LOCUS       NM_002348               2421 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens lymphocyte antigen 9 (LY9), transcript variant 1,
            mRNA.
ACCESSION   NM_002348
VERSION     NM_002348.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Hu,P., Cai,J., Yang,C., Xu,L., Ma,S., Song,H. and Yang,P.
  TITLE     SLAMF3 promotes Th17 differentiation and is reversed by iguratimod
            through JAK1/STAT3 pathway in primary Sjogren's syndrome
  JOURNAL   Int Immunopharmacol 126, 111282 (2024)
   PUBMED   38061117
  REMARK    GeneRIF: SLAMF3 promotes Th17 differentiation and is reversed by
            iguratimod through JAK1/STAT3 pathway in primary Sjogren's
            syndrome.
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Lin,Z., Tang,X., Cao,Y., Yang,L., Jiang,M., Li,X., Min,J., Chen,B.,
            Yang,Y. and Gu,C.
  TITLE     CD229 interacts with RASAL3 to activate RAS/ERK pathway in multiple
            myeloma proliferation
  JOURNAL   Aging (Albany NY) 14 (22), 9264-9279 (2022)
   PUBMED   36445333
  REMARK    GeneRIF: CD229 interacts with RASAL3 to activate RAS/ERK pathway in
            multiple myeloma proliferation.
            Erratum:[Aging (Albany NY). 2023 Aug 28;15(16):8528-8529. doi:
            10.18632/aging.205006.. PMID: 37635436]
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Ishibashi,M., Sunakawa-Kii,M., Kaito,Y., Kinoshita,R., Asayama,T.,
            Kuribayashi,Y., Inokuchi,K., Morita,R. and Tamura,H.
  TITLE     The SLAMF3 rs509749 polymorphism correlates with malignant
            potential in multiple myeloma
  JOURNAL   Exp Hematol 90, 72-79 (2020)
   PUBMED   32818503
  REMARK    GeneRIF: The SLAMF3 rs509749 polymorphism correlates with malignant
            potential in multiple myeloma.
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Ishibashi,M., Takahashi,R., Tsubota,A., Sasaki,M., Handa,H.,
            Imai,Y., Tanaka,N., Tsukune,Y., Tanosaki,S., Ito,S., Asayama,T.,
            Sunakawa,M., Kaito,Y., Kuribayashi-Hamada,Y., Onodera,A.,
            Moriya,K., Komatsu,N., Tanaka,J., Odajima,T., Sugimori,H.,
            Inokuchi,K. and Tamura,H.
  TITLE     SLAMF3-Mediated Signaling via ERK Pathway Activation Promotes
            Aggressive Phenotypic Behaviors in Multiple Myeloma
  JOURNAL   Mol Cancer Res 18 (4), 632-643 (2020)
   PUBMED   31974290
  REMARK    GeneRIF: SLAMF3-Mediated Signaling via ERK Pathway Activation
            Promotes Aggressive Phenotypic Behaviors in Multiple Myeloma.
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Zhou,T., Wang,G., Lyu,Y., Wang,L., Zuo,S., Zou,J., Sun,L., Zhao,W.,
            Shu,C., Yang,Y.G. and Hu,Z.
  TITLE     Upregulation of SLAMF3 on human T cells is induced by palmitic acid
            through the STAT5-PI3K/Akt pathway and features the chronic
            inflammatory profiles of type 2 diabetes
  JOURNAL   Cell Death Dis 10 (8), 559 (2019)
   PUBMED   31332162
  REMARK    GeneRIF: SLAMF3 expression is upregulated on T cells from type 2
            diabetes patients and associated with T-cell activation and
            cytokine production.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Sayos,J., Martin,M., Chen,A., Simarro,M., Howie,D., Morra,M.,
            Engel,P. and Terhorst,C.
  TITLE     Cell surface receptors Ly-9 and CD84 recruit the X-linked
            lymphoproliferative disease gene product SAP
  JOURNAL   Blood 97 (12), 3867-3874 (2001)
   PUBMED   11389028
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   de la Fuente,M.A., Tovar,V., Villamor,N., Zapater,N., Pizcueta,P.,
            Campo,E., Bosch,J. and Engel,P.
  TITLE     Molecular characterization and expression of a novel human
            leukocyte cell-surface marker homologous to mouse Ly-9
  JOURNAL   Blood 97 (11), 3513-3520 (2001)
   PUBMED   11369645
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Tovar,V., de la Fuente,M.A., Pizcueta,P., Bosch,J. and Engel,P.
  TITLE     Gene structure of the mouse leukocyte cell surface molecule Ly9
  JOURNAL   Immunogenetics 51 (10), 788-793 (2000)
   PUBMED   10970093
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Sandrin,M.S., Henning,M.M., Lo,M.F., Baker,E., Sutherland,G.R. and
            McKenzie,I.F.
  TITLE     Isolation and characterization of cDNA clones for Humly9: the human
            homologue of mouse Ly9
  JOURNAL   Immunogenetics 43 (1-2), 13-19 (1996)
   PUBMED   8537117
REFERENCE   10 (bases 1 to 2421)
  AUTHORS   Kingsmore,S.F., Souryal,C.A., Watson,M.L., Patel,D.D. and
            Seldin,M.F.
  TITLE     Physical and genetic linkage of the genes encoding Ly-9 and CD48 on
            mouse and human chromosomes 1
  JOURNAL   Immunogenetics 42 (1), 59-62 (1995)
   PUBMED   7797269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292048.1 and BC062589.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002348.3.
            
            Summary: LY9 belongs to the SLAM family of immunomodulatory
            receptors (see SLAMF1; MIM 603492) and interacts with the adaptor
            molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed
            16365421]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292048.1, AF244129.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263285.11/ ENSP00000263285.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2059              AK292048.1         1-2059
            2060-2421           BC062589.1         1102-1463
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2421
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /note="lymphocyte antigen 9"
                     /db_xref="GeneID:4063"
                     /db_xref="HGNC:HGNC:6730"
                     /db_xref="MIM:600684"
     exon            1..138
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1982
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; T-lymphocyte surface antigen Ly-9; cell surface
                     molecule Ly-9; SLAM family member 3; signaling lymphocytic
                     activation molecule 3"
                     /codon_start=1
                     /product="T-lymphocyte surface antigen Ly-9 isoform a
                     precursor"
                     /protein_id="NP_002339.2"
                     /db_xref="CCDS:CCDS30916.1"
                     /db_xref="GeneID:4063"
                     /db_xref="HGNC:HGNC:6730"
                     /db_xref="MIM:600684"
                     /translation="MVAPKSHTDDWAPGPFSSKPQRSQLQIFSSVLQTSLLFLLMGLR
                     ASGKDSAPTVVSGILGGSVTLPLNISVDTEIENVIWIGPKNALAFARPKENVTIMVKS
                     YLGRLDITKWSYSLCISNLTLNDAGSYKAQINQRNFEVTTEEEFTLFVYEQLQEPQVT
                     MKSVKVSENFSCNITLMCSVKGAEKSVLYSWTPREPHASESNGGSILTVSRTPCDPDL
                     PYICTAQNPVSQRSSLPVHVGQFCTDPGASRGGTTGETVVGVLGEPVTLPLALPACRD
                     TEKVVWLFNTSIISKEREEAATADPLIKSRDPYKNRVWVSSQDCSLKISQLKIEDAGP
                     YHAYVCSEASSVTSMTHVTLLIYRRLRKPKITWSLRHSEDGICRISLTCSVEDGGNTV
                     MYTWTPLQKEAVVSQGESHLNVSWRSSENHPNLTCTASNPVSRSSHQFLSENICSGPE
                     RNTKLWIGLFLMVCLLCVGIFSWCIWKRKGRCSVPAFCSSQAEAPADTPEPTAGHTLY
                     SVLSQGYEKLDTPLRPARQQPTPTSDSSSDSNLTTEEDEDRPEVHKPISGRYEVFDQV
                     TQEGAGHDPAPEGQADYDPVTPYVTEVESVVGENTMYAQVFNLQGKTPVSQKEESSAT
                     IYCSIRKPQVVPPPQQNDLEIPESPTYENFT"
     exon            139..468
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..744
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1086
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1356
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1458
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1512
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1844
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1913
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2421
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2403..2408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /note="hexamer: AATAAA"
     polyA_site      2421
                     /gene="LY9"
                     /gene_synonym="CD229; hly9; mLY9; SLAMF3"
                     /note="major polyA site"
ORIGIN      
        1 gaaaatagat catcatggtg gcaccaaaga gtcacacaga tgactgggct cctgggcctt
       61 tctccagtaa gccacagagg agtcagctgc aaatattctc ttctgttcta cagacctctc
      121 tcctcttcct gctcatggga ctaagagcct ctggaaagga ctcagcccca acagtggtgt
      181 cagggatcct agggggttcc gtgactctcc ccctaaacat ctcagtagac acagagattg
      241 agaacgtcat ctggattggt cccaaaaatg ctcttgcttt cgcacgtccc aaagaaaatg
      301 taaccattat ggtcaaaagc tacctgggcc gactagacat caccaagtgg agttactccc
      361 tgtgcatcag caatctgact ctgaatgatg caggatccta caaagcccag ataaaccaaa
      421 ggaattttga agtcaccact gaggaggaat tcaccctgtt cgtctatgag cagctgcagg
      481 agccccaagt caccatgaag tctgtgaagg tgtctgagaa cttctcctgt aacatcactc
      541 taatgtgctc cgtgaagggg gcagagaaaa gtgttctgta cagctggacc ccaagggaac
      601 cccatgcttc tgagtccaat ggaggctcca ttcttaccgt ctcccgaaca ccatgtgacc
      661 cagacctgcc atacatctgc acagcccaga accccgtcag ccagagaagc tccctccctg
      721 tccatgttgg gcagttctgt acagatccag gagcctccag aggaggaaca acgggggaga
      781 ctgtggtagg ggtcctggga gagccagtca ccctgccact tgcactccca gcctgccggg
      841 acacagagaa ggttgtctgg ttgtttaaca catccatcat tagcaaagag agggaagaag
      901 cagcaacggc agatccactc attaaatcca gggatcctta caagaacagg gtgtgggtct
      961 ccagccagga ctgctccctg aagatcagcc agctgaagat agaggacgcc ggcccctacc
     1021 atgcctacgt gtgctcagag gcctccagcg tcaccagcat gacacatgtc accctgctca
     1081 tctaccgcag gctgaggaag cccaaaatca cgtggagcct caggcacagt gaggatggca
     1141 tctgcaggat cagcctgacc tgctccgtgg aggacggggg aaacactgtc atgtacacat
     1201 ggaccccgct gcagaaggaa gctgttgtgt cccaagggga atcacacctc aatgtctcat
     1261 ggagaagcag tgaaaatcac cccaacctca catgcacagc cagcaaccct gtcagcagga
     1321 gttcccacca gtttctttct gagaacatct gttcaggacc tgagagaaac acaaagcttt
     1381 ggattgggtt gttcctgatg gtttgccttc tgtgcgttgg gatcttcagc tggtgcattt
     1441 ggaagcgaaa aggacggtgt tcagtcccag ccttctgttc cagccaagct gaggccccag
     1501 cggatacacc agaacccaca gctggccaca cgctatactc tgtgctctcc caaggatatg
     1561 agaagctgga cactcccctc aggcctgcca ggcaacagcc tacacccacc tcagacagca
     1621 gctctgacag caacctcaca actgaggagg atgaggacag gcctgaggtg cacaagccca
     1681 tcagtggaag atatgaggta tttgaccagg tcactcagga gggcgctgga catgacccag
     1741 cccctgaggg ccaagcagac tatgatcccg tcactccata tgtcacggaa gttgagtctg
     1801 tggttggaga gaacaccatg tatgcacaag tgttcaactt acagggaaag accccagttt
     1861 ctcagaagga agagagctca gccacaatct actgctccat acggaaacct caggtggtgc
     1921 caccaccaca acagaatgat cttgagattc ctgaaagtcc tacctatgaa aatttcacct
     1981 gaaaggaaaa gcagctgctg cctctctcct gggaccgtgg ggttggaaag tcagctggac
     2041 ctcatggggc ctggggctca cagacagaag cacctcagaa tttccttcag tgcctcagag
     2101 atgcctggat gtggcccctc cccctccttc tcacccttaa ggactcccaa acccattaat
     2161 agttcagaca caggctcctt cttggagcct atgggcttca gatgtctttg ccccatttgt
     2221 cacctcgcac acttatagcg tttcctcctc gaaattctac caagactggt caaatgttgc
     2281 tgaggggcct ggaccagctg tcctttacac caccttctca acactgctga aaagaaccca
     2341 agagaattgt cacacatgac acaagatgta cataatatca tgctcactgc agtgttattt
     2401 aaaataaaag gcaggaaata a
//
