LOCUS       NM_001128302            1378 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LYR motif containing 1 (LYRM1), transcript variant 3,
            mRNA.
ACCESSION   NM_001128302
VERSION     NM_001128302.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Yin,C., Xiao,Y., Zhang,W., Xu,E., Liu,W., Yi,X. and Chang,M.
  TITLE     DNA microarray analysis of genes differentially expressed in
            adipocyte differentiation
  JOURNAL   J Biosci 39 (3), 415-423 (2014)
   PUBMED   24845505
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Qin,Z.Y., Zhang,M., Guo,X.R., Wang,Y.M., Zhu,G.Z., Ni,Y.H.,
            Zhao,Y.P., Qiu,J., Kou,C.Z., Qin,R. and Cao,X.G.
  TITLE     alpha-Lipoic acid ameliorates impaired glucose uptake in LYRM1
            overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling
            pathway
  JOURNAL   J Bioenerg Biomembr 44 (5), 579-586 (2012)
   PUBMED   22820890
  REMARK    GeneRIF: alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced
            insulin resistance partially via its capacity to restore
            mitochondrial function and/or increase phosphorylation of IRS-1 and
            Akt.
REFERENCE   4  (bases 1 to 1378)
  AUTHORS   Cao,X.G., Kou,C.Z., Zhao,Y.P., Gao,C.L., Zhu,C., Zhang,C.M.,
            Ji,C.B., Qin,D.N., Zhang,M. and Guo,X.R.
  TITLE     Overexpression of LYRM1 induces mitochondrial impairment in 3T3-L1
            adipocytes
  JOURNAL   Mol Genet Metab 101 (4), 395-399 (2010)
   PUBMED   20826099
  REMARK    GeneRIF: overexpression of LYRM1 caused mitochondrial dysfunction
            in adipocytes, which might be responsible for the development of
            LYRM1-induced insulin resistance
REFERENCE   5  (bases 1 to 1378)
  AUTHORS   Zhu,C., Liu,Y.Q., Chen,F.K., Hu,D.L., Yu,Z.B. and Qian,L.M.
  TITLE     LYRM1, a gene that promotes proliferation and inhibits apoptosis
            during heart development
  JOURNAL   Molecules 15 (10), 6974-6982 (2010)
   PUBMED   20938407
  REMARK    GeneRIF: Data suggest that LYRM1 might have the potential to
            modulate cell growth, apoptosis, and heart development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1378)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1378)
  AUTHORS   Ma,Y., Qi,X., Du,J., Song,S., Feng,D., Qi,J., Zhu,Z., Zhang,X.,
            Xiao,H., Han,Z. and Hao,X.
  TITLE     Identification of candidate genes for human pituitary development
            by EST analysis
  JOURNAL   BMC Genomics 10, 109 (2009)
   PUBMED   19284880
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1378)
  AUTHORS   Qiu,J., Gao,C.L., Zhang,M., Chen,R.H., Chi,X., Liu,F., Zhang,C.M.,
            Ji,C.B., Chen,X.H., Zhao,Y.P., Li,X.N., Tong,M.L., Ni,Y.H. and
            Guo,X.R.
  TITLE     LYRM1, a novel gene promotes proliferation and inhibits apoptosis
            of preadipocytes
  JOURNAL   Eur J Endocrinol 160 (2), 177-184 (2009)
   PUBMED   19022914
  REMARK    GeneRIF: By increasing cell proliferation and lowering the rate of
            apoptosis, LYRM1 has the potential to modulate the size of the
            preadipocyte pool and influence adipose tissue homeostasis
REFERENCE   9  (bases 1 to 1378)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI547471.1, CX163936.1 and
            AL359616.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001128302.2.
            
            Summary: The protein encoded by this gene belongs to the
            mitochondrial leucine/tyrosine/arginine motif family of proteins.
            Proteins of this family are short polypeptides that contain a
            leucine/tyrosine/arginine motif near the N-terminus. This gene is
            widely expressed with high levels in omental adipose tissue of
            obese individuals. In adipose tissue, the protein is localized to
            the nucleus where it promotes preadipocyte proliferation and lowers
            the rate of apoptosis to regulate adipose tissue homeostasis.
            Overexpression of this gene in adipocytes causes abnormal
            mitochondrial morphology and mitochondrial dysfunction. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1059846.1,
                                           SRR3476690.197215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567954.6/ ENSP00000457333.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BI547471.1         24-47
            25-877              CX163936.1         7-859
            878-1378            AL359616.1         236-736
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..1378
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /note="LYR motif containing 1"
                     /db_xref="GeneID:57149"
                     /db_xref="HGNC:HGNC:25074"
                     /db_xref="MIM:614709"
     exon            1..119
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..488
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /note="isoform 1 is encoded by transcript variant 3; LYR
                     motif-containing protein 1"
                     /codon_start=1
                     /product="LYR motif-containing protein 1 isoform 1"
                     /protein_id="NP_001121774.1"
                     /db_xref="CCDS:CCDS10593.1"
                     /db_xref="GeneID:57149"
                     /db_xref="HGNC:HGNC:25074"
                     /db_xref="MIM:614709"
                     /translation="MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEA
                     RTLFRKNKNLTDTDLIKQCIDECTARIEIGLHYKIPYPRPIHLPPMGLTPLRGRGLRS
                     QEKLRKLSKPVYLRSHDEVS"
     exon            120..278
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..371
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..1378
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /note="hexamer: AATAAA"
     polyA_site      1378
                     /gene="LYRM1"
                     /gene_synonym="A211C6.1"
                     /note="major polyA site"
ORIGIN      
        1 ctactggacc agcctgtgct cggtcggcca cggctctgct gggctcctgg cgccgcctcc
       61 tcccagcccg ccgcgggctg cgcgcttctg tgggtggggg aaggcaggac tgacgcagaa
      121 tgacaacggc aacacgacaa gaagtccttg gcctctaccg cagcattttc aggcttgcga
      181 ggaaatggca ggcgacatca gggcagatgg aagacaccat caaagaaaaa cagtacatac
      241 taaatgaagc cagaacgctg ttccggaaaa acaaaaatct cacggacaca gacctaatta
      301 aacagtgtat agatgaatgc acagccagga ttgaaattgg actgcattac aagattcctt
      361 acccaaggcc aattcatctg cctccaatgg gccttacccc actccgaggc cggggacttc
      421 gaagccaaga gaaactgagg aaactttcca aaccagtata tctcagatct catgatgaag
      481 tttcctaatc tagaggaaag tttatttctg caaatgatga gccaactagt tattgaatgt
      541 aaaccagatg gcaaaacact tcttgattag gggcaaaaat tcaaatgtct tcttaaaacc
      601 tccacaattg attctccccc tgtgatgtaa acttagatat ccctagagtt tctcagcatc
      661 tttcttcctg agtggatggc attatcccta gaggtcatgg accttacatc ctcactgcag
      721 tcacctttgg aaacaagacc gaggcctgta gaaggaaagc ggaaggatgt aagagctgtt
      781 catgggaatt ccattcacca cacatgccag ctgatgcaaa gaaatttgcc agtcactgga
      841 agttactgtg gctactataa aactatgtac cactctcaga atattcttag gctttttttt
      901 tttcaagtta tagatttgct taaagtgagg ttttttggtg tgtgcttttt tgttgtcttt
      961 tgacccttcc agtttccaga caaacttgtc ttaaaaagtg catcattgga ttgaccatgg
     1021 tttttcatga aattttatga gatttctgcc ttaacaaaat gcatatattc cttatcttaa
     1081 agcctgtcat tacttaggat gcacttatag gatctgaaaa gctcacttta aactcatact
     1141 acattcgtta cgagtatttt acgttaacat aattgaaaag tacaaggtcc aagctggctt
     1201 tcaaattatg tctaaacaga aatgggacaa atagacttga aaatagaagg gatttattcc
     1261 acccctgcaa gggtagagtc aggtgagagt cccttggtga gtcatttgta catcagtgtc
     1321 atttcttctt aacctctgaa gaagatgggc atcagaaata aagacaaagc actatcaa
//
