LOCUS       NM_177477               4577 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Ly6/neurotoxin 1 (LYNX1), transcript variant 1, mRNA.
ACCESSION   NM_177477
VERSION     NM_177477.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4577)
  AUTHORS   Palumbo,T.B. and Miwa,J.M.
  TITLE     Lynx1 and the family of endogenous mammalian neurotoxin-like
            proteins and their roles in modulating nAChR function
  JOURNAL   Pharmacol Res 194, 106845 (2023)
   PUBMED   37437646
  REMARK    GeneRIF: Lynx1 and the family of endogenous mammalian
            neurotoxin-like proteins and their roles in modulating nAChR
            function.
            Review article
REFERENCE   2  (bases 1 to 4577)
  AUTHORS   Mineev,K.S., Kryukova,E.V., Kasheverov,I.E., Egorova,N.S.,
            Zhmak,M.N., Ivanov,I.A., Senko,D.A., Feofanov,A.V., Ignatova,A.A.,
            Arseniev,A.S., Utkin,Y.N. and Tsetlin,V.I.
  TITLE     Spatial Structure and Activity of Synthetic Fragments of Lynx1 and
            of Nicotinic Receptor Loop C Models
  JOURNAL   Biomolecules 11 (1), 1 (2020)
   PUBMED   33374963
  REMARK    GeneRIF: Spatial Structure and Activity of Synthetic Fragments of
            Lynx1 and of Nicotinic Receptor Loop C Models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4577)
  AUTHORS   Liu,H., Wang,A. and Ma,Y.
  TITLE     Increased Expression of LYNX1 in Ovarian Serous Cystadenocarcinoma
            Predicts Poor Prognosis
  JOURNAL   Biomed Res Int 2020, 1392674 (2020)
   PUBMED   33299855
  REMARK    GeneRIF: Increased Expression of LYNX1 in Ovarian Serous
            Cystadenocarcinoma Predicts Poor Prognosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4577)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4577)
  AUTHORS   Bychkov,M., Shenkarev,Z., Shulepko,M., Shlepova,O., Kirpichnikov,M.
            and Lyukmanova,E.
  TITLE     Water-soluble variant of human Lynx1 induces cell cycle arrest and
            apoptosis in lung cancer cells via modulation of alpha7 nicotinic
            acetylcholine receptors
  JOURNAL   PLoS One 14 (5), e0217339 (2019)
   PUBMED   31150435
  REMARK    GeneRIF: The ability of ws-Lynx1 to regulate homeostasis of
            epithelial cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4577)
  AUTHORS   Moriwaki,Y., Takada,K., Tsuji,S., Kawashima,K. and Misawa,H.
  TITLE     Transcriptional regulation of SLURP2, a psoriasis-associated gene,
            is under control of IL-22 in the skin: A special reference to the
            nested gene LYNX1
  JOURNAL   Int Immunopharmacol 29 (1), 71-75 (2015)
   PUBMED   26033490
  REMARK    GeneRIF: These findings provide new insights into the acetylcholine
            receptor-mediated regulatory mechanism of SLURP-2 expression in
            keratinocytes.
REFERENCE   7  (bases 1 to 4577)
  AUTHORS   Choi,S.H., Kong,H.K., Park,S.Y. and Park,J.H.
  TITLE     Metastatic effect of LY-6K gene in breast cancer cells
  JOURNAL   Int J Oncol 35 (3), 601-607 (2009)
   PUBMED   19639180
  REMARK    GeneRIF: LY-6K meaningfully participates in breast cancer cell
            metastasis
REFERENCE   8  (bases 1 to 4577)
  AUTHORS   Song,P., Sekhon,H.S., Fu,X.W., Maier,M., Jia,Y., Duan,J.,
            Proskosil,B.J., Gravett,C., Lindstrom,J., Mark,G.P., Saha,S. and
            Spindel,E.R.
  TITLE     Activated cholinergic signaling provides a target in squamous cell
            lung carcinoma
  JOURNAL   Cancer Res 68 (12), 4693-4700 (2008)
   PUBMED   18559515
  REMARK    GeneRIF: decreased Lynx1 is associated with squamous cell lung
            carcinoma
REFERENCE   9  (bases 1 to 4577)
  AUTHORS   Lee,J.W., Lee,Y.S., Yoo,K.H., Lee,K.H., Park,K., Ahn,T., Ko,C. and
            Park,J.H.
  TITLE     LY-6K gene: a novel molecular marker for human breast cancer
  JOURNAL   Oncol Rep 16 (6), 1211-1214 (2006)
   PUBMED   17089039
  REMARK    GeneRIF: LY-6K,a novel member protein of the Ly-6/uPAR superfamily,
            is a significant new molecular marker for diagnosis and gene
            therapy in patients with breast cancer.
REFERENCE   10 (bases 1 to 4577)
  AUTHORS   Miwa,J.M., Ibanez-Tallon,I., Crabtree,G.W., Sanchez,R., Sali,A.,
            Role,L.W. and Heintz,N.
  TITLE     lynx1, an endogenous toxin-like modulator of nicotinic
            acetylcholine receptors in the mammalian CNS
  JOURNAL   Neuron 23 (1), 105-114 (1999)
   PUBMED   10402197
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY110957.1, AC083841.9 and
            BU683767.1.
            
            On Nov 22, 2018 this sequence version replaced NM_177477.3.
            
            Summary: This gene encodes a GPI-anchored, cell membrane bound
            member of the Ly6/uPAR (LU) superfamily of proteins containing the
            unique three-finger LU domain. This protein interacts with
            nicotinic acetylcholine receptors (nAChRs), and is thought to
            function as a modulator of nAChR activity to prevent excessive
            excitation. Alternatively spliced transcript variants have been
            found for this gene. Read-through transcription between this gene
            and the neighboring downstream gene (SLURP2) generates
            naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion
            protein comprised of sequence sharing identity with each individual
            gene product. [provided by RefSeq, Sep 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.89761.1,
                                           SRR1803616.220668.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652477.1/ ENSP00000498325.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               HY110957.1         11-515
            506-4042            AC083841.9         112556-116092
            4043-4577           BU683767.1         24-558              c
FEATURES             Location/Qualifiers
     source          1..4577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4577
                     /gene="LYNX1"
                     /note="Ly6/neurotoxin 1"
                     /db_xref="GeneID:66004"
                     /db_xref="HGNC:HGNC:29604"
                     /db_xref="MIM:606110"
     exon            1..97
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..313
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..612
                     /gene="LYNX1"
                     /note="Ly-6 neurotoxin-like protein 1;
                     ly-6/neurotoxin-like protein 1; testicular tissue protein
                     Li 112; endogenous prototoxin LYNX1"
                     /codon_start=1
                     /product="ly-6/neurotoxin-like protein 1 precursor"
                     /protein_id="NP_803430.1"
                     /db_xref="CCDS:CCDS6389.1"
                     /db_xref="GeneID:66004"
                     /db_xref="HGNC:HGNC:29604"
                     /db_xref="MIM:606110"
                     /translation="MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVA
                     YCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGTGLATPATL
                     ALAPILLATLWGLL"
     exon            314..415
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..4577
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4558..4563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYNX1"
                     /note="hexamer: AATAAA"
     polyA_site      4577
                     /gene="LYNX1"
                     /note="major polyA site"
ORIGIN      
        1 agacacgcct acgattagac tcaggcaggc acctaccggc gagcggccgc gggtgactcc
       61 caggcgcggc ggtacctcac ggtggtgaag gtcacagggt tgcagcactc ccagtagacc
      121 aggagctccg ggaggcaggg ccggccccac gtcctctgcg caccaccctg agttggatcc
      181 tctgtgcgcc acccctgagt tggatccagg gctagctgct gttgacctcc ccactcccac
      241 gctgccctcc tgcctgcagc catgacgccc ctgctcaccc tgatcctggt ggtcctcatg
      301 ggcttacctc tggcccaggc cttggactgc cacgtgtgtg cctacaacgg agacaactgc
      361 ttcaacccca tgcgctgccc ggctatggtt gcctactgca tgaccacgcg cacctactac
      421 acccccacca ggatgaaggt cagtaagtcc tgcgtgcccc gctgcttcga gactgtgtat
      481 gatggctact ccaagcacgc gtccaccacc tcctgctgcc agtacgacct ctgcaacggc
      541 accggccttg ccaccccggc caccctggcc ctggccccca tcctcctggc caccctctgg
      601 ggtctcctct aaagcccccg aggcagaccc actcaagaac aaagctctcg agacacactg
      661 ctacaccctc gcacccagct caccctgcct caccctccac actccctgcg acctcctcag
      721 ccatgcccag ggtcaggact gtgggcaaga agacacccga cctcccccaa ccaccacacg
      781 acctcacttc gaggccttga cctttcgatg ctgtgtggga tcccaaaagt gtccggcttt
      841 gatgggctga tcagcccctc gcctgtccag ggctatttat ggggaggggc ccagtcaggc
      901 agggagcact gagcagatgg gagctgtggc caagcccacc ttctgggaag ccctaggaga
      961 ggcccctgcc tcagtctgcc cctggtgtgc tggggcaggg ggaagacaag gaatgcccgc
     1021 aggtggggtg gtggggagac tcttaggagg aaaggctcct ccaggcctag tcacgcttcc
     1081 tactgaggcc aggagctgcc aggaccggta cgggatcagg gctgtgggag gagggccttt
     1141 ggcaccggcc cctgtgctag gaagtctgcc aggcccgagt tggagccacc ccctgcaggg
     1201 gagggggcgg ctctgcctca gcaggcccca gggcccccga agtcacagaa gctttttcgg
     1261 gtccagcaag gggtgtgtgt cctctcagtc aaaccccttg acgtttccca ccccctcacg
     1321 gggagggcac caggcctgaa gctggcagga gctagggcca tgctatattt ggtgggtcct
     1381 ggacgctgac ccggccagcg ctattctggg cagggaggga aaggggcaga gcaggtggtc
     1441 ccccgagtcc tggtccccaa ccacagcagg acccagccga gcaaggcaaa agacgcagga
     1501 ctgggggatg cgcgcacagg ctgggggttg ggagcagcct ggggccggcg cgggcctggg
     1561 cgtgggaagg cggagcatgc caccctctcg tggccgtgcg ggggcgggag tggggagggt
     1621 ggggtgggga gggcggagac ccagcccctc ccccgcagcg ggatgcgcac agtgagtggg
     1681 tccctccatc accttccacc tggggatgca cccactggga gggcagggtg gaagccccag
     1741 ctgggtgtgt ggactcccag ggaccccacc ccaggcctgg gaagcagggg tcagcccaac
     1801 acgcaccaat ccatccccga tgcaggtagc ccagggagca cctgcccctg ctgtgaatgg
     1861 ggcattcggg ggcgtgagac cttttggtgc cagcggtcac gctgcacctg aggcccccac
     1921 ctgaccagtg ctcccagctc tggtgtcctg agaaaccctt caagccatcc cgcatgggca
     1981 ggatggtgac atatccatgt ggtaggattg tcccggcccc aaagtatggc cctggtcagg
     2041 ggagcccctg ctggaaattg catctccaga gctttgatgc aggacccctg ggggatcagg
     2101 gaatgagggt ctccacccca ggggtctcct tgcagtgagt ctatatgcag gcctgcgttc
     2161 tgctcctggg gctggttctg agtgcccagc ttcagtctcc tgagaacatg aggatgggag
     2221 ggggcagagt cttgctgagg gcacacccag ttcccgctgg aggaggacag tgccagtctt
     2281 ctgcaaaggg accttgggtg ggaacgggcc cggagcggga ggaacgtgac tccccagagg
     2341 gaagatgggc atcatactgg gcccagagct gggaaggagt tgctgccagc acagggtggg
     2401 cctggactcc cctcgcccct acccccagtg gttgtggctg tagccctaag cctggagagc
     2461 aggaccggcc cggggtgtct gggaggctgc caggtgcctc ccagagctcc caagggcccc
     2521 cacctgcaag tgccagcctc agggcagtgc ccaaatgagg ccctctcagc tgcagccagc
     2581 gatgccttgg gatgcttacc gggagggagg cggctttggg ctcctaagtc cttgggagag
     2641 gctgggagca gtcactgcgc ggcttgcgca agcccattgt cgggttgggt ggcttcctca
     2701 gccagggctg ggagggactc caggatcagg tcctccctgt ctcgagtctc agtggggtga
     2761 tggggaggag acctggccac ccatggctca ggggcagctg agaacaagga cctgctggag
     2821 ctggaagtgc tgtggtgttg aggggtgggg tgggcagctt ctcacacctg cctcctgcct
     2881 ccttctgtcc acctttccac caccctgacc tgtcccagcc ccacacatgg ttctgcctgg
     2941 ctggcctgcc cttggcacct ggcgtagagc acacagaagg cactcagcta atgctgggca
     3001 ggcccactca tggggagtgc gtggctgtgc agcaccaggg aaccggcaca gcagcgccgg
     3061 cagaaatcac agcagtaaac ttgtccgggt tgtatgcatc aaggtggcga tggacgtggg
     3121 tccccccact gcactgtggc cctgagcact gtatagcagc ccggcaatgg gagccattat
     3181 cttgcccctt tgacagagga ggacacagag gcacagggag gtgaagtagc tgccccacac
     3241 tagtgcctcc tcgctcactc accaccccct gcaccacagt gcagccgctt ctcccaccag
     3301 ctggggttcc ttggaccccc aagcctggga agggggaggt gagtttacaa aatggaaagc
     3361 ttaaaaggag aaaagtggaa ccagaggttt gagaagccct gagtggtaga gtaaggcctc
     3421 cagcgctgcc tctgggtgca gggcagagtg gcagaggaga gggggagagg cactgggcac
     3481 catgggggcc cagttcccac ttcggggatc tctctcgcag aaccgagggt ccccttcatg
     3541 ggggtagatg cccagggcta gctgttgcca ctgtctgtgt ggacctgagt cctggacatg
     3601 cccgagtgac tcaggagtgg ctgcttgggc gggctctgtc accctaggat gttatacatt
     3661 ctgggaactg gacaggagtg gctgcttggg cgggctctgg caccctggga tgttatacat
     3721 tctgggaact ggacaggagt ggctgcttgg gtgggctctg gcaccctggg atgttataca
     3781 ttctgggaac tgcaatcagc cactagagaa gtcggagcta caggaagtga ccctggggtg
     3841 ggacctgggg acatggccag gtcagcatgg ggacacccgg ctccagcagg agctctggtc
     3901 tgtcctgggg tctttggggg cagggctgcg gccctgggca ggcttcctcc aggcggaggt
     3961 cctggggaag tgggggagcc aggccagctg ccgcctcccc cactatgtag catctgattc
     4021 gtcatctctc atgaaggcga tttggttcat aactctgaaa ctctgaaaaa ggtcaaaaga
     4081 agcagagagg ccctcggtgg atatgccagc ttttctgccg gtgctttctc ccactactct
     4141 gggtggtctg ctctcctctt caaacctcag ctcgcaggga gggcctgaat ctgccagccc
     4201 ctcaggatct ccttccctct gggccctccc cagccttaag gagcctccca gacagaaggg
     4261 tggacagagc cacctgggca gcccgagaga cacacggggg tcctccctgt ggacagccct
     4321 gccagcttcc gcccagccct gagcttcatt tgcatcttga ggagtaaggg gtggtgaaat
     4381 gggaatgctg gtctggctca gctggtcgtg ggcataagtg cccgctgaat ggatggcatc
     4441 tctccctcct gtcttatgtt ctggggtcca ggtgcttccc agggccatgc ccctgctgct
     4501 aatgcttgcc ctaaccctta ccctaaccag cgtccagcgt cgtctcaccg agccgtaaat
     4561 aaatcaacag attcgca
//
