LOCUS       NM_001279359            2475 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens lysophospholipase 1 (LYPLA1), transcript variant 5,
            mRNA.
ACCESSION   NM_001279359
VERSION     NM_001279359.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Harris,W.T. 3rd, Altieri,I., Gieck,I. and Johnson,R.J.
  TITLE     A conserved but structurally divergent loop in acyl protein
            thioesterase 1 regulates its catalytic activity, ligand binding,
            and folded stability
  JOURNAL   Proteins 92 (6), 693-704 (2024)
   PUBMED   38179877
  REMARK    GeneRIF: A conserved but structurally divergent loop in acyl
            protein thioesterase 1 regulates its catalytic activity, ligand
            binding, and folded stability.
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Speck,S.L., Wei,X. and Semenkovich,C.F.
  TITLE     Depalmitoylation and cell physiology: APT1 as a mediator of
            metabolic signals
  JOURNAL   Am J Physiol Cell Physiol 326 (4), C1034-C1041 (2024)
   PUBMED   38344800
  REMARK    GeneRIF: Depalmitoylation and cell physiology: APT1 as a mediator
            of metabolic signals.
            Review article
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Huang,X., Yao,J., Liu,L., Chen,J., Mei,L., Huangfu,J., Luo,D.,
            Wang,X., Lin,C., Chen,X., Yang,Y., Ouyang,S., Wei,F., Wang,Z.,
            Zhang,S., Xiang,T., Neculai,D., Sun,Q., Kong,E., Tate,E.W. and
            Yang,A.
  TITLE     S-acylation of p62 promotes p62 droplet recruitment into
            autophagosomes in mammalian autophagy
  JOURNAL   Mol Cell 83 (19), 3485-3501 (2023)
   PUBMED   37802024
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Zhang,Y., Zheng,M., Zhang,L., Yuan,P., Zhou,J., Wang,Y. and Wang,H.
  TITLE     LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical
            Cancer by the miR-526b-5p /LYPLA1 Axis
  JOURNAL   Biochem Genet 60 (4), 1298-1312 (2022)
   PUBMED   34984578
  REMARK    GeneRIF: LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in
            Cervical Cancer by the miR-526b-5p /LYPLA1 Axis.
            Erratum:[Biochem Genet. 2023 Feb;61(1):448. doi:
            10.1007/s10528-022-10301-9.. PMID: 36352082]
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Wang,A., Johnson,C.A., Jones,Y., Ellisman,M.H. and Dennis,E.A.
  TITLE     Subcellular localization and PKC-dependent regulation of the human
            lysophospholipase A/acyl-protein thioesterase in WISH cells
  JOURNAL   Biochim Biophys Acta 1484 (2-3), 207-214 (2000)
   PUBMED   10760470
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Wang,A. and Dennis,E.A.
  TITLE     Mammalian lysophospholipases
  JOURNAL   Biochim Biophys Acta 1439 (1), 1-16 (1999)
   PUBMED   10395961
  REMARK    Review article
REFERENCE   8  (bases 1 to 2475)
  AUTHORS   Wang,A., Yang,H.C., Friedman,P., Johnson,C.A. and Dennis,E.A.
  TITLE     A specific human lysophospholipase: cDNA cloning, tissue
            distribution and kinetic characterization
  JOURNAL   Biochim Biophys Acta 1437 (2), 157-169 (1999)
   PUBMED   10064899
REFERENCE   9  (bases 1 to 2475)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 2475)
  AUTHORS   Bohn,E., Gerke,V., Kresse,H., Loffler,B.M. and Kunze,H.
  TITLE     Annexin II inhibits calcium-dependent phospholipase A1 and
            lysophospholipase but not triacyl glycerol lipase activities of rat
            liver hepatic lipase
  JOURNAL   FEBS Lett 296 (3), 237-240 (1992)
   PUBMED   1531641
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF052112.1, AA307642.1,
            AF035293.1 and AA827237.1.
            
            On May 31, 2019 this sequence version replaced NM_001279359.1.
            
            Summary: This gene encodes a member of the alpha/beta hydrolase
            superfamily. The encoded protein functions as a homodimer,
            exhibiting both depalmitoylating as well as lysophospholipase
            activity, and may be involved in Ras localization and signaling.
            Alternate splicing results in multiple transcript variants.
            Pseudogenes of this gene have been defined on chromosomes 4, 6, and
            7. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in its 5' coding region, and initiates translation at an alternate
            start codon, compared to variant 1. The encoded isoform (5) has a
            shorter and distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.2196.1,
                                           SRR1660807.224501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AF052112.1         71-202
            133-571             AA307642.1         1-439
            572-2464            AF035293.1         111-2003
            2465-2475           AA827237.1         12-22               c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..2475
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /note="lysophospholipase 1"
                     /db_xref="GeneID:10434"
                     /db_xref="HGNC:HGNC:6737"
                     /db_xref="MIM:605599"
     exon            1..193
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..225
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..251
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..777
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /EC_number="3.1.2.22"
                     /note="isoform 5 is encoded by transcript variant 5;
                     lysophospholipid-specific lysophospholipase; acyl-protein
                     thioesterase 1; palmitoyl-protein hydrolase; lysoPLA I;
                     lysophospholipase I"
                     /codon_start=1
                     /product="acyl-protein thioesterase 1 isoform 5"
                     /protein_id="NP_001266288.1"
                     /db_xref="GeneID:10434"
                     /db_xref="HGNC:HGNC:6737"
                     /db_xref="MIM:605599"
                     /translation="MGRSLCRPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAA
                     ENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRAS
                     FPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHS
                     SCQQEMMDVKQFIDKLLPPID"
     exon            252..299
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..370
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..444
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..546
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..723
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..2475
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2447..2452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /note="hexamer: AATAAA"
     polyA_site      2475
                     /gene="LYPLA1"
                     /gene_synonym="APT-1; APT1; hAPT1; LPL-I; LPL1"
                     /note="major polyA site"
ORIGIN      
        1 gttggcgcgc acgcgcctga gcgtgcgccc ggtggggccg gccgggactc gccgctcgca
       61 cgcccttggg ccgcggccgg gcgcccgctc ttccttccgc ttgcgctgtg agctgaggcg
      121 gtgtatgtgc ggcaataaca tgtcaacccc gctgcccgcc atcgtgcccg ccgcccggaa
      181 ggccaccgct gcggtgattt tcctgcatgg attgggagat actgggcacg gatgggcaga
      241 agcctttgca ggcctgttag gcctgttaca ttaaatatga acgtggctat gccttcatgg
      301 tttgatatta ttgggctttc accagattca caggaggatg aatctgggat taaacaggca
      361 gcagaaaata taaaagcttt gattgatcaa gaagtgaaga atggcattcc ttctaacaga
      421 attattttgg gagggttttc tcagggagga gctttatctt tatatactgc ccttaccaca
      481 cagcagaaac tggcaggtgt cactgcactc agttgctggc ttccacttcg ggcttccttt
      541 ccacagggtc ctatcggtgg tgctaataga gatatttcta ttctccagtg ccacggggat
      601 tgtgaccctt tggttcccct gatgtttggt tctcttacgg tggaaaaact aaaaacattg
      661 gtgaatccag ccaatgtgac ctttaaaacc tatgaaggta tgatgcacag ttcgtgtcaa
      721 caggaaatga tggatgtcaa gcaattcatt gataaactcc tacctccaat tgattgacgt
      781 cactaagagg ccttgtgtag aagtacacca gcatcattgt agtagagtgt aaaccttttc
      841 ccatgcccag tcttcaaatt tctaatgttt tgcagtgtta aaatgttttg caaatacatg
      901 ccaataacac agatcaaata atatctcctc atgagaaatt tatgatcttt taagtttcta
      961 tacatgtatt cttataagac gacccaggat ctactatatt agaatagatg aagcaggtag
     1021 cttctttttt ctcaaatgta attcagcaaa ataatacagt actgccacca gattttttat
     1081 tacatcattt gaaaattagc agtatgctta atgaaaattt gttcaggtat aaatgagcag
     1141 ttaagatata aacaatttat gcatgctgtg acttagtcta tggatttatt ccaaaattgc
     1201 ttagtcacca tgcagtgtct gtatttttat atatgtgttc atatatacat aatgattata
     1261 atacataata agaatgaggt ggtattacat tattcctaat aatagggata atgctgttta
     1321 ttgtcaagaa aaagtaaaat cgttctcttc aattaatggc ccttttattt tgggaccagg
     1381 cttttatttt ccctgatatt atttctattt aatactcttt tctctcaaga aaaaaaaaaa
     1441 agtttgtttt ttctttattg tccttcatag caggccaagt attgcctctc tgcaatagac
     1501 agctactgtc aatacatgct gtaatttgac attctgggtc acagatataa ggtatttaaa
     1561 atctatttat gctttataga gaaaccagac attaaaactt catgcactac ttatttcgaa
     1621 ttactgtacc ttatccaaat ttacacctag ctattaggat cttcaaccca ggtaacagga
     1681 ataattctgt ggtttcattt ttctgtaaac aactgaaaga ataattagat catattctag
     1741 tatgttctga aatatcttta agactgatct taaaaactaa cttctaagat gatttcatct
     1801 tctcatagta tagagtttac tttgtacacg tttgaaacca actactgtag aagatgagga
     1861 atctattgta attttttgct ttattttcat ctgccagtgg acttatttga aattttcact
     1921 ttagtcaaat tattttttgt attagttttt gatgcagaca taaaaatagc aatcatttta
     1981 aattgtcaaa atttccagat tactggtaaa aattatttga aaacaaactt atgggtaata
     2041 aaggctagtc agaaccctat accataaagt gtagttacca tacagattaa tatgtagcaa
     2101 aaatgtatgc ttgatatttc tcaactgtgt taatttttct gctgtattcc agctgaccaa
     2161 aacaatatta agaatgcatc tttataaatg ggtgctaatt gataatggaa ataatttagt
     2221 aatggactat acaggatgtt aataatgaag ccatatgttt atgtctggat ttaaaaattt
     2281 taaacaatca tttactatgt catttttctt taccttgaag aacataaact gttatttcac
     2341 ttctacaaat cagcaagata ttatttatgg caagaaatat tccattgaaa tattgtgctg
     2401 taacatggga aagtgtaaat gtttttcatg gtttctatca atgtgaaata aaatttaatt
     2461 ctgacttttc tgtga
//
