LOCUS       NM_014400               1642 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens LY6/PLAUR domain containing 3 (LYPD3), mRNA.
ACCESSION   NM_014400
VERSION     NM_014400.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1642)
  AUTHORS   Huang,F., Ren,Y., Hua,Y., Wang,Y., Li,R., Ji,N., Zeng,X., Bai,D.,
            Chen,Q., Zhou,X., Wu,J. and Li,J.
  TITLE     m6A-dependent mature miR-151-5p accelerates the malignant process
            of HNSCC by targeting LYPD3
  JOURNAL   Mol Biomed 5 (1), 27 (2024)
   PUBMED   39009906
  REMARK    GeneRIF: m6A-dependent mature miR-151-5p accelerates the malignant
            process of HNSCC by targeting LYPD3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1642)
  AUTHORS   Hu,Y.D., Wu,K., Liu,Y.J., Zhang,Q., Shen,H., Ji,J., Fang,D. and
            Xi,S.Y.
  TITLE     LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell
            stemness and mediates an immunosuppressive microenvironment
  JOURNAL   Biol Direct 18 (1), 72 (2023)
   PUBMED   37924160
  REMARK    GeneRIF: LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma
            cell stemness and mediates an immunosuppressive microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1642)
  AUTHORS   Yue,J., Zhu,T., Yang,J., Si,Y., Xu,X., Fang,Y. and Fu,W.
  TITLE     CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm
            via LYPD3 and GRIA4
  JOURNAL   Life Sci 253, 117533 (2020)
   PUBMED   32151690
REFERENCE   4  (bases 1 to 1642)
  AUTHORS   Hu,P., Huang,Y., Gao,Y., Yan,H., Li,X., Zhang,J., Wang,Y. and
            Zhao,Y.
  TITLE     Elevated Expression of LYPD3 Is Associated with Lung Adenocarcinoma
            Carcinogenesis and Poor Prognosis
  JOURNAL   DNA Cell Biol 39 (4), 522-532 (2020)
   PUBMED   32040344
  REMARK    GeneRIF: The authors explored the related pathways through which
            LYPD3 affects the pathogenesis and prognosis of lung adenocarcinoma
            by gene set enrichment analysis, and found that LYPD3 might affect
            the clinical manifestations of lung adenocarcinoma by regulating
            the P53 signaling pathway.
REFERENCE   5  (bases 1 to 1642)
  AUTHORS   Tang,L.X., Chen,G.H., Li,H., He,P., Zhang,Y. and Xu,X.W.
  TITLE     Long non-coding RNA OGFRP1 regulates LYPD3 expression by sponging
            miR-124-3p and promotes non-small cell lung cancer progression
  JOURNAL   Biochem Biophys Res Commun 505 (2), 578-585 (2018)
   PUBMED   30274775
  REMARK    GeneRIF: Long non-coding RNA OGFRP1 contributed to progression of
            non-small cell lung cancer at least partly through upregulating
            LYPD3 expression by sponging miR-124-3p.
REFERENCE   6  (bases 1 to 1642)
  AUTHORS   Hansen,L.V., Gardsvoll,H., Nielsen,B.S., Lund,L.R., Dano,K.,
            Jensen,O.N. and Ploug,M.
  TITLE     Structural analysis and tissue localization of human C4.4A: a
            protein homologue of the urokinase receptor
  JOURNAL   Biochem J 380 (Pt 3), 845-857 (2004)
   PUBMED   15012588
REFERENCE   7  (bases 1 to 1642)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1642)
  AUTHORS   Fletcher,G.C., Patel,S., Tyson,K., Adam,P.J., Schenker,M.,
            Loader,J.A., Daviet,L., Legrain,P., Parekh,R., Harris,A.L. and
            Terrett,J.A.
  TITLE     hAG-2 and hAG-3, human homologues of genes involved in
            differentiation, are associated with oestrogen receptor-positive
            breast tumours and interact with metastasis gene C4.4a and
            dystroglycan
  JOURNAL   Br J Cancer 88 (4), 579-585 (2003)
   PUBMED   12592373
  REMARK    GeneRIF: hAG-2 and hAG-3, human homologues of genes involved in
            differentiation, are associated with oestrogen receptor-positive
            breast tumours and interact with metastasis gene C4.4a and
            dystroglycan
REFERENCE   9  (bases 1 to 1642)
  AUTHORS   Smith,B.A., Kennedy,W.J., Harnden,P., Selby,P.J.,
            Trejdosiewicz,L.K. and Southgate,J.
  TITLE     Identification of genes involved in human urothelial cell-matrix
            interactions: implications for the progression pathways of
            malignant urothelium
  JOURNAL   Cancer Res 61 (4), 1678-1685 (2001)
   PUBMED   11245483
REFERENCE   10 (bases 1 to 1642)
  AUTHORS   Wurfel,J., Seiter,S., Stassar,M., Claas,A., Klas,R., Rosel,M.,
            Marhaba,R., Savelyeva,L., Schwab,M., Matzku,S. and Zoller,M.
  TITLE     Cloning of the human homologue of the metastasis-associated rat
            C4.4A
  JOURNAL   Gene 262 (1-2), 35-41 (2001)
   PUBMED   11179665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA837818.1, BP367221.1, BC039167.1 and AC018758.2.
            
            On Nov 23, 2018 this sequence version replaced NM_014400.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF082889.1, AJ223603.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244333.4/ ENSP00000244333.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA837818.1         72-72
            2-167               BP367221.1         48-213
            168-1635            BC039167.1         153-1620
            1636-1642           AC018758.2         92700-92706         c
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1642
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /note="LY6/PLAUR domain containing 3"
                     /db_xref="GeneID:27076"
                     /db_xref="HGNC:HGNC:24880"
                     /db_xref="MIM:609484"
     exon            1..116
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1078
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /note="2310061G07Rik; GPI-anchored metastasis-associated
                     protein homolog; ly6/PLAUR domain-containing protein 3;
                     MIG-C4; matrigel-induced gene C4 protein; GPI-anchored
                     metastasis-associated protein C4.4A homolog"
                     /codon_start=1
                     /product="ly6/PLAUR domain-containing protein 3 precursor"
                     /protein_id="NP_055215.2"
                     /db_xref="CCDS:CCDS12620.1"
                     /db_xref="GeneID:27076"
                     /db_xref="HGNC:HGNC:24880"
                     /db_xref="MIM:609484"
                     /translation="MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGC
                     SPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAF
                     IQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVS
                     CYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQG
                     SRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPT
                     SQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLA
                     ALLLAVAAGVLL"
     exon            117..248
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /inference="alignment:Splign:2.1.0"
     exon            249..419
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /inference="alignment:Splign:2.1.0"
     exon            420..581
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /inference="alignment:Splign:2.1.0"
     exon            582..1642
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /note="hexamer: AATAAA"
     polyA_site      1642
                     /gene="LYPD3"
                     /gene_synonym="C4.4A"
                     /note="major polyA site"
ORIGIN      
        1 acatccaggg gggacgccaa gggagcagga cggagccatg gaccccgcca ggaaagcagg
       61 tgcccaggcc atgatctgga ctgcaggctg gctgctgctg ctgctgcttc gcggaggagc
      121 gcaggccctg gagtgctaca gctgcgtgca gaaagcagat gacggatgct ccccgaacaa
      181 gatgaagaca gtgaagtgcg cgccgggcgt ggacgtctgc accgaggccg tgggggcggt
      241 ggagaccatc cacggacaat tctcgctggc agtgcggggt tgcggttcgg gactccccgg
      301 caagaatgac cgcggcctgg atcttcacgg gcttctggcg ttcatccagc tgcagcaatg
      361 cgctcaggat cgctgcaacg ccaagctcaa cctcacctcg cgggcgctcg acccggcagg
      421 taatgagagt gcatacccgc ccaacggcgt ggagtgctac agctgtgtgg gcctgagccg
      481 ggaggcgtgc cagggtacat cgccgccggt cgtgagctgc tacaacgcca gcgatcatgt
      541 ctacaagggc tgcttcgacg gcaacgtcac cttgacggca gctaatgtga ctgtgtcctt
      601 gcctgtccgg ggctgtgtcc aggatgaatt ctgcactcgg gatggagtaa caggcccagg
      661 gttcacgctc agtggctcct gttgccaggg gtcccgctgt aactctgacc tccgcaacaa
      721 gacctacttc tcccctcgaa tcccacccct tgtccggctg ccccctccag agcccacgac
      781 tgtggcctca accacatctg tcaccacttc tacctcggcc ccagtgagac ccacatccac
      841 caccaaaccc atgccagcgc caaccagtca gactccgaga cagggagtag aacacgaggc
      901 ctcccgggat gaggagccca ggttgactgg aggcgccgct ggccaccagg accgcagcaa
      961 ttcagggcag tatcctgcaa aaggggggcc ccagcagccc cataataaag gctgtgtggc
     1021 tcccacagct ggattggcag cccttctgtt ggccgtggct gctggtgtcc tactgtgagc
     1081 ttctccacct ggaaatttcc ctctcaccta cttctctggc cctgggtacc cctcttctca
     1141 tcacttcctg ttcccaccac tggactgggc tggcccagcc cctgtttttc caacattccc
     1201 cagtatcccc agcttctgct gcgctggttt gcggctttgg gaaataaaat accgttgtat
     1261 atattctgcc aggggtgttc tagctttttg aggacagctc ctgtatcctt ctcatccttg
     1321 tctctccgct tgtcctcttg tgatgttagg acagagtgag agaagtcagc tgtcacgggg
     1381 aaggtgagag agaggatgct aagcttccta ctcactttct cctagccagc ctggactttg
     1441 gagcgtgggg tgggtgggac aatggctccc cactctaagc actgcctccc ctactccccg
     1501 catctttggg gaatcggttc cccatatgtc ttccttacta gactgtgagc tcctcgaggg
     1561 cagggaccgt gccttatgtc tgtgtgtgat cagtttctgg cacataaatg cctcaataaa
     1621 gatttaatta ctttgtatag tg
//
