LOCUS       NM_006330               2515 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens lysophospholipase 1 (LYPLA1), transcript variant 1,
            mRNA.
ACCESSION   NM_006330
VERSION     NM_006330.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2515)
  AUTHORS   Harris,W.T. 3rd, Altieri,I., Gieck,I. and Johnson,R.J.
  TITLE     A conserved but structurally divergent loop in acyl protein
            thioesterase 1 regulates its catalytic activity, ligand binding,
            and folded stability
  JOURNAL   Proteins 92 (6), 693-704 (2024)
   PUBMED   38179877
  REMARK    GeneRIF: A conserved but structurally divergent loop in acyl
            protein thioesterase 1 regulates its catalytic activity, ligand
            binding, and folded stability.
REFERENCE   2  (bases 1 to 2515)
  AUTHORS   Speck,S.L., Wei,X. and Semenkovich,C.F.
  TITLE     Depalmitoylation and cell physiology: APT1 as a mediator of
            metabolic signals
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1034-C1041 (2024)
   PUBMED   38344800
  REMARK    GeneRIF: Depalmitoylation and cell physiology: APT1 as a mediator
            of metabolic signals.
            Review article
REFERENCE   3  (bases 1 to 2515)
  AUTHORS   Huang,X., Yao,J., Liu,L., Chen,J., Mei,L., Huangfu,J., Luo,D.,
            Wang,X., Lin,C., Chen,X., Yang,Y., Ouyang,S., Wei,F., Wang,Z.,
            Zhang,S., Xiang,T., Neculai,D., Sun,Q., Kong,E., Tate,E.W. and
            Yang,A.
  TITLE     S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy
  JOURNAL   Mol Cell 83 (19), 3485-3501 (2023)
   PUBMED   37802024
REFERENCE   4  (bases 1 to 2515)
  AUTHORS   Zhang,Y., Zheng,M., Zhang,L., Yuan,P., Zhou,J., Wang,Y. and Wang,H.
  TITLE     LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical
            Cancer by the miR-526b-5p /LYPLA1 Axis
  JOURNAL   Biochem Genet 60 (4), 1298-1312 (2022)
   PUBMED   34984578
  REMARK    GeneRIF: LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in
            Cervical Cancer by the miR-526b-5p /LYPLA1 Axis.
            Erratum:[Biochem Genet. 2023 Feb;61(1):448. doi:
            10.1007/s10528-022-10301-9.. PMID: 36352082]
REFERENCE   5  (bases 1 to 2515)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2515)
  AUTHORS   Wang,A., Johnson,C.A., Jones,Y., Ellisman,M.H. and Dennis,E.A.
  TITLE     Subcellular localization and PKC-dependent regulation of the human
            lysophospholipase A/acyl-protein thioesterase in WISH cells
  JOURNAL   Biochim Biophys Acta 1484 (2-3), 207-214 (2000)
   PUBMED   10760470
REFERENCE   7  (bases 1 to 2515)
  AUTHORS   Wang,A. and Dennis,E.A.
  TITLE     Mammalian lysophospholipases
  JOURNAL   Biochim Biophys Acta 1439 (1), 1-16 (1999)
   PUBMED   10395961
  REMARK    Review article
REFERENCE   8  (bases 1 to 2515)
  AUTHORS   Wang,A., Yang,H.C., Friedman,P., Johnson,C.A. and Dennis,E.A.
  TITLE     A specific human lysophospholipase: cDNA cloning, tissue
            distribution and kinetic characterization
  JOURNAL   Biochim Biophys Acta 1437 (2), 157-169 (1999)
   PUBMED   10064899
REFERENCE   9  (bases 1 to 2515)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 2515)
  AUTHORS   Bohn,E., Gerke,V., Kresse,H., Loffler,B.M. and Kunze,H.
  TITLE     Annexin II inhibits calcium-dependent phospholipase A1 and
            lysophospholipase but not triacyl glycerol lipase activities of rat
            liver hepatic lipase
  JOURNAL   FEBS Lett 296 (3), 237-240 (1992)
   PUBMED   1531641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF052112.1, AF035293.1 and
            AA827237.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006330.3.
            
            Summary: This gene encodes a member of the alpha/beta hydrolase
            superfamily. The encoded protein functions as a homodimer,
            exhibiting both depalmitoylating as well as lysophospholipase
            activity, and may be involved in Ras localization and signaling.
            Alternate splicing results in multiple transcript variants.
            Pseudogenes of this gene have been defined on chromosomes 4, 6, and
            7. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.212444.1,
                                           SRR1660803.8507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316963.8/ ENSP00000320043.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1468              AF052112.1         71-1538
            1469-2504           AF035293.1         968-2003
            2505-2515           AA827237.1         12-22               c
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..2515
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /note="lysophospholipase 1"
                     /db_xref="GeneID:10434"
                     /db_xref="HGNC:HGNC:6737"
                     /db_xref="MIM:605599"
     exon            1..193
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..817
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /EC_number="3.1.2.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysophospholipid-specific lysophospholipase; acyl-protein
                     thioesterase 1; palmitoyl-protein hydrolase; lysoPLA I;
                     lysophospholipase I"
                     /codon_start=1
                     /product="acyl-protein thioesterase 1 isoform 1"
                     /protein_id="NP_006321.1"
                     /db_xref="CCDS:CCDS6157.1"
                     /db_xref="GeneID:10434"
                     /db_xref="HGNC:HGNC:6737"
                     /db_xref="MIM:605599"
                     /translation="MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGI
                     RSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQ
                     EVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGA
                     NRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDV
                     KQFIDKLLPPID"
     exon            194..225
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..291
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..339
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..410
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..484
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..586
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..763
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2515
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2487..2492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /note="hexamer: AATAAA"
     polyA_site      2515
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /note="major polyA site"
ORIGIN      
        1 gttggcgcgc acgcgcctga gcgtgcgccc ggtggggccg gccgggactc gccgctcgca
       61 cgcccttggg ccgcggccgg gcgcccgctc ttccttccgc ttgcgctgtg agctgaggcg
      121 gtgtatgtgc ggcaataaca tgtcaacccc gctgcccgcc atcgtgcccg ccgcccggaa
      181 ggccaccgct gcggtgattt tcctgcatgg attgggagat actgggcacg gatgggcaga
      241 agcctttgca ggtatcagaa gttcacatat caaatatatc tgcccgcatg cgcctgttag
      301 gcctgttaca ttaaatatga acgtggctat gccttcatgg tttgatatta ttgggctttc
      361 accagattca caggaggatg aatctgggat taaacaggca gcagaaaata taaaagcttt
      421 gattgatcaa gaagtgaaga atggcattcc ttctaacaga attattttgg gagggttttc
      481 tcagggagga gctttatctt tatatactgc ccttaccaca cagcagaaac tggcaggtgt
      541 cactgcactc agttgctggc ttccacttcg ggcttccttt ccacagggtc ctatcggtgg
      601 tgctaataga gatatttcta ttctccagtg ccacggggat tgtgaccctt tggttcccct
      661 gatgtttggt tctcttacgg tggaaaaact aaaaacattg gtgaatccag ccaatgtgac
      721 ctttaaaacc tatgaaggta tgatgcacag ttcgtgtcaa caggaaatga tggatgtcaa
      781 gcaattcatt gataaactcc tacctccaat tgattgacgt cactaagagg ccttgtgtag
      841 aagtacacca gcatcattgt agtagagtgt aaaccttttc ccatgcccag tcttcaaatt
      901 tctaatgttt tgcagtgtta aaatgttttg caaatacatg ccaataacac agatcaaata
      961 atatctcctc atgagaaatt tatgatcttt taagtttcta tacatgtatt cttataagac
     1021 gacccaggat ctactatatt agaatagatg aagcaggtag cttctttttt ctcaaatgta
     1081 attcagcaaa ataatacagt actgccacca gattttttat tacatcattt gaaaattagc
     1141 agtatgctta atgaaaattt gttcaggtat aaatgagcag ttaagatata aacaatttat
     1201 gcatgctgtg acttagtcta tggatttatt ccaaaattgc ttagtcacca tgcagtgtct
     1261 gtatttttat atatgtgttc atatatacat aatgattata atacataata agaatgaggt
     1321 ggtattacat tattcctaat aatagggata atgctgttta ttgtcaagaa aaagtaaaat
     1381 cgttctcttc aattaatggc ccttttattt tgggaccagg cttttatttt ccctgatatt
     1441 atttctattt aatactcttt tctctcaaga aaaaaaaaaa agtttgtttt ttctttattg
     1501 tccttcatag caggccaagt attgcctctc tgcaatagac agctactgtc aatacatgct
     1561 gtaatttgac attctgggtc acagatataa ggtatttaaa atctatttat gctttataga
     1621 gaaaccagac attaaaactt catgcactac ttatttcgaa ttactgtacc ttatccaaat
     1681 ttacacctag ctattaggat cttcaaccca ggtaacagga ataattctgt ggtttcattt
     1741 ttctgtaaac aactgaaaga ataattagat catattctag tatgttctga aatatcttta
     1801 agactgatct taaaaactaa cttctaagat gatttcatct tctcatagta tagagtttac
     1861 tttgtacacg tttgaaacca actactgtag aagatgagga atctattgta attttttgct
     1921 ttattttcat ctgccagtgg acttatttga aattttcact ttagtcaaat tattttttgt
     1981 attagttttt gatgcagaca taaaaatagc aatcatttta aattgtcaaa atttccagat
     2041 tactggtaaa aattatttga aaacaaactt atgggtaata aaggctagtc agaaccctat
     2101 accataaagt gtagttacca tacagattaa tatgtagcaa aaatgtatgc ttgatatttc
     2161 tcaactgtgt taatttttct gctgtattcc agctgaccaa aacaatatta agaatgcatc
     2221 tttataaatg ggtgctaatt gataatggaa ataatttagt aatggactat acaggatgtt
     2281 aataatgaag ccatatgttt atgtctggat ttaaaaattt taaacaatca tttactatgt
     2341 catttttctt taccttgaag aacataaact gttatttcac ttctacaaat cagcaagata
     2401 ttatttatgg caagaaatat tccattgaaa tattgtgctg taacatggga aagtgtaaat
     2461 gtttttcatg gtttctatca atgtgaaata aaatttaatt ctgacttttc tgtga
//
