LOCUS       NM_001031749            2487 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LY6/PLAUR domain containing 5 (LYPD5), transcript
            variant A, mRNA.
ACCESSION   NM_001031749
VERSION     NM_001031749.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Kriegbaum,M.C., Clausen,O.P., Laerum,O.D. and Ploug,M.
  TITLE     Expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in
            non-invasive and invasive skin lesions
  JOURNAL   J Histochem Cytochem 63 (2), 142-154 (2015)
   PUBMED   25414274
  REMARK    GeneRIF: Expression of the Ly6/uPAR-domain proteins C4.4A and
            Haldisin in non-invasive and invasive skin lesions
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Davis,O.S., Band,G., Pirinen,M., Haworth,C.M., Meaburn,E.L.,
            Kovas,Y., Harlaar,N., Docherty,S.J., Hanscombe,K.B.,
            Trzaskowski,M., Curtis,C.J., Strange,A., Freeman,C., Bellenguez,C.,
            Su,Z., Pearson,R., Vukcevic,D., Langford,C., Deloukas,P., Hunt,S.,
            Gray,E., Dronov,S., Potter,S.C., Tashakkori-Ghanbaria,A.,
            Edkins,S., Bumpstead,S.J., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A., Duncanson,A., Jankowski,J.A., Markus,H.S.,
            Mathew,C.G., Palmer,C.N., Rautanen,A., Sawcer,S.J., Trembath,R.C.,
            Viswanathan,A.C., Wood,N.W., Barroso,I., Peltonen,L., Dale,P.S.,
            Petrill,S.A., Schalkwyk,L.S., Craig,I.W., Lewis,C.M., Price,T.S.,
            Donnelly,P., Plomin,R. and Spencer,C.C.
  CONSRTM   Wellcome Trust Case Control Consortium 2
  TITLE     The correlation between reading and mathematics ability at age
            twelve has a substantial genetic component
  JOURNAL   Nat Commun 5, 4204 (2014)
   PUBMED   25003214
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Gardsvoll,H., Kriegbaum,M.C., Hertz,E.P., Alpizar-Alpizar,W. and
            Ploug,M.
  TITLE     The urokinase receptor homolog Haldisin is a novel differentiation
            marker of stratum granulosum in squamous epithelia
  JOURNAL   J Histochem Cytochem 61 (11), 802-813 (2013)
   PUBMED   23896969
  REMARK    GeneRIF: The study identifies LYPD5 a novel differentiation marker
            of stratum granulosum in squamous epithelia.
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Michailidou,K., Hall,P., Gonzalez-Neira,A., Ghoussaini,M.,
            Dennis,J., Milne,R.L., Schmidt,M.K., Chang-Claude,J., Bojesen,S.E.,
            Bolla,M.K., Wang,Q., Dicks,E., Lee,A., Turnbull,C., Rahman,N.,
            Fletcher,O., Peto,J., Gibson,L., Dos Santos Silva,I.,
            Nevanlinna,H., Muranen,T.A., Aittomaki,K., Blomqvist,C., Czene,K.,
            Irwanto,A., Liu,J., Waisfisz,Q., Meijers-Heijboer,H., Adank,M., van
            der Luijt,R.B., Hein,R., Dahmen,N., Beckman,L., Meindl,A.,
            Schmutzler,R.K., Muller-Myhsok,B., Lichtner,P., Hopper,J.L.,
            Southey,M.C., Makalic,E., Schmidt,D.F., Uitterlinden,A.G.,
            Hofman,A., Hunter,D.J., Chanock,S.J., Vincent,D., Bacot,F.,
            Tessier,D.C., Canisius,S., Wessels,L.F., Haiman,C.A., Shah,M.,
            Luben,R., Brown,J., Luccarini,C., Schoof,N., Humphreys,K., Li,J.,
            Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Couch,F.J., Wang,X.,
            Vachon,C., Stevens,K.N., Lambrechts,D., Moisse,M., Paridaens,R.,
            Christiaens,M.R., Rudolph,A., Nickels,S., Flesch-Janys,D.,
            Johnson,N., Aitken,Z., Aaltonen,K., Heikkinen,T., Broeks,A.,
            Veer,L.J., van der Schoot,C.E., Guenel,P., Truong,T.,
            Laurent-Puig,P., Menegaux,F., Marme,F., Schneeweiss,A., Sohn,C.,
            Burwinkel,B., Zamora,M.P., Perez,J.I., Pita,G., Alonso,M.R.,
            Cox,A., Brock,I.W., Cross,S.S., Reed,M.W., Sawyer,E.J.,
            Tomlinson,I., Kerin,M.J., Miller,N., Henderson,B.E., Schumacher,F.,
            Le Marchand,L., Andrulis,I.L., Knight,J.A., Glendon,G.,
            Mulligan,A.M., Lindblom,A., Margolin,S., Hooning,M.J.,
            Hollestelle,A., van den Ouweland,A.M., Jager,A., Bui,Q.M.,
            Stone,J., Dite,G.S., Apicella,C., Tsimiklis,H., Giles,G.G.,
            Severi,G., Baglietto,L., Fasching,P.A., Haeberle,L., Ekici,A.B.,
            Beckmann,M.W., Brenner,H., Muller,H., Arndt,V., Stegmaier,C.,
            Swerdlow,A., Ashworth,A., Orr,N., Jones,M., Figueroa,J.,
            Lissowska,J., Brinton,L., Goldberg,M.S., Labreche,F., Dumont,M.,
            Winqvist,R., Pylkas,K., Jukkola-Vuorinen,A., Grip,M., Brauch,H.,
            Hamann,U., Bruning,T., Radice,P., Peterlongo,P., Manoukian,S.,
            Bonanni,B., Devilee,P., Tollenaar,R.A., Seynaeve,C., van
            Asperen,C.J., Jakubowska,A., Lubinski,J., Jaworska,K., Durda,K.,
            Mannermaa,A., Kataja,V., Kosma,V.M., Hartikainen,J.M.,
            Bogdanova,N.V., Antonenkova,N.N., Dork,T., Kristensen,V.N.,
            Anton-Culver,H., Slager,S., Toland,A.E., Edge,S., Fostira,F.,
            Kang,D., Yoo,K.Y., Noh,D.Y., Matsuo,K., Ito,H., Iwata,H., Sueta,A.,
            Wu,A.H., Tseng,C.C., Van Den Berg,D., Stram,D.O., Shu,X.O., Lu,W.,
            Gao,Y.T., Cai,H., Teo,S.H., Yip,C.H., Phuah,S.Y., Cornes,B.K.,
            Hartman,M., Miao,H., Lim,W.Y., Sng,J.H., Muir,K., Lophatananon,A.,
            Stewart-Brown,S., Siriwanarangsan,P., Shen,C.Y., Hsiung,C.N.,
            Wu,P.E., Ding,S.L., Sangrajrang,S., Gaborieau,V., Brennan,P.,
            McKay,J., Blot,W.J., Signorello,L.B., Cai,Q., Zheng,W.,
            Deming-Halverson,S., Shrubsole,M., Long,J., Simard,J.,
            Garcia-Closas,M., Pharoah,P.D., Chenevix-Trench,G., Dunning,A.M.,
            Benitez,J. and Easton,D.F.
  CONSRTM   Breast and Ovarian Cancer Susceptibility Collaboration; Hereditary
            Breast and Ovarian Cancer Research Group Netherlands (HEBON);
            kConFab Investigators; Australian Ovarian Cancer Study Group;
            GENICA (Gene Environment Interaction and Breast Cancer in Germany)
            Network
  TITLE     Large-scale genotyping identifies 41 new loci associated with
            breast cancer risk
  JOURNAL   Nat Genet 45 (4), 353-361 (2013)
   PUBMED   23535729
REFERENCE   6  (bases 1 to 2487)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 2487)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2487)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 2487)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC364960.1, AY358719.1, BC057816.1, BC044237.1, AC115522.2 and
            CF529795.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001031749.2.
            
            Transcript Variant: This variant (A) encodes the longer protein
            (isoform A).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057816.1, SRR1803615.233771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377950.8/ ENSP00000367185.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC364960.1         15-27
            14-334              AY358719.1         1-321
            335-647             BC057816.1         335-647
            648-1052            BC044237.1         267-671
            1053-1053           AC115522.2         37024-37024         c
            1054-2485           BC044237.1         673-2104
            2486-2487           CF529795.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2487
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /note="LY6/PLAUR domain containing 5"
                     /db_xref="GeneID:284348"
                     /db_xref="HGNC:HGNC:26397"
                     /db_xref="MIM:619618"
     exon            1..131
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..823
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /note="isoform A precursor is encoded by transcript
                     variant A; ly6/PLAUR domain-containing protein 5;
                     metastasis-associated protein; human antigen with
                     LU-domains expressed in skin"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 5 isoform A
                     precursor"
                     /protein_id="NP_001026919.2"
                     /db_xref="CCDS:CCDS46096.1"
                     /db_xref="GeneID:284348"
                     /db_xref="HGNC:HGNC:26397"
                     /db_xref="MIM:619618"
                     /translation="MAMGVPRVILLCLFGAALCLTGSQALQCYSFEHTYFGPFDLRAM
                     KLPSISCPHECFEAILSLDTGYRAPVTLVRKGCWTGPPAGQTQSNADALPPDYSVVRG
                     CTTDKCNAHLMTHDALPNLSQAPDPPTLSGAECYACIGVHQDDCAIGRSRRVQCHQDQ
                     TACFQGNGRMTVGNFSVPVYIRTCHRPSCTTEGTTSPWTAIDLQGSCCEGYLCNRKSM
                     TQPFTSASATTPPRALQVLALLLPVLLLVGLSA"
     exon            132..260
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /inference="alignment:Splign:2.1.0"
     exon            261..437
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /inference="alignment:Splign:2.1.0"
     exon            438..584
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /inference="alignment:Splign:2.1.0"
     exon            585..2487
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2173
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /note="major polyA site"
     polyA_site      2223
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /note="hexamer: CATAAA"
     polyA_site      2487
                     /gene="LYPD5"
                     /gene_synonym="HALDISIN; PRO4356"
                     /note="major polyA site"
ORIGIN      
        1 agtaaggaga accagccagg cagcacatca cagcgggagg agctgtccca ggtggcccag
       61 ctcagcaatg gcaatggggg tccccagagt cattctgctc tgcctctttg gggctgcgct
      121 ctgcctgaca gggtcccaag ccctgcagtg ctacagcttt gagcacacct actttggccc
      181 ctttgacctc agggccatga agctgcccag catctcctgt cctcatgagt gctttgaggc
      241 tatcctgtct ctggacaccg ggtatcgcgc gccggtgacc ctggtgcgga agggctgctg
      301 gaccgggcct cctgcgggcc agacgcaatc gaacgcggac gcgctgccgc cagactactc
      361 ggtggtgcgc ggctgcacaa ctgacaaatg caacgcccac ctcatgactc atgacgccct
      421 ccccaacctg agccaagcac ccgacccgcc gacgctcagc ggcgccgagt gctacgcctg
      481 tatcggggtc caccaggatg actgcgctat cggcaggtcc cgacgagtcc agtgtcacca
      541 ggaccagacc gcctgcttcc agggcaatgg cagaatgaca gttggcaatt tctcagtccc
      601 tgtgtacatc agaacctgcc accggccctc ctgcaccacc gagggcacca ccagcccctg
      661 gacagccatc gacctccagg gctcctgctg tgaggggtac ctctgcaaca ggaaatccat
      721 gacccagccc ttcaccagtg cttcagccac cacccctccc cgagcactac aggtcctggc
      781 cctgctcctc ccagtcctcc tgctggtggg gctctcagca tagaccgccc ctccaggatg
      841 ctggggacag ggctcacaca cctcattctt gctgcttcag cccctatcac atagctcact
      901 ggaaaatgat gttaaagtaa gaattgcact cctgtccctc tggccttcca tctctcccgc
      961 ccttgtgccc cacaacctgg ccaacagtac tggaagaaac tggacacagt caccagcatc
     1021 cccggggagg gcaaaacagc catgtcgtgc cccgatgaag agcaattctg atcacagctg
     1081 ttactcactg agcaccagcc aggcaccagg caccccataa cacggcttcc tgtgctctcc
     1141 ctccagagcc tgtcgcagct ctaggaggga gctatacaat gatgtcttta ttagtgtcat
     1201 catgagaagc ccaataagca gtatgcccta acagttagta ggccaggctc tggagctaag
     1261 ctgcatgggt tcaaatccca gctccaccat tcagcctgca gagaccatga gcgagttact
     1321 taagccaggc tctggagcta agctgcatgg gttcaaatcc cagctccagc attcagccta
     1381 cagagaccat gggtgagtta cttaagccag gctctggagc taagctgcat gggttcaaat
     1441 cccagctcca ccattcagcc tgcagagact gtgggtgagt tacttgagct ctctgtgcca
     1501 atattttctc acctataagg tggaggtgaa aataaactct ataacatgac aagaactact
     1561 tcacagtagt tgcagtgagg attcaacgag atgaacattt agtacttggg acacagcagt
     1621 ggcccagtgt aaatgggcta cttgtcataa gccctaagtc acaggtcaac aaactgagag
     1681 gcaaaagcac ttggttgagc ttgtgtatct agtgagtatg gattcaggga ccagattccc
     1741 agccccacga actgctaagc aaccccacct cctaaacaca tgagtgccga ttaacttcac
     1801 agaaaaacac acaaggcaaa gttcagcgag gtgaaattct ccaagctata aagatcaggg
     1861 aagacttcct ggaggaattc acccttgagc aaaatcctaa aggatcaata gtagctggca
     1921 aaaagaagca ggaggaagcg cattctaggt agaggagaca gcctggacaa aggtctgagg
     1981 gaggaaggag cacaaggagt gcaggacact ttcatgagtg caggacactt tcataactgc
     2041 atgaacttca tagagatggg atcctttagc atgttctctg tgcacatgct tgaccatgtt
     2101 ctttcacatg ctttttgcca cttgatcttt ccagcaactc agtgagagaa gcaaaaaagt
     2161 aagttgcatc ctgctattgt ctgaatgttt gtgtctcccc aaaattcatc ttttgaaacc
     2221 taattaccaa agtgatatta ctgggaggtg gggcctttgg gaggtggtga gatcatgagg
     2281 gtggagcccc catgaatagg attagtgccc ttataaaaga ggccctggag agctgccttg
     2341 ccccttccac cacatgagaa cacagccagc aggtgcctat aagcaagaaa gtgggttctc
     2401 accagccatc gaatctgctg gtgcattgat tgcagacttc ccagactcca gagctatgag
     2461 acataaattt ctgttgtgta taagcca
//
