LOCUS       NM_021221               2845 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens lymphocyte antigen 6 family member G5B (LY6G5B), mRNA.
ACCESSION   NM_021221
VERSION     NM_021221.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2845)
  AUTHORS   Hernandez-Torres,F., Rastrojo,A. and Aguado,B.
  TITLE     Intron retention and transcript chimerism conserved across mammals:
            Ly6g5b and Csnk2b-Ly6g5b as examples
  JOURNAL   BMC Genomics 14, 199 (2013)
   PUBMED   23521802
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2845)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 2845)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2845)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2845)
  AUTHORS   Valdes,A.M. and Thomson,G.
  CONSRTM   Type 1 Diabetes Genetics Consortium
  TITLE     Several loci in the HLA class III region are associated with T1D
            risk after adjusting for DRB1-DQB1
  JOURNAL   Diabetes Obes Metab 11 Suppl 1 (Suppl 1), 46-52 (2009)
   PUBMED   19143814
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2845)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2845)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2845)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Characterization of the five novel Ly-6 superfamily members encoded
            in the MHC, and detection of cells expressing their potential
            ligands
  JOURNAL   Protein Sci 15 (10), 2244-2256 (2006)
   PUBMED   17008713
REFERENCE   9  (bases 1 to 2845)
  AUTHORS   Mallya,M., Campbell,R.D. and Aguado,B.
  TITLE     Transcriptional analysis of a novel cluster of LY-6 family members
            in the human and mouse major histocompatibility complex: five genes
            with many splice forms
  JOURNAL   Genomics 80 (1), 113-123 (2002)
   PUBMED   12079290
REFERENCE   10 (bases 1 to 2845)
  AUTHORS   Albertella,M.R., Jones,H., Thomson,W., Olavesen,M.G. and
            Campbell,R.D.
  TITLE     Localization of eight additional genes in the human major
            histocompatibility complex, including the gene encoding the casein
            kinase II beta subunit (CSNK2B)
  JOURNAL   Genomics 36 (2), 240-251 (1996)
   PUBMED   8812450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662899.5.
            
            On Jul 8, 2021 this sequence version replaced NM_021221.2.
            
            Summary: LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6)
            genes located in the major histocompatibility complex (MHC) class
            III region on chromosome 6. Members of the LY6 superfamily
            typically contain 70 to 80 amino acids, including 8 to 10
            cysteines. Most LY6 proteins are attached to the cell surface by a
            glycosylphosphatidylinositol (GPI) anchor that is directly involved
            in signal transduction (Mallya et al., 2002 [PubMed
            12079290]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289364.1, ERR4352443.11927.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375864.5/ ENSP00000365024.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1033              AL662899.5         12317-13349
            1034-1162           AL662899.5         13497-13625
            1163-2845           AL662899.5         14205-15887
FEATURES             Location/Qualifiers
     source          1..2845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2845
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /note="lymphocyte antigen 6 family member G5B"
                     /db_xref="GeneID:58496"
                     /db_xref="HGNC:HGNC:13931"
                     /db_xref="MIM:610433"
     exon            1..1033
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             976..1581
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /note="lymphocyte antigen 6 complex locus protein G5b;
                     lymphocyte antigen 6 complex, locus G5B"
                     /codon_start=1
                     /product="lymphocyte antigen 6 complex locus protein G5b
                     precursor"
                     /protein_id="NP_067044.2"
                     /db_xref="CCDS:CCDS34400.1"
                     /db_xref="GeneID:58496"
                     /db_xref="HGNC:HGNC:13931"
                     /db_xref="MIM:610433"
                     /translation="MKVHMLVGVLVMVGFTVGKVPVPDIRTCHFCLVEDPSVGCISGS
                     EKCTISSSSLCMVITIYYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYD
                     YCNSWSSPQLQSSLPEPHDRPLALPLSDSQIQWFYQALNLSLPLPNFHAGTEPDGLDP
                     MVTLSLNLGLSFAELRRMYLFLNSSGLLVLPQAGLLTPHPS"
     exon            1034..1162
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..2845
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2823..2828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /note="hexamer: AATAAA"
     polyA_site      2845
                     /gene="LY6G5B"
                     /gene_synonym="C6orf19; G5b"
                     /note="major polyA site"
ORIGIN      
        1 ccaccctttc aggaaccctg tatggttttt agtttaaatt aaaggagtcg ttatcgtggt
       61 gggaatatga aataaagtag aagaaaaggc catgagctag tctgctggtg cttgctgttg
      121 gggaagggaa ggtgatggtg tgttggactc caggggccct catggcccag cccaccctcc
      181 ccagattgaa aaccaggaca gatttgtgct cagtggattg ggtggtgttt ttagtatgga
      241 gcagaacaga attcctagga ctgcgtgtga tgaaatgcaa ggtcaaaagg aaaagacaaa
      301 gcatatttca aagatgagaa atatttgttt ggatatctat gactgtctgt ttatactgta
      361 aggggcttaa tcagcagctc catcttttag ttttagttct aaaggaaaag tagcctaaag
      421 tcagtataac taaagggtgg aacgaggtgg gacaaggtcc ggaattgctg ctcagtgatg
      481 tgtgtgtgcc tgccgctggt ggagctgaga ctgctcatct cagaaggatg gggatgcttg
      541 atttcctggc caggttgtcc cagcacagtg gggattggcc ctgttgtatg acgaagacag
      601 cacatggtgg cagagataga tactaaccca tggactttcc aagggaggga ataggtcttt
      661 ggagggtatg caagacaaag gtagacactg gataaagaac ccggtagtgc ccaggtatta
      721 ccccatctgg gccattactc ccacactcag gaaccagacg ttgtgggtga ggacatgctg
      781 tccctcctgc caagtaataa cttccttccc agccaggatc ctgccccaag taggaatata
      841 gctctgcatt tacagcagct cctgctcaga ccttgtcaaa accaccctgc agcttaggat
      901 taaggagcat ggtcacagga aggtggggtt tcagggcatc ccctcaggaa ctgcccatct
      961 ccccagaatt ccaaaatgaa ggtccatatg cttgtaggtg tgctggtcat ggtgggcttc
     1021 acagtaggaa aggttcctgt tcccgacatc cggacgtgcc acttctgcct cgtagaagac
     1081 ccttctgtag gatgcatttc aggctcagag aagtgtacca tcagcagctc atccctgtgc
     1141 atggtgatca ccatctatta tgatgtcaag gttcgcttca tcgttcgagg ctgtggacag
     1201 tacatttcct accgctgcca agaaaaacgc aacacctact ttgcagagta ctggtatcag
     1261 gcccagtgct gtcagtacga ttattgcaac tcctggtcaa gcccccaact ccagagctct
     1321 ctgccggagc cccatgacag gcccctggcc ctgcctctgt ctgactccca gattcagtgg
     1381 ttctaccagg ccctgaacct ctccctgccc ctccccaatt tccatgctgg gacggagcct
     1441 gatggcctgg accccatggt cacactgtcc ctgaacctgg gcttgtcttt tgctgagctg
     1501 cgccgcatgt acttgttcct caatagttca ggacttttgg ttcttcccca ggctggactc
     1561 ttgacacctc acccttcctg aattccacag tgcaaatatc tttctgtaac accctcagca
     1621 tcctgcactg ccctctctga aaacacccac attctttggt cactgtgatt tcttaggcct
     1681 ccgtctgttg taccactagc atctatatga cttttgtgta attttctctc ttgaactctg
     1741 gtgctgtttt tttgtttgtt tgagacaaag tctcgctctg tcacccaggg tggagtgcag
     1801 tggcatgatc tctgctcact acaacctcca cctcccgggt tccagcgatt ctcctgcctc
     1861 agcctcccga gtagctggga ctacaggcgt gcaccaccac gcctggctaa ttttttgtat
     1921 ttttagtaga gacggggttt caccatgttg gtcaggctgg tctcgaactc ctgacctcgt
     1981 aatctgccct cctcgacctc ccaaagtgcc gggattacag gtgtgagcca ctgtgcctgt
     2041 ctgagctctg gtgctgttct tccccctaga aaagaatctc tagtgtggat tctgcccaga
     2101 caggctgacc tgagaaaggc acagtggttc ctccattcct tccccatcat ctgagtgttc
     2161 cagtatcccc catccctctc aatccagtca cctgcctatt gacatctagc tctgtttccc
     2221 ctgtcttgtc catgtctcta agacccagta ccagactgaa ctagcagcaa gaaggacgag
     2281 gaggccgggc atggtggctc acgccggtaa tcccagcact ttgggaggcc gaggtgggcg
     2341 gatcacttga gattgggagt ttgagaccag cctggccaac atggtaaaac ccgctctcta
     2401 ttaaaaatag aaaaatcagc tgggtgtggt ggcacacctc tgtaatccca gctactcagg
     2461 aggctgagac aggagaatca cttgaacccg ggaggcagag gttgcagtga gccgagatcg
     2521 cgccactgca ctccagcctg ggtgacacag tgagactccg tctccaaaaa aaaggatgag
     2581 gaatagaatt ctgtgcagat gtcctgactt ggcaattttg tgtccctgcc tcactgtctc
     2641 caccaacccc cgcctgtcct agtgttgttc tgcctcctgt cctctcttgc tctcttgtca
     2701 gtctctggct tcctcggccc catttcactt cactgagtcc tgacacccat ctccctaggg
     2761 gcctgtgaga ggagagggaa gggtctgttc tgctcagctc catgtccccc attttcctcc
     2821 acaataaact gggactgggc taaaa
//
