LOCUS       NM_015364                559 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens lymphocyte antigen 96 (LY96), transcript variant 1,
            mRNA.
ACCESSION   NM_015364
VERSION     NM_015364.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 559)
  AUTHORS   Ferrari,M.G., Jimenez-Uribe,A.P., Wang,L., Hoeppner,L.H.,
            Murugan,P., Hahm,E., Yu,J., Kuzel,T.M., Gradilone,S.A. and
            Mansini,A.P.
  TITLE     Myeloid differentiation factor-2/LY96, a potential predictive
            biomarker of metastasis and poor outcomes in prostate cancer:
            clinical implications as a potential therapeutic target
  JOURNAL   Oncogene 43 (7), 484-494 (2024)
   PUBMED   38135694
  REMARK    GeneRIF: Myeloid differentiation factor-2/LY96, a potential
            predictive biomarker of metastasis and poor outcomes in prostate
            cancer: clinical implications as a potential therapeutic target.
REFERENCE   2  (bases 1 to 559)
  AUTHORS   Hopp,M.T., Holze,J., Lauber,F., Holtkamp,L., Rathod,D.C.,
            Miteva,M.A., Prestes,E.B., Geyer,M., Manoury,B., Merle,N.S.,
            Roumenina,L.T., Bozza,M.T., Weindl,G. and Imhof,D.
  TITLE     Insights into the molecular basis and mechanism of heme-triggered
            TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2
  JOURNAL   Immunology 171 (2), 181-197 (2024)
   PUBMED   37885279
  REMARK    GeneRIF: Insights into the molecular basis and mechanism of
            heme-triggered TLR4 signalling: The role of heme-binding motifs in
            TLR4 and MD2.
REFERENCE   3  (bases 1 to 559)
  AUTHORS   Feldtmann,R., Kummel,A., Chamling,B., Strohbach,A., Lehnert,K.,
            Gross,S., Loerzer,L., Riad,A., Lindner,D., Westermann,D.,
            Fielitz,J., Dorr,M. and Felix,S.B.
  TITLE     Myeloid differentiation factor-2 activates monocytes in patients
            with dilated cardiomyopathy
  JOURNAL   Immunology 167 (1), 40-53 (2022)
   PUBMED   35502635
  REMARK    GeneRIF: Myeloid differentiation factor-2 activates monocytes in
            patients with dilated cardiomyopathy.
REFERENCE   4  (bases 1 to 559)
  AUTHORS   Asami,J. and Shimizu,T.
  TITLE     Structural and functional understanding of the toll-like receptors
  JOURNAL   Protein Sci 30 (4), 761-772 (2021)
   PUBMED   33576548
  REMARK    Review article
REFERENCE   5  (bases 1 to 559)
  AUTHORS   Zhang,P., Nguyen,J., Abdulla,F., Nelson,A.T., Beckman,J.D.,
            Vercellotti,G.M. and Belcher,J.D.
  TITLE     Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote
            Pro-Inflammatory Signaling in Endothelial Cells
  JOURNAL   Front Immunol 12, 632709 (2021)
   PUBMED   33841413
  REMARK    GeneRIF: Soluble MD-2 and Heme in Sickle Cell Disease Plasma
            Promote Pro-Inflammatory Signaling in Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 559)
  AUTHORS   Schromm,A.B., Lien,E., Henneke,P., Chow,J.C., Yoshimura,A.,
            Heine,H., Latz,E., Monks,B.G., Schwartz,D.A., Miyake,K. and
            Golenbock,D.T.
  TITLE     Molecular genetic analysis of an endotoxin nonresponder mutant cell
            line: a point mutation in a conserved region of MD-2 abolishes
            endotoxin-induced signaling
  JOURNAL   J Exp Med 194 (1), 79-88 (2001)
   PUBMED   11435474
REFERENCE   7  (bases 1 to 559)
  AUTHORS   da Silva Correia,J., Soldau,K., Christen,U., Tobias,P.S. and
            Ulevitch,R.J.
  TITLE     Lipopolysaccharide is in close proximity to each of the proteins in
            its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
  JOURNAL   J Biol Chem 276 (24), 21129-21135 (2001)
   PUBMED   11274165
REFERENCE   8  (bases 1 to 559)
  AUTHORS   Dziarski,R., Wang,Q., Miyake,K., Kirschning,C.J. and Gupta,D.
  TITLE     MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to
            lipopolysaccharide and enhances TLR2-mediated responses to
            Gram-positive and Gram-negative bacteria and their cell wall
            components
  JOURNAL   J Immunol 166 (3), 1938-1944 (2001)
   PUBMED   11160242
REFERENCE   9  (bases 1 to 559)
  AUTHORS   Kato,K., Morrison,A.M., Nakano,T., Tashiro,K. and Honjo,T.
  TITLE     ESOP-1, a secreted protein expressed in the hematopoietic, nervous,
            and reproductive systems of embryonic and adult mice
  JOURNAL   Blood 96 (1), 362-364 (2000)
   PUBMED   10891475
REFERENCE   10 (bases 1 to 559)
  AUTHORS   Shimazu,R., Akashi,S., Ogata,H., Nagai,Y., Fukudome,K., Miyake,K.
            and Kimoto,M.
  TITLE     MD-2, a molecule that confers lipopolysaccharide responsiveness on
            Toll-like receptor 4
  JOURNAL   J Exp Med 189 (11), 1777-1782 (1999)
   PUBMED   10359581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022868.10 and AC087672.7.
            
            On May 17, 2019 this sequence version replaced NM_015364.4.
            
            Summary: This gene encodes a protein which associates with
            toll-like receptor 4 on the cell surface and confers responsiveness
            to lipopolysaccyaride (LPS), thus providing a link between the
            receptor and LPS signaling. Studies of the mouse ortholog suggest
            that this gene may be involved in endotoxin neutralization.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.565086.1,
                                           SRR1163657.60102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284818.7/ ENSP00000284818.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AC022868.10        10890-11052         c
            164-253             AC087672.7         26298-26387
            254-382             AC087672.7         31503-31631
            383-435             AC087672.7         48291-48343
            436-559             AC087672.7         50458-50581
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.11"
     gene            1..559
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /note="lymphocyte antigen 96"
                     /db_xref="GeneID:23643"
                     /db_xref="HGNC:HGNC:17156"
                     /db_xref="MIM:605243"
     exon            1..163
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..534
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; myeloid differentiation protein-2; protein
                     MD-2"
                     /codon_start=1
                     /product="lymphocyte antigen 96 isoform 1 precursor"
                     /protein_id="NP_056179.4"
                     /db_xref="CCDS:CCDS6216.1"
                     /db_xref="GeneID:23643"
                     /db_xref="HGNC:HGNC:17156"
                     /db_xref="MIM:605243"
                     /translation="MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPI
                     SINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDY
                     SFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
                     "
     exon            164..253
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..382
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..435
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..559
                     /gene="LY96"
                     /gene_synonym="ESOP-1; ly-96; MD-2; MD2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattagttac tgatcctctt tgcatttgta aagctttgga gatattgaat catgttacca
       61 tttctgtttt tttccaccct gttttcttcc atatttactg aagctcagaa gcagtattgg
      121 gtctgcaact catccgatgc aagtatttca tacacctact gtgataaaat gcaataccca
      181 atttcaatta atgttaaccc ctgtatagaa ttgaaaagat ccaaaggatt attgcacatt
      241 ttctacattc caaggagaga tttaaagcaa ttatatttca atctctatat aactgtcaac
      301 accatgaatc ttccaaagcg caaagaagtt atttgccgag gatctgatga cgattactct
      361 ttttgcagag ctctgaaggg agagactgtg aatacaacaa tatcattctc cttcaaggga
      421 ataaaatttt ctaagggaaa atacaaatgt gttgttgaag ctatttctgg gagcccagaa
      481 gaaatgctct tttgcttgga gtttgtcatc ctacaccaac ctaattcaaa ttagaataaa
      541 ttgagtattt aaaaaaaaa
//
