LOCUS       NM_174898               1011 bp    mRNA    linear   PRI 17-JAN-2025
DEFINITION  Homo sapiens lysozyme g1 (LYG1), transcript variant 2, mRNA.
ACCESSION   NM_174898
VERSION     NM_174898.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1011)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1011)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1011)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1011)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 1011)
  AUTHORS   Irwin,D.M. and Gong,Z.
  TITLE     Molecular evolution of vertebrate goose-type lysozyme genes
  JOURNAL   J Mol Evol 56 (2), 234-242 (2003)
   PUBMED   12574869
REFERENCE   6  (bases 1 to 1011)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079447.4, BC029126.1 and BG194505.1.
            
            On Jun 2, 2019 this sequence version replaced NM_174898.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029126.1, BG194505.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308528.9/ ENSP00000311320.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC079447.4         104551-104571       c
            22-91               BC029126.1         1-70
            92-627              BG194505.1         34-569
            628-1011            BC029126.1         607-990
FEATURES             Location/Qualifiers
     source          1..1011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1011
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /note="lysozyme g1"
                     /db_xref="GeneID:129530"
                     /db_xref="HGNC:HGNC:27014"
                     /db_xref="MIM:621066"
     exon            1..148
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     exon            149..239
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     exon            240..314
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..856
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /note="lysozyme g-like protein 1; lysozyme G-like 1"
                     /codon_start=1
                     /product="lysozyme g-like protein 1 precursor"
                     /protein_id="NP_777558.1"
                     /db_xref="CCDS:CCDS2043.1"
                     /db_xref="GeneID:129530"
                     /db_xref="HGNC:HGNC:27014"
                     /db_xref="MIM:621066"
                     /translation="MSALWLLLGLLALMDLSESSNWGCYGNIQSLDTPGASCGIGRRH
                     GLNYCGVRASERLAEIDMPYLLKYQPMMQTIGQKYCMDPAVIAGVLSRKSPGDKILVN
                     MGDRTSMVQDPGSQAPTSWISESQVSQTTEVLTTRIKEIQRRFPTWTPDQYLRGGLCA
                     YSGGAGYVRSSQDLSCDFCNDVLARAKYLKRHGF"
     exon            315..419
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     exon            420..604
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     exon            605..737
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1011
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /inference="alignment:Splign:2.1.0"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /note="hexamer: ATTAAA"
     polyA_site      1011
                     /gene="LYG1"
                     /gene_synonym="LYGA1; SALW1939"
                     /note="major polyA site"
ORIGIN      
        1 ataataatta tgattattat tataatttat gagatgtcat aaatctctcc aaaataggat
       61 gagatgaaca cttttaacaa gagaacagga ctctatataa atcgctgtgg gctcaccacc
      121 tctaaggagg agcactgact gaagacagaa aaattgatga actgaagaag acatggtcca
      181 ttatgcctta caaacttaca cagtgctttg ggaattccaa agtactcagt ggagagaggt
      241 gtttcaggag ccgtagagcc agatcgtcat catgtctgca ttgtggctgc tgctgggcct
      301 ccttgccctg atggacttgt ctgaaagcag caactgggga tgctatggaa acatccaaag
      361 cctggacacc cctggagcat cttgtgggat tggaagacgt cacggcctga actactgtgg
      421 agttcgtgct tctgaaaggc tggctgaaat agacatgcca tacctcctga aatatcaacc
      481 catgatgcaa accattggcc aaaagtactg catggatcct gccgtgatcg ctggtgtctt
      541 gtccaggaag tctcccggtg acaaaattct ggtcaacatg ggcgatagga ctagcatggt
      601 gcaggaccct ggctctcaag ctcccacatc ctggattagt gagtctcagg tttcccagac
      661 aactgaagtt ctgactacta gaatcaaaga aatccagagg aggtttccaa cctggacccc
      721 tgaccagtac ctgagaggtg gactctgtgc ctacagtggg ggtgctggct atgtccgaag
      781 cagccaggac ctgagctgtg acttctgcaa tgatgtcctt gcacgagcca agtacctcaa
      841 gagacatggc ttctaacatc tcagatgaaa cccaagacca tgatcacata tgcagcctca
      901 aatgttacac agataaaact agccaagggc acctgtaact gggaatctga gtttgaccta
      961 aaagtcatta aaataacatg aatcacatta aaggaagaat tttgacctgc a
//
