LOCUS       NM_017527               2671 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member K (LY6K),
            transcript variant 1, mRNA.
ACCESSION   NM_017527
VERSION     NM_017527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Xu,C., Gong,R. and Yang,H.
  TITLE     Upregulation of LY6K induced by FTO-mediated demethylation promotes
            the tumorigenesis and metastasis of oral squamous cell carcinoma
            via CAV-1-mediated ERK1/2 signaling activation
  JOURNAL   Histol Histopathol 39 (10), 1359-1370 (2024)
   PUBMED   38469708
  REMARK    GeneRIF: Upregulation of LY6K induced by FTO-mediated demethylation
            promotes the tumorigenesis and metastasis of oral squamous cell
            carcinoma via CAV-1-mediated ERK1/2 signaling activation.
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Park,S., Park,D., Han,S., Chung,G.E., Soh,S., Ka,H.I., Joo,H.J. and
            Yang,Y.
  TITLE     LY6K depletion modulates TGF-beta and EGF signaling
  JOURNAL   Cancer Med 12 (11), 12593-12607 (2023)
   PUBMED   37076981
  REMARK    GeneRIF: LY6K depletion modulates TGF-beta and EGF signaling.
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Selvanesan,B.C., Varghese,S., Andrys-Olek,J., Arriaza,R.H.,
            Prakash,R., Tiwari,P.B., Hupalo,D., Gusev,Y., Patel,M.N.,
            Contente,S., Sanda,M., Uren,A., Wilkerson,M.D., Dalgard,C.L.,
            Shimizu,L.S., Chruszcz,M., Borowski,T. and Upadhyay,G.
  TITLE     Lymphocyte antigen 6K signaling to aurora kinase promotes
            advancement of the cell cycle and the growth of cancer cells, which
            is inhibited by LY6K-NSC243928 interaction
  JOURNAL   Cancer Lett 558, 216094 (2023)
   PUBMED   36805500
  REMARK    GeneRIF: Lymphocyte antigen 6K signaling to aurora kinase promotes
            advancement of the cell cycle and the growth of cancer cells, which
            is inhibited by LY6K-NSC243928 interaction.
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Geng,L., Wang,Z. and Tian,Y.
  TITLE     Down-regulation of ZNF252P-AS1 alleviates ovarian cancer
            progression by binding miR-324-3p to downregulate LY6K
  JOURNAL   J Ovarian Res 15 (1), 1 (2022)
   PUBMED   34980214
  REMARK    GeneRIF: Down-regulation of ZNF252P-AS1 alleviates ovarian cancer
            progression by binding miR-324-3p to downregulate LY6K.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Ali,M.M., Di Marco,M., Mahale,S., Jachimowicz,D., Kosalai,S.T.,
            Reischl,S., Statello,L., Mishra,K., Darnfors,C., Kanduri,M. and
            Kanduri,C.
  TITLE     LY6K-AS lncRNA is a lung adenocarcinoma prognostic biomarker and
            regulator of mitotic progression
  JOURNAL   Oncogene 40 (13), 2463-2478 (2021)
   PUBMED   33674747
  REMARK    GeneRIF: LY6K-AS lncRNA is a lung adenocarcinoma prognostic
            biomarker and regulator of mitotic progression.
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2671)
  AUTHORS   Ishikawa,N., Takano,A., Yasui,W., Inai,K., Nishimura,H., Ito,H.,
            Miyagi,Y., Nakayama,H., Fujita,M., Hosokawa,M., Tsuchiya,E.,
            Kohno,N., Nakamura,Y. and Daigo,Y.
  TITLE     Cancer-testis antigen lymphocyte antigen 6 complex locus K is a
            serologic biomarker and a therapeutic target for lung and
            esophageal carcinomas
  JOURNAL   Cancer Res 67 (24), 11601-11611 (2007)
   PUBMED   18089789
  REMARK    GeneRIF: Useful as a tumor biomarker and probably as a target for
            the development of new molecular therapies for cancer treatment.
REFERENCE   8  (bases 1 to 2671)
  AUTHORS   Suda,T., Tsunoda,T., Daigo,Y., Nakamura,Y. and Tahara,H.
  TITLE     Identification of human leukocyte antigen-A24-restricted epitope
            peptides derived from gene products upregulated in lung and
            esophageal cancers as novel targets for immunotherapy
  JOURNAL   Cancer Sci 98 (11), 1803-1808 (2007)
   PUBMED   17784873
  REMARK    GeneRIF: Data show that TTK protein kinase, lymphocyte antigen 6
            complex locus K and insulin-like growth factor (IGF)-II mRNA
            binding protein 3 are tumor-associated antigens recognized by
            cytotoxic T lymphocytes and HLA-A24-restricted epitope peptides.
REFERENCE   9  (bases 1 to 2671)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 2671)
  AUTHORS   de Nooij-van Dalen,A.G., van Dongen,G.A., Smeets,S.J.,
            Nieuwenhuis,E.J., Stigter-van Walsum,M., Snow,G.B. and
            Brakenhoff,R.H.
  TITLE     Characterization of the human Ly-6 antigens, the newly annotated
            member Ly-6K included, as molecular markers for head-and-neck
            squamous cell carcinoma
  JOURNAL   Int J Cancer 103 (6), 768-774 (2003)
   PUBMED   12516096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG491223.1, BC001291.1 and AC108002.3.
            
            On May 17, 2019 this sequence version replaced NM_017527.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: A downstream translational start codon is selected
            for this RefSeq based on its better conservation in mammalian
            species, on a strong Kozak signal, and on the presence of a
            predicted signal peptide in the protein N-terminus. Studies in
            PMID:18089789 support the secretion of this protein. An upstream
            in-frame start codon is also present but has a weaker Kozak signal
            and is poorly conserved. The use of the upstream start codon would
            result in a protein that lacks a predicted signal peptide and is 58
            aa longer at the N-terminus. Leaky scanning by ribosomes may allow
            translation initiation at the downstream start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.10957.1,
                                           SRR1660803.145998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000292430.10/
                                                ENSP00000292430.6
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               BG491223.1         1-374
            375-1714            BC001291.1         1-1340
            1715-2671           AC108002.3         26992-27948         c
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2671
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /note="lymphocyte antigen 6 family member K"
                     /db_xref="GeneID:54742"
                     /db_xref="HGNC:HGNC:24225"
                     /db_xref="MIM:615093"
     exon            1..520
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..915
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cancer/testis antigen 97; lymphocyte antigen
                     6K; up-regulated in lung cancer 10; lymphocyte antigen 6
                     complex, locus K"
                     /codon_start=1
                     /product="lymphocyte antigen 6K isoform 1 precursor"
                     /protein_id="NP_059997.3"
                     /db_xref="CCDS:CCDS6385.2"
                     /db_xref="GeneID:54742"
                     /db_xref="HGNC:HGNC:24225"
                     /db_xref="MIM:615093"
                     /translation="MALLALLLVVALPRVWTDANLTARQRDPEDSQRTDEGDNRVWCH
                     VCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRF
                     LLEEPMPFFYLKCCKIRYCNLEGPPINSSVFKEYAGSMGESCGGLWLAILLLLASIAA
                     GLSLS"
     exon            521..634
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /inference="alignment:Splign:2.1.0"
     exon            635..2671
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      984..989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /note="hexamer: ATTAAA"
     polyA_site      1007
                     /gene="LY6K"
                     /gene_synonym="CT97; HSJ001348; ly-6K; URLC10"
                     /note="major polyA site"
ORIGIN      
        1 gagttatcag aggtgagccc gtgctcttca gcggagaaga tcccctacct ggccgccggc
       61 cactttctgt gggccgtggg gtcctcaagg agacggccct tgggctcagg ggctgcgttt
      121 ccacacgcgc ctttcccagg gctcccgcgc ccgttcctgc ctggccgccg gccgctccaa
      181 cagcagcaca aggcgggact cagaaccggc gttcagggcc gccagcggcc gcgaggccct
      241 gagatgaggc tccaaagacc ccgacaggcc ccggcgggtg ggaggcgcgc gccccggggc
      301 gggcggggct ccccctaccg gccagacccg gggagaggcg cgcggaggct gcgaaggttc
      361 cagaagggcg gggagggggc gccgcgcgct gaccctccct gggcaccgct ggggacgatg
      421 gcgctgctcg ccttgctgct ggtcgtggcc ctaccgcggg tgtggacaga cgccaacctg
      481 actgcgagac aacgagatcc agaggactcc cagcgaacgg acgagggtga caatagagtg
      541 tggtgtcatg tttgtgagag agaaaacact ttcgagtgcc agaacccaag gaggtgcaaa
      601 tggacagagc catactgcgt tatagcggcc gtgaaaatat ttccacgttt tttcatggtt
      661 gcgaagcagt gctccgctgg ttgtgcagcg atggagagac ccaagccaga ggagaagcgg
      721 tttctcctgg aagagcccat gcccttcttt tacctcaagt gttgtaaaat tcgctactgc
      781 aatttagagg ggccacctat caactcatca gtgttcaaag aatatgctgg gagcatgggt
      841 gagagctgtg gtgggctgtg gctggccatc ctcctgctgc tggcctccat tgcagccggc
      901 ctcagcctgt cttgagccac gggactgcca cagactgagc cttccggagc atggactcgc
      961 tccagaccgt tgtcacctgt tgcattaaac ttgttttctg ttgattacct cttggtttga
     1021 cttcccaggg tcttgggatg ggagagtggg gatcaggtgc agttggctct taaccctcaa
     1081 gggttcttta actcacattc agaggaagtc cagatctcct gagtagtgat tttggtgaca
     1141 agtttttctc tttgaaatca aaccttgtaa ctcatttatt gctgatggcc actcttttcc
     1201 ttgactcccc tctgcctctg agggcttcag tattgatggg gagggaggcc taagtaccac
     1261 tcatggagag tatgtgctga gatgcttccg acctttcagg tgacgcagga acactggggg
     1321 agtctgaatg attggggtga agacatccct ggagtgaagg actcctcagc atggggggca
     1381 gtggggcaca cgttagggct gcccccattc cagtggtgga ggcgctgtgg atggctgctt
     1441 ttcctcaacc tttcctacca gattccagga ggcagaagat aactaattgt gttgaagaaa
     1501 cttagacttc acccaccagc tggcacaggt gcacagattc ataaattccc acacgtgtgt
     1561 gttcaacatc tgaaacttag gccaagtaga gagcatcagg gtaaatggcg ttcatttctc
     1621 tgttaagatg cagccatcca tggggagctg agaaatcaga ctcaaagttc caccaaaaac
     1681 aaatacaagg ggacttcaaa agttcacgaa aaaattgaat taaaagataa aaattaaaaa
     1741 atgttttatt tctcagcatg agctccatca aggtcgagac gcttctgcaa gtaatggtac
     1801 cagccattca gttcatccct aaagaattgg gcaccctggg aatttaacca tgccacttca
     1861 gtctttgtga cgttattaac tgaagaaaag tgggtgccct ttaaagattt tttaaaatta
     1921 taaaacagaa gtaaccaaat caggcctgga aggtgtatgc ctagtgattt cccattgaaa
     1981 ctctcacaaa actggccttg tttgatgaga ggaatgagca ggagcattgt catggtggag
     2041 aagggctctc tggtgaagct ttccggggtg acgatttcct gggtgttttc ctgctaaatc
     2101 gttggctgac tttctctata cactctcata ataagatgtt actgttcttt ggccctccag
     2161 aaagtcaata agcaagatgc cttgagcatt cacaaaacgg ttgccacgac ctttgccctt
     2221 gacatgtctg cttttactct gatgggacca cgcccacctc taggtagtca ttgctttgct
     2281 tgtgctttgc cttcaggagt gtactggtta agccacattt catctccggc tataattata
     2341 tgaagaaatg cttcaggatc ttgattccac ttgtttaaaa tggccataga acgcttttct
     2401 cttatctgca gctgagctgg gagaaagttt tggcacccac cgagtggaca gtttactcaa
     2461 ctttaatttc agtcagaatt gtgtaagctg aacaccttgg gatacctaca gcgttggcta
     2521 ttgtttctgc tgctattaat cagtcctctt aaattagggc acaaacaaga tgaattgttt
     2581 cctcacagac tgatgtggct ggcctgctgc tgtggacttc ctctccaaca tcatctcttc
     2641 tcttcttcca atgagttatc cacttactta a
//
