LOCUS       NM_001300770            1809 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens lysophospholipase like 1 (LYPLAL1), transcript variant
            3, mRNA.
ACCESSION   NM_001300770 XM_005273046
VERSION     NM_001300770.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Fan,Y., Gao,Y., Nie,L., Hou,T., Dan,W., Wang,Z., Liu,T., Wei,Y.,
            Wang,Y., Liu,B., Que,T., Lei,Y., Zeng,J., Ma,J., Wei,W. and Li,L.
  TITLE     Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the
            response to anti-tumor immunotherapy
  JOURNAL   Mol Cell 83 (19), 3520-3532 (2023)
   PUBMED   37802025
  REMARK    GeneRIF: Targeting LYPLAL1-mediated cGAS depalmitoylation enhances
            the response to anti-tumor immunotherapy.
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Li,S., Lv,J., Zhang,X., Zhang,Q., Li,Z., Lu,J., Huo,X., Guo,M.,
            Liu,X., Gao,R., Gong,J., Li,C., Li,W., Zhang,T., Wang,J., Chen,Z.
            and Du,X.
  TITLE     ELAVL4 promotes the tumorigenesis of small cell lung cancer by
            stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation
  JOURNAL   FASEB J 37 (10), e23170 (2023)
   PUBMED   37676718
  REMARK    GeneRIF: ELAVL4 promotes the tumorigenesis of small cell lung
            cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2
            activation.
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   Sliz,E., Sebert,S., Wurtz,P., Kangas,A.J., Soininen,P.,
            Lehtimaki,T., Kahonen,M., Viikari,J., Mannikko,M., Ala-Korpela,M.,
            Raitakari,O.T. and Kettunen,J.
  TITLE     NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show
            divergent metabolic effects
  JOURNAL   Hum Mol Genet 27 (12), 2214-2223 (2018)
   PUBMED   29648650
  REMARK    GeneRIF: Metabolic effects of LYPLAL1 rs12137855-C were similar,
            but statistically less robust, to the effects of GCKR rs1260326-T.
            TM6SF2 rs58542926-T displayed opposite metabolic effects when
            compared with the fatty liver associations.
REFERENCE   6  (bases 1 to 1809)
  AUTHORS   Burger,M., Zimmermann,T.J., Kondoh,Y., Stege,P., Watanabe,N.,
            Osada,H., Waldmann,H. and Vetter,I.R.
  TITLE     Crystal structure of the predicted phospholipase LYPLAL1 reveals
            unexpected functional plasticity despite close relationship to acyl
            protein thioesterases
  JOURNAL   J Lipid Res 53 (1), 43-50 (2012)
   PUBMED   22052940
  REMARK    GeneRIF: LYPLAL1 exhibits neither phospholipase nor triacylglycerol
            lipase activity, but rather accepts short-chain substrates
REFERENCE   7  (bases 1 to 1809)
  AUTHORS   Bille,D.S., Banasik,K., Justesen,J.M., Sandholt,C.H., Sandbaek,A.,
            Lauritzen,T., Jorgensen,T., Witte,D.R., Holm,J.C., Hansen,T. and
            Pedersen,O.
  TITLE     Implications of central obesity-related variants in LYPLAL1, NRXN3,
            MSRA, and TFAP2B on quantitative metabolic traits in adult Danes
  JOURNAL   PLoS One 6 (6), e20640 (2011)
   PUBMED   21674055
  REMARK    GeneRIF: central obesity-associated variants in LYPLAL1, NRXN3,
            MSRA, and TFAP2B
REFERENCE   8  (bases 1 to 1809)
  AUTHORS   Hotta,K., Nakamura,M., Nakamura,T., Matsuo,T., Nakata,Y.,
            Kamohara,S., Miyatake,N., Kotani,K., Komatsu,R., Itoh,N., Mineo,I.,
            Wada,J., Yoneda,M., Nakajima,A., Funahashi,T., Miyazaki,S.,
            Tokunaga,K., Kawamoto,M., Masuzaki,H., Ueno,T., Hamaguchi,K.,
            Tanaka,K., Yamada,K., Hanafusa,T., Oikawa,S., Yoshimatsu,H.,
            Nakao,K., Sakata,T., Matsuzawa,Y., Nakamura,Y. and Kamatani,N.
  TITLE     Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and
            their effect on visceral fat area in the Japanese population
  JOURNAL   J Hum Genet 55 (11), 738-742 (2010)
   PUBMED   20703240
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1809)
  AUTHORS   Lindgren,C.M., Heid,I.M., Randall,J.C., Lamina,C.,
            Steinthorsdottir,V., Qi,L., Speliotes,E.K., Thorleifsson,G.,
            Willer,C.J., Herrera,B.M., Jackson,A.U., Lim,N., Scheet,P.,
            Soranzo,N., Amin,N., Aulchenko,Y.S., Chambers,J.C., Drong,A.,
            Luan,J., Lyon,H.N., Rivadeneira,F., Sanna,S., Timpson,N.J.,
            Zillikens,M.C., Zhao,J.H., Almgren,P., Bandinelli,S., Bennett,A.J.,
            Bergman,R.N., Bonnycastle,L.L., Bumpstead,S.J., Chanock,S.J.,
            Cherkas,L., Chines,P., Coin,L., Cooper,C., Crawford,G., Doering,A.,
            Dominiczak,A., Doney,A.S., Ebrahim,S., Elliott,P., Erdos,M.R.,
            Estrada,K., Ferrucci,L., Fischer,G., Forouhi,N.G., Gieger,C.,
            Grallert,H., Groves,C.J., Grundy,S., Guiducci,C., Hadley,D.,
            Hamsten,A., Havulinna,A.S., Hofman,A., Holle,R., Holloway,J.W.,
            Illig,T., Isomaa,B., Jacobs,L.C., Jameson,K., Jousilahti,P.,
            Karpe,F., Kuusisto,J., Laitinen,J., Lathrop,G.M., Lawlor,D.A.,
            Mangino,M., McArdle,W.L., Meitinger,T., Morken,M.A., Morris,A.P.,
            Munroe,P., Narisu,N., Nordstrom,A., Nordstrom,P., Oostra,B.A.,
            Palmer,C.N., Payne,F., Peden,J.F., Prokopenko,I., Renstrom,F.,
            Ruokonen,A., Salomaa,V., Sandhu,M.S., Scott,L.J., Scuteri,A.,
            Silander,K., Song,K., Yuan,X., Stringham,H.M., Swift,A.J.,
            Tuomi,T., Uda,M., Vollenweider,P., Waeber,G., Wallace,C.,
            Walters,G.B., Weedon,M.N., Witteman,J.C., Zhang,C., Zhang,W.,
            Caulfield,M.J., Collins,F.S., Davey Smith,G., Day,I.N.,
            Franks,P.W., Hattersley,A.T., Hu,F.B., Jarvelin,M.R., Kong,A.,
            Kooner,J.S., Laakso,M., Lakatta,E., Mooser,V., Morris,A.D.,
            Peltonen,L., Samani,N.J., Spector,T.D., Strachan,D.P., Tanaka,T.,
            Tuomilehto,J., Uitterlinden,A.G., van Duijn,C.M., Wareham,N.J.,
            Hugh,Watkins., Waterworth,D.M., Boehnke,M., Deloukas,P., Groop,L.,
            Hunter,D.J., Thorsteinsdottir,U., Schlessinger,D., Wichmann,H.E.,
            Frayling,T.M., Abecasis,G.R., Hirschhorn,J.N., Loos,R.J.,
            Stefansson,K., Mohlke,K.L., Barroso,I. and McCarthy,M.I.
  CONSRTM   Wellcome Trust Case Control Consortium; Procardis Consortia; Giant
            Consortium
  TITLE     Genome-wide association scan meta-analysis identifies three Loci
            influencing adiposity and fat distribution
  JOURNAL   PLoS Genet 5 (6), e1000508 (2009)
   PUBMED   19557161
  REMARK    GeneRIF: TFAP2B, LYPLAL1 and MSRA are associated with adiposity and
            fat distribution.
            GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
            Erratum:[PLoS Genet. 2009 Jul;5(7). doi:
            10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928]
REFERENCE   10 (bases 1 to 1809)
  AUTHORS   David,D., Cardoso,J., Marques,B., Marques,R., Silva,E.D., Santos,H.
            and Boavida,M.G.
  TITLE     Molecular characterization of a familial translocation implicates
            disruption of HDAC9 and possible position effect on TGFbeta2 in the
            pathogenesis of Peters' anomaly
  JOURNAL   Genomics 81 (5), 489-503 (2003)
   PUBMED   12706107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY106571.1, AY341430.1, AA424278.1, BC016711.1, AL360093.11 and
            BF115063.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001300770.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (c) is
            shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.881490.1,
                                           SRR1803617.39626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                HY106571.1         49-61
            14-357              AY341430.1         1-344
            358-358             AA424278.1         423-423
            359-768             BC016711.1         408-817
            769-1749            AL360093.11        112082-113062
            1750-1809           BF115063.1         19-78               c
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1809
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="lysophospholipase like 1"
                     /db_xref="GeneID:127018"
                     /db_xref="HGNC:HGNC:20440"
                     /db_xref="MIM:616548"
     exon            1..104
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..679
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /EC_number="3.1.2.22"
                     /note="isoform c is encoded by transcript variant 3;
                     lysophospholipase-like protein 1"
                     /codon_start=1
                     /product="lysophospholipase-like protein 1 isoform c"
                     /protein_id="NP_001287699.1"
                     /db_xref="CCDS:CCDS73032.1"
                     /db_xref="GeneID:127018"
                     /db_xref="HGNC:HGNC:20440"
                     /db_xref="MIM:616548"
                     /translation="MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQV
                     LNQDLTFQHIKIIYPTAPPRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRI
                     LIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHG
                     TADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEME
                     KQK"
     exon            105..204
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     exon            205..326
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     exon            327..442
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     exon            443..1809
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /inference="alignment:Splign:2.1.0"
     regulatory      757..762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="hexamer: ATTAAA"
     polyA_site      778
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="major polyA site"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
                     /note="hexamer: AATAAA"
     polyA_site      1809
                     /gene="LYPLAL1"
                     /gene_synonym="Q96AV0"
ORIGIN      
        1 agtggcatca gcgatggcgg ctgcgtcggg gtcggttctg cagcgctgta tcgtgtcgcc
       61 ggcagggagg catagcgcct ctctgatctt cctgcatggc tcaggtgatt ctggacaagg
      121 attaagaatg tggatcaagc aggttttaaa tcaagattta acattccaac acataaaaat
      181 tatttatcca acagctcctc ccagatttaa aataaccaat gactgcccag aacaccttga
      241 atcaattgat gtcatgtgtc aagtgcttac tgatttgatt gatgaagaag taaaaagtgg
      301 catcaagaag aacaggatat taataggagg attctctatg ggaggatgca tggcaataca
      361 tttagcatat agaaatcatc aagatgtggc aggagtattt gctctttcta gttttctgaa
      421 taaagcatct gctgtttacc aggctcttca gaagagtaat ggtgtacttc ctgaattatt
      481 tcagtgtcat ggtactgcag atgagttagt tcttcattct tgggcagaag agacaaactc
      541 aatgttaaaa tctctaggag tgaccacgaa gtttcatagt tttccaaatg tttaccatga
      601 gctaagcaaa actgagttag acatattgaa gttatggatt cttacaaagc tgccaggaga
      661 aatggaaaaa caaaaatgaa tgaatcaaga gtgatttgtt aatgtaagtg taatgtcttt
      721 gtgaaaagtg atttttactg ccaaattata atgataatta aaatattaag aaataacact
      781 ttcctgactt ttttattatt aaaatgctta tcactgtaga cagtagctaa tcttattaat
      841 gaaaaacaat agacaaacat ctgtgcataa tttttcagac acaattctgt aaatatttgg
      901 aaacctttta agtatttaaa cttttaaatt tttgaaataa agtattctaa actaatataa
      961 ataaggacaa tgaaaaaaca tgaaaggact tagcataatg ttattttatc ttttctacaa
     1021 ctttgtttaa attacctttc caaagatatt tgtgtttatg taattttcca cggaataaca
     1081 ttaatactct aggtttataa accggtttca cattatttca tttgatcatc acaagagctt
     1141 tgtgaagtaa gccgagaagt tgttactggt atttaataat agcaatagag gagttaaaga
     1201 ctttcccaca gcttgcaggt caagacaaga aattcaggtc tcctaattct cagtggagct
     1261 ctatttctgt taacccaaat tgctgctctg ttttaggtct caatttcatc tgtaaaatga
     1321 tactaatagt acttatccca ttggattttt gttgagattt aaataaatag ccaaaagcca
     1381 atacataata aacactcaat aaagattaac cataaggaga gtcatgatct ggttccagga
     1441 atacattgtt agatgactga aaaattgtat tacttcaatg aaaatactat aaataataac
     1501 attttcatat attagttggt tctcatgcat acataatcta attttatttg atcctcacaa
     1561 ctgtttaagt tttattaaat atacattatc cctatttgta taaatagaat catacaatac
     1621 ctgcctgctt tcattcaaca aaattatcat gagatttttc catgttgtgt acatcaatag
     1681 ttcatctatt ttattgctca gtaatattcc attgtgtgga tgtatcacta tttgtttaca
     1741 cattcaccac tgatatataa gttgcttcca gtgtgaggct gttttaaata aagctgctat
     1801 gaatattca
//
