LOCUS       NM_025262               1420 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member G5C (LY6G5C), mRNA.
ACCESSION   NM_025262
VERSION     NM_025262.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Harney,S.M., Vilarino-Guell,C., Adamopoulos,I.E., Sims,A.M.,
            Lawrence,R.W., Cardon,L.R., Newton,J.L., Meisel,C., Pointon,J.J.,
            Darke,C., Athanasou,N., Wordsworth,B.P. and Brown,M.A.
  TITLE     Fine mapping of the MHC Class III region demonstrates association
            of AIF1 and rheumatoid arthritis
  JOURNAL   Rheumatology (Oxford) 47 (12), 1761-1767 (2008)
   PUBMED   18835879
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Characterization of the five novel Ly-6 superfamily members encoded
            in the MHC, and detection of cells expressing their potential
            ligands
  JOURNAL   Protein Sci 15 (10), 2244-2256 (2006)
   PUBMED   17008713
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Transcriptional analysis of a novel cluster of LY-6 family members
            in the human and mouse major histocompatibility complex: five genes
            with many splice forms
  JOURNAL   Genomics 80 (1), 113-123 (2002)
   PUBMED   12079290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662899.5.
            
            On Jul 8, 2021 this sequence version replaced NM_025262.3.
            
            Summary: LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6)
            genes located in the major histocompatibility complex (MHC) class
            III region on chromosome 6. Members of the LY6 superfamily
            typically contain 70 to 80 amino acids, including 8 to 10
            cysteines. Most LY6 proteins are attached to the cell surface by a
            glycosylphosphatidylinositol (GPI) anchor that is directly involved
            in signal transduction (Mallya et al., 2002 [PubMed
            12079290]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ315542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383237.5/ ENSP00000372724.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-815               AL662899.5         22594-23408         c
            816-983             AL662899.5         21442-21609         c
            984-1420            AL662899.5         19025-19461         c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1420
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /note="lymphocyte antigen 6 family member G5C"
                     /db_xref="GeneID:80741"
                     /db_xref="HGNC:HGNC:13932"
                     /db_xref="MIM:610434"
     exon            1..815
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /inference="alignment:Splign:2.1.0"
     CDS             695..1147
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /note="lymphocyte antigen-6 G5C; lymphocyte antigen 6
                     complex locus protein G5c; lymphocyte antigen 6 complex,
                     locus G5C"
                     /codon_start=1
                     /product="lymphocyte antigen 6 complex locus protein G5c
                     precursor"
                     /protein_id="NP_079538.3"
                     /db_xref="CCDS:CCDS34401.2"
                     /db_xref="GeneID:80741"
                     /db_xref="HGNC:HGNC:13932"
                     /db_xref="MIM:610434"
                     /translation="MRFMAGPAGSQSLGPLCFHSSPQALYTVLLIVLVMMSLVFGKFV
                     PVNWEPPQPLPFPKYLRCYRCLLETKELGCLLGSDICLTPAGSSCITLHKKNSSGSDV
                     MVSDCRSKEQMSDCSNTRTSPVSGFWIFSQYCFLDFCNDPQNRGLYTP"
     exon            816..983
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1420
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="LY6G5C"
                     /gene_synonym="C6orf20; G5C; LY6G5CA; LY6G5CB; NG33"
                     /note="major polyA site"
ORIGIN      
        1 agacagacca catgtttcct atcttggaaa atggtaccac ttccttgtgc aagcctaccc
       61 ctgttccctc acccctcgtt cagtccaaca gcaaatctgt ccagtcttct aactgtatct
      121 caggttcatt agccccgctt cctcgtccct gctcgtcttc tgccggacca gtccgccatc
      181 ttgtgaccgg actcgggaat agcgtcctac ttcccggcgg cctccactct tgacccaaat
      241 gcaatgtgca gccatggcaa tcttttataa acagaaatcc gatcaagtta ctcctctgcc
      301 gaaatccctc tggtcagtgg tttaactgtc gaggtgctcc tggcagcact ctgccctccc
      361 cacatcattg ctggtggact tgtctcccct actagactgt gccctgtgag ggtggagact
      421 ttgtgcaggg ttgtatcccc agcatctgat gcagtgattc aataaacatc tgtccaatta
      481 ataggaaaga cagttccttt tctcattccc ctattgctgg tcccctgccc tcaagcagga
      541 tgttatgccc cagagtggct gtgggtgcga acattctgcc cctctggctg gtctggcact
      601 gatttccacc ctgagctggt gttgcctctc tccttcctct tggccaacct ctcttccacc
      661 aatataagcc caaactggag gccagcaggc agtcatgcgt tttatggcag gccctgcagg
      721 gagccagagt ctgggtcccc tgtgcttcca cagcagcccc caagccctct acacggtcct
      781 cttaatagtg ctggtcatga tgagcttggt gtttggtaag tttgttcctg tcaattggga
      841 accccctcaa ccacttccat tccccaaata cctgcgctgc taccgatgcc tcttggagac
      901 caaggagtta gggtgccttc tgggatctga catctgcctc accccagctg gcagcagctg
      961 catcactctc cacaaaaaga acagcagcgg ttctgacgtc atggtgagtg actgccgaag
     1021 taaggagcag atgagtgatt gttcaaatac ccgaacttct ccggtgtctg gcttctggat
     1081 attctctcaa tactgcttcc tggatttctg caatgaccct caaaacagag ggctctatac
     1141 tccttagtgt gactgcagca aactttggtg taaaattcca ccagtttcca gccaccttcc
     1201 tgacttctat ctgggcttgg ccaggacttc tagtccctca taccagccct ccttgcctcc
     1261 ctccagccac tggaccccag ccttggctct tcctcttggt tgacgccctt cagcacactt
     1321 actgctactc tgtaccccca gccctactgc ccaccaggtt tcctctcttg tcccctagtc
     1381 cctggatgtt tctcccaaat aaatttgtgt gtaaactgtt
//
