LOCUS       NM_177476               4589 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Ly6/neurotoxin 1 (LYNX1), transcript variant 2, mRNA.
ACCESSION   NM_177476
VERSION     NM_177476.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4589)
  AUTHORS   Palumbo,T.B. and Miwa,J.M.
  TITLE     Lynx1 and the family of endogenous mammalian neurotoxin-like
            proteins and their roles in modulating nAChR function
  JOURNAL   Pharmacol Res 194, 106845 (2023)
   PUBMED   37437646
  REMARK    GeneRIF: Lynx1 and the family of endogenous mammalian
            neurotoxin-like proteins and their roles in modulating nAChR
            function.
            Review article
REFERENCE   2  (bases 1 to 4589)
  AUTHORS   Mineev,K.S., Kryukova,E.V., Kasheverov,I.E., Egorova,N.S.,
            Zhmak,M.N., Ivanov,I.A., Senko,D.A., Feofanov,A.V., Ignatova,A.A.,
            Arseniev,A.S., Utkin,Y.N. and Tsetlin,V.I.
  TITLE     Spatial Structure and Activity of Synthetic Fragments of Lynx1 and
            of Nicotinic Receptor Loop C Models
  JOURNAL   Biomolecules 11 (1), 1 (2020)
   PUBMED   33374963
  REMARK    GeneRIF: Spatial Structure and Activity of Synthetic Fragments of
            Lynx1 and of Nicotinic Receptor Loop C Models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4589)
  AUTHORS   Liu,H., Wang,A. and Ma,Y.
  TITLE     Increased Expression of LYNX1 in Ovarian Serous Cystadenocarcinoma
            Predicts Poor Prognosis
  JOURNAL   Biomed Res Int 2020, 1392674 (2020)
   PUBMED   33299855
  REMARK    GeneRIF: Increased Expression of LYNX1 in Ovarian Serous
            Cystadenocarcinoma Predicts Poor Prognosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4589)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4589)
  AUTHORS   Bychkov,M., Shenkarev,Z., Shulepko,M., Shlepova,O., Kirpichnikov,M.
            and Lyukmanova,E.
  TITLE     Water-soluble variant of human Lynx1 induces cell cycle arrest and
            apoptosis in lung cancer cells via modulation of alpha7 nicotinic
            acetylcholine receptors
  JOURNAL   PLoS One 14 (5), e0217339 (2019)
   PUBMED   31150435
  REMARK    GeneRIF: The ability of ws-Lynx1 to regulate homeostasis of
            epithelial cancer cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4589)
  AUTHORS   Moriwaki,Y., Takada,K., Tsuji,S., Kawashima,K. and Misawa,H.
  TITLE     Transcriptional regulation of SLURP2, a psoriasis-associated gene,
            is under control of IL-22 in the skin: A special reference to the
            nested gene LYNX1
  JOURNAL   Int Immunopharmacol 29 (1), 71-75 (2015)
   PUBMED   26033490
  REMARK    GeneRIF: These findings provide new insights into the acetylcholine
            receptor-mediated regulatory mechanism of SLURP-2 expression in
            keratinocytes.
REFERENCE   7  (bases 1 to 4589)
  AUTHORS   Choi,S.H., Kong,H.K., Park,S.Y. and Park,J.H.
  TITLE     Metastatic effect of LY-6K gene in breast cancer cells
  JOURNAL   Int J Oncol 35 (3), 601-607 (2009)
   PUBMED   19639180
  REMARK    GeneRIF: LY-6K meaningfully participates in breast cancer cell
            metastasis
REFERENCE   8  (bases 1 to 4589)
  AUTHORS   Song,P., Sekhon,H.S., Fu,X.W., Maier,M., Jia,Y., Duan,J.,
            Proskosil,B.J., Gravett,C., Lindstrom,J., Mark,G.P., Saha,S. and
            Spindel,E.R.
  TITLE     Activated cholinergic signaling provides a target in squamous cell
            lung carcinoma
  JOURNAL   Cancer Res 68 (12), 4693-4700 (2008)
   PUBMED   18559515
  REMARK    GeneRIF: decreased Lynx1 is associated with squamous cell lung
            carcinoma
REFERENCE   9  (bases 1 to 4589)
  AUTHORS   Lee,J.W., Lee,Y.S., Yoo,K.H., Lee,K.H., Park,K., Ahn,T., Ko,C. and
            Park,J.H.
  TITLE     LY-6K gene: a novel molecular marker for human breast cancer
  JOURNAL   Oncol Rep 16 (6), 1211-1214 (2006)
   PUBMED   17089039
  REMARK    GeneRIF: LY-6K,a novel member protein of the Ly-6/uPAR superfamily,
            is a significant new molecular marker for diagnosis and gene
            therapy in patients with breast cancer.
REFERENCE   10 (bases 1 to 4589)
  AUTHORS   Miwa,J.M., Ibanez-Tallon,I., Crabtree,G.W., Sanchez,R., Sali,A.,
            Role,L.W. and Heintz,N.
  TITLE     lynx1, an endogenous toxin-like modulator of nicotinic
            acetylcholine receptors in the mammalian CNS
  JOURNAL   Neuron 23 (1), 105-114 (1999)
   PUBMED   10402197
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG701653.1, AC083841.9,
            BM172253.1 and BU683767.1.
            
            On Aug 13, 2020 this sequence version replaced NM_177476.3.
            
            Summary: This gene encodes a GPI-anchored, cell membrane bound
            member of the Ly6/uPAR (LU) superfamily of proteins containing the
            unique three-finger LU domain. This protein interacts with
            nicotinic acetylcholine receptors (nAChRs), and is thought to
            function as a modulator of nAChR activity to prevent excessive
            excitation. Alternatively spliced transcript variants have been
            found for this gene. Read-through transcription between this gene
            and the neighboring downstream gene (SLURP2) generates
            naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion
            protein comprised of sequence sharing identity with each individual
            gene product. [provided by RefSeq, Sep 2017].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon compared to variant 1. Variants 1-4 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG701653.1, BM172253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA2142670 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BG701653.1         1-3
            4-4                 AC083841.9         110812-110812
            5-592               BM172253.1         4-591
            593-4054            AC083841.9         112631-116092
            4055-4589           BU683767.1         24-558              c
FEATURES             Location/Qualifiers
     source          1..4589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4589
                     /gene="LYNX1"
                     /note="Ly6/neurotoxin 1"
                     /db_xref="GeneID:66004"
                     /db_xref="HGNC:HGNC:29604"
                     /db_xref="MIM:606110"
     exon            1..109
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..325
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..624
                     /gene="LYNX1"
                     /note="Ly-6 neurotoxin-like protein 1;
                     ly-6/neurotoxin-like protein 1; testicular tissue protein
                     Li 112; endogenous prototoxin LYNX1"
                     /codon_start=1
                     /product="ly-6/neurotoxin-like protein 1 precursor"
                     /protein_id="NP_803429.1"
                     /db_xref="CCDS:CCDS6389.1"
                     /db_xref="GeneID:66004"
                     /db_xref="HGNC:HGNC:29604"
                     /db_xref="MIM:606110"
                     /translation="MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVA
                     YCMTTRTYYTPTRMKVSKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGTGLATPATL
                     ALAPILLATLWGLL"
     exon            326..427
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..4589
                     /gene="LYNX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4570..4575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYNX1"
                     /note="hexamer: AATAAA"
     polyA_site      4589
                     /gene="LYNX1"
                     /note="major polyA site"
ORIGIN      
        1 gagggggttg ggaagctcga agccgcaggc ctgactctgg cctttggcat cctggggttg
       61 gcctgggcaa atgtgtcgtg agagacggat ttgttgttct cgggaaggcg gttgcagcac
      121 tcccagtaga ccaggagctc cgggaggcag ggccggcccc acgtcctctg cgcaccaccc
      181 tgagttggat cctctgtgcg ccacccctga gttggatcca gggctagctg ctgttgacct
      241 ccccactccc acgctgccct cctgcctgca gccatgacgc ccctgctcac cctgatcctg
      301 gtggtcctca tgggcttacc tctggcccag gccttggact gccacgtgtg tgcctacaac
      361 ggagacaact gcttcaaccc catgcgctgc ccggctatgg ttgcctactg catgaccacg
      421 cgcacctact acacccccac caggatgaag gtcagtaagt cctgcgtgcc ccgctgcttc
      481 gagactgtgt atgatggcta ctccaagcac gcgtccacca cctcctgctg ccagtacgac
      541 ctctgcaacg gcaccggcct tgccaccccg gccaccctgg ccctggcccc catcctcctg
      601 gccaccctct ggggtctcct ctaaagcccc cgaggcagac ccactcaaga acaaagctct
      661 cgagacacac tgctacaccc tcgcacccag ctcaccctgc ctcaccctcc acactccctg
      721 cgacctcctc agccatgccc agggtcagga ctgtgggcaa gaagacaccc gacctccccc
      781 aaccaccaca cgacctcact tcgaggcctt gacctttcga tgctgtgtgg gatcccaaaa
      841 gtgtccggct ttgatgggct gatcagcccc tcgcctgtcc agggctattt atggggaggg
      901 gcccagtcag gcagggagca ctgagcagat gggagctgtg gccaagccca ccttctggga
      961 agccctagga gaggcccctg cctcagtctg cccctggtgt gctggggcag ggggaagaca
     1021 aggaatgccc gcaggtgggg tggtggggag actcttagga ggaaaggctc ctccaggcct
     1081 agtcacgctt cctactgagg ccaggagctg ccaggaccgg tacgggatca gggctgtggg
     1141 aggagggcct ttggcaccgg cccctgtgct aggaagtctg ccaggcccga gttggagcca
     1201 ccccctgcag gggagggggc ggctctgcct cagcaggccc cagggccccc gaagtcacag
     1261 aagctttttc gggtccagca aggggtgtgt gtcctctcag tcaaacccct tgacgtttcc
     1321 caccccctca cggggagggc accaggcctg aagctggcag gagctagggc catgctatat
     1381 ttggtgggtc ctggacgctg acccggccag cgctattctg ggcagggagg gaaaggggca
     1441 gagcaggtgg tcccccgagt cctggtcccc aaccacagca ggacccagcc gagcaaggca
     1501 aaagacgcag gactggggga tgcgcgcaca ggctgggggt tgggagcagc ctggggccgg
     1561 cgcgggcctg ggcgtgggaa ggcggagcat gccaccctct cgtggccgtg cgggggcggg
     1621 agtggggagg gtggggtggg gagggcggag acccagcccc tcccccgcag cgggatgcgc
     1681 acagtgagtg ggtccctcca tcaccttcca cctggggatg cacccactgg gagggcaggg
     1741 tggaagcccc agctgggtgt gtggactccc agggacccca ccccaggcct gggaagcagg
     1801 ggtcagccca acacgcacca atccatcccc gatgcaggta gcccagggag cacctgcccc
     1861 tgctgtgaat ggggcattcg ggggcgtgag accttttggt gccagcggtc acgctgcacc
     1921 tgaggccccc acctgaccag tgctcccagc tctggtgtcc tgagaaaccc ttcaagccat
     1981 cccgcatggg caggatggtg acatatccat gtggtaggat tgtcccggcc ccaaagtatg
     2041 gccctggtca ggggagcccc tgctggaaat tgcatctcca gagctttgat gcaggacccc
     2101 tgggggatca gggaatgagg gtctccaccc caggggtctc cttgcagtga gtctatatgc
     2161 aggcctgcgt tctgctcctg gggctggttc tgagtgccca gcttcagtct cctgagaaca
     2221 tgaggatggg agggggcaga gtcttgctga gggcacaccc agttcccgct ggaggaggac
     2281 agtgccagtc ttctgcaaag ggaccttggg tgggaacggg cccggagcgg gaggaacgtg
     2341 actccccaga gggaagatgg gcatcatact gggcccagag ctgggaagga gttgctgcca
     2401 gcacagggtg ggcctggact cccctcgccc ctacccccag tggttgtggc tgtagcccta
     2461 agcctggaga gcaggaccgg cccggggtgt ctgggaggct gccaggtgcc tcccagagct
     2521 cccaagggcc cccacctgca agtgccagcc tcagggcagt gcccaaatga ggccctctca
     2581 gctgcagcca gcgatgcctt gggatgctta ccgggaggga ggcggctttg ggctcctaag
     2641 tccttgggag aggctgggag cagtcactgc gcggcttgcg caagcccatt gtcgggttgg
     2701 gtggcttcct cagccagggc tgggagggac tccaggatca ggtcctccct gtctcgagtc
     2761 tcagtggggt gatggggagg agacctggcc acccatggct caggggcagc tgagaacaag
     2821 gacctgctgg agctggaagt gctgtggtgt tgaggggtgg ggtgggcagc ttctcacacc
     2881 tgcctcctgc ctccttctgt ccacctttcc accaccctga cctgtcccag ccccacacat
     2941 ggttctgcct ggctggcctg cccttggcac ctggcgtaga gcacacagaa ggcactcagc
     3001 taatgctggg caggcccact catggggagt gcgtggctgt gcagcaccag ggaaccggca
     3061 cagcagcgcc ggcagaaatc acagcagtaa acttgtccgg gttgtatgca tcaaggtggc
     3121 gatggacgtg ggtcccccca ctgcactgtg gccctgagca ctgtatagca gcccggcaat
     3181 gggagccatt atcttgcccc tttgacagag gaggacacag aggcacaggg aggtgaagta
     3241 gctgccccac actagtgcct cctcgctcac tcaccacccc ctgcaccaca gtgcagccgc
     3301 ttctcccacc agctggggtt ccttggaccc ccaagcctgg gaagggggag gtgagtttac
     3361 aaaatggaaa gcttaaaagg agaaaagtgg aaccagaggt ttgagaagcc ctgagtggta
     3421 gagtaaggcc tccagcgctg cctctgggtg cagggcagag tggcagagga gagggggaga
     3481 ggcactgggc accatggggg cccagttccc acttcgggga tctctctcgc agaaccgagg
     3541 gtccccttca tgggggtaga tgcccagggc tagctgttgc cactgtctgt gtggacctga
     3601 gtcctggaca tgcccgagtg actcaggagt ggctgcttgg gcgggctctg tcaccctagg
     3661 atgttataca ttctgggaac tggacaggag tggctgcttg ggcgggctct ggcaccctgg
     3721 gatgttatac attctgggaa ctggacagga gtggctgctt gggtgggctc tggcaccctg
     3781 ggatgttata cattctggga actgcaatca gccactagag aagtcggagc tacaggaagt
     3841 gaccctgggg tgggacctgg ggacatggcc aggtcagcat ggggacaccc ggctccagca
     3901 ggagctctgg tctgtcctgg ggtctttggg ggcagggctg cggccctggg caggcttcct
     3961 ccaggcggag gtcctgggga agtgggggag ccaggccagc tgccgcctcc cccactatgt
     4021 agcatctgat tcgtcatctc tcatgaaggc gatttggttc ataactctga aactctgaaa
     4081 aaggtcaaaa gaagcagaga ggccctcggt ggatatgcca gcttttctgc cggtgctttc
     4141 tcccactact ctgggtggtc tgctctcctc ttcaaacctc agctcgcagg gagggcctga
     4201 atctgccagc ccctcaggat ctccttccct ctgggccctc cccagcctta aggagcctcc
     4261 cagacagaag ggtggacaga gccacctggg cagcccgaga gacacacggg ggtcctccct
     4321 gtggacagcc ctgccagctt ccgcccagcc ctgagcttca tttgcatctt gaggagtaag
     4381 gggtggtgaa atgggaatgc tggtctggct cagctggtcg tgggcataag tgcccgctga
     4441 atggatggca tctctccctc ctgtcttatg ttctggggtc caggtgcttc ccagggccat
     4501 gcccctgctg ctaatgcttg ccctaaccct taccctaacc agcgtccagc gtcgtctcac
     4561 cgagccgtaa ataaatcaac agattcgca
//
