LOCUS       NM_175735                964 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens lysozyme g2 (LYG2), mRNA.
ACCESSION   NM_175735
VERSION     NM_175735.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Huang,P., Yang,Z., Bao,J., Zhang,N. and Li,W.
  TITLE     [Purification of human goose-type lysozyme 2 (HLysG2) from human
            seminal plasma and analysis of its enzymatic properties]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33 (3), 320-325 (2017)
   PUBMED   28274309
  REMARK    GeneRIF: HLysG2 was identified and purified from human seminal
            plasma and showed a significant killing effect on Micrococcus
            lysodeikticus, Bacillus subtilis and Staphylococcus aureus.
REFERENCE   3  (bases 1 to 964)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 964)
  AUTHORS   Huang,P., Li,W.S., Xie,J., Yang,X.M., Jiang,D.K., Jiang,S. and
            Yu,L.
  TITLE     Characterization and expression of HLysG2, a basic goose-type
            lysozyme from the human eye and testis
  JOURNAL   Mol Immunol 48 (4), 524-531 (2011)
   PUBMED   21093056
  REMARK    GeneRIF: HLysG2 is a potent antibacterial protein that may play a
            role in the innate immunity of the human eye.
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Irwin,D.M. and Gong,Z.
  TITLE     Molecular evolution of vertebrate goose-type lysozyme genes
  JOURNAL   J Mol Evol 56 (2), 234-242 (2003)
   PUBMED   12574869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079447.4.
            
            On May 11, 2021 this sequence version replaced NM_175735.3.
            
            Summary: The protein encoded by this gene contains a SLT domain, a
            protein domain present in bacterial lytic transglycosylase (SLT)
            and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the
            cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic
            acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            CDS exon combination :: BC100882.3 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000333017.7/
                                                ENSP00000327533.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC079447.4         58977-59040         c
            65-182              AC079447.4         58394-58511         c
            183-250             AC079447.4         57592-57659         c
            251-391             AC079447.4         50054-50194         c
            392-588             AC079447.4         48636-48832         c
            589-727             AC079447.4         47373-47511         c
            728-964             AC079447.4         45620-45856         c
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..964
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /note="lysozyme g2"
                     /db_xref="GeneID:254773"
                     /db_xref="HGNC:HGNC:29615"
                     /db_xref="MIM:616547"
     exon            1..64
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     exon            65..182
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..250
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..846
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /EC_number="3.2.1.17"
                     /note="lysozyme g-like protein 2; lysozyme G-like 2"
                     /codon_start=1
                     /product="lysozyme g-like protein 2 precursor"
                     /protein_id="NP_783862.2"
                     /db_xref="CCDS:CCDS2042.1"
                     /db_xref="GeneID:254773"
                     /db_xref="HGNC:HGNC:29615"
                     /db_xref="MIM:616547"
                     /translation="MLSSVVFWGLIALIGTSRGSYPFSHSMKPHLHPRLYHGCYGDIM
                     TMKTSGATCDANSVMNCGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAII
                     SRESHGGSVLQDGWDHRGLKFGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQ
                     KKFPTWSVAQHLKGGLSAFKSGIEAIATPSDIDNDFVNDIIARAKFYKRQSF"
     exon            251..391
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..588
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..727
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..964
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      945..950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /note="hexamer: ATTAAA"
     polyA_site      964
                     /gene="LYG2"
                     /gene_synonym="LYGA2; LYGH; LYSG2"
                     /note="major polyA site"
ORIGIN      
        1 atactggtac ggggatcata tgacattgga atgggaacaa aaagcaggag acccaatatt
       61 tcagcctatg ttacaggaca aaggccgtcg ctttgtaaaa gcttgaagtg cagtttgctg
      121 ctgagtacag aagacctttg caaacagaga ggggagattt tctctgtaag gttgcaaaca
      181 aggtcctgga agataagatt ccccgccatg ttatcctccg tggtgttttg gggactaatt
      241 gccctcattg gcacttccag gggctcatac cccttcagtc actcaatgaa gcctcaccta
      301 catccacgcc tgtaccacgg ctgctatggg gacatcatga ccatgaagac ctctggggcc
      361 acttgtgatg caaacagtgt gatgaactgc gggatccgtg gttctgaaat gtttgctgag
      421 atggatttga gggccataaa accttaccag actctgatca aagaagtcgg gcagagacat
      481 tgcgtggacc ctgctgtcat cgcagccatc atctccaggg aaagccatgg cggatctgtc
      541 ctgcaagacg gctgggacca caggggactt aaatttggct tgatgcagct tgataaacaa
      601 acgtaccacc ctgtcggtgc ctgggatagc aaagagcacc tttcacaggc tactgggatt
      661 ctaacagaga gaattaaggc aatccagaaa aaattcccca cgtggagtgt tgctcagcac
      721 ctcaaaggtg gtctctcagc ttttaagtca ggaattgaag cgattgccac cccatcggac
      781 atagacaatg acttcgtcaa tgatatcatt gctcgagcta agttctataa aagacaaagc
      841 ttctaggcaa agctctgtgg gtgggccagg ttggcagagt gctcagatgg ccgcctttga
      901 gagttttacg tgaatgtgtt gtatacaaca ctggcaaaga aatgattaaa atcatgaaag
      961 aaaa
//
