LOCUS       NM_138794               1857 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens lysophospholipase like 1 (LYPLAL1), transcript variant
            1, mRNA.
ACCESSION   NM_138794
VERSION     NM_138794.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Fan,Y., Gao,Y., Nie,L., Hou,T., Dan,W., Wang,Z., Liu,T., Wei,Y.,
            Wang,Y., Liu,B., Que,T., Lei,Y., Zeng,J., Ma,J., Wei,W. and Li,L.
  TITLE     Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the
            response to anti-tumor immunotherapy
  JOURNAL   Mol Cell 83 (19), 3520-3532 (2023)
   PUBMED   37802025
  REMARK    GeneRIF: Targeting LYPLAL1-mediated cGAS depalmitoylation enhances
            the response to anti-tumor immunotherapy.
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Li,S., Lv,J., Zhang,X., Zhang,Q., Li,Z., Lu,J., Huo,X., Guo,M.,
            Liu,X., Gao,R., Gong,J., Li,C., Li,W., Zhang,T., Wang,J., Chen,Z.
            and Du,X.
  TITLE     ELAVL4 promotes the tumorigenesis of small cell lung cancer by
            stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation
  JOURNAL   FASEB J 37 (10), e23170 (2023)
   PUBMED   37676718
  REMARK    GeneRIF: ELAVL4 promotes the tumorigenesis of small cell lung
            cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2
            activation.
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Sliz,E., Sebert,S., Wurtz,P., Kangas,A.J., Soininen,P.,
            Lehtimaki,T., Kahonen,M., Viikari,J., Mannikko,M., Ala-Korpela,M.,
            Raitakari,O.T. and Kettunen,J.
  TITLE     NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show
            divergent metabolic effects
  JOURNAL   Hum Mol Genet 27 (12), 2214-2223 (2018)
   PUBMED   29648650
  REMARK    GeneRIF: Metabolic effects of LYPLAL1 rs12137855-C were similar,
            but statistically less robust, to the effects of GCKR rs1260326-T.
            TM6SF2 rs58542926-T displayed opposite metabolic effects when
            compared with the fatty liver associations.
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Burger,M., Zimmermann,T.J., Kondoh,Y., Stege,P., Watanabe,N.,
            Osada,H., Waldmann,H. and Vetter,I.R.
  TITLE     Crystal structure of the predicted phospholipase LYPLAL1 reveals
            unexpected functional plasticity despite close relationship to acyl
            protein thioesterases
  JOURNAL   J Lipid Res 53 (1), 43-50 (2012)
   PUBMED   22052940
  REMARK    GeneRIF: LYPLAL1 exhibits neither phospholipase nor triacylglycerol
            lipase activity, but rather accepts short-chain substrates
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Bille,D.S., Banasik,K., Justesen,J.M., Sandholt,C.H., Sandbaek,A.,
            Lauritzen,T., Jorgensen,T., Witte,D.R., Holm,J.C., Hansen,T. and
            Pedersen,O.
  TITLE     Implications of central obesity-related variants in LYPLAL1, NRXN3,
            MSRA, and TFAP2B on quantitative metabolic traits in adult Danes
  JOURNAL   PLoS One 6 (6), e20640 (2011)
   PUBMED   21674055
  REMARK    GeneRIF: central obesity-associated variants in LYPLAL1, NRXN3,
            MSRA, and TFAP2B
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Hotta,K., Nakamura,M., Nakamura,T., Matsuo,T., Nakata,Y.,
            Kamohara,S., Miyatake,N., Kotani,K., Komatsu,R., Itoh,N., Mineo,I.,
            Wada,J., Yoneda,M., Nakajima,A., Funahashi,T., Miyazaki,S.,
            Tokunaga,K., Kawamoto,M., Masuzaki,H., Ueno,T., Hamaguchi,K.,
            Tanaka,K., Yamada,K., Hanafusa,T., Oikawa,S., Yoshimatsu,H.,
            Nakao,K., Sakata,T., Matsuzawa,Y., Nakamura,Y. and Kamatani,N.
  TITLE     Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and
            their effect on visceral fat area in the Japanese population
  JOURNAL   J Hum Genet 55 (11), 738-742 (2010)
   PUBMED   20703240
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Lindgren,C.M., Heid,I.M., Randall,J.C., Lamina,C.,
            Steinthorsdottir,V., Qi,L., Speliotes,E.K., Thorleifsson,G.,
            Willer,C.J., Herrera,B.M., Jackson,A.U., Lim,N., Scheet,P.,
            Soranzo,N., Amin,N., Aulchenko,Y.S., Chambers,J.C., Drong,A.,
            Luan,J., Lyon,H.N., Rivadeneira,F., Sanna,S., Timpson,N.J.,
            Zillikens,M.C., Zhao,J.H., Almgren,P., Bandinelli,S., Bennett,A.J.,
            Bergman,R.N., Bonnycastle,L.L., Bumpstead,S.J., Chanock,S.J.,
            Cherkas,L., Chines,P., Coin,L., Cooper,C., Crawford,G., Doering,A.,
            Dominiczak,A., Doney,A.S., Ebrahim,S., Elliott,P., Erdos,M.R.,
            Estrada,K., Ferrucci,L., Fischer,G., Forouhi,N.G., Gieger,C.,
            Grallert,H., Groves,C.J., Grundy,S., Guiducci,C., Hadley,D.,
            Hamsten,A., Havulinna,A.S., Hofman,A., Holle,R., Holloway,J.W.,
            Illig,T., Isomaa,B., Jacobs,L.C., Jameson,K., Jousilahti,P.,
            Karpe,F., Kuusisto,J., Laitinen,J., Lathrop,G.M., Lawlor,D.A.,
            Mangino,M., McArdle,W.L., Meitinger,T., Morken,M.A., Morris,A.P.,
            Munroe,P., Narisu,N., Nordstrom,A., Nordstrom,P., Oostra,B.A.,
            Palmer,C.N., Payne,F., Peden,J.F., Prokopenko,I., Renstrom,F.,
            Ruokonen,A., Salomaa,V., Sandhu,M.S., Scott,L.J., Scuteri,A.,
            Silander,K., Song,K., Yuan,X., Stringham,H.M., Swift,A.J.,
            Tuomi,T., Uda,M., Vollenweider,P., Waeber,G., Wallace,C.,
            Walters,G.B., Weedon,M.N., Witteman,J.C., Zhang,C., Zhang,W.,
            Caulfield,M.J., Collins,F.S., Davey Smith,G., Day,I.N.,
            Franks,P.W., Hattersley,A.T., Hu,F.B., Jarvelin,M.R., Kong,A.,
            Kooner,J.S., Laakso,M., Lakatta,E., Mooser,V., Morris,A.D.,
            Peltonen,L., Samani,N.J., Spector,T.D., Strachan,D.P., Tanaka,T.,
            Tuomilehto,J., Uitterlinden,A.G., van Duijn,C.M., Wareham,N.J.,
            Hugh,Watkins., Waterworth,D.M., Boehnke,M., Deloukas,P., Groop,L.,
            Hunter,D.J., Thorsteinsdottir,U., Schlessinger,D., Wichmann,H.E.,
            Frayling,T.M., Abecasis,G.R., Hirschhorn,J.N., Loos,R.J.,
            Stefansson,K., Mohlke,K.L., Barroso,I. and McCarthy,M.I.
  CONSRTM   Wellcome Trust Case Control Consortium; Procardis Consortia; Giant
            Consortium
  TITLE     Genome-wide association scan meta-analysis identifies three Loci
            influencing adiposity and fat distribution
  JOURNAL   PLoS Genet 5 (6), e1000508 (2009)
   PUBMED   19557161
  REMARK    GeneRIF: TFAP2B, LYPLAL1 and MSRA are associated with adiposity and
            fat distribution.
            GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
            Erratum:[PLoS Genet. 2009 Jul;5(7). doi:
            10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928]
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   David,D., Cardoso,J., Marques,B., Marques,R., Silva,E.D., Santos,H.
            and Boavida,M.G.
  TITLE     Molecular characterization of a familial translocation implicates
            disruption of HDAC9 and possible position effect on TGFbeta2 in the
            pathogenesis of Peters' anomaly
  JOURNAL   Genomics 81 (5), 489-503 (2003)
   PUBMED   12706107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY106571.1, BC016711.1, AA424278.1, AL360093.11 and BF115063.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138794.4.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.433853.1,
                                           SRR3476690.842901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366928.10/ ENSP00000355895.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 HY106571.1         49-51
            4-405               BC016711.1         5-406
            406-406             AA424278.1         423-423
            407-816             BC016711.1         408-817
            817-1797            AL360093.11        112082-113062
            1798-1857           BF115063.1         19-78               c
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1857
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="lysophospholipase like 1"
                     /db_xref="GeneID:127018"
                     /db_xref="HGNC:HGNC:20440"
                     /db_xref="MIM:616548"
     exon            1..104
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..727
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /EC_number="3.1.2.22"
                     /note="isoform a is encoded by transcript variant 1;
                     lysophospholipase-like protein 1"
                     /codon_start=1
                     /product="lysophospholipase-like protein 1 isoform a"
                     /protein_id="NP_620149.2"
                     /db_xref="CCDS:CCDS1522.1"
                     /db_xref="GeneID:127018"
                     /db_xref="HGNC:HGNC:20440"
                     /db_xref="MIM:616548"
                     /translation="MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQV
                     LNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLT
                     DLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQA
                     LQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTEL
                     DILKLWILTKLPGEMEKQK"
     exon            105..204
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     exon            205..374
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     exon            375..490
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     exon            491..1857
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="hexamer: ATTAAA"
     polyA_site      826
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="major polyA site"
     regulatory      1835..1840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
ORIGIN      
        1 agtggcatca gcgatggcgg ctgcgtcggg gtcggttctg cagcgctgta tcgtgtcgcc
       61 ggcagggagg catagcgcct ctctgatctt cctgcatggc tcaggtgatt ctggacaagg
      121 attaagaatg tggatcaagc aggttttaaa tcaagattta acattccaac acataaaaat
      181 tatttatcca acagctcctc ccagatcata tactcctatg aaaggaggaa tctccaatgt
      241 atggtttgac agatttaaaa taaccaatga ctgcccagaa caccttgaat caattgatgt
      301 catgtgtcaa gtgcttactg atttgattga tgaagaagta aaaagtggca tcaagaagaa
      361 caggatatta ataggaggat tctctatggg aggatgcatg gcaatacatt tagcatatag
      421 aaatcatcaa gatgtggcag gagtatttgc tctttctagt tttctgaata aagcatctgc
      481 tgtttaccag gctcttcaga agagtaatgg tgtacttcct gaattatttc agtgtcatgg
      541 tactgcagat gagttagttc ttcattcttg ggcagaagag acaaactcaa tgttaaaatc
      601 tctaggagtg accacgaagt ttcatagttt tccaaatgtt taccatgagc taagcaaaac
      661 tgagttagac atattgaagt tatggattct tacaaagctg ccaggagaaa tggaaaaaca
      721 aaaatgaatg aatcaagagt gatttgttaa tgtaagtgta atgtctttgt gaaaagtgat
      781 ttttactgcc aaattataat gataattaaa atattaagaa ataacacttt cctgactttt
      841 ttattattaa aatgcttatc actgtagaca gtagctaatc ttattaatga aaaacaatag
      901 acaaacatct gtgcataatt tttcagacac aattctgtaa atatttggaa accttttaag
      961 tatttaaact tttaaatttt tgaaataaag tattctaaac taatataaat aaggacaatg
     1021 aaaaaacatg aaaggactta gcataatgtt attttatctt ttctacaact ttgtttaaat
     1081 tacctttcca aagatatttg tgtttatgta attttccacg gaataacatt aatactctag
     1141 gtttataaac cggtttcaca ttatttcatt tgatcatcac aagagctttg tgaagtaagc
     1201 cgagaagttg ttactggtat ttaataatag caatagagga gttaaagact ttcccacagc
     1261 ttgcaggtca agacaagaaa ttcaggtctc ctaattctca gtggagctct atttctgtta
     1321 acccaaattg ctgctctgtt ttaggtctca atttcatctg taaaatgata ctaatagtac
     1381 ttatcccatt ggatttttgt tgagatttaa ataaatagcc aaaagccaat acataataaa
     1441 cactcaataa agattaacca taaggagagt catgatctgg ttccaggaat acattgttag
     1501 atgactgaaa aattgtatta cttcaatgaa aatactataa ataataacat tttcatatat
     1561 tagttggttc tcatgcatac ataatctaat tttatttgat cctcacaact gtttaagttt
     1621 tattaaatat acattatccc tatttgtata aatagaatca tacaatacct gcctgctttc
     1681 attcaacaaa attatcatga gatttttcca tgttgtgtac atcaatagtt catctatttt
     1741 attgctcagt aatattccat tgtgtggatg tatcactatt tgtttacaca ttcaccactg
     1801 atatataagt tgcttccagt gtgaggctgt tttaaataaa gctgctatga atattca
//
