LOCUS       NM_194317               4011 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens LY6/PLAUR domain containing 6 (LYPD6), transcript
            variant 2, mRNA.
ACCESSION   NM_194317
VERSION     NM_194317.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4011)
  AUTHORS   Kulbatskii,D., Shenkarev,Z., Bychkov,M., Loktyushov,E.,
            Shulepko,M., Koshelev,S., Povarov,I., Popov,A., Peigneur,S.,
            Chugunov,A., Kozlov,S., Sharonova,I., Efremov,R., Skrebitsky,V.,
            Tytgat,J., Kirpichnikov,M. and Lyukmanova,E.
  TITLE     Human Three-Finger Protein Lypd6 Is a Negative Modulator of the
            Cholinergic System in the Brain
  JOURNAL   Front Cell Dev Biol 9, 662227 (2021)
   PUBMED   34631692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4011)
  AUTHORS   Paramonov,A.S., Kocharovskaya,M.V., Tsarev,A.V., Kulbatskii,D.S.,
            Loktyushov,E.V., Shulepko,M.A., Kirpichnikov,M.P., Lyukmanova,E.N.
            and Shenkarev,Z.O.
  TITLE     Structural Diversity and Dynamics of Human Three-Finger Proteins
            Acting on Nicotinic Acetylcholine Receptors
  JOURNAL   Int J Mol Sci 21 (19), 7280 (2020)
   PUBMED   33019770
  REMARK    GeneRIF: Structural Diversity and Dynamics of Human Three-Finger
            Proteins Acting on Nicotinic Acetylcholine Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4011)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4011)
  AUTHORS   Zhao,Y., Ren,J., Lu,W., Harlos,K. and Jones,E.Y.
  TITLE     Structure of the Wnt signaling enhancer LYPD6 and its interactions
            with the Wnt coreceptor LRP6
  JOURNAL   FEBS Lett 592 (18), 3152-3162 (2018)
   PUBMED   30069874
  REMARK    GeneRIF: Results indicate the key role in the interaction of
            LY6/PLAUR domain containing 6 (LYPD6) with LDL receptor related
            protein 6 (LRP6).
REFERENCE   5  (bases 1 to 4011)
  AUTHORS   Arvaniti,M., Jensen,M.M., Soni,N., Wang,H., Klein,A.B., Thiriet,N.,
            Pinborg,L.H., Muldoon,P.P., Wienecke,J., Imad Damaj,M.,
            Kohlmeier,K.A., Gondre-Lewis,M.C., Mikkelsen,J.D. and Thomsen,M.S.
  TITLE     Functional interaction between Lypd6 and nicotinic acetylcholine
            receptors
  JOURNAL   J Neurochem 138 (6), 806-820 (2016)
   PUBMED   27344019
  REMARK    GeneRIF: the Lynx protein Lypd6 binds to nAChRs in human brain
            extracts, and that recombinant Lypd6 decreases nicotine-induced ERK
            phosphorylation
REFERENCE   6  (bases 1 to 4011)
  AUTHORS   Ozhan,G., Sezgin,E., Wehner,D., Pfister,A.S., Kuhl,S.J.,
            Kagermeier-Schenk,B., Kuhl,M., Schwille,P. and Weidinger,G.
  TITLE     Lypd6 enhances Wnt/beta-catenin signaling by promoting Lrp6
            phosphorylation in raft plasma membrane domains
  JOURNAL   Dev Cell 26 (4), 331-345 (2013)
   PUBMED   23987510
  REMARK    GeneRIF: Lypd6 appears to control Lrp6 activation specifically in
            membrane rafts, which is essential for downstream signaling.
REFERENCE   7  (bases 1 to 4011)
  AUTHORS   Zhang,Y., Lang,Q., Li,J., Xie,F., Wan,B. and Yu,L.
  TITLE     Identification and characterization of human LYPD6, a new member of
            the Ly-6 superfamily
  JOURNAL   Mol Biol Rep 37 (4), 2055-2062 (2010)
   PUBMED   19653121
  REMARK    GeneRIF: The cloning and characterization of a novel human LU
            domain containing gene, LYPD6, isolated from human testis cDNA
            library, is reported.
REFERENCE   8  (bases 1 to 4011)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007394.4.
            
            On Aug 31, 2019 this sequence version replaced NM_194317.4.
            
            Summary: Members of the LY6 protein family (see SLURP1; MIM
            606119), such as LYPD6, have at least one 80-amino acid LU domain
            that contains 10 conserved cysteines with a defined
            disulfide-bonding pattern (Zhang et al., 2010 [PubMed
            19653121]).[supplied by OMIM, Apr 2010].
            
            Transcript Variant: This variant (2) uses a different segment for
            its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358623.1, SRR7346977.1385925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334166.9/ ENSP00000334463.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC007394.4         156427-156562       c
            137-325             AC007394.4         49323-49511         c
            326-424             AC007394.4         38002-38100         c
            425-555             AC007394.4         18374-18504         c
            556-4011            AC007394.4         13011-16466         c
FEATURES             Location/Qualifiers
     source          1..4011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.2"
     gene            1..4011
                     /gene="LYPD6"
                     /note="LY6/PLAUR domain containing 6"
                     /db_xref="GeneID:130574"
                     /db_xref="HGNC:HGNC:28751"
                     /db_xref="MIM:613359"
     exon            1..136
                     /gene="LYPD6"
                     /inference="alignment:Splign:2.1.0"
     exon            137..325
                     /gene="LYPD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..723
                     /gene="LYPD6"
                     /note="ly6/PLAUR domain-containing protein 6"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 6 precursor"
                     /protein_id="NP_919298.1"
                     /db_xref="CCDS:CCDS2188.1"
                     /db_xref="GeneID:130574"
                     /db_xref="HGNC:HGNC:28751"
                     /db_xref="MIM:613359"
                     /translation="MEPGPALAWLLLLSLLADCLKAAQSRDFTVKDIIYLHPSTTPYP
                     GGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEEC
                     LSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPRCMSVIV
                     SCLWLWLGLML"
     exon            326..424
                     /gene="LYPD6"
                     /inference="alignment:Splign:2.1.0"
     exon            425..555
                     /gene="LYPD6"
                     /inference="alignment:Splign:2.1.0"
     exon            556..4011
                     /gene="LYPD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      957..962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD6"
                     /note="hexamer: CATAAA"
     polyA_site      980
                     /gene="LYPD6"
                     /note="major polyA site"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD6"
                     /note="hexamer: AATAAA"
     polyA_site      3497
                     /gene="LYPD6"
                     /note="major polyA site"
     regulatory      3986..3991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD6"
                     /note="hexamer: AGTAAA"
     polyA_site      4011
                     /gene="LYPD6"
ORIGIN      
        1 ctcgctcctt ccctgagctc ccgggctccg gcagcgggct ggcggggcgc cgcattgcac
       61 actctggggg cgccgcagtg ttcgtgggat ggggcagcgg gctgcagctg gcggccggaa
      121 tccgcgcgca gcccgggtgc aagttctctc ctgttgccct gagtgcccac tcccaggccc
      181 tctgtatgag tgacacttca gtctgccatg gaacctggcc ctgctctggc ctggctcctg
      241 ctcctgagcc tgctggcgga ttgtctgaaa gctgctcagt cccgagactt cacagtgaaa
      301 gacattatct acctccatcc ttcaaccaca ccatatcctg gtggatttaa atgtttcacc
      361 tgtgaaaagg cagcagacaa ttatgagtgc aaccgatggg ctccagacat ctactgccct
      421 cgagagacca gatactgcta cactcagcac acaatggaag tcacaggaaa cagtatctca
      481 gtcaccaaac gctgtgtccc actggaagag tgcttatcca ctggctgcag agactccgag
      541 catgaaggcc acaaggtctg cacttcttgt tgtgaaggaa atatctgtaa cttgccactg
      601 ccccgaaatg aaactgatgc cacatttgcc acgacgtcac ctataaatca gacaaatggg
      661 cacccacgct gtatgtcagt gatagtgtcc tgcttgtggt tgtggttagg gctcatgtta
      721 tagtggctca gtggctccat gtgttaatag cgatccatgg ggatctcgat ggtccacaga
      781 cctgcatgag tcattggcct gacagtaatt acacatgtga gacacaacac tcttggaggt
      841 catcacagcc aagcattgcc acttaccatg aggaataaat gttgcttcat tgtagccatt
      901 ttgagtctaa ccgagactca tcaaagcctt ctgtcagtac agcccaagtt ccataccata
      961 aacgtttgtt ttcattccaa gaagtagttc tgcatttatc gagatctggg gttcttaatt
     1021 tggaagaata catgcatgag atgcagtagg tcctgagact gtaagatatt aggagtatgt
     1081 tataggggca tgtatagatg tgggcttttc aggagaaaag taaccattgg tttaaatata
     1141 atcatgagtt catttgtagc tttagaattt taaaacattg actccaaact gaatggacta
     1201 tttccttgga aattctgact gagtccctgg aagagtagta attccaacaa ttccagccat
     1261 ttgttcaatt aattttccca acattcttct cccagtgctg ggaatcacat ttcctctgtt
     1321 ctgtgcagaa gacaaaaagg caatcataaa agtttgttat atttgtgggg gtgcctggag
     1381 gaggattttc ctcaacttaa tggagccact gtccataaag tggctgttat cccttcatat
     1441 aattggtgag atcagccttc tccttgactt ggcacctaat tatgcttcat gagatcctag
     1501 attccacctg agtcaattgt gtccagagcc ccaaaccagg atggagttgt tttccccaga
     1561 tatggggttc tattcagcca tagataatct agacagagga tttcagaatg aaaggaaaaa
     1621 tgtgtggaga ttagtcctag ttcattctga gggccgacta agtggctcag ccagcttctt
     1681 actccatctg cagttcatac tgccaaagag ctcccacttc caaatcccca gtgactttat
     1741 ggagaagatt ctgcattaaa ttgtctttcg aatgatgggg aagcaaggca taatatgcga
     1801 tgatgaggag aaagtagacc agtgaggtga ttgcaagact aacaaggaga ctcaatggga
     1861 agtttttctt tcttttagat attgcttttg aagtagatgg taaaattttt gtcatccttc
     1921 ttgtattttt tgtaccccaa gttacaattt ttcttcttcc ttgtaaataa tttaaacagt
     1981 atttattttt gtaaggcata actagaaact aaaatatatt ctaaaaaatt cattattctg
     2041 aacaaagtga tcaaattaga atacatattt ttcaacagtg gtagagcttt taatatatgt
     2101 ttattgaaag ttatctataa tacttgcacc agtgttgaaa aaagttaaca tgtaggcaag
     2161 agcaatatgt ttgtctcaag gatttttcca tggtttcctc agtgatggtg tcctggaatt
     2221 attcaggtgg tgaccatcac tggtctaagt ttgtgtgcag ggttttcaga tgtgtttttg
     2281 tgaaacttgg tagaaccatg gctaataaag aggacagtgt tgtcagggtc catctgccct
     2341 ccatagaaaa atgtctctgg ctcataaaat gagactccct cagggactaa atatgaactg
     2401 acagcagtaa ctctgataca gaataatcta aattgcatca aatggcctta attcagagtt
     2461 tgttaggctt atcagtatgt tgcttttaat tggggtggga aagtagaggg agagaaagca
     2521 agacatttat taagcacctc gtatgtgcca ggcactatgc taagcacttt acataagtta
     2581 ggattaatcc ctgcaagaat cctataaaga atgttactag catttacact tcccaaatga
     2641 aggtaccaaa gctcaaacgc aatgttgtga agctgtttcc ttcagattta ggttatgtgg
     2701 gatgatgtgg gattgaagag gaaagaaagg tgggattatc cccctaggaa gactttcagg
     2761 cctgacttca taggaattca tccatcttat catgtggagt ttatctcacc ctgctgttgc
     2821 aggatgctat ttgcatgtgt ccccaggtga tgttttttct ttggggagta ggggtttggc
     2881 ttcctcattc atccctcttg ctaaaagagg agatagttga tgttgcatct aaagatgcta
     2941 taagacaatg aaagtttgat gttgtacata cctacaagta ccatttttgt gcatgattac
     3001 actccactga catcttccaa gtactgcatg tgattgaata agaaacaaga aagtgaccac
     3061 accaaagcct ccctggctgg tgtagaggga tcaggtccac agtggtgcag attcaaccac
     3121 cacccaggga gtgcttgcag actctgcata gatgttgctg catgtgtccc atgtgcctgt
     3181 cagaatggca gtgtttaatt ctcttgaaag aaagttattt gctcactatc cccagcctca
     3241 aggagccaag gaagagtcat tcacatggaa ggtccgggac tggtcagcca ctctgacttt
     3301 tctaccacat taaattctcc attacatctc aatattggta atggcttaag tgtaaagagc
     3361 catgatgtgt atattaagct atgtgccaca tatttatttt tagactctcc acagcattca
     3421 tgtcaatatg ggattaatgc ctaaactttg taaatattgt acagtttgta aatcaatgaa
     3481 taaaggtttt gagtgtatct taccaggctc ctccctgcaa atgcacatgt caatcaatga
     3541 ttaatgcacc caggttatgt acaaggcact gggcttagca ccacagggaa cttccttcca
     3601 gaggcttgct ttctagttgt gtagacaaga atacatgcat gagaagatac aagacaattc
     3661 acccatgcca aatgattcat acaggctgtt taagtactgc agaaaataaa agaaggaaag
     3721 gctaccagac ttttcaataa ggtctacagc ttcccaagag catgtctttg ttaaatcagg
     3781 aaatataaaa attatgtgtg tatgtgtatg tatatatata taccacccta ttaactattt
     3841 taaaatcgta ttctattttg ggggttgtgt taatgatgat gaaccagaaa agattttctc
     3901 ttgatggttt cttcaacagg aaacagatat tggaatagtg tacatgtcat ttttatctat
     3961 acaatgaatt tattatattt ttcttagtaa agtgatagac attgaaagca a
//
