LOCUS       NM_173506               2036 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens LY6/PLAUR domain containing 4 (LYPD4), transcript
            variant 1, mRNA.
ACCESSION   NM_173506
VERSION     NM_173506.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2036)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   2  (bases 1 to 2036)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243967.3, AK292305.1 and BC034629.2.
            
            On Nov 22, 2018 this sequence version replaced NM_173506.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292305.1, SRR5189667.120340.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609812.6/ ENSP00000476510.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC243967.3         67222-67231
            11-772              AK292305.1         1-762
            773-856             AC243967.3         67994-68077
            857-1453            AK292305.1         842-1438
            1454-2036           BC034629.2         469-1051
FEATURES             Location/Qualifiers
     source          1..2036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2036
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /note="LY6/PLAUR domain containing 4"
                     /db_xref="GeneID:147719"
                     /db_xref="HGNC:HGNC:28659"
     exon            1..1106
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1293
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /inference="alignment:Splign:2.1.0"
     CDS             1227..1967
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ly6/PLAUR domain-containing protein 4; sperm
                     membrane receptor; testicular tissue protein Li 159"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 4 isoform 1
                     precursor"
                     /protein_id="NP_775777.3"
                     /db_xref="CCDS:CCDS12587.1"
                     /db_xref="GeneID:147719"
                     /db_xref="HGNC:HGNC:28659"
                     /translation="MGPQHLRLVQLFCLLGAISTLPRAGALLCYEATASRFRAVAFHN
                     WKWLLMRNMVCKLQEGCEETLVFIETGTARGVVGFKGCSSSSSYPAQISYLVSPPGVS
                     IASYSRVCRSYLCNNLTNLEPFVKLKASTPKSITSASCSCPTCVGEHMKDCLPNFVTT
                     NSCPLAASTCYSSTLKFQAGFLNTTFLLMGCAREHNQLLADFHHIGSIKVTEVLNILE
                     KSQIVGAASSRQDPAWGVVLGLLFAFRD"
     exon            1294..1437
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1764
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2036
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /note="hexamer: AATAAA"
     polyA_site      2036
                     /gene="LYPD4"
                     /gene_synonym="SMR"
                     /note="major polyA site"
ORIGIN      
        1 gaccaagccc ggtctgtgca cgggttgcct cgtttctggc cttcccttgc cttgtacctc
       61 gacttcgcgc gtggcttgtt tttgctgagt ggaggcctgc gttttctgtt atgtctcttc
      121 cggtgcccca caactcctga gctacccttc ttttatgcgt tctctcccag cgctgtgatt
      181 accgggttgc ttaccgggcc ctccttcctc agattgcacc cctttccttg tgtctcttct
      241 tgtctttgtg tcggttgtga ttttcctaat ctctgatttt ccttttctct cggacgctct
      301 ccctcttcgg acccattttc tcccgtgctt catgccctga tagcctggcc ccttcccggc
      361 ttccttcgct accggggacg cctctagttt ttctgaattt ctggctggct ccaccctccg
      421 cgttcatctt cctcaagagt tcgcccctct gggggctcct ctgtgtaatc gtcgccttct
      481 ctgggtattt ctgtgaactc cgtctcacac catcccgcca tcttctctgc cttggcccct
      541 tttctctgta cagccagctc tgtgtccttt tcttctcccc ctctaaaatc gactcctctt
      601 ctccctgaga gccccacctt tgtgccccac tcctcatttt cctacgcctc cctctctctg
      661 ctggtcctct ctctccctgc aaggttccat tccatcaatt tgtttgtctt ttgtaggggt
      721 ggcatcccct ctgactactg ctccatcctt tttttttttt tttttttttt tttttttgct
      781 tgaggatttc acttcaatct tttctggttg cgtctccact tgtactcagc ttgttaggtc
      841 caggtccagt tgttctgcat ctgaggctgg cgtgtgctgt cttctctgat tggcctaatc
      901 tccctcaccc ccgtgagatc tgttgtcagc cttcgtttct ctttcctgtg tcccagcttt
      961 tctgcgggtc ttggcacctt tcttggccac agatttctgg gttacagagc atgtgtgtct
     1021 gaggcattgc aggcagaaaa gggtggccga cgtgacctct agctggactg ctgggcaggg
     1081 gagctgtcct agataaaatt ggaaagaaac agtgacccag agacaggtgg acaaagaatt
     1141 cggggactga tgggaactga gcttgggatc cagactgaaa ctgattccag actgacctct
     1201 agcacccagg acccagacac agggccatgg gaccccagca tttgagactt gtgcagctgt
     1261 tctgccttct aggggccatc tccactctgc ctcgggctgg agctcttttg tgctatgaag
     1321 caacagcctc aagattcaga gctgttgctt tccataactg gaagtggctt ctgatgagga
     1381 acatggtgtg taagctgcaa gagggctgcg aggagacgct agtgttcatt gagacaggga
     1441 ctgcaagggg agtcgtgggc tttaaaggct gcagctcgtc ttcgtcttac cctgcgcaaa
     1501 tctcctacct tgtttcccca cccggagtgt ccattgcctc ctacagtcgc gtctgccggt
     1561 cttatctctg caacaacctc accaatttgg agccttttgt gaaactcaag gccagcactc
     1621 ctaagtctat cacatctgcg tcctgtagct gcccgacctg tgtgggcgag cacatgaagg
     1681 attgcctccc aaattttgtc accactaatt cttgcccctt ggctgcttct acgtgttaca
     1741 gttccacctt aaaatttcag gcagggtttc tcaataccac cttcctcctc atggggtgtg
     1801 ctcgtgaaca taaccagctt ttagcagatt ttcatcatat tgggagcatc aaagtgactg
     1861 aggtcctcaa catcttagag aagtctcaga ttgttggtgc agcatcctcc aggcaagatc
     1921 ctgcttgggg tgtcgtctta ggcctcctgt ttgccttcag ggactgacca tctagctgca
     1981 cccgacaagc acccagactc tttcacataa caaataaaat agcagagttc cctttc
//
