 ttttactctt actcataaaa ggtattgtag aatacaaaag gtttttcaaa ctggttttgt
     3361 ctttgattgg cttttataat ccacacttca aagaagaaat gcatttaact tttaataact
     3421 tagtcaaaaa gtataatgtt gccttgcctt gcataacctt taactattgc aaatgatgtt
     3481 ttgtccttcc cctttgtcca gtattttcca aatggtcaac agtttaaaca tttaagcttg
     3541 cactgagaaa ccttgccaca tttcagcagt tttgttttgc ttttggtgga gagcacctga
     3601 tcgcgacttt acagccaatg tatttactct aaattacact tttatagata caaggtaaag
     3661 tgtagctggg tgaaggcact caggagccat aaaatgtggt caaccacaat aaattaaaat
     3721 gtaagctaaa caaagtattc acacttgcat ttttttaata aggaatttaa gatccatagt
     3781 atctttaatg cttggaagag acacaaattc aaggtgataa aaatattaat tagaagacac
     3841 ataacatgcc tcaagtatat caacacttga ctccacaaac aaggcataac catgaaaaca
     3901 acactccctt tattttgggc tcccaaaatc aaaagttaga actaatttat ttaatcacag
     3961 atatttagta tactcaataa tgcactaaca atttctttaa aaaaacacta atactgtaca
     4021 gtatttctgt gttttagttt ttcccacagc tgttgaaaat ttcagccttg atttgaaaca
     4081 tgacctgcat gacaggctat aagttgtcaa tagttctttt tctttggaaa agtacagttg
     4141 tggcatttac tcactttagc agatagctaa aagggaaaaa taaggaaaaa tatacactgg
     4201 acctgcagtt aagtttttga caatgccaag gatcaaaaac agatgaaaca acatttgctg
     4261 aagatgaaaa ggtattgcat tggtcttaat agatgttgcc atctctgggt gaggatgctg
     4321 actgagcctg ttctgtgtct tcatcacctc tatttgtttc ttcttctacg acagacctcc
     4381 aagagacaag atccatgtag taagccacac taggtccttt tgacccttct cattcttctg
     4441 tagtctcttc cctgtgactt ttgacaaaaa tactcagttc acaatattag ctgcctgctt
     4501 ctgatgggta ggaggtaatc aaaatactcc caccaaagca ctctatggtc tagacttgat
     4561 acttaaaatt tagttttcag cattcctcaa caaggatacc ttgaggtaat aggagatatt
     4621 ttggtaagtg aaaataattc ctgcttggaa cacagcctac tgaactcagg atttaatttc
     4681 ttgagtatta ggcagttctc aataaattga tgtatactga ggaatgattc taaagaggtt
     4741 agtgatatcc tgtttgagaa tagatttaga aaactgaagg tactctccag ctctacaatt
     4801 ctgtattagg aacaataggg aaatgagaaa gtgcctctat attgcaatct aatgagtctc
     4861 tgggggaaga ctgtctacct gcgtagtagt tgagaacaag acaagctccc aaacacatga
     4921 aaatcaactt gaaataacat caaattcagc ctgggcaata tcatgagacc ttatatctac
     4981 aaaaaattag ccaggactgg tggcacacgc ctgtagtccc aagctacttg cgaggttgag
     5041 gcaggaggat cacgagcctg agaggccaag gctgcagtga ggtgtgatca tgccactgca
     5101 ctccagtctg ggtgacagag caagaccctg tctcaacaaa ataaaaaaca tcaaattcat
     5161 tccatattca ggtaacagtg acatatatct actgaattat ttttctttta ggaatgtcta
     5221 tatctatgga ttgtcactat aaaaaaaaga aaaaacccta aaactgagct tgacaaaggg
     5281 aataaaagca tactttgttt ttcttggtgt ccccatgtta ataaatcatt tcttctcttt
     5341 ggctcaa
//
