LOCUS       NM_177964               1345 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LY6/PLAUR domain containing 6B (LYPD6B), transcript
            variant 1, mRNA.
ACCESSION   NM_177964
VERSION     NM_177964.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1345)
  AUTHORS   Paramonov,A.S., Kocharovskaya,M.V., Tsarev,A.V., Kulbatskii,D.S.,
            Loktyushov,E.V., Shulepko,M.A., Kirpichnikov,M.P., Lyukmanova,E.N.
            and Shenkarev,Z.O.
  TITLE     Structural Diversity and Dynamics of Human Three-Finger Proteins
            Acting on Nicotinic Acetylcholine Receptors
  JOURNAL   Int J Mol Sci 21 (19), 7280 (2020)
   PUBMED   33019770
  REMARK    GeneRIF: Structural Diversity and Dynamics of Human Three-Finger
            Proteins Acting on Nicotinic Acetylcholine Receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1345)
  AUTHORS   Ochoa,V., George,A.A., Nishi,R. and Whiteaker,P.
  TITLE     The prototoxin LYPD6B modulates heteromeric alpha3beta4-containing
            nicotinic acetylcholine receptors, but not alpha7 homomers
  JOURNAL   FASEB J 30 (3), 1109-1119 (2016)
   PUBMED   26586467
REFERENCE   3  (bases 1 to 1345)
  CONSRTM   Cross-Disorder Group of the Psychiatric Genomics Consortium
  TITLE     Identification of risk loci with shared effects on five major
            psychiatric disorders: a genome-wide analysis
  JOURNAL   Lancet 381 (9875), 1371-1379 (2013)
   PUBMED   23453885
  REMARK    Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE   4  (bases 1 to 1345)
  AUTHORS   Ni,J., Lang,Q., Bai,M., Zhong,C., Chen,X., Wan,B. and Yu,L.
  TITLE     Cloning and characterization of a human LYPD7, a new member of the
            Ly-6 superfamily
  JOURNAL   Mol Biol Rep 36 (4), 697-703 (2009)
   PUBMED   18360792
  REMARK    GeneRIF: LYPD7 was especially highly expressed in testis, lung,
            stomach, and prostate.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073271.4 and AC009230.3.
            
            On Nov 23, 2018 this sequence version replaced NM_177964.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040176.2, CN359803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409642.8/ ENSP00000387077.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC073271.4         103249-103351       c
            104-174             AC073271.4         11097-11167         c
            175-246             AC009230.3         20715-20786
            247-398             AC009230.3         65204-65355
            399-497             AC009230.3         68265-68363
            498-628             AC009230.3         72943-73073
            629-1345            AC009230.3         74497-75213
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.2"
     gene            1..1345
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /note="LY6/PLAUR domain containing 6B"
                     /db_xref="GeneID:130576"
                     /db_xref="HGNC:HGNC:27018"
     exon            1..103
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     exon            104..174
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..793
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /note="isoform a is encoded by transcript variant 1;
                     cancer/testis antigen 116; ly6/PLAUR domain-containing
                     protein 6B"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 6B isoform
                     a"
                     /protein_id="NP_808879.2"
                     /db_xref="CCDS:CCDS46423.1"
                     /db_xref="GeneID:130576"
                     /db_xref="HGNC:HGNC:27018"
                     /translation="MLLITLSANLFTVPERSLTTTFSFSRYKSSDRPAHKVSMLLLCH
                     ALAIAVVQIVIFSESWAFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWA
                     EDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCE
                     GMICNVELPTNHTNAVFAVMHAQRTSGSSAPTLYLPVLAWVFVLPLL"
     exon            175..246
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     exon            247..398
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     exon            399..497
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     exon            498..628
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1345
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1317..1322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /note="hexamer: AATAAA"
     polyA_site      1345
                     /gene="LYPD6B"
                     /gene_synonym="CT116; LYPD7"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgcggt agcagccaac gccggcccca ggcgggtgcg ctgggagcct gggccgggag
       61 ccgggtgagg gcgccgagag gctcggtggg cgcgggcggc gagatatgcc acacttctgc
      121 ctgctgttgg caaccctcct ggactaggct gctcttgtta atcacatgga tgttgctgat
      181 tactctgagt gcaaaccttt tcactgttcc agagaggagc ctgacaacca cattctcctt
      241 ctcaagatat aagagttcgg accgcccagc acacaaggtc agcatgctgc tcctctgtca
      301 cgctctcgct atagctgttg tccagatcgt tatcttctca gaaagctggg catttgccaa
      361 gaacatcaac ttctataatg tgaggcctcc tctcgaccct acaccatttc caaatagctt
      421 caagtgcttt acttgtgaaa acgcagggga taattataac tgcaatcgat gggcagaaga
      481 caaatggtgt ccacaaaata cacagtactg tttgacagtt catcacttca ccagccacgg
      541 aagaagcaca tccatcacca aaaagtgtgc ctccagaagt gaatgtcatt ttgtcggttg
      601 ccaccacagc cgagattctg aacatacgga gtgtaggtct tgctgtgaag gaatgatctg
      661 caatgtagaa ttacccacca atcacactaa tgcagtgttt gccgtaatgc acgctcagag
      721 aacatctggc agcagtgccc ccacactcta cctaccagtg cttgcctggg tctttgtgct
      781 tccattgctg tgatgccacc attcctagga gaggcagaga ccagcctcta aagcacaagc
      841 caaaaactgt gtgaacggtg aactttggag tgaagatcaa tcttgcactt ggtgaagagt
      901 gcacattgga cctcaaggcg aaagccagtg gtttgcttgg ataaaatgtt cccgcatgag
      961 gccacaggac tgaggatggg aatttggcag ggcctgagaa gatggtctga cttccaggct
     1021 tcctggtcaa agagagctac gtttgggcag ttctgcagag aggatcctgg caactagtcc
     1081 cacctgacta ggcctttagc tgaaaggatt tcttgacctc cttgactgcc tcagaggctg
     1141 ccaggtcaaa ccctcttgtt tatgtgatta gctcagagca tctctatgaa atctaaccct
     1201 tcccctcatg agaaagcagt tttccccacc aacagcatag tcaatgagaa aggcaactgt
     1261 acgaagaaaa cttccagtgg aactaatatg aaatctattt gcaaattatg gggggaaata
     1321 aagcttttaa attatacaat gtaaa
//
