LOCUS       NM_001009909            5212 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leucine zipper protein 2 (LUZP2), transcript variant
            1, mRNA.
ACCESSION   NM_001009909 XM_370616
VERSION     NM_001009909.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5212)
  AUTHORS   Li,Y., Deng,G., Qi,Y., Zhang,H., Jiang,H., Geng,R., Ye,Z., Liu,B.
            and Chen,Q.
  TITLE     Downregulation of LUZP2 Is Correlated with Poor Prognosis of
            Low-Grade Glioma
  JOURNAL   Biomed Res Int 2020, 9716720 (2020)
   PUBMED   32695826
  REMARK    GeneRIF: Downregulation of LUZP2 Is Correlated with Poor Prognosis
            of Low-Grade Glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5212)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 5212)
  AUTHORS   Cummings,A.C., Jiang,L., Velez Edwards,D.R., McCauley,J.L.,
            Laux,R., McFarland,L.L., Fuzzell,D., Knebusch,C., Caywood,L.,
            Reinhart-Mercer,L., Nations,L., Gilbert,J.R., Konidari,I.,
            Tramontana,M., Cuccaro,M.L., Scott,W.K., Pericak-Vance,M.A. and
            Haines,J.L.
  TITLE     Genome-wide association and linkage study in the Amish detects a
            novel candidate late-onset Alzheimer disease gene
  JOURNAL   Ann Hum Genet 76 (5), 342-351 (2012)
   PUBMED   22881374
REFERENCE   4  (bases 1 to 5212)
  AUTHORS   Loo,S.K., Shtir,C., Doyle,A.E., Mick,E., McGough,J.J.,
            McCracken,J., Biederman,J., Smalley,S.L., Cantor,R.M., Faraone,S.V.
            and Nelson,S.F.
  TITLE     Genome-wide association study of intelligence: additive effects of
            novel brain expressed genes
  JOURNAL   J Am Acad Child Adolesc Psychiatry 51 (4), 432-440 (2012)
   PUBMED   22449649
REFERENCE   5  (bases 1 to 5212)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   6  (bases 1 to 5212)
  AUTHORS   Benyamin,B., McRae,A.F., Zhu,G., Gordon,S., Henders,A.K.,
            Palotie,A., Peltonen,L., Martin,N.G., Montgomery,G.W.,
            Whitfield,J.B. and Visscher,P.M.
  TITLE     Variants in TF and HFE explain approximately 40% of genetic
            variation in serum-transferrin levels
  JOURNAL   Am J Hum Genet 84 (1), 60-65 (2009)
   PUBMED   19084217
REFERENCE   7  (bases 1 to 5212)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 5212)
  AUTHORS   Wu,M., Michaud,E.J. and Johnson,D.K.
  TITLE     Cloning, functional study and comparative mapping of Luzp2 to mouse
            chromosome 7 and human chromosome 11p13-11p14
  JOURNAL   Mamm Genome 14 (5), 323-334 (2003)
   PUBMED   12856284
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA706662.1, BC132829.1,
            AC087373.4, AK126974.1 and AL832641.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001009909.3.
            
            Summary: This gene encodes a leucine zipper protein. This protein
            is deleted in some patients with Wilms tumor-Aniridia-Genitourinary
            anomalies-mental Retardation (WAGR) syndrome. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.216111.1, AL832641.3
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336930.11/ ENSP00000336817.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               DA706662.1         84-208
            126-2983            BC132829.1         1-2858
            2984-2984           AC087373.4         107383-107383
            2985-5210           AK126974.1         2111-4336
            5211-5212           AL832641.3         5204-5205
FEATURES             Location/Qualifiers
     source          1..5212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.3"
     gene            1..5212
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /note="leucine zipper protein 2"
                     /db_xref="GeneID:338645"
                     /db_xref="HGNC:HGNC:23206"
                     /db_xref="MIM:608178"
     exon            1..253
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1232
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="leucine zipper protein 2 isoform 1 precursor"
                     /protein_id="NP_001009909.2"
                     /db_xref="CCDS:CCDS31446.1"
                     /db_xref="GeneID:338645"
                     /db_xref="HGNC:HGNC:23206"
                     /db_xref="MIM:608178"
                     /translation="MKFSPAHYLLPLLPALVLSTRQDYEELEKQLKEVFKERSTILRQ
                     LTKTSRELDGIKVNLQSLKNDEQSAKTDVQKLLELGQKQREEMKSLQEALQNQLKETS
                     EKAEKHQATINFLKTEVERKSKMIRDLQNENKSLKNKLLSGNKLCGIHAEESKKIQAQ
                     LKELRYGKKDLLFKAQQLTDLEQKLAVAKNELEKAALDRESQMKAMKETVQLCLTSVF
                     RDQPPPPLSLITSNPTRMLLPPRNIASKLPDAAAKSKPQQSASGNNESSQVESTKEGN
                     PSTTACDSQDEGRPCSMKHKESPPSNATAETEPIPQKLQMPPCSECEVKKAPEKPLTS
                     FEGMAAREEKIL"
     exon            254..371
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            372..442
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            443..524
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            525..587
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            588..650
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            651..713
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            714..788
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            789..956
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1049
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1127
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..5212
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5158..5163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /note="hexamer: AATAAA"
     polyA_site      5178
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /note="major polyA site"
     regulatory      5193..5198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /note="hexamer: AATAAA"
     polyA_site      5212
                     /gene="LUZP2"
                     /gene_synonym="KFSP2566; PRO6246"
                     /note="major polyA site"
ORIGIN      
        1 actcctgaag atactcctcg ctcccagcgc ctgccttccc caggcgtccg ttcgtgtgcc
       61 cgtctccgcc tttccgcctc ggaagagcgc tcatcactgg ctggggacag agccgggcac
      121 caaggagcga caggatcccg aagagagaga gagaaggcag cgagggaagg aggaccccgg
      181 caggcagcag catgaaattc agcccagcgc actacctgct gcctctcctg cctgcgctgg
      241 tcctcagcac cagacaggac tatgaagagc tagaaaagca gctgaaagaa gtctttaagg
      301 agcgaagcac cattcttcgt cagctgacaa agacatcaag agaacttgat ggaattaaag
      361 tcaatcttca gtccttaaaa aacgatgagc agtctgccaa aactgatgtt cagaaacttc
      421 tggaattagg acagaaacaa agagaagaaa tgaagtctct tcaggaggcc ctgcaaaatc
      481 agcttaagga gacatcagag aaagcagaaa aacaccaggc tactattaat tttttaaaga
      541 ctgaagttga aagaaagagc aaaatgatcc gagacctcca gaatgagaat aaaagcttga
      601 aaaacaaact cttgtcagga aacaagctct gtggcattca cgcagaagag tcaaaaaaaa
      661 tccaagccca gctgaaggag cttcgttatg ggaagaagga tttattattt aaggcgcagc
      721 agcttactga tctggaacaa aaattagctg tagccaaaaa tgaactggag aaagcagctc
      781 ttgacaggga gtcacagatg aaagcaatga aagagactgt gcagctctgc ttgacatctg
      841 ttttccgtga tcagcctcct ccccctttga gtttaatcac atcaaatcca actcggatgt
      901 tactcccacc caggaatatt gcctctaagc ttccagatgc agcggccaaa agcaagcctc
      961 aacaaagtgc ttctggaaac aatgagagct ctcaagttga gtcaacaaag gaaggaaatc
     1021 caagtaccac tgcctgtgac tctcaagatg agggcagacc gtgttccatg aagcacaaag
     1081 aaagtccccc aagtaatgcc actgcagaaa ccgagcctat cccacagaaa ttgcaaatgc
     1141 ctccttgctc tgaatgtgag gtgaaaaaag ccccagaaaa accattgacc agctttgaag
     1201 ggatggcagc tagagaagaa aaaatactgt aaatactaag aaactgtgtt aaaaacgtcc
     1261 atttgctatt gtcttcatat tctttttaga ccacaagctt gatggaaata ctgtttctaa
     1321 agcatgcaac tttttcacaa ttttatgtaa ctttataaag tagcctacac attttcaaag
     1381 attccagacc aattatgatc cttaagcaat aacctcattg aattgaatac ccacagtcag
     1441 aaatattttg ttgtcaacag taaattgtcc catataaatt ggtctggttt aactcaaatg
     1501 ctatctaaca tgtaattctc ccggttcatt tggatatcta gtacttctat gatatagttg
     1561 tcaaaatcaa ctggaggata ataaaatatt gtgggttctc agcattctta gaatccaaat
     1621 tacaaccata tcagtaaggg tttggtccac atgagccaac tgaagtcatt ttcctcaagg
     1681 ttggaatttg tgccaaccta aatacgttgt ttctttgatg gtgtttattg ctattggtat
     1741 tattttgaac taataacaat tattttgtct aaataatgct aagacaattc tgttaagaat
     1801 tttgtcagct aacataattc attaagtatg tttggcatca tatggacaaa atatttggat
     1861 gaatgactaa atttctgaca caattaaata ttttggcatt ctatagacac atctcctatg
     1921 tatgtctact gtaattaatc caagttaata accaagtttt ctgaaatact tggcaggatt
     1981 tttggtatga agttgggtag tggaataggg aatgaagagt gagttctaaa atacaaatat
     2041 gaaagcaggt aatatatatc acaaaacagg ggtctgatga aagtacaata gccatgttga
     2101 ttcaataaac ccagatgcat attttttgaa aaccaatgtg ttattgaaac aaatcaatgg
     2161 cagtgttaat ccataagagt tctgattttc tataggaata tcactaatca aaaaaatgca
     2221 ctcatgaata attggaagat agctcacaag caagaggaat tgacccttga ataattatct
     2281 gattaatagg tttcataggg cattcaaagt tgcagactca gttaatgact acagttaagt
     2341 tgtctggact gaaaagtcat ttcttttgtt tagaaccttt ttgcaaccgt agaaagcata
     2401 ttaaaccatt ggttttgcag gatggatctg tcaaaccaca atatatacat ttggatcagt
     2461 gtatcctagg agacagttaa taaaaatgta ttaaaggaaa tctttaatca ataaatgaac
     2521 ttagattctg agatttaatg gcatacctct gatcaaaatg gcatatttaa agaaatttaa
     2581 agatttggag aattggaaaa tatcgttagc tgtaaaagta atattatgac atatttatgt
     2641 agcacttcta ttttcagaat agttcagtgt cattcattag cacaggcagg tcccaaccac
     2701 aatggttcaa cttaacggtt ttttcatgat tctgtgaaag cttcataatt tctacatgct
     2761 ttgaattttg aattttgtta ttttttggag ggctagtgat acatggtcca tgaaatattc
     2821 aacactttat tataaaatag ggtttgtgtt agacaatttg cccaactgta ggatgaggta
     2881 tatgttctga gcacgtttaa gcaggtttaa gttagggtgg gctatgattt tccatttagg
     2941 tatctgaaat gcatttcaga cttacaatgt tttcaacctt tgacttcttt atctgtatgt
     3001 aatcctattg ttaaatcaag gagcattcat atttttcata aaaccggcta cccaaggaaa
     3061 aaaataatta gctttatgga tgatccatag agctttcaga tgaagtgact aggataaaat
     3121 aaaagatgaa ggtctgaggt ttcttctgac tccttcatat ttctaaaaat aatcatacaa
     3181 actagaatac tgctagtctc ccaagtcctg ttccttgtaa ttctcccact gttctcagtg
     3241 gccctaacca tctctatagg ttcctgacag ggaagcagat catttagttt taatttatgt
     3301 tcagtctccc acctccaccc tggggcccaa cttcccttgc aggccttgtg ggtcctatag
     3361 aaagttattc accatgtaat ctagcacagc atgttttgaa gcatctttgg aatgaaaaaa
     3421 aagaagaatc aggctgttat ttcctgaaat tgttatgaga gataacatgt tgaaaggtaa
     3481 gaactcaggt tgatattaat catgttttta tcaatcttca ttttaaagtt gtttttgttc
     3541 tgtatattct aaattccttt tattaattcc tggcttgatc aagtgggctt tggatccata
     3601 tgattttttt tttttttttt ttttgagatg aaatctcgct cttgttgccc aggctggagt
     3661 gcaatggagc gatcttggct cactgcaact ctgcttccca ggttcaagtg attctccctg
     3721 cctccgcctc ccaagtagct gggattacag gtacctgcca ccatgcccgg ctaattttta
     3781 tatttttaat agagacgggg tttcaccatg ttggccaggc tggtctcgaa ctcctgacct
     3841 caggcgatcc acctgcctca gtctcctccc aaaatgctgg gattacaggt gtgagccacc
     3901 gtgcctggcc agtgtgtttt tttcctttaa atatatatgg cattatacat ccagcaaagt
     3961 ttactgtgtt atactcattg catcatttgt ttaaaaaaaa aaaagaaact tgtagcagga
     4021 gacatttaaa aatatattta ggagttcctt ttaataacta agttagagac tctctttcag
     4081 taagttctat gactgtacct taatgaatgc attttattta tctcaatttt tatttgcttc
     4141 aaaatagaat cggataagtt taaaatgttc ctcttacatt tgtgaatgtg tctatgagag
     4201 aggggccatt tctcacatat tttaattaac aactaaataa acagacgttg ttttaaagga
     4261 attaacactt aaatcccaac catcctcata tagaataaaa tatcaaccta aatctttact
     4321 atagatagta taattctatt atgtacctgt aatgataagc attgaaagat tatttacatt
     4381 ttgaaaaaca tggaattgat tcttattaag aaaaaagata ttttccaatg gagtaacttg
     4441 ttttaataga ggtacaacca gaaccaacaa ttgtatttct ctatagttat tttaaaatag
     4501 taatcaatgc tatgtatttg atgtatatgt ttctaaatta gaaatttctt ttggctttgt
     4561 gtttttttaa tgtgcgttaa atatgtaaac tgaacctgtt cctaaaatgc attaaacttg
     4621 aatgctgtgt ctatccaatg ccaaaatgct cagaagaaaa gtgaataatt cagtcattca
     4681 tctggatgta gttttctgtg taatctcaaa tatctgaata ttgaaaaaac taggttgcta
     4741 acttttttca ttccttatgc aaatgtttag catcatagtg ctgtttcaga tacagatctg
     4801 tttcatcaaa tatcctcaat tacaagtcta agacagttat atgtaaagaa aatgtattat
     4861 tttagatgaa caatgtggat aactgaacta aaacgatatt tgtgaacttt gctataatga
     4921 aatcttttat ttttatagct caggtattgt aattagcact aattgcagca gagactgaaa
     4981 taattattga caccgtagag taccatagag taggttgaac tggccagacc tagacaatga
     5041 agaaaacaca tactgtttac ttaggagaca ttttcttagt cgtgtgtata gtcctaaatt
     5101 tccccaaact atgtgttcat ttggattgtg ttatataata acagtcgaat gatgaagaat
     5161 aaaagatgct gaaagatggc ctatttttgt tcaataaaga ttgttacaag aa
//
