LOCUS       NM_001353334            1305 bp    mRNA    linear   PRI 27-OCT-2020
DEFINITION  Homo sapiens LY6G6F-LY6G6D readthrough (LY6G6F-LY6G6D), mRNA.
ACCESSION   NM_001353334
VERSION     NM_001353334.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1305)
  AUTHORS   Calvanese V, Mallya M, Campbell RD and Aguado B.
  TITLE     Regulation of expression of two LY-6 family genes by intron
            retention and transcription induced chimerism
  JOURNAL   BMC Mol Biol 9, 81 (2008)
   PUBMED   18817541
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662899.5 and KU253636.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001353334.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring LY6G6F (lymphocyte antigen 6
            family member G6F) and LY6G6D (lymphocyte antigen 6 family member
            G6D) genes on chromosome 6. The readthrough transcript encodes a
            fusion protein that shares sequence identity with each individual
            gene product. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195764.1, KU253636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529, SAMN03465405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 58530, 259215
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL662899.5         49207-49209
            4-1223              KU253636.1         1-1220
            1224-1305           AL662899.5         60179-60260
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1305
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /note="LY6G6F-LY6G6D readthrough"
                     /db_xref="GeneID:110599563"
                     /db_xref="HGNC:HGNC:38821"
     exon            1..93
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1190
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /note="megakaryocyte-enhanced gene transcript 1 protein"
                     /codon_start=1
                     /product="LY6G6F-LY6G6D protein precursor"
                     /protein_id="NP_001340263.1"
                     /db_xref="CCDS:CCDS87383.1"
                     /db_xref="GeneID:110599563"
                     /db_xref="HGNC:HGNC:38821"
                     /translation="MAVLFLLLFLCGTPQAADNMQAIYVALGEAVELPCPSPPTLHGD
                     EHLSWFCSPAAGSFTTLVAQVQVGRPAPDPGKPGRESRLRLLGNYSLWLEGSKEEDAG
                     RYWCAVLGQHHNYQNWRVYDVLVLKGSQLSARAADGSPCNVLLCSVVPSRRMDSVTWQ
                     EGKGPVRGRVQSFWGSEAALLLVCPGEGLSEPRSRRPRIIRCLMTHNKGVSFSLAASI
                     DASPALCAPSTGWDMPWILMLLLTMGQGVVILALSIVLWRQRVRGAPGRGNRMRCYNC
                     GGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNPPVTLIHQHPACVAAHHCNQVETESV
                     GDVTYPAHRDCYLGDLCNSAVASHVAPAGILAAAATALTCLLPGLWSG"
     exon            94..423
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..687
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..843
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..966
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1305
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1283..1288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /note="hexamer: ATTAAA"
     polyA_site      1305
                     /gene="LY6G6F-LY6G6D"
                     /gene_synonym="G6F-LY6G6D; MEGT-1; MEGT1"
                     /note="major polyA site"
ORIGIN      
        1 acaccaggtc ttggagcaag agaacttggc aggctctccc catggcagtc ttattcctcc
       61 tcctgttcct atgtggaact ccccaggctg cagacaacat gcaggccatc tatgtggcct
      121 tgggggaggc agtagagctg ccatgtccct caccacctac tctacatggg gacgaacacc
      181 tgtcatggtt ctgcagccct gcagcaggct ccttcaccac cctggtagcc caagtccaag
      241 tgggcaggcc agccccagac cctggaaaac caggaaggga atccaggctc agactgctgg
      301 ggaactattc tttgtggttg gagggatcca aagaggaaga tgccgggcgg tactggtgcg
      361 ctgtgctagg tcagcaccac aactaccaga actggagggt gtacgacgtc ttggtgctca
      421 aaggatccca gttatctgca agggctgcag atggatcccc ctgcaatgtc ctcctgtgct
      481 ctgtggtccc cagcagacgc atggactctg tgacctggca ggaagggaag ggtcccgtga
      541 ggggccgtgt tcagtccttc tggggcagtg aggctgccct gctcttggtg tgtcctgggg
      601 aggggctttc tgagcccagg agccgaagac caagaatcat ccgctgcctc atgactcaca
      661 acaaaggggt cagctttagc ctggcagcct ccatcgatgc ttctcctgcc ctctgtgccc
      721 cttccacggg ctgggacatg ccttggattc tgatgctgct gctcacaatg ggccagggag
      781 ttgtcatcct ggccctcagc atcgtgctct ggaggcagag ggtccgtggg gctccaggca
      841 gaggaaaccg aatgcggtgc tacaactgtg gtggaagccc cagcagttct tgcaaagagg
      901 ccgtgaccac ctgtggcgag ggcagacccc agccaggcct ggaacagatc aagctacctg
      961 gaaacccccc agtgaccttg attcaccaac atccagcctg cgtcgcagcc catcattgca
     1021 atcaagtgga gacagagtcg gtgggagacg tgacttatcc agcccacagg gactgctacc
     1081 tgggagacct gtgcaacagc gccgtggcaa gccatgtggc ccctgcaggc attttggctg
     1141 cagcagctac cgccctgacc tgtctcttgc caggactgtg gagcggatag ggggagtagg
     1201 agtagagaag ggaacaaggg agcaagggaa caagggacat ctgaacatct aatgtgagaa
     1261 gagaaacatc cttctgtgag tcattaaaat ctatgaacca ctcta
//
