LOCUS       NM_025261                893 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member G6C (LY6G6C), mRNA.
ACCESSION   NM_025261
VERSION     NM_025261.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 893)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 893)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 893)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 893)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 893)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Characterization of the five novel Ly-6 superfamily members encoded
            in the MHC, and detection of cells expressing their potential
            ligands
  JOURNAL   Protein Sci 15 (10), 2244-2256 (2006)
   PUBMED   17008713
REFERENCE   6  (bases 1 to 893)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   7  (bases 1 to 893)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Transcriptional analysis of a novel cluster of LY-6 family members
            in the human and mouse major histocompatibility complex: five genes
            with many splice forms
  JOURNAL   Genomics 80 (1), 113-123 (2002)
   PUBMED   12079290
REFERENCE   8  (bases 1 to 893)
  AUTHORS   Ribas,G., Neville,M., Wixon,J.L., Cheng,J. and Campbell,R.D.
  TITLE     Genes encoding three new members of the leukocyte antigen 6
            superfamily and a novel member of Ig superfamily, together with
            genes encoding the regulatory nuclear chloride ion channel protein
            (hRNCC) and an N omega-N omega-dimethylarginine
            dimethylaminohydrolase homologue, are found in a 30-kb segment of
            the MHC class III region
  JOURNAL   J Immunol 163 (1), 278-287 (1999)
   PUBMED   10384126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662899.5, AY359119.1 and BC036302.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025261.2.
            
            Summary: LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6)
            genes located in the major histocompatibility complex (MHC) class
            III region on chromosome 6. Members of the LY6 superfamily
            typically contain 70 to 80 amino acids, including 8 to 10
            cysteines. Most LY6 proteins are attached to the cell surface by a
            glycosylphosphatidylinositol (GPI) anchor that is directly involved
            in signal transduction (Mallya et al., 2002 [PubMed
            12079290]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036302.1, AY359119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375819.3/ ENSP00000364978.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL662899.5         64076-64087         c
            13-892              AY359119.1         1-880
            893-893             BC036302.1         856-856
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..893
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /note="lymphocyte antigen 6 family member G6C"
                     /db_xref="GeneID:80740"
                     /db_xref="HGNC:HGNC:13936"
                     /db_xref="MIM:610435"
     exon            1..119
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..445
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /note="lymphocyte antigen-6 G6C; lymphocyte antigen 6
                     complex locus protein G6c; lymphocyte antigen 6 complex,
                     locus G6C"
                     /codon_start=1
                     /product="lymphocyte antigen 6 complex locus protein G6c
                     precursor"
                     /protein_id="NP_079537.1"
                     /db_xref="CCDS:CCDS4714.1"
                     /db_xref="GeneID:80740"
                     /db_xref="HGNC:HGNC:13936"
                     /db_xref="MIM:610435"
                     /translation="MKALMLLTLSVLLCWVSADIRCHSCYKVPVLGCVDRQSCRLEPG
                     QQCLTTHAYLGKMWVFSNLRCGTPEEPCQEAFNQTNRKLGLTYNTTCCNKDNCNSAGP
                     RPTPALGLVFLTSLAGLGLWLLH"
     exon            120..230
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /inference="alignment:Splign:2.1.0"
     exon            231..893
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      560..565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /note="hexamer: ATTAAA"
     polyA_site      581
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
     regulatory      875..880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /note="hexamer: AATAAA"
     polyA_site      893
                     /gene="LY6G6C"
                     /gene_synonym="C6orf24; G6c; NG24"
                     /note="major polyA site"
ORIGIN      
        1 agagctggat ccttgaaaat ctactctatc agctgctgtg gttgccacca ttctcaggac
       61 cctcgccatg aaagccctta tgctgctcac cctgtctgtt ctgctctgct gggtctcagc
      121 tgacattcgc tgtcactcct gctacaaggt ccctgtgctg ggctgtgtgg accggcagtc
      181 ctgccgcctg gagccaggac agcaatgcct gacaacacat gcataccttg gtaagatgtg
      241 ggttttctcc aatctgcgct gtggcacacc agaagagccc tgtcaggagg ccttcaacca
      301 aaccaaccgc aagctgggtc tgacatataa caccacctgc tgcaacaagg acaactgcaa
      361 cagcgcagga ccccggccca ctccagccct gggccttgtc ttccttacct ccttggctgg
      421 ccttggcctc tggctgctgc actgagactc attccattgg ctgcccctcc tcccacctgc
      481 cttggcctga gcctctctcc ctgtgtctct gtatcccctg gctttacaga atcgtctctc
      541 cctagctccc atttctttaa ttaaacactg ttccgagtgg tctcctcatc catccttccc
      601 acctcacacc cttcactctc ctttttctgg gtcccttccc acttccttcc aggacctcca
      661 ttggctccta gaagggctcc ccactttgct tcctatactc tgctgtcccc tacttgagga
      721 gggattggga tctgggcctg aaatggggct tctgtgttgt ccccagtgaa ggctcccaca
      781 aggacctgat gacctcactg tacagagctg actccccaaa cccaggctcc catatgtacc
      841 ccatccccca tactcacctc tttccatttt gagtaataaa tgtctgagtc tga
//
