LOCUS       NM_001406478            2834 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member S (LY6S),
            transcript variant 2, mRNA.
ACCESSION   NM_001406478
VERSION     NM_001406478.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2834)
  AUTHORS   Liu,D., Xu,C., Liu,Y., Ouyang,W., Lin,S., Xu,A., Zhang,Y., Xie,Y.,
            Huang,Q., Zhao,W., Chen,Z., Wang,L., Chen,S., Huang,J., Wu,Z.B. and
            Sun,X.
  TITLE     A systematic survey of LU domain-containing proteins reveals a
            novel human gene, LY6A, which encodes the candidate ortholog of
            mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors
  JOURNAL   Front Med 17 (3), 458-475 (2023)
   PUBMED   36928550
REFERENCE   2  (bases 1 to 2834)
  AUTHORS   Shmerling,M., Chalik,M., Smorodinsky,N.I., Meeker,A., Roy,S.,
            Sagi-Assif,O., Meshel,T., Danilevsky,A., Shomron,N., Levinger,S.,
            Nishry,B., Baruchi,D., Shargorodsky,A., Ziv,R.,
            Sarusi-Portuguez,A., Lahav,M., Ehrlich,M., Braschi,B., Bruford,E.,
            Witz,I.P. and Wreschner,D.H.
  TITLE     LY6S, a New IFN-Inducible Human Member of the Ly6a Subfamily
            Expressed by Spleen Cells and Associated with Inflammation and
            Viral Resistance
  JOURNAL   Immunohorizons 6 (4), 253-272 (2022)
   PUBMED   35440514
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083982.13.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000706920.2/
                                                ENSP00000516627.1
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC083982.13        56085-56222         c
            139-217             AC083982.13        55793-55871         c
            218-334             AC083982.13        55196-55312         c
            335-2834            AC083982.13        51351-53850         c
FEATURES             Location/Qualifiers
     source          1..2834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2834
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /note="lymphocyte antigen 6 family member S"
                     /db_xref="GeneID:105375795"
                     /db_xref="HGNC:HGNC:54397"
     exon            1..138
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /inference="alignment:Splign:2.1.0"
     exon            139..217
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..552
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /note="Lymphocyte antigen 6S"
                     /codon_start=1
                     /product="lymphocyte antigen 6S precursor"
                     /protein_id="NP_001393407.1"
                     /db_xref="GeneID:105375795"
                     /db_xref="HGNC:HGNC:54397"
                     /translation="MSSLQAMKTLSLVLLVALLSMERAQGLRCYRCLAVLEGASCSVV
                     SCPFLDGVCVSQKVSVFGSKVRGENKLSLLSCQKDVGFPLLKLTSAVVDSQISCCKGD
                     LCNAVVLAASSPWALCVQLLLSLGSVFLWALL"
     exon            218..334
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /inference="alignment:Splign:2.1.0"
     exon            335..2834
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2834
                     /gene="LY6S"
                     /gene_synonym="LY6A"
                     /note="major polyA site"
ORIGIN      
        1 ctctctctgg caagcctgca gggcaagtgg ctgagaatca gccagaggga ggaaagtgag
       61 gaggggtgga ccaggcctgg gagggtcctg ggtgggggcg ctaaggagag gaggtgcagt
      121 acagccatgg ggctctggca ccctggaatg agcagtctcc aggccatgaa gaccttgtcc
      181 ctggtcctgc tggtggccct gctgagcatg gagagagctc agggtctgcg ctgctacaga
      241 tgcttggcgg tcttggaagg ggcctcctgc agcgtggtct cgtgcccctt cctggatggg
      301 gtctgtgtct cccagaaagt gagcgtcttt ggcagtaaag tgagagggga gaacaagctc
      361 tccctcctct cctgccagaa ggacgtcgga ttccccctgc tgaaacttac aagtgccgtt
      421 gtggactccc agatctcttg ctgcaaggga gacctctgca atgcggtggt cctggcagcc
      481 agcagcccct gggccctgtg cgtacagctc ctgctcagcc tggggtcagt cttcctctgg
      541 gccctgctgt gagggccttt cccgccctct cccccgcagg cctaccctct gtccctgtgc
      601 gtcaccagct gcttggtttt gaagagctgc ctcactgaat tgcaggaatt ctggtgtggc
      661 ttttcagcca tgagatcagg ggaaggatgt ggccagggca gaggtcgggg cttccctgtc
      721 agggaacata tccctgctta aactccttgt cctctgggcc caggccctcc agcccatgcc
      781 ccccaacaac accacttttt tcagagctgg gcctcagaga ccaggcccca ccactggctg
      841 cttgggacct agggtcatag agaaaccgtg gcccagggcg ggagtcccca gctccatcca
      901 gcttgccact aacttgccga ggagccaggg ccaacccctc agctctctgg gctacctgaa
      961 tccaagcaag gagggaacgt ggtcccaggg ggccctgctg gcctcccaca caggatgagg
     1021 gcctccctct caaggtcaac aaacagccct ttgctgaccc actcagcgtc agcactcggc
     1081 ttcttcctca ccattcctga ggccgcccac ctgccactct gacctcaggc ctctgcaaca
     1141 tcctgctggc accatggcct tggggaggtg ctcctggggc acgggtgccc ccccagggac
     1201 cagaacccac agagtgccag gctcatggct cttctggcag aactcttgcc atgtggctcc
     1261 agggaacatc tgagtagggt tgtcagagag cctctggatg gtcaccaaga ggcagagctc
     1321 ctgcggccac cagccatcct gtggtgtggg ccaggcctgt catttctgtg ccctggctag
     1381 ggctcccatg atgccccgtg tcaggggtta gactggtctc ccctggtggt gggagaaagg
     1441 ggctccttca ggactgcact ctggacagaa agtcagggct gggctcagaa tggtctgggt
     1501 ggacggtcat ctcagcctgg agtcagggct gggctgagaa cgccctgggt ggacggtcgt
     1561 ctcagcctgg agtcagggct gggctgagaa cgccctgggt ggacggccgt ctcagcctgg
     1621 agtcagggct gggctgagaa cgccctgggt ggacggccgt ctcagcctgg agtcagggct
     1681 gggctgagaa cgccctgggt ggacggccgt ctcagcctgg agtcagggct gggctgagaa
     1741 cgccctgggt ggacggccgt ctcagcctgg agtcagggct gggctgagaa cgccctgggt
     1801 ggacggccgt ctcagcctgg agtcagggct gggctcagaa cagtctgggt ggacggctat
     1861 tgtcagggac cccaaacaga gggaccggct gaagccatgg aagaagaaca taaattgtga
     1921 agatttcatg gacatttatt agttccccaa attaatactt ttataatttc ttatgcctgt
     1981 ctttactgca atctctgaac ataaattgtg aagatttcat ggacacttat cacttcccca
     2041 atcaataccc ttgtgatttc ctatgcctgt ctttaatctt ttaatcccat catcttcgta
     2101 agctgaggag gatgtatatt gcctcaggac cctgtgatga ttgtgttaac tgcacaaatt
     2161 gtttgcagag catgtgtgtt tgaacaatat gaaatctggg taccttgaaa aaagaacagg
     2221 gtaacagcaa cgttcaggga acaagagaga tcaccttaaa ctctggttgc ctgtgagcca
     2281 ggtgaaacag agccatattt ctcttctttc aaaagcaaat aggagaaata tcgctgaatt
     2341 ctttttctca gcaaggaaca tccctgagaa agagaatgta tccctaaggg gaggcctctg
     2401 aaatgtctgc tttggggacg gctgcctttt acagttgtag ataagggatg aaataagccc
     2461 cagtctcccg cagtgctccc aggcttatta ggatgaggaa attcccgcct aataaatttt
     2521 ggtcagactg gttgtctgct ctcaaaccct gtctcctgat aagatgttat caatgacaat
     2581 gtgtgcccaa aacttcatta gcaattttaa tttcgccccg gtcccgtggt cctgtgatct
     2641 cgccctgcct ccgtttgcct tgtgatatct tattaccttg tgaagcatgt gatctctgtg
     2701 acccacatcc tatttgtaca ctccctcccc ttctgaaaat cactaataaa aatttgctgg
     2761 ttttacggct cagggggcat cacggaacct gccgacatgt gatgtctccc ccggacgccc
     2821 agctttgaaa tttc
//
