LOCUS       NM_001135655             942 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member H (LY6H),
            transcript variant 3, mRNA.
ACCESSION   NM_001135655
VERSION     NM_001135655.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 942)
  AUTHORS   Wu,M., Liu,C.Z., Barrall,E.A., Rissman,R.A. and Joiner,W.J.
  TITLE     Unbalanced Regulation of alpha7 nAChRs by Ly6h and NACHO
            Contributes to Neurotoxicity in Alzheimer's Disease
  JOURNAL   J Neurosci 41 (41), 8461-8474 (2021)
   PUBMED   34446574
  REMARK    GeneRIF: Unbalanced Regulation of alpha7 nAChRs by Ly6h and NACHO
            Contributes to Neurotoxicity in Alzheimer's Disease.
REFERENCE   2  (bases 1 to 942)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 942)
  AUTHORS   Horie,M., Okutomi,K., Taniguchi,Y., Ohbuchi,Y., Suzuki,M. and
            Takahashi,E.
  TITLE     Isolation and characterization of a new member of the human Ly6
            gene family (LY6H)
  JOURNAL   Genomics 53 (3), 365-368 (1998)
   PUBMED   9799603
REFERENCE   4  (bases 1 to 942)
  AUTHORS   LeClair,K.P., Palfree,R.G., Flood,P.M., Hammerling,U. and
            Bothwell,A.
  TITLE     Isolation of a murine Ly-6 cDNA reveals a new multigene family
  JOURNAL   EMBO J 5 (12), 3227-3234 (1986)
   PUBMED   3028776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB502453.1 and BC030192.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001135655.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region, compared to variant 1, resulting in an isoform (b)
            that is longer at the N-terminus, compared to isoform a. Both
            variants 2 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028894.1, ERR279837.6913.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342752.9/ ENSP00000342711.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DB502453.1         31-89
            60-942              BC030192.1         1-883
FEATURES             Location/Qualifiers
     source          1..942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..942
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /note="lymphocyte antigen 6 family member H"
                     /db_xref="GeneID:4062"
                     /db_xref="HGNC:HGNC:6728"
                     /db_xref="MIM:603625"
     exon            1..124
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..608
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; lymphocyte antigen 6H; ly-6H; lymphocyte
                     antigen 6 complex, locus H"
                     /codon_start=1
                     /product="lymphocyte antigen 6H isoform b precursor"
                     /protein_id="NP_001129127.1"
                     /db_xref="CCDS:CCDS47926.1"
                     /db_xref="GeneID:4062"
                     /db_xref="HGNC:HGNC:6728"
                     /db_xref="MIM:603625"
                     /translation="MLAPQRTRAPSPRAAPRPTRSMLPAAMKGLGLALLAVLLCSAPA
                     HGLWCQDCTLTTNSSHCTPKQCQPSDTVCASVRITDPSSSRKDHSVNKMCASSCDFVK
                     RHFFSDYLMGFINSGILKVDVDCCEKDLCNGAAGAGHSPWALAGGLLLSLGPALLWAG
                     P"
     exon            125..252
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /inference="alignment:Splign:2.1.0"
     exon            253..372
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /inference="alignment:Splign:2.1.0"
     exon            373..942
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      919..924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /note="hexamer: AATAAA"
     polyA_site      942
                     /gene="LY6H"
                     /gene_synonym="NMLY6"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcggct gcgttccccg aaagacgagg ctgcgcccgg attccggtcc gcagggagac
       61 cgaagggcac agctccccgc gccgcgcacg ccgcccgagc ccggagtgcg gacacccccg
      121 ggatgcttgc gccccagagg acccgcgccc caagcccccg cgccgccccc aggcccaccc
      181 ggagcatgct gcctgcagcc atgaagggcc tcggcctggc gctgctggcc gtcctgctgt
      241 gctcggcgcc cgctcatggc ctgtggtgcc aggactgcac cctgaccacc aactccagcc
      301 attgcacccc aaagcagtgc cagccgtccg acacggtgtg tgccagtgtc cgaatcaccg
      361 atcccagcag cagcaggaag gatcactcgg tgaacaagat gtgtgcctcc tcctgtgact
      421 tcgttaagcg acactttttc tcagactatc tgatggggtt tattaactct gggatcttaa
      481 aggtcgacgt ggactgctgc gagaaggatt tgtgcaatgg ggcggcaggg gcagggcaca
      541 gcccctgggc cctggccggg gggctcctgc tcagcctggg gcctgccctc ctctgggctg
      601 ggccctgatg tctcctcctt cccacggggc ttctgagctt gctcccctga gcctgtggct
      661 gccctctccc cagcctggcg tggctggggc tgggggcagc cttggcccag ctccgtggct
      721 gtggcctgtg gctctcactc ctcccccgac gtgaagcctc cctgtctctc cgccagctct
      781 gagtcccagg cagctggaca tctccaggaa accaggccat ctgggcagga ggcctgggga
      841 tgagggtggg gggggacccc caggtcccgg aggggaagtg aagcaacagc ccagctggaa
      901 gggcgtcttc tgcggagaaa taaagtcact tttgagtcct ga
//
