LOCUS       NM_002350               5872 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens LYN proto-oncogene, Src family tyrosine kinase (LYN),
            transcript variant 1, mRNA.
ACCESSION   NM_002350
VERSION     NM_002350.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   An,G., Hui,J., Zhang,W., Fan,A., Zhou,Y., Zhao,X., Lu,Y. and
            Wang,X.
  TITLE     A novel lncRNA associated with the prognosis of patients with
            colorectal cancer resists apoptosis through the LYN/BCL-2 pathway
  JOURNAL   Biochem Biophys Res Commun 723, 150177 (2024)
   PUBMED   38810320
  REMARK    GeneRIF: A novel lncRNA associated with the prognosis of patients
            with colorectal cancer resists apoptosis through the LYN/BCL-2
            pathway.
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Tsantikos,E., Gottschalk,T.A., L'Estrange-Stranieri,E.,
            O'Brien,C.A., Raftery,A.L., Wickramasinghe,L.C., McQualter,J.L.,
            Anderson,G.P. and Hibbs,M.L.
  TITLE     Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung
            Cancer
  JOURNAL   Am J Respir Cell Mol Biol 69 (1), 99-112 (2023)
   PUBMED   37014138
  REMARK    GeneRIF: Enhanced Lyn Activity Causes Severe, Progressive Emphysema
            and Lung Cancer.
REFERENCE   3  (bases 1 to 5872)
  AUTHORS   Ahn,W.S., Kim,H.D., Kim,T.S., Ahn,M.J., Park,Y.J. and Kim,J.
  TITLE     Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug
            Resistance (MDR1) gene
  JOURNAL   BMB Rep 56 (5), 302-307 (2023)
   PUBMED   36724904
  REMARK    GeneRIF: Phosphorylation of rpS3 by Lyn increases translation of
            Multi-Drug Resistance (MDR1) gene.
REFERENCE   4  (bases 1 to 5872)
  AUTHORS   de Jesus,A.A., Chen,G., Yang,D., Brdicka,T., Ruth,N.M., Bennin,D.,
            Cebecauerova,D., Malcova,H., Freeman,H., Martin,N., Svojgr,K.,
            Passo,M.H., Bhuyan,F., Alehashemi,S., Rastegar,A.T., Uss,K.,
            Kardava,L., Marrero,B., Duric,I., Omoyinmi,E., Peldova,P.,
            Lee,C.R., Kleiner,D.E., Hadigan,C.M., Hewitt,S.M., Pittaluga,S.,
            Carmona-Rivera,C., Calvo,K.R., Shah,N., Balascakova,M., Fink,D.L.,
            Kotalova,R., Parackova,Z., Peterkova,L., Kuzilkova,D., Campr,V.,
            Sramkova,L., Biancotto,A., Brooks,S.R., Manes,C., Meffre,E.,
            Harper,R.L., Kuehn,H., Kaplan,M.J., Brogan,P., Rosenzweig,S.D.,
            Merchant,M., Deng,Z., Huttenlocher,A., Moir,S.L., Kuhns,D.B.,
            Boehm,M., Skvarova Kramarzova,K. and Goldbach-Mansky,R.
  TITLE     Constitutively active Lyn kinase causes a cutaneous small vessel
            vasculitis and liver fibrosis syndrome
  JOURNAL   Nat Commun 14 (1), 1502 (2023)
   PUBMED   36932076
  REMARK    GeneRIF: Constitutively active Lyn kinase causes a cutaneous small
            vessel vasculitis and liver fibrosis syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5872)
  AUTHORS   Vom Stein,A.F., Rebollido-Rios,R., Lukas,A., Koch,M., von Lom,A.,
            Reinartz,S., Bachurski,D., Rose,F., Bozek,K., Abdallah,A.T.,
            Kohlhas,V., Saggau,J., Zolzer,R., Zhao,Y., Bruns,C.,
            Brockelmann,P.J., Lohneis,P., Buttner,R., Haupl,B., Oellerich,T.,
            Nguyen,P.H. and Hallek,M.
  TITLE     LYN kinase programs stromal fibroblasts to facilitate leukemic
            survival via regulation of c-JUN and THBS1
  JOURNAL   Nat Commun 14 (1), 1330 (2023)
   PUBMED   36899005
  REMARK    GeneRIF: LYN kinase programs stromal fibroblasts to facilitate
            leukemic survival via regulation of c-JUN and THBS1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5872)
  AUTHORS   Alai,M., Mui,A.L., Cutler,R.L., Bustelo,X.R., Barbacid,M. and
            Krystal,G.
  TITLE     Steel factor stimulates the tyrosine phosphorylation of the
            proto-oncogene product, p95vav, in human hemopoietic cells
  JOURNAL   J Biol Chem 267 (25), 18021-18025 (1992)
   PUBMED   1381360
REFERENCE   7  (bases 1 to 5872)
  AUTHORS   Uchiumi,F., Semba,K., Yamanashi,Y., Fujisawa,J., Yoshida,M.,
            Inoue,K., Toyoshima,K. and Yamamoto,T.
  TITLE     Characterization of the promoter region of the src family gene lyn
            and its trans activation by human T-cell leukemia virus type
            I-encoded p40tax
  JOURNAL   Mol Cell Biol 12 (9), 3784-3795 (1992)
   PUBMED   1508184
REFERENCE   8  (bases 1 to 5872)
  AUTHORS   Bielke,W., Ziemieki,A., Kappos,L. and Miescher,G.C.
  TITLE     Expression of the B cell-associated tyrosine kinase gene Lyn in
            primary neuroblastoma tumours and its modulation during the
            differentiation of neuroblastoma cell lines
  JOURNAL   Biochem Biophys Res Commun 186 (3), 1403-1409 (1992)
   PUBMED   1510669
REFERENCE   9  (bases 1 to 5872)
  AUTHORS   Torigoe,T., Saragovi,H.U. and Reed,J.C.
  TITLE     Interleukin 2 regulates the activity of the lyn protein-tyrosine
            kinase in a B-cell line
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2674-2678 (1992)
   PUBMED   1557373
REFERENCE   10 (bases 1 to 5872)
  AUTHORS   Cichowski,K., McCormick,F. and Brugge,J.S.
  TITLE     p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated
            platelets
  JOURNAL   J Biol Chem 267 (8), 5025-5028 (1992)
   PUBMED   1544885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB990993.1, AK290494.1,
            BC068551.1, BU954348.1, BG059526.1, DA948647.1 and AC046176.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002350.3.
            
            Summary: This gene encodes a tyrosine protein kinase, which maybe
            involved in the regulation of mast cell degranulation, and
            erythroid differentiation. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.201265.1,
                                           SRR1803614.239434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519728.6/ ENSP00000428924.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               CB990993.1         34-226
            194-1334            AK290494.1         112-1252
            1335-3083           BC068551.1         1272-3020
            3084-3549           BU954348.1         150-615
            3550-3736           BG059526.1         2-188               c
            3737-4150           DA948647.1         132-545
            4151-5872           AC046176.13        40477-42198         c
FEATURES             Location/Qualifiers
     source          1..5872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..5872
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /note="LYN proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:4067"
                     /db_xref="HGNC:HGNC:6735"
                     /db_xref="MIM:165120"
     exon            1..269
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            270..406
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1813
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /EC_number="2.7.10.2"
                     /note="isoform A is encoded by transcript variant 1;
                     tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma
                     viral related oncogene homolog; lck/Yes-related novel
                     protein tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase Lyn isoform A"
                     /protein_id="NP_002341.1"
                     /db_xref="CCDS:CCDS6162.1"
                     /db_xref="GeneID:4067"
                     /db_xref="HGNC:HGNC:6735"
                     /db_xref="MIM:165120"
                     /translation="MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRP
                     VPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKA
                     KSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESET
                     LKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGL
                     CRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKT
                     LKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSD
                     EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI
                     EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNA
                     DVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY
                     QQQP"
     exon            407..452
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            453..558
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            559..657
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            658..761
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            762..911
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1064
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1247
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1324
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1478
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1610
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..5872
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3064..3069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /note="hexamer: AATACA"
     polyA_site      3084
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /note="major polyA site"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /note="hexamer: GATAAA"
     polyA_site      3411
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
     regulatory      3715..3720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /note="hexamer: ATTAAA"
     polyA_site      3735
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
     regulatory      5853..5858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
                     /note="hexamer: AATAAA"
     polyA_site      5872
                     /gene="LYN"
                     /gene_synonym="JTK8; p53Lyn; p56Lyn; SAIDV"
ORIGIN      
        1 agttcctctc ccgccgcgcc gggccgcgct gccgctcgct ccccggccgt ggcgcctccg
       61 ggccagacgc gctgcagcct ccagcccgcg gcaagcgggg cggccgcgcc acccccggcc
      121 ccgcgccagc agcccctcgc cgcgcgtcca gcgttcccgg ccagcagcct ccccatacgc
      181 aggtcctgct gggccgcccc gtcgcgcccc ccactctgaa ctcaagtcac cgtggagctc
      241 cgccgccccg aaactttcac cgcgagcggg aaatatggga tgtataaaat caaaagggaa
      301 agacagcttg agtgacgatg gagtagattt gaagactcaa ccagtacgta atactgaaag
      361 aactatttat gtgagagatc caacgtccaa taaacagcaa aggccagttc cagaatctca
      421 gcttttacct ggacagaggt ttcaaactaa agatccagag gaacaaggag acattgtggt
      481 agccttgtac ccctatgatg gcatccaccc ggacgacttg tctttcaaga aaggagagaa
      541 gatgaaagtc ctggaggagc atggagaatg gtggaaagca aagtcccttt taacaaaaaa
      601 agaaggcttc atccccagca actatgtggc caaactcaac accttagaaa cagaagagtg
      661 gtttttcaag gatataacca ggaaggacgc agaaaggcag cttttggcac caggaaatag
      721 cgctggagct ttccttatta gagaaagtga aacattaaaa ggaagcttct ctctgtctgt
      781 cagagacttt gaccctgtgc atggtgatgt tattaagcac tacaaaatta gaagtctgga
      841 taatgggggc tattacatct ctccacgaat cacttttccc tgtatcagcg acatgattaa
      901 acattaccaa aagcaggcag atggcttgtg cagaagattg gagaaggctt gtattagtcc
      961 caagccacag aagccatggg ataaagatgc ctgggagatc ccccgggagt ccatcaagtt
     1021 ggtgaaaagg cttggcgctg ggcagtttgg ggaagtctgg atgggttact ataacaacag
     1081 taccaaggtg gctgtgaaaa ccctgaagcc aggaactatg tctgtgcaag ccttcctgga
     1141 agaagccaac ctcatgaaga ccctgcagca tgacaagctc gtgaggctct acgctgtggt
     1201 caccagggag gagcccattt acatcatcac cgagtacatg gccaagggca gtttgctgga
     1261 tttcctgaag agcgatgaag gtggcaaagt gctgcttcca aagctcattg acttttctgc
     1321 tcagattgca gagggaatgg catacatcga gcggaagaac tacattcacc gggacctgcg
     1381 agcagctaat gttctggtct ccgagtcact catgtgcaaa attgcagatt ttggccttgc
     1441 tagagtaatt gaagataatg agtacacagc aagggaaggt gctaagttcc ctattaagtg
     1501 gacggctcca gaagcaatca actttggatg tttcactatt aagtctgatg tgtggtcctt
     1561 tggaatcctc ctatacgaaa ttgtcaccta tgggaaaatt ccctacccag ggagaactaa
     1621 tgccgacgtg atgaccgccc tgtcccaggg ctacaggatg ccccgtgtgg agaactgccc
     1681 agatgagctc tatgacatta tgaaaatgtg ctggaaagaa aaggcagaag agagaccaac
     1741 gtttgactac ttacagagcg tcctggatga tttctacaca gccacggaag ggcaatacca
     1801 gcagcagcct tagagcacag ggagacccgt ccatttggca ggggtggctg cctcatttag
     1861 agaggaaaag taaccatcac tggttgcact tatgatttca tgtgcgggga tcatctgccg
     1921 tgcctggatc ctgaaataga ggctaaatta ctcaggaaga acaccctcta aatgggaaag
     1981 tattctgtac tcttagatgg attctccact cagttgcaac ttggacttgt cctcagcagc
     2041 tggtaatctt gctctgcttg acaacatctg agtgcagccg tttgagaaga aaacatctat
     2101 tctctccaaa aatgcaccca actagctcta tgtttacaaa tggacatagg actcaaagtt
     2161 tcagagacca ttgcaatgaa tccccaataa ttgcagaact aaactcattt ataaagctaa
     2221 aataaccgga tatatacata gcatgacatt tctttgtgct ttggcttact tgtttaaaaa
     2281 aaaaaaaaaa ctaatccaac ctgttagatt ttgcaggtga agtcagcagc ttaaaaatgt
     2341 ctttcccaga tttcaatgat ttttttcccc ctacctccca aaatctgaga ctgttaaaac
     2401 atttttcttc tatgaacact gctcagacct gctagacatg ccataggagt ggcgtgcaca
     2461 tctctctctc ttccagcagg aggagcccgt gagcacgcac agctgccctg tctgctcacc
     2521 cgaaggcacc gggctcacct ggacctccca ggaaagggag aagagcctca gaaactgctc
     2581 tgtgtttaga aggaatattt ttaagagtcc agctttttca tttccacaat ttcctatatc
     2641 cagatttgtt ttgacaatgt agtttggaag aactaagatt ctaatctctg aagaacctta
     2701 tagggccttc taaaacataa gagtttcctt tgttgcttca aatatttgaa cattatgtta
     2761 aagatcaagt attaatttta gttgtactct agaaagctaa agtgccacat tcggggctat
     2821 ttttatgatt cagcaatctt ttctaaattg tgtagcatgt gtatgagact atttataccc
     2881 aaggatatga aggaacataa gtgactacaa ggctctaata agccacggtg gcaggaggtt
     2941 caagcggttc tgttcactaa atttttctcc tgtaagcttt gaatggaaac ttctgtatca
     3001 catgatgtgt ttcacttatg ctgttgtgta tatacctaat atttctattt ttgattttat
     3061 tttaatacac ctcgtccaat aacatctcaa gctttttatt tgcatttaca ttttcagctg
     3121 tggtcagtgt aaaaattggt catcagctgg gggcggggtg gttagaagtg attcaacaga
     3181 gctacatgct ttaaacttgc ccaagttcta cctccttcct ttgaacattt cagattggag
     3241 aaccaaggag ttgattgcct gaacacctga acatccgttt atgggggcca gatagaattt
     3301 gttttcaaat aggcttaaca ggcatcatta aaatttcatt ctgtgtgttt tgtttaggct
     3361 tgaggtgctt agaagatggg ataaaatatt ctactttttt ctaaatttta actttgtttc
     3421 ctatgtgatt tttttaaatg tcctttctaa aatattctaa aattattgat tcacaagtgc
     3481 catgttcaga actatagaat attactgtta cataatgtct gcacagctgg tcccttgatt
     3541 cagtggtaag gtttttgtgt acacccccct gcttgcattt tatttcagaa ccacaagtat
     3601 tacccaatat gttacatgga gaggaactat aaagaatccc taaggcaaaa agaagtctct
     3661 agaaaatgac tagaggtttt ttttttagca taacaaattt atttaaagaa aattattaaa
     3721 tttatcttcg ccttgttttg cttctcccag ttcctcctct tcttgccatt ttccacttgt
     3781 ctttccctcc caatcaagcc tgtgatcctt acctccatgt gggcccttca ccagcttggg
     3841 cctcatctct ggtgtccagc atgtgtggaa gtcacacgtt cccttgatga acagcacaca
     3901 cagtctcctt acttagctat aggtttccag cctccctgtg acagacaggc ataatgaggg
     3961 gctgaatagg tgtttgtagc attttcgggt atccagtggt gtgcaaaatg gctcatgtca
     4021 tcacacctca ggttattgta gagaactgga aagacagaat ccatactccc taccgccaag
     4081 attctgactt agctgttgtg cagcgggaga tgtatgtcag tctattttaa aagcttctcc
     4141 agtcagctag acacagtggc tcatgcctgt aatctcagca ctttgggagg ctaaggcagg
     4201 aggatcgctt gagctcagga gttagacacc agcctgagca atatagcaag tctctacaaa
     4261 aaattttaaa aattagctaa gtgtggtggc acatacctat ggtcccagct actcaggagg
     4321 ctgaggtggg aggattgctt gagcccagga agtcaaggct gcagtgagct atgatcgtgc
     4381 cactgcactc cagcctgggc aagagtgaga ccctgtctca aaaaaaaaaa ccaaaaaaac
     4441 aaaaaaaccc ttccctggtg aatataatgt atgctcagtc ttgagagtca ccatttggtt
     4501 tgacccatat tacaaagccc agccttcttt ttcctcagat ggtttcattt ctcaaagggg
     4561 agtggaagag aaggaaggag gaaaaaaacg tgccttcctt cctggtgaac atgaagctca
     4621 ctgaacctaa aggagactca caggctagaa accagtgtcc ttagtagtag gggccacctg
     4681 gggcttccgt ggcttctcca ggcatacctc ctgaggttcc acagaatccc cttgcagaaa
     4741 gtacttctga tgagccactg ggaacgtgta ctgtccaagc ccccttctag gggaaattca
     4801 ctgccacaga agccagcagc cctggctgtc ccaagggtgc ataaaaggat aataactaaa
     4861 aggagggaat taattttgtt gcctacacca gggatagatc gagggcactg aaagcatcat
     4921 aagtataaac tcatctccac gtcagcttgt ggagtctgct ttctcgctct ctcttttttt
     4981 tttttttttg acagagtctc actctgtcac gcaggctaga gttgcagtgg tgcgatctca
     5041 gctcattgca acctccccct ctctggttgg agcgattctt ctcctgcctc agcctcccta
     5101 gtagctggaa ctacaggcac acaccatctc gcctggctaa tttttgtatt tttagtagag
     5161 atggggtttc accatgttag ccaggctggt ctcgaactcc tgacctcagg cgatccgcct
     5221 gcctcggctt cccaaagtgc tgggattaca agtgtgagcc actgtgcccg gtcggggtct
     5281 gctttctctt tattccccgt cctctcacaa actacatcca ggggcggtag ctgctaaaag
     5341 gactcaattc tgcaacctca gcttctgaca ccttcaaata aattaaatgc tggtcctagg
     5401 gctcgctccc cagctcttct gatgtcactg ccaggttcca cagccagttg tcggacatct
     5461 cctgcttcct cagccaagaa cacctctcag atgagatcaa accgcccagc tttcctctta
     5521 gcatcttcct ttattttcca cttctggctg gtggaagaga gatcgtagtt ctctattccc
     5581 tacattttaa ctccacgaat attttagatt aagtgaagtc ttgctgttct tcctgatgga
     5641 aatggtaatt ataaacatac aaagataccc atacacacat tctttactca gggccctctt
     5701 gtgctttggc aaatgataaa aattatctct aactcacaca acgaccctgg aagatctgga
     5761 caatgctatc actatttcac agctgagaga tcgggagcat ttaaagccac agaaggaata
     5821 gattggcttc gcttcatatt gtttccttgt gaaataaaac cagtgaaaca cc
//
