LOCUS       NM_004271                859 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lymphocyte antigen 86 (LY86), mRNA.
ACCESSION   NM_004271
VERSION     NM_004271.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 859)
  AUTHORS   Zhao,M., Liu,A., Mo,L., Wan,G., Lu,F., Chen,L., Fu,S., Chen,H.,
            Fu,T. and Deng,H.
  TITLE     Higher expression of PLEK and LY86 as the potential biomarker of
            carotid atherosclerosis
  JOURNAL   Medicine (Baltimore) 102 (42), e34445 (2023)
   PUBMED   37861500
  REMARK    GeneRIF: Higher expression of PLEK and LY86 as the potential
            biomarker of carotid atherosclerosis.
REFERENCE   2  (bases 1 to 859)
  AUTHORS   Biswas,M., Yamazaki,T., Tomono,S., Karnan,S., Takagi,H.,
            Ichimonji,I., Inui,M., Nagaoka,F., Hosokawa,Y. and
            Akashi-Takamura,S.
  TITLE     Cell surface expression of human RP105 depends on N-glycosylation
            of MD-1
  JOURNAL   FEBS Lett 596 (24), 3211-3231 (2022)
   PUBMED   35849076
REFERENCE   3  (bases 1 to 859)
  AUTHORS   Salviano-Silva,A., Farias,T.D.J., Bumiller-Bini,V., Castro,M.S.,
            Lobo-Alves,S.C., Busch,H., Pfohler,C., Worm,M., Goebeler,M., van
            Beek,N., Franke,A., Wittig,M., Zillikens,D., de Almeida,R.C.,
            Hundt,J.E., Boldt,A.B.W., Ibrahim,S., Augusto,D.G.,
            Petzl-Erler,M.L., Schmidt,E. and Malheiros,D.
  TITLE     Genetic variability of immune-related lncRNAs: polymorphisms in
            LINC-PINT and LY86-AS1 are associated with pemphigus foliaceus
            susceptibility
  JOURNAL   Exp Dermatol 30 (6), 831-840 (2021)
   PUBMED   33394553
  REMARK    GeneRIF: Genetic variability of immune-related lncRNAs:
            polymorphisms in LINC-PINT and LY86-AS1 are associated with
            pemphigus foliaceus susceptibility.
REFERENCE   4  (bases 1 to 859)
  AUTHORS   de Vries,D.H., Matzaraki,V., Bakker,O.B., Brugge,H., Westra,H.J.,
            Netea,M.G., Franke,L., Kumar,V. and van der Wijst,M.G.P.
  TITLE     Integrating GWAS with bulk and single-cell RNA-sequencing reveals a
            role for LY86 in the anti-Candida host response
  JOURNAL   PLoS Pathog 16 (4), e1008408 (2020)
   PUBMED   32251450
  REMARK    GeneRIF: LY86 knockdown results in reduced monocyte migration
            towards the chemokine MCP-1, thereby implying that this reduced
            migration may underlie the increased susceptibility to candidemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 859)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 859)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 859)
  AUTHORS   Ogata,H., Su,I., Miyake,K., Nagai,Y., Akashi,S., Mecklenbrauker,I.,
            Rajewsky,K., Kimoto,M. and Tarakhovsky,A.
  TITLE     The toll-like receptor protein RP105 regulates lipopolysaccharide
            signaling in B cells
  JOURNAL   J Exp Med 192 (1), 23-29 (2000)
   PUBMED   10880523
REFERENCE   8  (bases 1 to 859)
  AUTHORS   Begum,N.A., Tsuji,S., Nomura,M., Shida,K., Azuma,I., Hayashi,A.,
            Matsumoto,M., Seya,T. and Toyoshima,K.
  TITLE     Human MD-1 homologue is a BCG-regulated gene product in monocytes:
            its identification by differential display
  JOURNAL   Biochem Biophys Res Commun 256 (2), 325-329 (1999)
   PUBMED   10079183
REFERENCE   9  (bases 1 to 859)
  AUTHORS   Miura,Y., Shimazu,R., Miyake,K., Akashi,S., Ogata,H., Yamashita,Y.,
            Narisawa,Y. and Kimoto,M.
  TITLE     RP105 is associated with MD-1 and transmits an activation signal in
            human B cells
  JOURNAL   Blood 92 (8), 2815-2822 (1998)
   PUBMED   9763566
REFERENCE   10 (bases 1 to 859)
  AUTHORS   Miyake,K., Shimazu,R., Kondo,J., Niki,T., Akashi,S., Ogata,H.,
            Yamashita,Y., Miura,Y. and Kimoto,M.
  TITLE     Mouse MD-1, a molecule that is physically associated with RP105 and
            positively regulates its expression
  JOURNAL   J Immunol 161 (3), 1348-1353 (1998)
   PUBMED   9686597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD695164.1 and BC038846.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004271.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.310014.1,
                                           SRR1163658.254199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230568.5/ ENSP00000230568.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               CD695164.1         84-591
            509-859             BC038846.1         538-888
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.1"
     gene            1..859
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /note="lymphocyte antigen 86"
                     /db_xref="GeneID:9450"
                     /db_xref="HGNC:HGNC:16837"
                     /db_xref="MIM:605241"
     exon            1..151
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..504
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /note="MD-1, RP105-associated; ly-86; protein MD-1"
                     /codon_start=1
                     /product="lymphocyte antigen 86 precursor"
                     /protein_id="NP_004262.1"
                     /db_xref="CCDS:CCDS4498.1"
                     /db_xref="GeneID:9450"
                     /db_xref="HGNC:HGNC:16837"
                     /db_xref="MIM:605241"
                     /translation="MKGFTATLFLWTLIFPSCSGGGGGKAWPTHVVCSDSGLEVLYQS
                     CDPLQDFGFSVEKCSKQLKSNINIRFGIILREDIKELFLDLALMSQGSSVLNFSYPIC
                     EAALPKFSFCGRRKGEQIYYAGPVNNPEFTIPQGEYQVLLELYTEKRSTVACANATIM
                     CS"
     exon            152..238
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..367
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..420
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..859
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      839..844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /note="hexamer: AATAAA"
     polyA_site      859
                     /gene="LY86"
                     /gene_synonym="dJ80N2.1; MD-1; MD1; MMD-1"
                     /note="major polyA site"
ORIGIN      
        1 atacaggccc ccaccatgaa gggtttcaca gccactctct tcctctggac tctgattttt
       61 cccagctgca gtggaggcgg cggtgggaaa gcctggccca cacacgtggt ctgtagcgac
      121 agcggcttgg aagtgctcta ccagagttgc gatccattac aagattttgg cttttctgtt
      181 gaaaagtgtt ccaagcaatt aaaatcaaat atcaacatta gatttggaat tattctgaga
      241 gaggacatca aagagctttt tcttgaccta gctctcatgt ctcaaggctc atctgttttg
      301 aatttctcct atcccatctg tgaggcggct ctgcccaagt tttctttctg tggaagaagg
      361 aaaggagagc agatttacta tgctgggcct gtcaataatc ctgaatttac tattcctcag
      421 ggagaatacc aggttttgct ggaactgtac actgaaaaac ggtccaccgt ggcctgtgcc
      481 aatgctacta tcatgtgctc ctgactgtgg cctgtagcaa aaatcacagc cagctgcatc
      541 tcgtgggacc tccaagctcc tctgactgaa cctactgtgg gaggagaagc agctgatgac
      601 agagagaggc tctacaaaga agcgccccca aagagtgcag ctgctaattt tagtcccagg
      661 accagacatc cccagactcc acagatgtaa tgaagtcccc gaatgtatct gtttctaagg
      721 agcctcttgg cagtccttaa gcagtcttga gggtccatcc tttttctcta attggtcgcc
      781 tcccaccaga ctcacctgct tttcaacttt ttaggagtgc ttcctcacag ttaccaagaa
      841 taaagaaagc tggccacca
//
