LOCUS       NM_021246                525 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member G6D (LY6G6D), mRNA.
ACCESSION   NM_021246
VERSION     NM_021246.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 525)
  AUTHORS   Naqvi,M., Abbasi,W.A., Samma,M.K., Gabol,A.A., Innocent,C.,
            Iqbal,S., Fatima,S. and Ali,K.
  TITLE     Decoding LY6G6D in colorectal cancer: Unraveling biomarker
            potential and therapeutic insights
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (6), 14-20 (2024)
   PUBMED   38836687
  REMARK    GeneRIF: Decoding LY6G6D in colorectal cancer: Unraveling biomarker
            potential and therapeutic insights.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 525)
  AUTHORS   Corrales,L., Hipp,S., Martin,K., Sabarth,N., Tirapu,I., Fuchs,K.,
            Thaler,B., Walterskirchen,C., Bauer,K., Fabits,M., Bergmann,M.,
            Binder,C., Chetta,P.M., Vogt,A.B. and Adam,P.J.
  TITLE     LY6G6D is a selectively expressed colorectal cancer antigen that
            can be used for targeting a therapeutic T-cell response by a T-cell
            engager
  JOURNAL   Front Immunol 13, 1008764 (2022)
   PUBMED   36159851
  REMARK    GeneRIF: LY6G6D is a selectively expressed colorectal cancer
            antigen that can be used for targeting a therapeutic T-cell
            response by a T-cell engager.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 525)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 525)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 525)
  AUTHORS   Giordano,G., Parcesepe,P., D'Andrea,M.R., Coppola,L., Di Raimo,T.,
            Remo,A., Manfrin,E., Fiorini,C., Scarpa,A., Amoreo,C.A.,
            Conciatori,F., Milella,M., Caruso,F.P., Cerulo,L., Porras,A. and
            Pancione,M.
  TITLE     JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex,
            locus G6D (LY6G6D) expression drives mismatch repair proficient
            colorectal cancer
  JOURNAL   J Exp Clin Cancer Res 38 (1), 28 (2019)
   PUBMED   30670049
  REMARK    GeneRIF: Combined targeting of STAT5 and MAPK pathways has superior
            therapeutic effects on immune resistance. In addition, the new
            identified LY6G6D antigen is a promising molecular target for human
            microsatellite-stable colorectal cancers
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 525)
  AUTHORS   Beliakov,I.S., Karakasheva,T.A. and Mazurenko,N.N.
  TITLE     [Detection of LY6G6D gene exon-intron structure,]
  JOURNAL   Mol Biol (Mosk) 43 (4), 590-598 (2009)
   PUBMED   19807019
  REMARK    GeneRIF: Frequencies of the DRB1, DQA1, DQB1 and TNFA alleles in
            immigrant population of West Siberia
REFERENCE   7  (bases 1 to 525)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 525)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Characterization of the five novel Ly-6 superfamily members encoded
            in the MHC, and detection of cells expressing their potential
            ligands
  JOURNAL   Protein Sci 15 (10), 2244-2256 (2006)
   PUBMED   17008713
REFERENCE   9  (bases 1 to 525)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Transcriptional analysis of a novel cluster of LY-6 family members
            in the human and mouse major histocompatibility complex: five genes
            with many splice forms
  JOURNAL   Genomics 80 (1), 113-123 (2002)
   PUBMED   12079290
REFERENCE   10 (bases 1 to 525)
  AUTHORS   Ribas,G., Neville,M., Wixon,J.L., Cheng,J. and Campbell,R.D.
  TITLE     Genes encoding three new members of the leukocyte antigen 6
            superfamily and a novel member of Ig superfamily, together with
            genes encoding the regulatory nuclear chloride ion channel protein
            (hRNCC) and an N omega-N omega-dimethylarginine
            dimethylaminohydrolase homologue, are found in a 30-kb segment of
            the MHC class III region
  JOURNAL   J Immunol 163 (1), 278-287 (1999)
   PUBMED   10384126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662899.5.
            
            On Nov 24, 2020 this sequence version replaced NM_021246.3.
            
            Summary: LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6)
            genes located in the major histocompatibility complex (MHC) class
            III region on chromosome 6. Members of the LY6 superfamily
            typically contain 70 to 80 amino acids, including 8 to 10
            cysteines. Most LY6 proteins are attached to the cell surface by a
            glycosylphosphatidylinositol (GPI) anchor that is directly involved
            in signal transduction (Mallya et al., 2002 [PubMed
            12079290]).[supplied by OMIM, Apr 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KU253638.1, AJ315535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375825.8/ ENSP00000364985.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL662899.5         57689-57751
            64-186              AL662899.5         57843-57965
            187-525             AL662899.5         59922-60260
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..525
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /note="lymphocyte antigen 6 family member G6D"
                     /db_xref="GeneID:58530"
                     /db_xref="HGNC:HGNC:13935"
                     /db_xref="MIM:606038"
     exon            1..63
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..410
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /note="lymphocyte antigen-6 G6D; lymphocyte antigen 6
                     complex locus protein G6d; protein Ly6-D;
                     megakaryocyte-enhanced gene transcript 1 protein;
                     lymphocyte antigen 6 complex, locus G6D"
                     /codon_start=1
                     /product="lymphocyte antigen 6 complex locus protein G6d
                     precursor"
                     /protein_id="NP_067069.2"
                     /db_xref="CCDS:CCDS34404.1"
                     /db_xref="GeneID:58530"
                     /db_xref="HGNC:HGNC:13935"
                     /db_xref="MIM:606038"
                     /translation="MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGE
                     GRPQPGLEQIKLPGNPPVTLIHQHPACVAAHHCNQVETESVGDVTYPAHRDCYLGDLC
                     NSAVASHVAPAGILAAAATALTCLLPGLWSG"
     exon            64..186
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /inference="alignment:Splign:2.1.0"
     exon            187..525
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      503..508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /note="hexamer: ATTAAA"
     polyA_site      525
                     /gene="LY6G6D"
                     /gene_synonym="C6orf23; G6D; LY6-D; MEGT1; NG25"
                     /note="major polyA site"
ORIGIN      
        1 agactgcgat gaaaccccag tttgttggga tcttgctcag ctccctgcta ggggctgcct
       61 tgggaaaccg aatgcggtgc tacaactgtg gtggaagccc cagcagttct tgcaaagagg
      121 ccgtgaccac ctgtggcgag ggcagacccc agccaggcct ggaacagatc aagctacctg
      181 gaaacccccc agtgaccttg attcaccaac atccagcctg cgtcgcagcc catcattgca
      241 atcaagtgga gacagagtcg gtgggagacg tgacttatcc agcccacagg gactgctacc
      301 tgggagacct gtgcaacagc gccgtggcaa gccatgtggc ccctgcaggc attttggctg
      361 cagcagctac cgccctgacc tgtctcttgc caggactgtg gagcggatag ggggagtagg
      421 agtagagaag ggaacaaggg agcaagggaa caagggacat ctgaacatct aatgtgagaa
      481 gagaaacatc cttctgtgag tcattaaaat ctatgaacca ctcta
//
