LOCUS       NM_005583               1481 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens LYL1 basic helix-loop-helix family member (LYL1),
            mRNA.
ACCESSION   NM_005583
VERSION     NM_005583.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Chen,Q., Cevher,M.A., Jiang,Q., Wang,S., Sun,X., Roeder,R.G. and
            Chen,M.
  TITLE     LYL1 facilitates AETFC assembly and gene activation by recruiting
            CARM1 in t(8;21) AML
  JOURNAL   Proc Natl Acad Sci U S A 119 (42), e2213718119 (2022)
   PUBMED   36215477
  REMARK    GeneRIF: LYL1 facilitates AETFC assembly and gene activation by
            recruiting CARM1 in t(8;21) AML.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Fang,F., Lu,J., Sang,X., Tao,Y.F., Wang,J.W., Zhang,Z.M.,
            Zhang,Y.P., Li,X.L., Xie,Y., Wu,S.Y., Chu,X.R., Li,G., Wu,D.,
            Chen,Y.L., Yu,J.J., Jia,S.Q., Feng,C.X., Tian,Y.Y., Li,Z.H.,
            Ling,J., Hu,S.Y. and Pan,J.
  TITLE     Super-enhancer profiling identifies novel critical and targetable
            cancer survival gene LYL1 in pediatric acute myeloid leukemia
  JOURNAL   J Exp Clin Cancer Res 41 (1), 225 (2022)
   PUBMED   35842703
  REMARK    GeneRIF: Super-enhancer profiling identifies novel critical and
            targetable cancer survival gene LYL1 in pediatric acute myeloid
            leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Zhang,M.M., Liu,N., Zhang,Y.L., Rong,B., Wang,X.L., Xu,C.H.,
            Xie,Y.Y., Shen,S., Zhu,J., Nimer,S.D., Chen,Z., Chen,S.J.,
            Roeder,R.G., Lan,F., Wang,L., Huang,Q.H. and Sun,X.J.
  TITLE     Destabilization of AETFC through C/EBPalpha-mediated repression of
            LYL1 contributes to t(8;21) leukemic cell differentiation
  JOURNAL   Leukemia 33 (7), 1822-1827 (2019)
   PUBMED   30755707
  REMARK    GeneRIF: Repression of LYL1 contributes to t(8;21) leukemic cell
            differentiation.
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Kim,S.I., Lee,J.W., Lee,N., Lee,M., Kim,H.S., Chung,H.H., Kim,J.W.,
            Park,N.H., Song,Y.S. and Seo,J.S.
  TITLE     LYL1 gene amplification predicts poor survival of patients with
            uterine corpus endometrial carcinoma: analysis of the Cancer genome
            atlas data
  JOURNAL   BMC Cancer 18 (1), 494 (2018)
   PUBMED   29716549
  REMARK    GeneRIF: Despite not being identified as an independent prognostic
            factor in UCEC, LYL1 gene amplification is associated with other
            poor prognostic factors and correlated with upregulation of
            cancer-related pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Ferrier,R., Nougarede,R., Doucet,S., Kahn-Perles,B., Imbert,J. and
            Mathieu-Mahul,D.
  TITLE     Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105
  JOURNAL   Oncogene 18 (4), 995-1005 (1999)
   PUBMED   10023675
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Miyamoto,A., Cui,X., Naumovski,L. and Cleary,M.L.
  TITLE     Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes
            with distinctive DNA-binding properties in hematolymphoid cells
  JOURNAL   Mol Cell Biol 16 (5), 2394-2401 (1996)
   PUBMED   8628307
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Wadman,I., Li,J., Bash,R.O., Forster,A., Osada,H., Rabbitts,T.H.
            and Baer,R.
  TITLE     Specific in vivo association between the bHLH and LIM proteins
            implicated in human T cell leukemia
  JOURNAL   EMBO J 13 (20), 4831-4839 (1994)
   PUBMED   7957052
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Kuo,S.S., Mellentin,J.D., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Cleary,M.L.
  TITLE     Structure, chromosome mapping, and expression of the mouse Lyl-1
            gene
  JOURNAL   Oncogene 6 (6), 961-968 (1991)
   PUBMED   2067848
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Saltman,D.L., Mellentin,J.D., Smith,S.D. and Cleary,M.L.
  TITLE     Mapping of translocation breakpoints on the short arm of chromosome
            19 in acute leukemias by in situ hybridization
  JOURNAL   Genes Chromosomes Cancer 2 (4), 259-265 (1990)
   PUBMED   2268576
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Mellentin,J.D., Smith,S.D. and Cleary,M.L.
  TITLE     lyl-1, a novel gene altered by chromosomal translocation in T cell
            leukemia, codes for a protein with a helix-loop-helix DNA binding
            motif
  JOURNAL   Cell 58 (1), 77-83 (1989)
   PUBMED   2752424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002796.2 and AI554151.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005583.4.
            
            Summary: This gene represents a basic helix-loop-helix
            transcription factor. The encoded protein may play roles in blood
            vessel maturation and hematopoeisis. A translocation between this
            locus and the T cell receptor beta locus (GeneID 6957) on
            chromosome 7 has been associated with acute lymphoblastic leukemia.
            [provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002796.2, M22637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264824.5/ ENSP00000264824.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1054              BC002796.2         10-1063
            1055-1481           AI554151.1         7-433               c
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1481
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /note="LYL1 basic helix-loop-helix family member"
                     /db_xref="GeneID:4066"
                     /db_xref="HGNC:HGNC:6734"
                     /db_xref="MIM:151440"
     exon            1..328
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /inference="alignment:Splign:2.1.0"
     exon            329..687
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1195
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /note="class A basic helix-loop-helix protein 18;
                     lymphoblastic leukemia derived sequence 1; lymphoblastic
                     leukemia associated hematopoiesis regulator 1"
                     /codon_start=1
                     /product="protein lyl-1"
                     /protein_id="NP_005574.2"
                     /db_xref="CCDS:CCDS12292.1"
                     /db_xref="GeneID:4066"
                     /db_xref="HGNC:HGNC:6734"
                     /db_xref="MIM:151440"
                     /translation="MCPPQAQAEVGPTMTEKAEMVCAPSPAPAPPPKPASPGPPQVEE
                     VGHRGGSSPPRLPPGVPVISLGHSRPPGVAMPTTELGTLRPPLLQLSTLGTAPPTLAL
                     HYHPHPFLNSVYIGPAGPFSIFPSSRLKRRPSHCELDLAEGHQPQKVARRVFTNSRER
                     WRQQNVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYIGFLVRLLRDQAAALAAGPT
                     PPGPRKRPVHRVPDDGARRGSGRRAEAAARSQPAPPADPDGSPGGAARPIKMEQTALS
                     PEVR"
     exon            688..779
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1481
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1481
                     /gene="LYL1"
                     /gene_synonym="bHLHa18"
                     /note="major polyA site"
ORIGIN      
        1 ccttatctgc actgggccag catcctccgg ccgctgcgcc gccaggggtg agagggagga
       61 aaccgggccg ccgggggcgg ggagaaggcg ggccggcccg ggagccgctc actttccctg
      121 ggggggacct acgcggagac ctcggctatc ctggccttcc gaggcccacg aggaggcgcg
      181 gcccaacgcc ggggcctgga gcattgaggc cggaccctcg cgagacagca gagcctggcc
      241 tgacgctgga aaccacaccc tggcccagac tgccagccct gacgggacag agccagggca
      301 ctcaccaggc tgcaagaaca gtgctggggt gagtaccccc acgtcggggt ccatgtgccc
      361 gcctcaggca caggcagagg tgggccccac catgactgag aaggcagaga tggtgtgtgc
      421 ccccagccca gcgcctgccc caccccctaa gcctgcctcg cctgggcccc cgcaggtgga
      481 ggaggtgggc caccgaggag gctcctcgcc ccccaggctg ccacctggtg taccagtgat
      541 cagcctgggc cacagcaggc ccccaggggt agccatgccc accacagagc tgggcactct
      601 gcggcccccg ctgctgcaac tctccaccct gggaactgcc ccgcccactt tggccctgca
      661 ctaccaccct caccccttcc tcaacagtgt ctacattggg ccagcaggac cttttagcat
      721 cttccctagc agccggttga agcggagacc aagccactgt gagctggacc tggctgaggg
      781 gcaccagccc cagaaggtgg cccggcgcgt gttcaccaac agccgggagc gctggcggca
      841 gcagaacgtt aacggcgcct tcgccgagct gaggaagctg ctgccgacgc acccgcccga
      901 ccggaagctg agcaagaacg aggtgctccg cctagccatg aagtacatcg gcttcctggt
      961 gcggctgctg cgcgaccaag ccgcagctct ggccgcaggc cccacccctc ccgggcctcg
     1021 caaacggccg gtgcaccggg tcccagacga cggcgcccgc cggggatccg gacgcagggc
     1081 cgaggcggca gcgcgctcgc agcccgcgcc cccggccgac cccgacggca gccccggtgg
     1141 agcggcccgg cccatcaaga tggagcaaac cgctttgagc ccagaggtgc ggtgaccgca
     1201 cgcggcagca cctctgagcc ggagggcacc agggactcgg cccagggccg tcaaggaaag
     1261 ggcagtggac gtgctgcgca tgttcgggag cgaactcccc cgaagaagga ccagtgaaga
     1321 cgtcaggggc aaggtctcgg gggtccggaa gggtgatcat cgacccccaa gggacccgca
     1381 gacccttaaa aaaatcaccc acaaccctct ggaagtggcc ttgcccggtc cccttcccag
     1441 gggcgaggtc ggcaaagcaa catggcagag cagtcatagg a
//
