LOCUS       NM_016383               1746 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leucine zipper protein 4 (LUZP4), transcript variant
            1, mRNA.
ACCESSION   NM_016383
VERSION     NM_016383.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Viphakone,N., Cumberbatch,M.G., Livingstone,M.J., Heath,P.R.,
            Dickman,M.J., Catto,J.W. and Wilson,S.A.
  TITLE     Luzp4 defines a new mRNA export pathway in cancer cells
  JOURNAL   Nucleic Acids Res 43 (4), 2353-2366 (2015)
   PUBMED   25662211
  REMARK    GeneRIF: Luzp4 is an RNA-binding protein which associates with the
            TREX mRNA export complex subunit Uap56. Luzp4 also binds the
            principal mRNA export receptor Nxf1, enhances its RNA binding
            activity and complements Alyref knockdown in vivo. Luzp4 displays
            all features of an mRNA export adaptor. Whilst Luzp4 is
            up-regulated in a range of tumours, it appears preferentially
            expressed in melanoma cells where it is required for growth.
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Tureci,O., Sahin,U., Koslowski,M., Buss,B., Bell,C., Ballweber,P.,
            Zwick,C., Eberle,T., Zuber,M., Villena-Heinsen,C., Seitz,G. and
            Pfreundschuh,M.
  TITLE     A novel tumour associated leucine zipper protein targeting to sites
            of gene transcription and splicing
  JOURNAL   Oncogene 21 (24), 3879-3888 (2002)
   PUBMED   12032826
  REMARK    GeneRIF: A novel tumour associated leucine zipper protein targeting
            to sites of gene transcription and splicing.
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Sahin,U., Koslowski,M., Tureci,O., Eberle,T., Zwick,C., Romeike,B.,
            Moringlane,J.R., Schwechheimer,K., Feiden,W. and Pfreundschuh,M.
  TITLE     Expression of cancer testis genes in human brain tumors
  JOURNAL   Clin Cancer Res 6 (10), 3916-3922 (2000)
   PUBMED   11051238
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC239923.3, DB035084.1,
            AF124430.1 and AK093369.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016383.4.
            
            Summary: This gene encodes a leucine-zipper protein that was first
            defined as a cancer testis antigens. The encoded protein is an RNA
            binding protein that interacts with the mRNA export receptor
            nuclear RNA export factor 2. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.364378.1,
                                           SRR5189667.137125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371920.4/ ENSP00000360988.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC239923.3         90516-90517
            3-38                DB035084.1         1-36
            39-1174             AF124430.1         7-1142
            1175-1737           AK093369.1         1045-1607
            1738-1739           AF124430.1         1706-1707
            1740-1746           AC239923.3         108358-108364
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..1746
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /note="leucine zipper protein 4"
                     /db_xref="GeneID:51213"
                     /db_xref="HGNC:HGNC:24971"
                     /db_xref="MIM:300616"
     exon            1..136
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..987
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HOM-TES-85 tumor antigen; cancer/testis antigen 28; tumor
                     antigen HOM-TES-85"
                     /codon_start=1
                     /product="leucine zipper protein 4 isoform 1"
                     /protein_id="NP_057467.1"
                     /db_xref="CCDS:CCDS14567.1"
                     /db_xref="GeneID:51213"
                     /db_xref="HGNC:HGNC:24971"
                     /db_xref="MIM:300616"
                     /translation="MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDDIIIYKELEGTNA
                     EEEKNKRQNHSKKESPSRQQSKAHRHRHRRGYSRCRSNSEEGNHDKKPSQKPSGFKSG
                     QHPLNGQPLIEQEKCSDNYEAQAEKNQGQSEGNQHQSEGNPDKSEESQGQPEENHHSE
                     RSRNHLERSLSQSDRSQGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERS
                     HGHSERSHGHSKRSRSQGDLVDTQSDLIATQRDLIATQKDLIATQRDLIATQRDLIVT
                     QRDLVATERDLINQSGRSHGQSERHQRYSTGKNTITT"
     exon            137..268
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /inference="alignment:Splign:2.1.0"
     exon            269..387
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /inference="alignment:Splign:2.1.0"
     exon            388..1746
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1720..1725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /note="hexamer: AATAAA"
     polyA_site      1746
                     /gene="LUZP4"
                     /gene_synonym="CT-28; CT-8; CT28; HOM-TES-85"
                     /note="major polyA site"
ORIGIN      
        1 acacgcgccc tacctcggag tgtgtggcgc catgatgcag ggaagatggc ttcgtttcgg
       61 aagctaacgc tttctgaaaa agtgccgcca aatcatccca gtcggaaaaa ggttaacttc
      121 ctagatatgt ctctagacga cattataatc tataaagagt tagaagggac aaatgctgaa
      181 gaagaaaaga ataaaagaca gaaccatagt aaaaaggaat cgccttcaag acagcaatca
      241 aaagctcata gacatcgcca tcggagaggc tactcaagat gcagaagcaa ctctgaggaa
      301 ggaaatcatg ataaaaaacc atcccaaaaa ccttctggat tcaagtctgg acaacaccct
      361 ttaaatgggc agcctttaat tgagcaggag aagtgcagtg acaattatga ggcccaagca
      421 gagaagaatc aaggccagtc agaggggaac cagcatcaat cagaaggaaa tccggacaaa
      481 tcagaagaat cccagggcca accagaagaa aatcatcatt ctgagcgatc ccgaaaccac
      541 ttagagagat ctctttctca gtcagacaga tctcaagggc agctaaagag acatcatccc
      601 caatatgaga gatctcatgg ccaatacaag agatctcatg gtcaatctga gagatctcat
      661 ggccactcag agagatctca tggtcactca gagagatctc atggtcactc agagagatct
      721 catggtcact caaagagatc tcgtagccag ggagatcttg tggacactca gagtgatctc
      781 atagccactc agagagatct catagccact cagaaagatc tcatagccac tcagagagat
      841 ctcatagcca ctcagagaga tctcatagtc actcagagag atctcgtggc cactgagaga
      901 gatctcataa atcagtcagg gagatctcat ggccaatcag aaagacatca gagatactca
      961 acaggtaaaa atacaataac tacttaatca tcagaacaat gtgttgaatt ctgtggaaat
     1021 agaaaagcat atatctatat tctaatggct aaatatgtat ttgttgaaac atgtatattg
     1081 ggacaaagac ataaatatta gaatggaggt aatacataca tagtatcaat attgtttcaa
     1141 cttgatgtcc tctaagctat catccagtta cccaggatgt cccattaagt tgttcccggt
     1201 aggtctgctt tccctggaag agccgtatgt actcagcctt tcctattggg ccttccccac
     1261 aattagaata ttttgactta gtgtcctgtc ccccttggac gttccaactt gacttagtgt
     1321 ccagtgcccc ttggacattc caacctggta ggtaagctaa tctaacaact aactgccaaa
     1381 ttgataatat ataatctatg ataatgaata tctcttttgt gtctccttcc taagccatcc
     1441 tcagagagtc cttagcagac aaatggtaga tgtatctttg ggcagctgaa cttttctgct
     1501 ttcctcaaat cagaccatat gagaggatat attctatgca tagatgtaat gctaaccttc
     1561 tgaatatatt ttgaatacat ttatatattc actgttgcct tataaaactg ttagggtagg
     1621 tctgtctacc ctagcaaaag aaacacagaa atttaaatgt actgggagtt atgttgttaa
     1681 aaacacaaga tatgttaact gcagtttgtt tggttattca ataaaagttt tagttttaat
     1741 ttctca
//
