LOCUS       NM_173800               4604 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens laeverin (LVRN), mRNA.
ACCESSION   NM_173800
VERSION     NM_173800.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4604)
  AUTHORS   Zhang,E.T., Hannibal,R.L., Badillo Rivera,K.M., Song,J.H.T.,
            McGowan,K., Zhu,X., Meinhardt,G., Knofler,M., Pollheimer,J.,
            Urban,A.E., Folkins,A.K., Lyell,D.J. and Baker,J.C.
  TITLE     PRG2 and AQPEP are misexpressed in fetal membranes in placenta
            previa and percretadagger
  JOURNAL   Biol Reprod 105 (1), 244-257 (2021)
   PUBMED   33982062
  REMARK    GeneRIF: PRG2 and AQPEP are misexpressed in fetal membranes in
            placenta previa and percretadagger.
REFERENCE   2  (bases 1 to 4604)
  AUTHORS   Feng,X., Wei,Z., Zhang,S., Zhou,J., Wu,J., Luan,B., Du,Y. and
            Zhao,H.
  TITLE     Overexpression of LVRN impedes the invasion of trophoblasts by
            inhibiting epithelial-mesenchymal transition
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (2), 249-257 (2021)
   PUBMED   33355358
  REMARK    GeneRIF: Overexpression of LVRN impedes the invasion of
            trophoblasts by inhibiting epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 4604)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4604)
  AUTHORS   Pihl,K., Sorensen,S., Nystad,M., Acharya,G. and Jorgensen,F.S.
  TITLE     Maternal serum laeverin (aminopeptidase Q) measured in the first
            trimester of pregnancy does not predict preeclampsia
  JOURNAL   J Matern Fetal Neonatal Med 32 (20), 3348-3351 (2019)
   PUBMED   29681208
  REMARK    GeneRIF: First trimester maternal serum laeverin level cannot be
            used to predict preeclampsia.
REFERENCE   5  (bases 1 to 4604)
  AUTHORS   Nystad,M., Sitras,V., Nordbakken,C.V., Pedersen,M.I. and Acharya,G.
  TITLE     Laeverin protein expression in normal and preeclamptic placentas
            using tissue microarray analysis
  JOURNAL   Acta Obstet Gynecol Scand 97 (5), 536-544 (2018)
   PUBMED   29355889
  REMARK    GeneRIF: Laeverin is expressed in all trophoblast cell types of
            normal and preeclamptic placentas. Expression pattern of laeverin
            in trophoblast cells is heterogeneous and not necessarily
            membrane-bound.
REFERENCE   6  (bases 1 to 4604)
  AUTHORS   Johnson,M.P., Roten,L.T., Dyer,T.D., East,C.E., Forsmo,S.,
            Blangero,J., Brennecke,S.P., Austgulen,R. and Moses,E.K.
  TITLE     The ERAP2 gene is associated with preeclampsia in Australian and
            Norwegian populations
  JOURNAL   Hum Genet 126 (5), 655-666 (2009)
   PUBMED   19578876
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4604)
  AUTHORS   Maruyama,M., Hattori,A., Goto,Y., Ueda,M., Maeda,M., Fujiwara,H.
            and Tsujimoto,M.
  TITLE     Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine
            aminopeptidase belonging to the M1 family of aminopeptidases
  JOURNAL   J Biol Chem 282 (28), 20088-20096 (2007)
   PUBMED   17525158
  REMARK    GeneRIF: is a novel bestatin-sensitive leucine aminopeptidase;
            plays important roles in human placentation by regulating
            biological activity of key peptides at the embryo-maternal
            interface
REFERENCE   8  (bases 1 to 4604)
  AUTHORS   Haas,C.S., Creighton,C.J., Pi,X., Maine,I., Koch,A.E., Haines,G.K.,
            Ling,S., Chinnaiyan,A.M. and Holoshitz,J.
  TITLE     Identification of genes modulated in rheumatoid arthritis using
            complementary DNA microarray analysis of lymphoblastoid B cell
            lines from disease-discordant monozygotic twins
  JOURNAL   Arthritis Rheum 54 (7), 2047-2060 (2006)
   PUBMED   16804865
  REMARK    GeneRIF: The 3 most significantly overexpressed genes in rheumatoid
            arthritis were laeverin, 11beta-hydroxysteroid dehydrogenase type 2
            (a steroid pathway enzyme), and cysteine-rich, angiogenic inducer
            61 (a known angiogenic factor).
REFERENCE   9  (bases 1 to 4604)
  AUTHORS   Fujiwara,H., Higuchi,T., Sato,Y., Nishioka,Y., Zeng,B.X.,
            Yoshioka,S., Tatsumi,K., Ueda,M. and Maeda,M.
  TITLE     Regulation of human extravillous trophoblast function by
            membrane-bound peptidases
  JOURNAL   Biochim Biophys Acta 1751 (1), 26-32 (2005)
   PUBMED   15897020
  REMARK    GeneRIF: A novel membrane-bound cell surface peptidase, laeverin
            (FLJ90650), was found to be specifically expressed on extravillous
            trophoblasts that had almost ceased invasion into maternal decidual
            tissues.
            Review article
REFERENCE   10 (bases 1 to 4604)
  AUTHORS   Fujiwara,H., Higuchi,T., Yamada,S., Hirano,T., Sato,Y.,
            Nishioka,Y., Yoshioka,S., Tatsumi,K., Ueda,M., Maeda,M. and
            Fujii,S.
  TITLE     Human extravillous trophoblasts express laeverin, a novel protein
            that belongs to membrane-bound gluzincin metallopeptidases
  JOURNAL   Biochem Biophys Res Commun 313 (4), 962-968 (2004)
   PUBMED   14706636
  REMARK    GeneRIF: Extravillous trophoblasts express laeverin, a novel
            protein that belongs to membrane-bound gluzincin
            metallopeptidases(laeverin)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010282.6, BC109023.1, AY560010.1, BC060869.1, BX096521.1 and
            AC034236.5.
            
            On Nov 23, 2018 this sequence version replaced NM_173800.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY560010.1, AK291655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357872.9/ ENSP00000350541.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-806               AC010282.6         95104-95909         c
            807-2182            BC109023.1         692-2067
            2183-3398           AY560010.1         2092-3307
            3399-3815           BC060869.1         3347-3763
            3816-3817           BX096521.1         201-202
            3818-4600           BC060869.1         3764-4546
            4601-4604           AC034236.5         152456-152459       c
FEATURES             Location/Qualifiers
     source          1..4604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.1"
     gene            1..4604
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /note="laeverin"
                     /db_xref="GeneID:206338"
                     /db_xref="HGNC:HGNC:26904"
                     /db_xref="MIM:610046"
     exon            1..838
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..3116
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /note="AP-Q; CHL2 antigen"
                     /codon_start=1
                     /product="aminopeptidase Q"
                     /protein_id="NP_776161.3"
                     /db_xref="CCDS:CCDS4124.1"
                     /db_xref="GeneID:206338"
                     /db_xref="HGNC:HGNC:26904"
                     /db_xref="MIM:610046"
                     /translation="MGPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVP
                     PSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWL
                     VPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRG
                     PLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLRE
                     GLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNM
                     PKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEIRIWARKD
                     AIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDES
                     GLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVIN
                     YFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGAS
                     MARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNI
                     MDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKNRTLLTSNDTWIVPILWIKNGTTQP
                     LVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIP
                     VIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVSEVN
                     IYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGLED
                     CLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEKI
                     QLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEVGRYVAKDFLVNNWQ
                     AVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIRVHANLQTIKNEN
                     LKNKKLSARIAAWLRRNT"
     exon            839..981
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1121
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1248
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1403
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1517
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1658
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1724
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1790
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1963
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2040
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2180
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2236
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2390
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2485
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2593
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2761
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2899
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2975
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..4604
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /note="hexamer: AACAAA"
     polyA_site      3395
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /note="hexamer: AATAAA"
     polyA_site      4604
                     /gene="LVRN"
                     /gene_synonym="APQ; AQPEP; TAQPEP"
                     /note="major polyA site"
ORIGIN      
        1 agtccgtcca ggctcttcca ggaggaagag gcacgataca agagaggagg ggcaggggtc
       61 gcagcactga acaccctggc cggggttttg acagctgcca cagtctctga gctccagcct
      121 cgcgcctgaa cccggtccct gccatggggc ccccttccag ctcaggcttc tatgtgagcc
      181 gcgcagtggc cctgctgctg gctgggctgg tagccgccct cctgctggcg ctggccgtac
      241 tcgccgcctt gtacggccac tgcgagcgcg tcccaccgtc ggagctgcct ggactcaggg
      301 acttggaagc cgagtcttcc cctcccctca ggcagaagcc gacgccaacc ccgaaaccca
      361 gcagtgcacg cgagctagcg gtgacgacca ccccgagcaa ctggcgaccc ccggggccct
      421 gggaccagct acgcctgccg ccctggctcg tgccgctgca ctacgatctg gagctgtggc
      481 cgcagctgag gcccgacgag cttccggccg ggtctttgcc cttcactggc cgcgtgaaca
      541 tcacggtgcg ctgcacggtg gccacctctc gactgctgct gcatagcctc ttccaggact
      601 gcgagcgcgc cgaggtgcgg ggaccccttt ccccgggcac tgggaacgcc acagtgggcc
      661 gcgtgcccgt ggacgacgtg tggttcgcgc tggacacgga atacatggtg ctggagctca
      721 gtgagcccct gaaacctggt agcagctacg agctgcagct tagcttctcg ggcctggtga
      781 aggaagacct cagggaggga ctcttcctca acgtctacac cgaccagggc gagcgcaggg
      841 ccctgttagc gtcccagctg gaaccaacat ttgccaggta tgttttccct tgttttgatg
      901 agccagctct gaaggcaact tttaatatta caatgattca tcatccaagt tatgtggccc
      961 tttccaacat gccaaagcta ggtcagtctg aaaaagaaga tgtgaatgga agcaaatgga
     1021 ctgttacaac cttttccact acgccccaca tgccaactta cttagtcgca tttgttatat
     1081 gtgactatga ccacgtcaac agaacagaaa ggggcaagga gatacgcatc tgggcccgga
     1141 aagatgcaat tgcaaatgga agtgcagact ttgctttgaa catcacaggt cccatcttct
     1201 cttttctgga ggatttgttt aatatcagtt actctcttcc aaaaacagat ataattgcct
     1261 tgcctagttt tgacaaccat gcaatggaaa actggggact aatgatattt gatgaatcag
     1321 gattgttgtt ggaaccaaaa gatcaactga cagaaaaaaa gactctgatc tcctatgttg
     1381 tctcccacga gattggacac cagtggtttg gaaacttggt taccatgaat tggtggaaca
     1441 atatctggct caacgagggt tttgcatctt attttgagtt tgaagtaatt aactacttta
     1501 atcctaaact cccaagaaat gagatctttt tttctaacat tttacataat atcctcagag
     1561 aagatcacgc cctggtgact agagctgtgg ccatgaaggt ggaaaatttc aaaacaagtg
     1621 aaatacagga actctttgac atatttactt acagcaaggg agcgtctatg gcccggatgc
     1681 tttcttgttt cttgaatgag catttatttg tcagtgcact caagtcatat ttgaagacat
     1741 tttcctactc aaacgctgag caagatgatc tatggaggca ttttcaaatg gccatagatg
     1801 accagagtac agttattttg ccagcaacaa taaaaaacat aatggacagt tggacacacc
     1861 agagtggttt tccagtgatc actttaaatg tgtctactgg cgtcatgaaa caggagccat
     1921 tttatcttga aaacattaaa aatcggactc ttctaaccag caatgacaca tggattgtcc
     1981 ctattctttg gataaaaaat ggaactacac aacctttagt ctggctagat caaagcagca
     2041 aagtattccc agaaatgcaa gtttcagatt ctgaccatga ctgggtgatt ttgaatttga
     2101 atatgactgg atattataga gttaattatg ataaattagg ttggaagaaa ctaaatcaac
     2161 aacttgaaaa ggatcctaag gcgattcctg ttattcacag actgcagttg attgatgatg
     2221 ccttttcctt gtctaaaaac aattatattg agattgaaac agcacttgag ttaaccaagt
     2281 accttgctga agaagatgaa attatagtat ggcatacagt cttggtaaac ttggtaacca
     2341 gggatcttgt ttctgaggtg aacatctatg atatatactc attattaaag aggtacctat
     2401 taaagagact taatttaata tggaatattt attcaactat aattcgtgaa aatgtgttgg
     2461 cattacaaga tgactactta gctctaatat cactggaaaa actttttgta actgcgtgtt
     2521 ggttgggcct tgaagactgc cttcagctgt caaaagaact tttcgcaaaa tgggtggatc
     2581 atccagaaaa tgaaatacct tatccaatta aagatgtggt tttatgttat ggcattgcct
     2641 tgggaagtga taaagagtgg gacatcttgt taaatactta cactaataca acaaacaaag
     2701 aagaaaagat tcaacttgct tatgcaatga gctgcagcaa agacccatgg atacttaaca
     2761 gatatatgga gtatgccatc agcacatctc cattcacttc taatgaaaca aatataattg
     2821 aggttgtggc ttcatctgaa gttggccggt atgtcgcaaa agacttctta gtcaacaact
     2881 ggcaagctgt gagtaaaagg tatggaacac aatcattgat taatctaata tatacaatag
     2941 ggagaaccgt aactacagat ttacagattg tggagctgca gcagtttttc agtaacatgt
     3001 tggaggaaca ccagaggatc agagttcatg ccaacttaca gacaataaag aatgaaaatc
     3061 tgaaaaacaa gaagctaagt gccaggatag ctgcgtggct aaggagaaac acatagcttg
     3121 tggctatctt tcagcactcc tcttgcatat tataatgtag tttgttcaca gttttgtctt
     3181 ccaatacttt gtgagtctgg aaaaccacac attttatttg tatttcagtc acatttatta
     3241 ctcagagtgc cattcttctc atattgtcat gtttggccct gagggtgggt gattgctgac
     3301 aattttgcca atgctgctgt atttctggga aagatgtcac ttcatgttgg gttataatcc
     3361 cacagaattt actttaaatg tcacgtaaaa acaaattcac ctaagatagt cttgcttatt
     3421 ttgttgcgaa ggccagtgga atataaaaat caatggcatt aatgaggagc acattctttg
     3481 ctgagggaaa taacagtttt tccaggccct agggtttatt tagttcaaca ttgaagattg
     3541 aaaagactaa tgagaagata acatgacaat ataaaaagac agaaactcaa aaagtatatt
     3601 cactagaaga cagtggagcc aaagaaaagc aagttgaaaa agaaagagga gacaatttaa
     3661 cgagccctaa aggcaagaag tgtgtcttct cctgcccatt tctctctccc acagtacatc
     3721 ctgcattgaa ccacgtgttg ctggttacta aactttatgg tgtcacaaaa agacaaatga
     3781 ttgtaggatc catggaagtg cacttaggct tgctgtggtg gaggccatag tggagatgaa
     3841 ggctctgctc tgaagctctt aattgtgtat tcaccagtgg gatggacacc ctttcagcct
     3901 aagcgtacga gtgaaaacaa tgatgtcaaa agacaatagc aagtataggc tactatttag
     3961 ggcaaaagga atcttgaaat gaaagaaaca gaactaaaag gctaactgga gcataatcct
     4021 tacagttttg cactcagggg attaagtttg aaacatagtg tcttttggcc aaattgaacc
     4081 tacttgtaat gtggaccaac ttactttaca cattttcatc agtcccaatg tatggaatta
     4141 gcttagtttt ctcatgcttg attaaaacaa gacaactaaa gctaatcatt cctcttctag
     4201 actttgtgta tatgatttaa tcttttattt ttatttttgt agaatggggg taaaactaca
     4261 aatctcctcc tcagggtgat atttttaaag attaaggagt atgacatcaa ttaacagtct
     4321 ttaaagatgt tacatacgct caaagcaatg tgattaagac tttttgccta tttcttgtat
     4381 aagttaaggc agccataaat gaaaatacaa aacaaacgtt tgcttttgta tttgattcac
     4441 aagaggattc tccctgagtg tcaggggagg ctgtgggact tcaccacgtg gacaaacgaa
     4501 agcacaggct actcagactt ggccacaggt cataggtcag agaatttttt cttcaaatgt
     4561 agaaatgtaa attttcagca ataaaatatc tgcatgccta caaa
//
