LOCUS       NM_001085474            1162 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens LY6/PLAUR domain containing 8 (LYPD8), transcript
            variant 1, mRNA.
ACCESSION   NM_001085474 XM_937494
VERSION     NM_001085474.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1162)
  AUTHORS   Hsu,C.C., Okumura,R., Motooka,D., Sasaki,R., Nakamura,S., Iida,T.
            and Takeda,K.
  TITLE     Alleviation of colonic inflammation by Lypd8 in a mouse model of
            inflammatory bowel disease
  JOURNAL   Int Immunol 33 (7), 359-372 (2021)
   PUBMED   33822948
  REMARK    GeneRIF: Alleviation of colonic inflammation by Lypd8 in a mouse
            model of inflammatory bowel disease.
REFERENCE   2  (bases 1 to 1162)
  AUTHORS   Xu,J., Qian,J., Zhang,W., Chen,E., Zhang,G., Cao,G., Wang,F.,
            Shen,X., Zhou,W. and Song,Z.
  TITLE     LYPD8 regulates the proliferation and migration of colorectal
            cancer cells through inhibiting the secretion of IL-6 and TNF-alpha
  JOURNAL   Oncol Rep 41 (4), 2389-2395 (2019)
   PUBMED   30816524
  REMARK    GeneRIF: Study results revealed that the expression of LYPD8 was
            significantly reduced in the colorectal cancer (CRC) tissue
            compared with that in precancerous tissue and normal tissue. The
            results also revealed increased levels of P65 and STAT3
            phosphorylation and increased secretion of IL6 and TNFalpha in CRC
            tissue compared with levels in precancerous tissue.
            Erratum:[Oncol Rep. 2021 May;45(5):53. doi: 10.3892/or.2021.8004..
            PMID: 33882644]
REFERENCE   3  (bases 1 to 1162)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FP885904.3, AEKP01210869.1, FP476111.2 and CR589904.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001085474.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590317.4/ ENSP00000466070.2
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                FP885904.3         373-427             c
            56-109              FP885904.3         1-54                c
            110-203             AEKP01210869.1     7097-7190           c
            204-304             FP476111.2         8121-8221           c
            305-424             FP476111.2         7615-7734           c
            425-589             FP476111.2         5380-5544           c
            590-727             FP476111.2         2233-2370           c
            728-1162            CR589904.4         36938-37372         c
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1162
                     /gene="LYPD8"
                     /note="LY6/PLAUR domain containing 8"
                     /db_xref="GeneID:646627"
                     /db_xref="HGNC:HGNC:44208"
                     /db_xref="MIM:617067"
     exon            1..55
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     exon            56..203
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     exon            204..304
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..966
                     /gene="LYPD8"
                     /note="phospholipase inhibitor; ly6/PLAUR
                     domain-containing protein 8"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 8
                     preproprotein"
                     /protein_id="NP_001078943.2"
                     /db_xref="CCDS:CCDS73059.1"
                     /db_xref="GeneID:646627"
                     /db_xref="HGNC:HGNC:44208"
                     /db_xref="MIM:617067"
                     /translation="MKGILVAGITAVLVAAVESLSCVQCNSWEKSCVNSIASECPSHA
                     NTSCISSSASSSLETPVRLYQNMFCSAENCSEETHITAFTVHVSAEEHFHFVSQCCQG
                     KECSNTSDALDPPLKNVSSNAECPACYESNGTSCHGKPWKCYEEEQCVFLVAELKNDI
                     ESKSLVLKGCSNVSNATCQFLSGENKTLGGVIFRKFECANVNSLTPTSAPTTSHNVGS
                     KASLYLLALASLLLRGLLP"
     exon            305..424
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     exon            425..589
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     exon            590..727
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1162
                     /gene="LYPD8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1133..1138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD8"
                     /note="hexamer: ATTAAA"
     polyA_site      1162
                     /gene="LYPD8"
                     /note="major polyA site"
ORIGIN      
        1 aagcctctac tgggaaccac cttctgtagg acagtcacca ggccagatcc agaagcctct
       61 ctaggctcca gctttctctg tggaagatga cagcaattat agcaggaccc tgccaggctg
      121 tcgaaaagat tccgcaataa aactttgcca gtgggaagta cctagtgaaa cggcctaaga
      181 tgccacttct tctcatgtcc caggcttgag gccctgtggt ccccatcctt gggagaagtc
      241 agctccagca ccatgaaggg catcctcgtt gctggtatca ctgcagtgct tgttgcagct
      301 gtagaatctc tgagctgcgt gcagtgtaat tcatgggaaa aatcctgtgt caacagcatt
      361 gcctctgaat gtccctcaca tgccaacacc agctgtatca gctcctcagc cagctcctct
      421 ctagagacac cagtcagatt ataccagaat atgttctgct cagcggagaa ctgcagtgag
      481 gagacacaca ttacagcctt cactgtccac gtgtctgctg aagaacactt tcattttgta
      541 agccagtgct gccaaggaaa ggaatgcagc aacaccagcg atgccctgga ccctcccctg
      601 aagaacgtgt ccagcaacgc agagtgccct gcttgttatg aatctaatgg aacttcctgt
      661 catgggaagc cctggaaatg ctatgaagaa gaacagtgtg tctttctagt tgcagaactt
      721 aagaatgaca ttgagtctaa gagtctcgtg ctgaaaggct gttccaacgt cagtaacgcc
      781 acctgtcagt tcctgtctgg tgaaaacaag actcttggag gagtcatctt tcgaaagttt
      841 gagtgtgcaa atgtaaacag cttaaccccc acgtctgcac caaccacttc ccacaacgtg
      901 ggctccaaag cttccctcta cctcttggcc cttgccagcc tccttcttcg gggactgctg
      961 ccctgaggtc ctggggctgc actttgccca gcaccccatt tctgcttctc tgaggtccag
     1021 agcaccccct gcggtgctga caccctcttt ccctgctctg ccccgtttaa ctgcccagta
     1081 agtgggagtc acaggtctcc aggcaatgcc gacagctgcc ttgttcttca ttattaaagc
     1141 actggttcat tcactgccca aa
//
