LOCUS       NM_023946                941 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens LYNX1-SLURP2 readthrough (LYNX1-SLURP2), mRNA.
ACCESSION   NM_023946
VERSION     NM_023946.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 941)
  AUTHORS   Moriwaki Y, Takada K, Tsuji S, Kawashima K and Misawa H.
  TITLE     Transcriptional regulation of SLURP2, a psoriasis-associated gene,
            is under control of IL-22 in the skin: A special reference to the
            nested gene LYNX1
  JOURNAL   Int Immunopharmacol 29 (1), 71-75 (2015)
   PUBMED   26033490
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083841.9 and BC032306.1.
            
            On Jun 2, 2019 this sequence version replaced NM_023946.4.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring LYNX1 and SLURP2 genes. The
            readthrough transcript encodes a fusion protein comprised of
            sequence sharing identity with each individual gene product. The
            significance of this read-through transcription and the function of
            the resulting protein product have not yet been determined.
            [provided by RefSeq, Sep 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032306.1, BI518282.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 66004, 432355
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC083841.9         109959-109982
            25-714              BC032306.1         1-690
            715-747             AC083841.9         123265-123297
            748-941             BC032306.1         724-917
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..941
                     /gene="LYNX1-SLURP2"
                     /note="LYNX1-SLURP2 readthrough"
                     /db_xref="GeneID:111188157"
                     /db_xref="HGNC:HGNC:52291"
     exon            1..114
                     /gene="LYNX1-SLURP2"
                     /inference="alignment:Splign:2.1.0"
     exon            115..330
                     /gene="LYNX1-SLURP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..674
                     /gene="LYNX1-SLURP2"
                     /codon_start=1
                     /product="LYNX1-SLURP2 protein precursor"
                     /protein_id="NP_076435.1"
                     /db_xref="GeneID:111188157"
                     /db_xref="HGNC:HGNC:52291"
                     /translation="MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVA
                     YCMTTRTSAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRVLSNTEDLPLVTKMC
                     HIGCPDIPSLGLGPYVSIACCQTSLCNHD"
     exon            331..432
                     /gene="LYNX1-SLURP2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..537
                     /gene="LYNX1-SLURP2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..941
                     /gene="LYNX1-SLURP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      912..917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYNX1-SLURP2"
                     /note="hexamer: AATAAA"
     polyA_site      941
                     /gene="LYNX1-SLURP2"
                     /note="major polyA site"
ORIGIN      
        1 ggtgccggcc gacaaacgac gcggcgcggg cgagtgggcg gaggcggctg cggggaaggc
       61 tgggctgccg cgggacgcgg tgaagatagc ctgcggagtg tccgggctga acacggttgc
      121 agcactccca gtagaccagg agctccggga ggcagggccg gccccacgtc ctctgcgcac
      181 caccctgagt tggatcctct gtgcgccacc cctgagttgg atccagggct agctgctgtt
      241 gacctcccca ctcccacgct gccctcctgc ctgcagccat gacgcccctg ctcaccctga
      301 tcctggtggt cctcatgggc ttacctctgg cccaggcctt ggactgccac gtgtgtgcct
      361 acaacggaga caactgcttc aaccccatgc gctgcccggc tatggttgcc tactgcatga
      421 ccacgcgcac ctctgcagcc gaagccatat ggtgtcacca gtgcacgggc ttcggagggt
      481 gctcccatgg atccagatgc ctgagggact ccacccactg tgtcaccact gccacccggg
      541 tcctcagcaa caccgaggat ttgcctctgg tcaccaagat gtgccacata ggctgccccg
      601 atatccccag cctgggcctg ggcccctacg tatccatcgc ttgctgccag accagcctct
      661 gcaaccatga ctgacggctg ccctcctcca ggcccccgga cgctcagccc ccacagcccc
      721 cacagcctgg cgccagggct cacagctgcc cctccctcga gactggccag cccacctctc
      781 ccggcctctg cagccaccgt ccagcaccgc ttgtcctagg gaagtcctgc gtggagtctt
      841 gcctcaatct gctgccgtcc aagcctgggg cccatcgtgc ctgccgcccc ttcaggtccc
      901 gacctcccca caataaaatg tgattggatc gtgtggtaca a
//
